UCP2 mediates ghrelin’s action on NPY/AgRP neurons by lowering free radicals

Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1

Wu, Z., Puigserver, P., Andersson, U., Zhang, C., Adelmant, G., Mootha, V., Troy, A., Cinti, S., Lowell, B., Scarpulla, R. C., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80611-x · Cited by 4,139

Ghrelin induces adiposity in rodents

Tschöp, M., Smiley, D. L., & Heiman, M. L. (2000) · Nature · doi:10.1038/35038090 · Cited by 3,949

Anorexigenic and Orexigenic Hormone Modulation of Mammalian Target of Rapamycin Complex 1 Activity and the Regulation of Hypothalamic Agouti-Related Protein mRNA Expression

Watterson, K. R., Bestow, D., Gallagher, J. R., Hamilton, D. L., Ashford, F. B., Meakin, P. J., & Ashford, M. L. J. (2012) · Neurosignals · doi:10.1159/000334144 · Cited by 3,395

Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus

Cowley, M. A., Smart, J. L., Rubinstein, M., Cerdán, M. G., Diano, S., Horvath, T. L., Cone, R. D., & Low, M. J. (2001) · Nature · doi:10.1038/35078085 · Cited by 2,356

The Distribution and Mechanism of Action of Ghrelin in the CNS Demonstrates a Novel Hypothalamic Circuit Regulating Energy Homeostasis

Cowley, M. A., Smith, R. G., Diano, S., Tschöp, M., Pronchuk, N., Grove, K. L., Strasburger, C. J., Bidlingmaier, M., Esterman, M., Heiman, M. L., et al. (2003) · Neuron · doi:10.1016/s0896-6273(03)00063-1 · Cited by 1,679

AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus

Minokoshi, Y., Alquier, T., Furukawa, N., Kim, Y.-B., Lee, A., Xue, B., Mu, J., Foufelle, F., Ferré, P., Birnbaum, M. J., et al. (2004) · Nature · doi:10.1038/nature02440 · Cited by 1,637

Superoxide activates mitochondrial uncoupling proteins

Echtay, K. S., Roussel, D., St-Pierre, J., Jekabsons, M. B., Cadenas, S., Stuart, J. A., Harper, J. A., Roebuck, S. J., Morrison, A., Pickering, S., et al. (2002) · Nature · doi:10.1038/415096a · Cited by 1,382

Mitochondrial superoxide: production, biological effects, and activation of uncoupling proteins

Brand, M. D., Affourtit, C., Esteves, T. C., Green, K., Lambert, A. J., Miwa, S., Pakay, J. L., & Parker, N. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.05.034 · Cited by 1,032

Rapid Rewiring of Arcuate Nucleus Feeding Circuits by Leptin

Pinto, S., Roseberry, A. G., Liu, H., Diano, S., Shanabrough, M., Cai, X., Friedman, J. M., & Horvath, T. L. (2004) · Science · doi:10.1126/science.1089459 · Cited by 987

Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite

Abizaid, A., Liu, Z.-W., Andrews, Z. B., Shanabrough, M., Borok, E., Elsworth, J. D., Roth, R. H., Sleeman, M. W., Picciotto, M. R., Tschöp, M. H., et al. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29867 · Cited by 984

Recent Insights into the Role of Hypothalamic AMPK Signaling Cascade upon Metabolic Control

Schneeberger, M., & Claret, M. (2012) · Frontiers in Neuroscience · doi:10.3389/fnins.2012.00185 · Cited by 42

Unacylated Ghrelin Suppresses Ghrelin-Induced Neuronal Activity in the Hypothalamus and Brainstem of Male Rats

Stevanović, D., Grefhorst, A., Themmen, A. P. N., POPOVIC, V. M., Holstege, J. C., Haasdijk, E. D., Trajković, V., van der Lely, A. J., & Delhanty, P. J. D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0098180 · Cited by 40

The Role of Ghrelin in Neuroprotection after Ischemic Brain Injury

Spencer, S., Miller, A. A., & Andrews, Z. (2013) · Brain Science · doi:10.3390/brainsci3010344 · Cited by 40

Differential gene regulation of GHSR signaling pathway in the arcuate nucleus and NPY neurons by fasting, diet-induced obesity, and 17β-estradiol

