UCP2 mediates ghrelin’s action on NPY/AgRP neurons by lowering free radicals

Andrews, Zane B., Liu, Zhong-Wu, Walllingford, Nicholas, Erion, Derek M., Borok, Erzsebet, Friedman, Jeffery M., Tschöp, Matthias H., Shanabrough, Marya, Cline, Gary, Shulman, Gerald I., Coppola, Anna, Gao, Xiao-Bing, Horvath, Tamas L., Diano, Sabrina·2008·Nature

Cited by (709)

Items 601–700 of 709

  1. Molecular characterization and expression of the SiUCP2 gene in sea urchin Strongylocentrotus intermedius
    Lingshu Han, Zijiao Quan, Bing Han, Beichen Ding, Xiaofang Huang, Heng Wang, Yaqing Chang, Jun Ding · 2021 · Journal of Oceanology and Limnology
  2. Neuroendocrine Regulation of Energy Metabolism
    Marcelo O. Dietrich, Tamás L. Horváth · 2012 · Endocrinology and Metabolism
  3. Neurochemical Effects of Long Term Consumption of High Fat Diet
    A. A. Farooqui · 2015 · Springer eBooks
  4. Loss of Autophagy in Hypothalamic Neurons May Be Involved in the Pathogenesis of Obesity
    Yenniffer Ávalos, María Paz Hernández‐Cáceres, Lilian Toledo, Eugenia Morselli · 2017 · Elsevier eBooks
  5. Hypothalamic Control of Appetite and Energy Metabolism
    Alex Reichenbach, Romana Stark, Zane Bruce Andrews · 2013
  6. A STUDY COMPARING THE ANORECTIC ACTIVITY OF HOT AND COLD AQUEOUS EXTRACTS OF DOLICHOS BIFLORUS LINN. SEEDS IN FREELY FEEDING RATS
    S Shanmugapriya, R Senthurselvi, K. Bhuvaneswari · 2016 · International Journal of Pharmacy and Pharmaceutical Sciences
  7. Ghrelin
    Omar Al–Massadi, Kristy M. Heppner, Rubén Nogueiras, Diego Pérez–Tilve, Matthias H. Tschöp · 2013 · Elsevier eBooks
  8. Food intake regulation: Relevance to bariatric and metabolic endoscopic therapies
    Daniel Gonzalez Izundegui, Sneha Singh, Andres J Acosta · 2020 · Techniques and Innovations in Gastrointestinal Endoscopy
  9. Malnourishment during early lactation disrupts the ontogenetic distribution of the CART and α-MSH anorexigenic molecules in the arcuate/paraventricular pathway and lateral hypothalamus in male rats
    Michael Luis Martins Rocha, P.P. Fernandes, Frank Tenório, Alex C. Manhães, Penha Cristina Barradas · 2020 · Brain Research
  10. Neural Control of Homeostatic Feeding and Food Selection
    Yasuhiko Minokoshi · 2020 · IntechOpen eBooks
  11. Ghrelin: Neuropeptide Regulator of Metabolism
    Pablo J. Enriori, Zane Bruce Andrews, Michael Alexander Cowley · 2012 · Humana Press eBooks
  12. Helicobacter pyloriInfection and Metabolic Disease
    Hyung Hun Kim · 2013 · Korean Journal of Medicine
  13. Effects of the combination of intermittent fasting and physical exercise on autophagic and leptin pathway in the hypothalamus of obese mice
    Luciana da C. Oliveira · 2022 · Digital Library of Theses and Dissertations (Universidade de São Paulo)
  14. Achieving dopamine homeostasis to combat brain-gut functional impairment: behavioral and neurogenetic correlates of reward deficiency syndrome
    Kenneth Blum, Bernard William Downs, Debasis Bagchi, Gene‐Jack Wang, Panyotis K. Thanos, Igor Elman, Rehan Jalali, Abdalla Bowirrat, David A. Baron, Diwanshu Soni et al. · 2022 · Elsevier eBooks
  15. Unveiling the veil of adipokines: A meta-analysis and systematic review in amyotrophic lateral sclerosis
