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PRDM16 controls a brown fat/skeletal muscle switch
Open accessAbstract
Brown fat can increase energy expenditure and protect against obesity through a specialized program of uncoupled respiration. Here we show by in vivo fate mapping that brown, but not white, fat cells arise from precursors that express Myf5, a gene previously thought to be expressed only in the myogenic lineage. We also demonstrate that the transcriptional regulator PRDM16 (PRD1-BF1-RIZ1 homologous domain containing 16) controls a bidirectional cell fate switch between skeletal myoblasts and brown fat cells. Loss of PRDM16 from brown fat precursors causes a loss of brown fat characteristics and promotes muscle differentiation. Conversely, ectopic expression of PRDM16 in myoblasts induces their differentiation into brown fat cells. PRDM16 stimulates brown adipogenesis by binding to PPAR-gamma (peroxisome-proliferator-activated receptor-gamma) and activating its transcriptional function. Finally, Prdm16-deficient brown fat displays an abnormal morphology, reduced thermogenic gene expression and elevated expression of muscle-specific genes. Taken together, these data indicate that PRDM16 specifies the brown fat lineage from a progenitor that expresses myoblast markers and is not involved in white adipogenesis.
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“Emerging evidence suggests that brown adipocytes located in different anatomical locations may arise from different developmental origins.”
From Cellular bioenergetics as a target for obesity therapy (2010) · cites this paper as [92]
In the citing paper
“Most recently, lineage-tracing studies have indicated that myf5-expressing progenitors can give rise to both skeletal muscle and the preformed BAT, in the interscapular and peri-renal depots 92 (Figure 3).”
From Cellular bioenergetics as a target for obesity therapy (2010) · cites this paper as [92]
In the citing paper
“However, not all brown fat cells are derived from myf5-expressing progenitors. For example, the brown fat cells emerging in white fat in response to β3-adrenergic stimulation are not marked by the myf5-driven fluorescent protein 92.”
From Cellular bioenergetics as a target for obesity therapy (2010) · cites this paper as [92]
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“Current data suggest that in rodents, PRDM16 plays an important role in specifying brown fat cell fate for the interscapular, but not systemic brown adipose depots 92.”
From Cellular bioenergetics as a target for obesity therapy (2010) · cites this paper as [92]
In the citing paper
“The genetic program leading to brown adipose tissue development, and potentially to the high abundance of mitochondria, is initiated by the zinc-finger protein PRDM16 (202)(203)(204).”
From The role of mitochondria in the pathogenesis of type 2 diabetes (2010) · cites this paper as [203]
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Citations
Cites
Brown Adipose Tissue: Function and Physiological Significance
CANNON, B., & NEDERGAARD, J. (2004) · Physiological Reviews · doi:10.1152/physrev.00015.2003 · Cited by 6,433
Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor
Tontonoz, P., Hu, E., & Spiegelman, B. M. (1994) · Cell · doi:10.1016/0092-8674(94)90006-x · Cited by 3,564
Self-citationCre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus
Srinivas, S., Watanabe, T., Lin, C.-S., William, C. M., Tanabe, Y., Jessell, T. M., & Costantini, F. (2001) · BMC Developmental Biology · doi:10.1186/1471-213x-1-4 · Cited by 3,121
15-Deoxy-Δ12,14-Prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ
FORMAN, B. M., Tontonoz, P., Chen, J., Brun, R. P., Spiegelman, B. M., & Evans, R. M. (1995) · Cell · doi:10.1016/0092-8674(95)90193-0 · Cited by 2,857
Self-citationPPARγ Is Required for the Differentiation of Adipose Tissue In Vivo and In Vitro