Yasrebi, A., Hsieh, A., Mamounis, K. J., Krumm, E. A., Yang, J., Magby, J. P., Hu, P., & Roepke, T. A. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.11.007 · Cited by 40

Melanocortin-3 Receptors and Metabolic Homeostasis

Begriche, K., Clemence, G., McDonald, P. H., & Butler, A. A. (2013) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-386933-3.00004-2 · Cited by 42

Hypothalamic Mitochondrial Dysfunction as a Target in Obesity and Metabolic Disease

Cuñarro, J., Casado, S., Lugilde, J., & Tovar, S. A. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00283 · Cited by 41

Impaired Expression of Uncoupling Protein 2 Causes Defective Postischemic Angiogenesis in Mice Deficient in AMP-Activated Protein Kinase α Subunits

Xu, M.-J., Song, P., Shirwany, N., Liang, B., Xing, J., Viollet, B., Wang, X., Zhu, Y., & Zou, M.-H. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.227991 · Cited by 39

Is there a role for ghrelin in central dopaminergic systems? Focus on nigrostriatal and mesocorticolimbic pathways

Stievenard, A., Méquinion, M., Andrews, Z. B., Destée, A., Chartier-Harlin, M.-C., Viltart, O., & Vanbesien-Mailliot, C. C. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.11.021 · Cited by 39

Differential effects of central ghrelin on fatty acid metabolism in hypothalamic ventral medial and arcuate nuclei

Gao, S., Casals, N., Keung, W., Moran, T. H., & Lopaschuk, G. D. (2013) · Physiology & Behavior · doi:10.1016/j.physbeh.2013.03.030 · Cited by 40

Ghrelin mediated neuroprotection - A possible therapy for Parkinson's disease?

Morgan, A. H., Rees, D. J., Andrews, Z. B., & Davies, J. S. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.12.027 · Cited by 40

Mild Impairment of Mitochondrial OXPHOS Promotes Fatty Acid Utilization in POMC Neurons and Improves Glucose Homeostasis in Obesity

Timper, K., Paeger, L., Sánchez-Lasheras, C., Varela, L., Jaïs, A., Nolte, H., Vogt, M. C., Hausen, A. C., Heilinger, C., Evers, N., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.09.034 · Cited by 41

AgRP neurons trigger long-term potentiation and facilitate food seeking

Wang, C., Zhou, W., He, Y., Yang, T., Xu, P., Yang, Y., Cai, X., Wang, J., Liu, H., Yu, M., et al. (2021) · Translational Psychiatry · doi:10.1038/s41398-020-01161-1 · Cited by 40

Drug targeting of leptin resistance

Santoro, A. N., Raso, G. M., & Meli, R. (2015) · Life Sciences · doi:10.1016/j.lfs.2015.05.012 · Cited by 41

5′‐AMP‐activated protein kinase activity is elevated early during primary brain tumor development in the rat

Jang, T., Calaoagan, J. M., Kwon, E. E., Samuelsson, S. J., Recht, L. D., & Laderoute, K. R. (2010) · International Journal of Cancer · doi:10.1002/ijc.25558 · Cited by 39

Ghrelin inhibits hydrogen peroxide-induced apoptotic cell death of oligodendrocytes via ERK and p38MAPK signaling.

Lee, J., Oh, T., & Yune, T. (2011) · Endocrinology · doi:10.1210/en.2011-0090 · Cited by 40

A novel neuropeptide Y neuronal pathway linking energy state and reproductive behavior

Muroi, Y., & Ishii, T. (2016) · Neuropeptides · doi:10.1016/j.npep.2016.09.002 · Cited by 41

Glutathionylation of UCP2 sensitizes drug resistant leukemia cells to chemotherapeutics

Pfefferle, A., Mailloux, R. J., Adjeitey, C. N., & Harper, M. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2012.10.006 · Cited by 39

POMC Neurons Dysfunction in Diet-induced Metabolic Disease: Hallmark or Mechanism of Disease?