    Hamid Abbasi, Neda Jourabchi‐Ghadim, Ali Asgarzadeh, Mobin Mirshekari, Mehrangiz Ebrahimi‐Mameghani · 2024 · Neuroscience
  16. Ameliorative Effect of Raspberry Ketone on Hypothalamic Inflammation in High Fat Diet-Induced Obese Mice
    Yao Zhao, Zhenhua ZHU, Xingyou Chen, Xiaoping Li · 2024 · Journal of Nutritional Science and Vitaminology
  17. Potential Mitochondria-Related Key Genes in Post-Traumatic Stress Disorder Analyzed by Machine Learning Methods
    Ke Li, Gaomeng Luo, Mingyue Fu, Runming Liu, Wei Wei, Mian Peng · 2025 · Neuropsychiatric Disease and Treatment
  18. Brain Nutrient Sensing: A Unifying Framework
    Clémence Blouet, Gary J. Schwartz · 2025 · Annual Review of Physiology
  19. Transcriptome changes in overweight neutered female dogs undergoing a weight loss program with or without Spirulina (Arthrospira platensis) supplementation
    Greta Mucignat, Davide Stefanutti, Marianna Pauletto, Edoardo Pietropoli, Rosa Maria Lopparelli, Mery Giantin, Mauro Dacasto, Rebecca Ricci · 2026 · BMC Veterinary Research
  20. Targeting Gβγ subunits in hypothalamic AgRP neurons to treat obesity
    Xuan Ye, Xiaoyue Xiong, Xinyu Wang, Yunqi Wang, Yun Heng Shen, Heng Zhang, Rong Zhang, Liwei Chen, Peng Zhang, Yi Zhang et al. · 2026 · Metabolism
  21. Neurobiological mechanisms of second-generation antipsychotic-induced obesity: Interactions between ghrelin signaling and neurotransmitter systems
    Nevena S. Zogovic, Ana Despotović, Maja Misirkic-Marjanovic, Ljubica M. Vucicevic, Kristina Janjetović · 2026 · Brain Research Bulletin
  22. Targeting macrophage metabolism: Ghrelin regulates macrophage polarization via dual modulation of the AMPK/mTOR axis in immune-mediated diseases
    Shiwang Wu, Zheng Chang, Xinyi Ye, Yamei Huang, Haotian Yuan, Huiyi Wang, Si Chen, Nan Zhang, Shan Wang · 2026 · International Immunopharmacology
  23. Ghrelin, a Gastric Hormone with Diverse Functions
    Ziru Li, Jie Luo, Yin Li, Weizhen Zhang · 2012 · InTech eBooks
  24. Reactive oxygen species signaling influences feeding behaviour
    John Lyngdoh, Julie Birdie Wahlang, Banylla Nongkynrih · 2015 · International Journal of Research in Medical Sciences
  25. Molecular analysis of central feeding regulation in hypothalamic nuclei using the siRNA vectors–NPY system
    Hiroshi Higuchi, Tomohiro Shiiya, Shin-ichi Murase · 2011 · Folia Pharmacologica Japonica
  26. Food intake regulation by hypothalamic AMPK
    Yasuhiko Minokoshi · 2011 · Folia Pharmacologica Japonica
  27. Mediation of oxidative stress in hypothalamic ghrelin‐associated appetite control in rats treated with phenylpropanolamine
    Cong Yu, Shu‐Chen Chu, P.‐N. Chen, Ya‐Chu Hsieh, Dong‐Yih Kuo · 2016 · Genes Brain & Behavior
  28. 3.15 Neuronal Energy Production
    Bahar Hazal Yalçınkaya, Seda Genç, Mustafa Özilgen, Bayram Yılmaz · 2018 · Elsevier eBooks
  29. Actinodaphnine and Rutacridone as New T-Cell Protein Tyrosine Phosphatase Inhibitors for Drug Development of Obesity
    Yeniar Fitrianingrum, Dono Indarto, R Kusumawati, Yuliana Heri Suselo · 2019 · IOP Conference Series Materials Science and Engineering
  30. Effects of mitochondrial uncoupling protein 2 inhibition by Genipin on rat bone marrow mesenchymal stem cells under hypoxia and serum deprivation (H/SD) conditions.
