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Cited by 36T-cell and B-cell ImmunologyDevelopmental Biology and Gene RegulationGene Regulatory Network Analysis

Hematopoiesis and T‐cell specification as a model developmental system

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Rothenberg, Ellen V., Kueh, Hao Yuan, Yui, Mary A., Zhang, Jingli A.·2016·Immunological Reviews
DOI 10.1111/imr.12417PMC PMC4837658
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Abstract

Summary: The pathway to generate T cells from hematopoietic stem cells guides progenitors through a succession of fate choices while balancing differentiation progression against proliferation, stage to stage. Many elements of the regulatory system that controls this process are known, but the requirement for multiple, functionally distinct transcription factors needs clarification in terms of gene network architecture. Here, we compare the features of the T‐cell specification system with the rule sets underlying two other influential types of gene network models: first, the combinatorial, hierarchical regulatory systems that generate the orderly, synchronized increases in complexity in most invertebrate embryos; second, the dueling ‘master regulator’ systems that are commonly used to explain bistability in microbial systems and in many fate choices in terminal differentiation. The T‐cell specification process shares certain features with each of these prevalent models but differs from both of them in central respects. The T‐cell system is highly combinatorial but also highly dose‐sensitive in its use of crucial regulatory factors. The roles of these factors are not always T‐lineage‐specific, but they balance and modulate each other's activities long before any mutually exclusive silencing occurs. T‐cell specification may provide a new hybrid model for gene networks in vertebrate developmental systems.

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  • Some PU.1 expression is still detectable at later stages, in the same individual cells that go through T-cell commitment marked by Bcl11b activation.

    “intracellular protein staining confirmed that some PU.1 expression is still detectable at later stages, in the same individual cells that go through T-cell commitment (marked by activation of the Bcl11b gene) (33, 93).”

    From Mechanisms of Action of Hematopoietic Transcription Factor PU.1 in Initiation of T-Cell Development (2019) · cites this paper as [93]

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Authors
Rothenberg, E. V., Kueh, H. Y., Yui, M. A., & Zhang, J. A.
Affiliations
California Institute of Technology (US)
Corresponding author
Rothenberg, Ellen V.
ORCID
Venue
Immunological Reviews
Publisher
Wiley
Published
2016-04-18
Volume
271
Issue
1
Pages
72-97
ISSN
  • 0105-2896 (ISSN-L)
  • 1600-065X
DOI
10.1111/imr.12417
PMC
PMC4837658
OpenAlex
W2341654127
Cited by
36
References
30
Citations by year
2026: 1 · 2025: 6 · 2023: 2 · 2022: 2 · 2021: 4 · 2020: 5 · 2019: 8 · 2018: 2 · 2017: 3 · 2016: 3
FWCI
0.51
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Immunological Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • CaltechAUTHORS (California Institute of Technology) (submittedVersion)
Funders
National Institutes of Health (RC2CA148278, R01AI083514, R01AI095943, R01CA90233, R01HD076915, R01HL119102, R01AI064590, K99HL119638A)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
Keywords
hematopoiesis, hematopoietic stem cells, transcription factors, gene regulatory networks, combinatorial regulation, bistability, dosage sensitivity
MeSH terms
Animals, Cell Differentiation, Hematopoiesis, Hematopoietic Stem Cells, Humans, Immune System, Models, Biological, T-Lymphocytes, Gene Expression Regulation, Developmental, Cell Lineage, Gene Regulatory Networks

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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