Quarta, C., Fioramonti, X., & Cota, D. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.09.031 · Cited by 41

Neuronal control of peripheral nutrient partitioning

Manceau, R., Majeur, D., & Alquier, T. (2020) · Diabetologia · doi:10.1007/s00125-020-05104-9 · Cited by 42

Drp1 is required for AgRP neuronal activity and feeding

Jin, S., Yoon, N. A., Liu, Z.-W., Song, J. E., Horvath, T. L., Kim, J. D., & Diano, S. (2021) · eLife · doi:10.7554/elife.64351 · Cited by 39

Mitochondrial Fission Governed by Drp1 Regulates Exogenous Fatty Acid Usage and Storage in Hela Cells

Song, J.-E., Alves, T. C., Stutz, B., Šestan-Peša, M., Kilian, N., Jin, S., Diano, S., Kibbey, R. G., & Horváth, T. L. (2021) · Metabolites · doi:10.3390/metabo11050322 · Cited by 37

Uncoupling Protein-2 and the Potential Link Between Metabolism and Longevity

Andrews, Z. B. (2010) · Current Aging Science · doi:10.2174/1874609811003020102 · Cited by 40

Transient Receptor Potential Canonical 3 (TRPC3) Channels Are Required for Hypothalamic Glucose Detection and Energy Homeostasis

Chrétien, C., Fenech, C., Liénard, F., Grall, S., Chevalier, C., Chaudy, S., Brénachot, X., Bergès, R., Louche, K., Stark, R., et al. (2016) · Diabetes · doi:10.2337/db16-1114 · Cited by 40

Ghrelin At the Interface of Obesity and Reward

Schellekens, H., Dinan, T. G., & Cryan, J. F. (2013) · Vitamins and hormones · doi:10.1016/b978-0-12-407766-9.00013-4 · Cited by 38

Hindbrain lactostasis regulates hypothalamic AMPK activity and metabolic neurotransmitter mRNA and protein responses to hypoglycemia

Gujar, A. D., Ibrahim, B. A., Tamrakar, P., Cherian, A. K., & Briski, K. P. (2013) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00151.2013 · Cited by 37

Hypothalamic redox balance and leptin signaling - Emerging role of selenoproteins

Gong, T., Torres, D. J., Berry, M. J., & Pitts, M. W. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.02.038 · Cited by 38

Genes involved in fatty acid metabolism: Molecular characterization and hypothalamic mRNA response to energy status and neuropeptide Y treatment in the orange-spotted grouper Epinephelus coioides

Tang, Z., Sun, C., Yan, A., Wu, S., Qin, C., Zhang, Y., & Li, W. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.06.020 · Cited by 37

Inactivation of the Constitutively Active Ghrelin Receptor Attenuates Limbic Seizure Activity in Rodents

Portelli, J., Thielemans, L. A., Donck, L. V., Loyens, E., Coppens, J., Aourz, N., Aerssens, J., Vermoesen, K., Clinckers, R., Schallier, A., et al. (2012) · Neurotherapeutics · doi:10.1007/s13311-012-0125-x · Cited by 36

Ghrelin, peptide YY and their hypothalamic targets differentially regulate spontaneous physical activity

Pfluger, P. T., Castañeda, T. R., Heppner, K. M., Strassburg, S., Kruthaupt, T., Chaudhary, N., Halem, H. A., Culler, M. D., Datta, R., Burget, L., et al. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.04.025 · Cited by 37

Naloxone, but Not Valsartan, Preserves Responses to Hypoglycemia After Antecedent Hypoglycemia

Poplawski, M. M., Mastaitis, J. W., & Mobbs, C. V. (2010) · Diabetes · doi:10.2337/db10-0326 · Cited by 34

The effects of intracerebroventricular infusion of irisin on feeding behaviour in rats.

Tekin, S., Erden, Y., Ozyalın, F., Çiğremiş, Y., Çolak, C., & Sandal, S. (2017) · Neuroscience Letters · doi:10.1016/j.neulet.2017.02.066 · Cited by 38

A Comparative Perspective on Wnt/β-Catenin Signalling in Cell Fate Determination

Garcin, C. L., & Habib, S. J. (2017) · Results and problems in cell differentiation · doi:10.1007/978-3-319-53150-2_15 · Cited by 40

Naturally occurring mutations in G protein-coupled receptors associated with obesity and type 2 diabetes mellitus

Liu, T., Ji, R.-L., & Tao, Y.-X. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.108044 · Cited by 34