    Qi Zhang, Shi-Peng Wang, Lili Li, Yao Zhang · 2017 · PubMed Central
  31. Ghrelin Regulation of AMPK in the Hypothalamus and Peripheral Tissues
    Miski Scerif, Blerina Kola, Márta Korbonits · 2012 · Humana Press eBooks
  32. Hypothalamic Glucose Hypersensitivity-Induced Insulin Secretion in the Obese Zücker Rat Is Reversed by Central Ghrelin Treatment
    Lionel Carneiro, Claire Fenech, Fabienne Liénard, Sylvie Grall, Besma Abed, Joulia Haydar, C. Allard, Lucie Delphine Desmoulins, Romain Paccoud, Marie‐Claude Brindisi et al. · 2023 · Antioxidants and Redox Signaling
  33. Fatty Acids and Hypothalamic Dysfunction in Obesity
    Gustavo D. Pimentel, Cristina Contreras, Miguel López · 2016 · Elsevier eBooks
  34. Obesity and Stress: The Melanocortin Connection
    Sara Singhal, Jennifer Wootton Hill · 2018 · Springer eBooks
  35. The Anorectic Phenotype of the anx/anx Mouse Is Associated with Hypothalamic Dysfunction
    Ida A. K. Nilsson, Tomas G. M. Hökfelt, Martin Schalling · 2020 · Neuromethods
  36. Life is an Engineering Marvel of Water: It’s Water that Manages Noise to Synthesis Life
    Pushpendra Singh, Kanad Ray, Anirban Bandyopadhyay · 2022 · Studies in Rhythm Engineering
  37. The role of the hypothalamus in the maintenance of energy balance and peripheral glucose control
    Luis Varela, Tamás L. Horváth · 2015 · Wiley eBooks
  38. WITHDRAWN: Ghrelin in obesity and endocrine diseases
    Miski Scerif, Anthony Peter Goldstone, Márta Korbonits · 2011 · Molecular and Cellular Endocrinology
  39. Comparative secretome analysis of rat stomach under different nutritional status
    Lucía L. Senín, Arturo Roca-Rivada, Cecilia Castelao, Jana Alonso, Cintia Folgueira, Felipe F. Casanueva, María Pardo, Luisa Maria Seoane · 2015 · Data in Brief
  40. Mitochondria in Control of Hypothalamic Metabolic Circuits
    Carole M. Nasrallah, Tamás L. Horváth · 2015 · Wiley eBooks
  41. Ghrelin - The Defender of Fat in the Face of Stress: Implications in Obesity Treatment
    Zachary R. Patterson · 2014 · Carleton University's Institutional Repository (MacOdrum Library, Carleton University)
  42. Dinner for Two: Digging into how Ghrelin and Endocannabinoid Systems Interact in the Ventral Tegmental Area to Regulate Non-Homeostatic Feeding
    Alexander Edwards · 2020
  43. Nuevas acciones de p53: Homeostasis metabólica y efecto orexigénico de ghrelin
    Velasquez Raimundo, D. Vitullo Alfredo · 2012 · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
  44. Central Glucose Sensing and Control of Food Intake and Energy Homeostasis
    Lourdes Mounien, Bernard Thorens · 2011 · Wiley eBooks
  45. Ghrelin, Lipid Metabolism, and Metabolic Syndrome
    Pablo Blanco Martínez de Morentin, Sulay A. Tovar, Rubén Nogueiras, Miguel López, Carlos Diéguez · 2013 · Wiley eBooks
  46. Regulación de la secreción de GH, la ingesta y el metabolismo lipídico por péptidos derivados del gen de ghrelin
    V del Villar, María Jesús · 2011 · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
  47. HYPOTHALAMIC REGULATION OF FOOD INTAKE - FOCUS ON THE ANX/ANX MOUSE
    Ida A. K. Nilsson · 2010 · Figshare
  48. Study of carnitine palmitoyltransferase 1A (CPT1A) in adipose tissue. Effects on obesity, inflammation and insulin resistance
    Maria Ida Malandrino · 2013 · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