Food-induced dopamine signaling in AgRP neurons promotes feeding

Zhang, Q., Tang, Q., Purohit, N. M., Davenport, J. B., Brennan, C. D., Patel, R. K., Godschall, E., Zwiefel, L. S., Spano, A., Campbell, J. N., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111718 · Cited by 35

Neuron-Specific Deletion of Peroxisome Proliferator-Activated Receptor Delta (PPARδ) in Mice Leads to Increased Susceptibility to Diet-Induced Obesity

Kocalis, H. E., Turney, M. K., Printz, R. L., Laryea, G. N., Muglia, L. J., Davies, S. S., Stanwood, G. D., McGuinness, O. P., & Niswender, K. D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042981 · Cited by 35

Minireview: Central Sirt1 Regulates Energy Balance via the Melanocortin System and Alternate Pathways

Toorie, A. M., & Nillni, E. A. (2014) · Molecular Endocrinology · doi:10.1210/me.2014-1115 · Cited by 35

Cellular Signal Mechanisms of Reward-Related Plasticity in the Hippocampus

Isokawa, M. (2012) · Neural Plasticity · doi:10.1155/2012/945373 · Cited by 35

UCP2 overexpression worsens mitochondrial dysfunction and accelerates disease progression in a mouse model of amyotrophic lateral sclerosis

Peixoto, P. M. V., Kim, H., Sider, B., Starkov, A. A., Horváth, T. L., & Manfredi, G. (2013) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2013.10.002 · Cited by 36

Emerging roles for hypothalamic microglia as regulators of physiological homeostasis

Rosin, J. M., & Kurrasch, D. M. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.100748 · Cited by 37

Metabolic mystery: aging, obesity, diabetes, and the ventromedial hypothalamus

Mobbs, C. V., Moreno, C. L., & Poplawski, M. M. (2013) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2013.05.007 · Cited by 34

Administration of multipotent mesenchymal stromal cells restores liver regeneration and improves liver function in obese mice with hepatic steatosis after partial hepatectomy

Ezquer, F. E., Bahamonde, J., Huang, Y.-L., & Ezquer, M. (2017) · Stem Cell Research & Therapy · doi:10.1186/s13287-016-0469-y · Cited by 35

Ghrelin’s Role as a Major Regulator of Appetite and Its Other Functions in Neuroendocrinology

Lim, C. T., Kola, B., Korbonits, M., & Grossman, A. B. (2010) · Progress in Brain Research · doi:10.1016/s0079-6123(10)82008-4 · Cited by 34

Long-Term Increased Carnitine Palmitoyltransferase 1A Expression in Ventromedial Hypotalamus Causes Hyperphagia and Alters the Hypothalamic Lipidomic Profile

Mera, P., Mir, J. F., Fabriàs, G., Casas, J., Costa, A. S. H., Malandrino, M. I., Fernández–Löpez, J., Remesar, X., Gao, S., Chohnan, S., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097195 · Cited by 38

Ucp2-dependent microglia-neuronal coupling controls ventral hippocampal circuit function and anxiety-like behavior

Yasumoto, Y., Stoiljković, M., Kim, J. D., Šestan-Peša, M., Gao, X., Diano, S., & Horváth, T. L. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01105-1 · Cited by 33

Ghrelin Receptor Regulates Appetite and Satiety during Aging in Mice by Regulating Meal Frequency and Portion Size but Not Total Food Intake

Lin, L., Nuotio-Antar, A. M., Ma, X., Liu, F., Fiorotto, M. L., & Sun, Y. (2014) · Journal of Nutrition · doi:10.3945/jn.114.191171 · Cited by 34

Carnitine palmitoyltransferase‐1c gain‐of‐function in the brain results in postnatal microencephaly

Reamy, A. A., & Wolfgang, M. J. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07312.x · Cited by 35

Ghrelin O-Acyltransferase Assays and Inhibition

Taylor, M. S., Hwang, Y., Hsiao, P.-Y., Boeke, J. D., & Cole, P. A. (2012) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/b978-0-12-381272-8.00013-1 · Cited by 33

Action of Neurotransmitter: A Key to Unlock the AgRP Neuron Feeding Circuit

Liu, T., Wang, Q., Berglund, E. D., & Tong, Q. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2012.00200 · Cited by 34