  49. UCP2 Overexpression Worsens Mitochondrial Dysfunction and Accelerates Disease Progression in a Mouse Model of Amyotrophic Lateral Sclerosis
    Pablo Marco Veras Peixoto, Hyun‐Jeong Kim, Giovanni Manfredi · 2014 · Biophysical Journal
  50. INFLUENCE OF ALCOHOL ON SOME APPETITE- REGULATING HORMONES IN MAN
    Jan Calissendorff · 2008
  51. Regulation of Pancreatic Beta Cell Mass and Function by Proghrelin Derived Peptides
    Stephanie Nelson · 2010 · Library and Archives Canada (Government of Canada)
  52. [The efficacy of immunomodulating therapy in patients with chronic cholestatic liver diseases].
    A M Petrunia, Iu A Enenko · 1996 · PubMed
  53. The Central Nervous System in Metabolic Syndrome
    Luís Martins, Andrew J. Whittle, Rubén Nogueiras, Antonio Vidal‐Puig, Carlos Diéguez, Miguel López · 2013 · Springer eBooks
  54. The role of neuronal peroxisome proliferator-activated receptor delta in diet-induced obesity and hypothalamic inflammation
    Heidi E. Kocalis · 2012
  55. Plasticity of Brain Feeding Circuits in Response to Food
    Tamás L. Horváth · 2012 · Springer eBooks
  56. Role of insulin receptor substrate 1 in energy homeostasis in vivo
    Oliver Stöhr · 2012 · Kölner Universitäts PublikationsServer (Universität zu Köln)
  57. Understanding the mechanisms underlying the neuroprotective role of calorie restriction in Parkinson’s Disease
    Jacqueline A. Bayliss · 2017 · Figshare
  58. The Anorectic Phenotype of the anx/anx Mouse Is Related to Hypothalamic Dysfunction
    Ida A. K. Nilsson, Charlotte Lindfors, Tomas G. M. Hökfelt, Martin Schalling, Jeanette E. Johansen · 2012 · Neuromethods
  59. The Biochemistry of Hunger Stimulating Hormone: Why Understanding This Cascade In Hypothalamus Is Beneficial
    Mahjabin Rashid, Md. Shariful Islam · 2015 · Biochemistry & Physiology Open Access
  60. Obesity and Appetite: Central Control Mechanisms
    Tamás L. Horváth · 2016 · Elsevier eBooks
  61. Investigating the CaMKKβ signalling pathway and its role in the regulation of blood pressure
    Jiexin Zhao · 2014
  62. Regulation of Lipophagy
    Nuria Martínez-López · 2017 · CRC Press eBooks
  63. CNS hormonal and nutritional regulation of glucose and energy homeostasis
    Mona A. Abraham · 2017 · TSpace (University of Toronto)
  64. Role of Mitochondria in Brain Nutrient Sensing: Control of Energy Balance and Dysregulation in Obesity and Type 2 Diabetes
    Corinne Leloup, Luc Pénicaud · 2019 · Elsevier eBooks
  65. GHRELIN AND INSULIN RESISTANCE IN A SAMPLE OF IRAQI WOMEN WITH POLYCYSTIC OVARY SYNDROME
    Amal A. Hussein, Rayah Baban, Alaa G. Hussein · 2014 · DOAJ (DOAJ: Directory of Open Access Journals)
  66. The Role of Ghrelin and Ghrelin O-Acyltransferase in Obesity: Targets for Treatment
    Martin K. Wellman · 2016
  67. Acylated Ghrelin Increases in Young Adults with Obesity Due to Lack of Sleep
    Vicente Campos, Reyna-Echeveste EI · 2021 · Endocrinology and Disorders
  68. Characterisation of the ghrelinergic system in human models of neurodegenerative diseases
    Maria Carla Carisi · 2021 · Cronfa (Swansea University)
  69. Visualizing a Convergence of Three Mitochondrial Molecule mRNAs for Drp1/Mfn2/Ucp4 on Soma of Cerebellar Purkinje Cells by RNAscope
    Hui Liu, Tingting Luo, Feifei Wu, Baolin Guo, Kun-Long Zhang, Shujiao Li, Xiaodong Li, Ruiqing Wang, Jinghao Chen, Lu Wang et al. · 2021 · Research Square