Gastric mechanosensitive channel Piezo1 regulates ghrelin production and food intake

Zhao, Y., Liu, Y., Tao, T., Zhang, J., Guo, W., Deng, H., Han, M., Mo, H., Tong, X., Song, L., et al. (2024) · Nature Metabolism · doi:10.1038/s42255-024-00995-z · Cited by 34

Changes in expression of hepatic genes involved in energy metabolism during hibernation in captive, adult, female Japanese black bears (Ursus thibetanus japonicus)

Shimozuru, M., Kamine, A., & Tsubota, T. (2012) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/j.cbpb.2012.06.007 · Cited by 32

Human torpor: translating insights from nature into manned deep space expedition

Shi, Z., Qin, M., Huang, L., Xu, T., Chen, Y., Hu, Q., Peng, S., Peng, Z., Qu, L., Chen, S., et al. (2020) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12671 · Cited by 31

A nexus of lipid and O-Glcnac metabolism in physiology and disease

Lockridge, A. D., & Hanover, J. A. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.943576 · Cited by 35

The CB1 receptor mediates the peripheral effects of ghrelin on AMPK activity but not on growth hormone release

Kola, B., Wittmann, G., Bodnár, I., Amin, F., Lim, C. T., Oláh, M., Christ‐Crain, M., Lolli, F., van Thuijl, H., Leontiou, C. A., et al. (2013) · The FASEB Journal · doi:10.1096/fj.13-232918 · Cited by 33

Suppression of Ghrelin Exacerbates HFCS-Induced Adiposity and Insulin Resistance

Ma, X., Lin, L., Yue, J., Wu, C., Guo, C., Wang, R., Yu, K.-J., Devaraj, S., Murano, P. S., Chen, Z., et al. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18061302 · Cited by 35

Metabolic Adaptations to Weight Loss: A Brief Review

Martínez-Gómez, M. G., & Roberts, B. M. (2022) · Journal of Strength & Conditioning Research · doi:10.1519/jsc.0000000000003991 · Cited by 32

Irisin increases the expression of anorexigenic and neurotrophic genes in mouse brain

Natalicchio, A., Marrano, N., Biondi, G., Dipaola, L., Spagnuolo, R., Cignarelli, A., Perrini, S., Laviola, L., & Giorgino, F. (2020) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3238 · Cited by 31

Nutritional and hormonal regulation of uncoupling protein 2

Yonezawa, T., Kurata, R., Hosomichi, K., Kono, A., Kimura, M., & Inoko, H. (2009) · IUBMB Life · doi:10.1002/iub.264 · Cited by 32

Diverse and Complementary Effects of Ghrelin and Obestatin

Villarreal, D., Pradhan, G., Zhou, Y., Xue, B., & Sun, Y. (2022) · Biomolecules · doi:10.3390/biom12040517 · Cited by 37

A Comparative Study on Conformation and Ligand Binding of the Neuronal Uncoupling Proteins

Ivanova, M. V., Hoang, T. A., McSorley, F. R., Krnac, G., Smith, M. D., & Jelokhani‐Niaraki, M. (2009) · Biochemistry · doi:10.1021/bi901742g · Cited by 31

Unexpected Long-Term Protection of Adult Offspring Born to High-Fat Fed Dams against Obesity Induced by a Sucrose-Rich Diet

Couvreur, O., Férézou, J., Gripois, D., Sérougne, C., Crépin, D., Aubourg, A., Gertler, A., Vacher, C., & Taouis, M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018043 · Cited by 31

Endocrine and Metabolic Actions of Ghrelin

Gasco, V., Beccuti, G., Marotta, F., Benso, A., Granata, R., Broglio, F., & Ghigo, E. (2010) · Endocrine Development · doi:10.1159/000262531 · Cited by 30

Hypothalamic Lipids and the Regulation of Energy Homeostasis

Carlos Diégueza, B., Gema Frühbeckb, C., & peza, B. M. L. O. (2009) · Obesity Facts · doi:10.1159/000209251 · Cited by 33

Ghrelin: New Molecular Pathways Modulating Appetite and Adiposity

Nogueiras, R., Williams, L. M., & Diéguez, C. (2010) · Obesity Facts · doi:10.1159/000321265 · Cited by 30

Ghrelin Attenuates Brain Injury after Traumatic Brain Injury and Uncontrolled Hemorrhagic Shock in Rats

Qi, L., Cui, X.-X., Dong, W., Barrera, R., Nicastro, J. M., Coppa, G., Wang, P., & Wu, R.-Q. (2012) · Molecular Medicine · doi:10.2119/molmed.2011.00390 · Cited by 33

The role of nitric oxide signaling in food intake; insights from the inner mitochondrial membrane peptidase 2 mutant mice

Han, C., Zhao, Q., & Lu, B. (2013) · Redox Biology · doi:10.1016/j.redox.2013.10.003 · Cited by 30

Impaired oxidative capacity due to decreased CPT1b levels as a contributing factor to fat accumulation in obesity

Ratner, C., Madsen, A. N., Kristensen, L. V., Skov, L. J., Pedersen, K. S., Mortensen, O. H., Knudsen, G. M., Raun, K., & Holst, B. (2015) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00219.2014 · Cited by 31

Direct versus indirect actions of ghrelin on hypothalamic NPY neurons

Hashiguchi, H., Sheng, Z., Routh, V. H., Gerzanich, V., Simard, J. M., & Bryan, J. (2017) · PLoS ONE · doi:10.1371/journal.pone.0184261 · Cited by 29

Endocrine factors in the hypothalamic regulation of food intake in females: a review of the physiological roles and interactions of ghrelin, leptin, thyroid hormones, oestrogen and insulin

Somogyi, V., Gyorffy, A., Scalise, T. J., Kiss, D. S., Goszleth, G., Bartha, T., Frenyo, V. L., & Zsarnovszky, A. (2011) · Nutrition Research Reviews · doi:10.1017/s0954422411000035 · Cited by 37

CaMK1D signalling in AgRP neurons promotes ghrelin-mediated food intake

Vivot, K., Mészáros, G., Pangou, E., Zhang, Z., Qu, M., Erbs, E., Yeghiazaryan, G., Quiñones, M., Grandgirard, E., Schneider, A., et al. (2023) · Nature Metabolism · doi:10.1038/s42255-023-00814-x · Cited by 29

Ecto-nucleoside triphosphate diphosphohydrolase 3 in the ventral and lateral hypothalamic area of female rats: morphological characterization and functional implications

Kiss, D. S., Zsarnovszky, A., Horvath, K., Győrffy, A., Bartha, T., Hazai, D., Sótonyi, P., Somogyi, V., Frenyó, L. V., & Diano, S. (2009) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-7-31 · Cited by 29

Review of Novel Aspects of the Regulation of Ghrelin Secretion

Al–Massadi, O., Lear, P., Müller, T. D., López, M., Diéguez, C., Tschöp, M. H., & Nogueiras, R. (2014) · Current Drug Metabolism · doi:10.2174/1389200215666140505153723 · Cited by 29

UCP2 Knockout Suppresses Mouse Skin Carcinogenesis

Li, W., Zhang, C., Jackson, K. L., Shen, X., Jin, R., Li, G., Kevil, C. G., Gu, X., Shi, R., & Zhao, Y. (2015) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-14-0297-t · Cited by 29

Plasticity of calcium-permeable AMPA glutamate receptors in Pro-opiomelanocortin neurons

Suyama, S., Ralevski, A., Liu, Z. W., Dietrich, M. O., Yada, T., Simonds, S. E., Cowley, M. A., Gao, X., Diano, S., & Horváth, T. L. (2017) · eLife · doi:10.7554/elife.25755 · Cited by 27

Targeting AgRP neurons to maintain energy balance: Lessons from animal models

Zagmutt, S., Mera, P., Soler‐Vázquez, M. C., Herrero, L., & Serra, D. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.07.008 · Cited by 30

Mitochondrial Dynamics in the Brain Are Associated With Feeding, Glucose Homeostasis, and Whole-Body Metabolism

Haigh, J., New, L. E., & Filippi, B. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.580879 · Cited by 30

Role of Reactive Oxygen Species in Hypothalamic Regulation of Energy Metabolism

Diano, S. (2013) · Endocrinology and Metabolism · doi:10.3803/enm.2013.28.1.3 · Cited by 30