  70. Faculty Opinions recommendation of Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance.
    Jorge Enrique Silva · 2012 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  71. Tamas Horvath: The hunger view on body, brain and behavior
    Tamás L. Horváth, Joy Hirsch, Zoltán Molnár · 2022 · Elsevier eBooks
  72. Faculty Opinions recommendation of Autophagy in hypothalamic AgRP neurons regulates food intake and energy balance.
    Toshihiro Nakajima, Naoko Yagishita · 2011 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  73. Faculty Opinions recommendation of Hunger states switch a flip-flop memory circuit via a synaptic AMPK-dependent positive feedback loop.
    William F. Colmers · 2011 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  74. Faculty Opinions recommendation of Peroxisome proliferation-associated control of reactive oxygen species sets melanocortin tone and feeding in diet-induced obesity.
    Lora K. Heisler · 2012 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  75. Identification and Design of a Novel Family of Mitochondrial Protonophores for Bioenergetics Analysis and the Treatment of Ischemia-Reperfusion Injury
    Brandon M. Kenwood · 2014
  76. Ghrelin-dependent mechanisms of food reward. Part 1. Ghrelin and dopamine
    Boris A. Reikhardt, Petr Dmitrievich Shabanov · 2022 · Reviews on Clinical Pharmacology and Drug Therapy
  77. Receptores LXR e seu papel na modulação do metabolismo e função de macrófagos residentes do tecido adiposo: uma nova ferramenta para o tratamento de doenças metabólicas
    Jéssica Aparecida da Silva Pereira · 2022 · Digital Library of Theses and Dissertations (Universidade de São Paulo)
  78. Hormone des Hypothalamus und der Hypophyse
    Josef Köhrle, Lutz Schomburg, Ulrich Schweizer · 2022 · Springer eBooks
  79. Differential expression of uncoupling protein gene in feed efficient cattle
    Amitava Dey, Shanker Dayal, Neeraj Kumar, RAMESH TIWARI, Nazrul Haque, Purushottam Kaushik · 2019 · The Indian Journal of Animal Sciences
  80. Nodweddu effaith signalu ghrelin-GHS-R ar awtoffagi niwronaidd
    Luke D. Roberts · 2022 · Cronfa (Swansea University)
  81. Temporal regulation of AgRP neurons mediates context-induced feeding
    Felicia M. Reed, Harry Dempsey, Rachel Clarke, Alex Reichenbach, Mathieu Méquinion, Romana Stark, Sasha Rawlinson, Claire J. Foldi, Sarah Haas Lockie, Zane Bruce Andrews · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  82. A Magyar Honvédség élelmezés-ellátásának modernizációs lehetőségei
    Zoltán Répás, Csaba Attila Bakos, Ferenc Hajdú, Orsolya Buzás-Bereczki, Zoltán Győri · 2023 · Honvédségi Szemle
  83. Homeostatic and Endocrine Response Underlying Protective Effects by Molecular Hydrogen
    Mami Noda, Назаров Евгений Иванович · 2024 · Advances in biochemistry in health and disease
  84. RNA-sequencing Reveals Altered Gene Expression in the Ventromedial Hypothalamus Following Predator Odor Exposure