Ghrelin Protects Rats Against Traumatic Brain Injury and Hemorrhagic Shock Through Upregulation of UCP2

Qi, L., Cui, X., Dong, W., Barrera, R., Coppa, G. F., Wang, P., & Wu, R. (2014) · Annals of Surgery · doi:10.1097/sla.0000000000000328 · Cited by 28

Peripheral and Central Nutrient Sensing Underlying Appetite Regulation

Augustine, V., Gökçe, S. K., & Oka, Y. (2018) · Trends in Neurosciences · doi:10.1016/j.tins.2018.05.003 · Cited by 32

Points of integration between the intracellular energy sensor AMP-activated protein kinase (AMPK) activity and the somatotroph axis function

Tulipano, G., Faggi, L., Sibilia, V., & Giustina, A. (2012) · Endocrine · doi:10.1007/s12020-012-9732-x · Cited by 28

Glucose Availability Predicts the Feeding Response to Ghrelin in Male Mice, an Effect Dependent on AMPK in AgRP Neurons

Lockie, S. H., Stark, R., Méquinion, M., Ch’ng, S. S., Kong, D., Spanswick, D. C., Lawrence, A. J., & Andrews, Z. B. (2018) · Endocrinology · doi:10.1210/en.2018-00536 · Cited by 27

The anx/anx Mouse – A Valuable Resource in Anorexia Nervosa Research

Nilsson, I. A. K. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00059 · Cited by 28

Activation of UCP2 by anethole trithione suppresses neuroinflammation after intracerebral hemorrhage

Yan, X., Fu-you, X., Ji, J.-J., Song, P. K., Pei, Y.-Q., He, M., Wang, Z., You, S., Hua, Z., Cheng, J. G., et al. (2021) · Acta Pharmacologica Sinica · doi:10.1038/s41401-021-00698-1 · Cited by 28

Hypothalamic carnitine metabolism integrates nutrient and hormonal feedback to regulate energy homeostasis

Stark, R., Reichenbach, A., & Andrews, Z. B. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.08.002 · Cited by 28

Exercise as a Therapeutic Strategy for Obesity: Central and Peripheral Mechanisms

Zhang, Y., Wang, R., Liu, T., & Wang, R. (2024) · Metabolites · doi:10.3390/metabo14110589 · Cited by 27

The Anorexigenic Effect of Serotonin Is Mediated by the Generation of NADPH Oxidase-Dependent ROS

Fang, X.-L., Shu, G., Yu, J., Wang, L., Yang, J., Zeng, Q.-J., Cheng, X. L., Zhang, Z., Wang, S., Gao, P., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053142 · Cited by 29

Uncoupling protein 2 protects mice from aging

Hirose, M., Schilf, P., Lange, F., Mayer, J., Reichart, G., Maity, P., Jöhren, O., Schwaninger, M., Scharffetter‐­Kochanek, K., Sina, C., et al. (2016) · Mitochondrion · doi:10.1016/j.mito.2016.06.004 · Cited by 27

Molecular evolution of uncoupling proteins and implications for brain function

Gaudry, M. J., & Jastroch, M. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.12.027 · Cited by 28

Peripheral ghrelin stimulates feeding behavior and positive energy balance in a sciurid hibernator

Healy, J. E., Bateman, J. L., Ostrom, C. E., & Florant, G. L. (2011) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.01.013 · Cited by 26

Malonyl-CoA mediates leptin hypothalamic control of feeding independent of inhibition of CPT-1a

Gao, S., Keung, W., Serra, D., Wang, W., Carrasco, P., Casals, N., Hegardt, F. G., Moran, T. H., & Lopaschuk, G. D. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00092.2011 · Cited by 29

UCP2 as a Potential Biomarker for Adjunctive Metabolic Therapies in Tumor Management

Vallejo, F. A., Vanni, S., & Graham, R. M. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.640720 · Cited by 27

Ghrelin treatment protects lactotrophs from apoptosis in the pituitary of diabetic rats

Granado, M., Chowen, J. A., García‐Cáceres, C., Delgado-Rubín, A., Barrios, V., Castillero, E., Argente, J., & Frago, L. M. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.06.006 · Cited by 26

An eGFP-expressing subpopulation of growth hormone secretagogue receptor cells are distinct from kisspeptin, tyrosine hydroxylase, and RFamide-related peptide neurons in mice

Smith, J. T., Reichenbach, A., Lemus, M. B., Mani, B. K., Zigman, J. M., & Andrews, Z. B. (2013) · Peptides · doi:10.1016/j.peptides.2013.06.012 · Cited by 25

microRNA-33 controls hunger signaling in hypothalamic AgRP neurons

Price, N. L., Fernández-Tussy, P., Varela, L., Cardelo, M. P., Shanabrough, M., Aryal, B., de Cabo, R., Suárez, Y., Horvath, T. L., & Fernández-Hernando, C. (2024) · Nature Communications · doi:10.1038/s41467-024-46427-0 · Cited by 25

Ghrelin regulates hypothalamic prolyl carboxypeptidase expression in mice

Jeong, J. K., Kim, J. D., & Diano, S. (2013) · Molecular Metabolism · doi:10.1016/j.molmet.2013.01.002 · Cited by 25

Serum Acylated Ghrelin Is Negatively Correlated with the Insulin Resistance In the CODING study

Amini, P., Wadden, D., Cahill, F., Randell, E. W., Vasdev, S., Chen, X., Gulliver, W. P., Zhang, W., Zhang, H., Yi, Y., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045657 · Cited by 26

mTORC1-dependent increase in oxidative metabolism in POMC neurons regulates food intake and action of leptin

Haissaguerre, M., Ferrière, A., Simon, V., Saucisse, N., Dupuy, N., André, C., Clark, S., Guzmán‐Quevedo, O., Tabarin, A., & Cota, D. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.04.002 · Cited by 25

Targeting carnitine palmitoyltransferase 1 isoforms in the hypothalamus: A promising strategy to regulate energy balance

Rodríguez‐Rodríguez, R., Fosch, A., García-Chica, J., Zagmutt, S., & Casals, N. (2023) · Journal of Neuroendocrinology · doi:10.1111/jne.13234 · Cited by 25

New Insights in Ghrelin Orexigenic Effect

Diéguez, C., Boit, K. D., Novelle, M. G., de Morentin, P. B. M., Nogueiras, R., & López, M. (2010) · Frontiers of hormone research · doi:10.1159/000318511 · Cited by 28

Role of the AMP-activated protein kinase (AMPK) signaling pathway in the orexigenic effects of endogenous ghrelin

Verhulst, P., Janssen, S., Tack, J. F., & Depoortere, I. (2011) · Regulatory Peptides · doi:10.1016/j.regpep.2011.09.001 · Cited by 25

Mitochondria controlled by UCP2 determine hypoxia-induced synaptic remodeling in the cortex and hippocampus

Varela, L., Schwartz, M. L., & Horváth, T. L. (2016) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.01.004 · Cited by 25

Food for Thought

Ray, L. B. (2008) · Science Signaling · doi:10.1126/scisignal.133ec293

Central mechanisms involved in the orexigenic actions of ghrelin

Andrews, Z. B. (2011) · Peptides · doi:10.1016/j.peptides.2011.05.014 · Cited by 160

Role of the Energy Sensor AMP-Activated Protein Kinase (AMPK) and Its Downstream Effector Uncoupling Protein 2 (UCP2) in the Orexigenic Effect of Endogenous Ghrelin

Verhulst, P., Janssen, S., Tack, J. F., & Depoortere, I. (2011) · Gastroenterology · doi:10.1016/s0016-5085(11)60178-9

The “Leptin Switch” Mechanism in Gastric Vagal Afferents

Kentish, S. J., O’Donnell, T. A., Wittert, G., Blackshaw, L. A., & Page, A. J. (2011) · Gastroenterology · doi:10.1016/s0016-5085(11)60180-7

Ghrelin receptors mediate ghrelin‐induced excitation of agouti‐related protein/neuropeptide Y but not pro‐opiomelanocortin neurons

Chen, S., Chen, H., Zhou, J., Pradhan, G., Sun, Y., Pan, H., & Li, D. (2017) · Journal of Neurochemistry · doi:10.1111/jnc.14080 · Cited by 112