    Ashely Shemery, Megan Gibson, Erin Gorrell, Diamond Daniel, Helen Piontkivska, Colleen M. Novak · 2024 · F1000Research
  85. The Injection of Ghrelin (OXE-103) Improves Subacute Concussion Symptom Burden and Quality of Life
    Michael A. Rippee, Michael S. Wyand, Jamie Chen, Amelia Kirchhoff-Rowald, Suzanne L. Hunt, Vishal Bansal · 2025 · Neurotrauma Reports
  86. Molecular mechanisms of reactive oxygen species and regulation of gene expression in cardiometabolic syndrome
    Martyna Fronczek, Maciej Banach, Marcin Goławski, Tadeusz Osadnik · 2025 · Elsevier eBooks
  87. Characterizing hypothalamic damage patterns in pigs with metabolic disorders by transcriptome analysis
    Huanqi Peng, Kaiyi Zhang, Jiakun Miao, Yu Yang, Shuang Xu, Tianwen Wu, Cong Tao, Yanfang Wang, Shulin Yang · 2025 · Journal of Endocrinological Investigation
  88. Metabolic Syndrome as a Disorder of the Brain with Its Origins in the Perinatal Period
    Undurti Narasimha Das · 2011 · Springer eBooks
  89. Ghrelin Regulation of Learning, Memory, and Neurodegeneration
    Tamás L. Horváth · 2012 · Humana Press eBooks
  90. Modulación de los canales de calcio presinápticos por variantes de receptores acoplados a proteína G humanos: "el receptor opioide mu y el receptor de ghrelina"
    Eduardo Javier López Soto · 2015
  91. The roles of the preproghrelin-derived peptides - ghrelin, desacyl ghrelin and obestatin - in prostate cancer
    de Amorim, Laura Assante Miranda · 2012 · Faculty of Science and Technology; Institute of Health and Biomedical Innovation
  92. Gallein targets AMPK in AgRP neurons: A new anti-obesity hypothalamic strategy?
    Miguel López, Christos Socrates Mantzoros · 2026 · Metabolism
  93. R-spondin 1 restores hypothalamic glucose-sensing and systemic glucose homeostasis via Wnt signaling in diet-induced obese mice
    Ming‐Liang Lee, Shawn He, Takashi Abe, Ching-Pu Chang, Ryosuke Enoki, Chitoku Toda · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  94. Détection des nutriments et contrôle central de la prise alimentaire
    Fabien Delaere · 2009 · theses.fr (ABES)
  95. Modulation de la dépression synaptique à long terme dans le noyau du tractus solitaire par le statut nutritionnel
    Abdessattar Khlaifia · 2015 · theses.fr (ABES)
  96. Impact de l'acide octanoïque alimentaire sur l'octanoylation de la Ghréline, chez le rat
    Fanny L. Lemarié · 2016
  97. Exploration de la plasticité neuronale et gliale dans le système à mélanocortine à l'échelle des repas dans un modèle murin.
    Danaé Nuzzaci · 2017 · theses.fr (ABES)
  98. Triglyceride-sensing in the mesocorticolimbic system and reward-driven behaviour control
    Chloé Berland · 2018 · theses.fr (ABES)
  99. Rôle du transporteur mitochondrial UCP2 dans la leucémie
    Tiphaine Sancerni · 2019 · theses.fr (ABES)
  100. Effets des enképhalines sur la contractilité intestinale : conséquences sur l'axe intestin-cerveau-périphérie dans le contrôle du métabolisme glucidique
    Arnaud Bessac · 2020 · theses.fr (ABES)