Rosen, E. D., Sarraf, P., Troy, A. E., Bradwin, G., Moore, K. J., Milstone, D. S., Spiegelman, B. M., & Mortensen, R. M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80211-7 · Cited by 2,081
Self-citationPPARγ Is Required for Placental, Cardiac, and Adipose Tissue Development
Barak, Y., Nelson, M. C., Ong, E. S., Jones, Y., Ruiz‐Lozano, P., Chien, K. R., Koder, A., & Evans, R. M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80209-9 · Cited by 1,983
Unexpected evidence for active brown adipose tissue in adult humans
Nedergaard, J., Bengtsson, T., & Cannon, B. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00691.2006 · Cited by 1,824
Developmental Origin of Fat: Tracking Obesity to Its Source
Gesta, S., Tseng, Y.-H., & Kahn, C. R. (2007) · Cell · doi:10.1016/j.cell.2007.10.004 · Cited by 1,508
Asymmetric self-renewal and commitment of satellite stem cells in muscle
Kuang, S., Kuroda, K., Le Grand, F., & Rudnicki, M. A. (2007) · Cell · doi:10.1016/j.cell.2007.03.044 · Cited by 1,449
Self-citationMolecular Regulation of Adipogenesis
Rosen, E. D., & Spiegelman, B. M. (2000) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.16.1.145 · Cited by 1,310
Self-citation
Cited by
Sorted by citations
Items 501–600 of 1,008
Improved methodologies for the study of adipose biology: insights gained and opportunities ahead
Wang, Q. A., Scherer, P. E., & Gupta, R. K. (2014) · Journal of Lipid Research · doi:10.1194/jlr.r046441 · Cited by 88
Jmjd3-Mediated H3K27me3 Dynamics Orchestrate Brown Fat Development and Regulate White Fat Plasticity
Pan, D., Huang, L., Zhu, L. J., Zou, T., Ou, J., Zhou, W., & Wang, Y. (2015) · Developmental Cell · doi:10.1016/j.devcel.2015.11.002 · Cited by 83
“…is known about how Myf5+Pax7+ progenitor cells are fated and progressed into brown preadipocytes during lineage commitment (Lepper and Fan, 2010; Seale et al., 2008), we have a great deal of molecular understanding of the terminal differentiation process from preadipocytes to mature adipocytes.”
BackgroundLi, S., Mi, L., Yu, L., Yu, Q., Liu, T., Wang, G.-X., Zhao, X.-Y., Wu, J., & Lin, J. D. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1703494114 · Cited by 84
Switching on the furnace: Regulation of heat production in brown adipose tissue
Li, L., Li, B., Li, M., & Speakman, J. R. (2019) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2019.07.005 · Cited by 87
Emerging debates and resolutions in brown adipose tissue research
Cypess, A. M., Cannon, B., Nedergaard, J., Kazak, L., Chang, D. C., Krakoff, J. A., Tseng, Y., Schéele, C., Boucher, J., Petrovič, N., et al. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.11.002 · Cited by 93
Self-citationGlucocorticoid Receptor Accelerates, but Is Dispensable for, Adipogenesis
Park, Y.-K., & Ge, K. (2016) · Molecular and Cellular Biology · doi:10.1128/mcb.00260-16 · Cited by 84
“Myf5-Cre specifically deletes genes flanked by loxP sites in somitic precursor cells giving rise to both BAT and skeletal muscles in the back (11).”
BackgroundMolecular Nutrition Research—The Modern Way Of Performing Nutritional Science
Norheim, F., Gjelstad, I., Hjorth, M., Vinknes, K., Langleite, T., Holen, T., Jensen, J., Dalen, K., Karlsen, A., Kielland, A., et al. (2012) · Nutrients · doi:10.3390/nu4121898 · Cited by 83
A Multifunctional Protein, EWS, Is Essential for Early Brown Fat Lineage Determination
Park, J. H., Kang, H. J., Kang, S. I., Lee, J., Hur, J., Ge, K., Mueller, E., Li, H., Lee, B.-C., & Lee, S. B. (2013) · Developmental Cell · doi:10.1016/j.devcel.2013.07.002 · Cited by 85
“These brownfat-like cells (termed brite or beige cells) are generated from Myf5-negative cells residing in perivascular regions of various WAT depots (Gupta et al., 2012; Tran et al., 2012).”
BackgroundResultInfluentialJouy, S. H., Mohan, S., Scichilone, G., Mostafa, A., & Mahmoud, A. M. (2024) · Biomedicines · doi:10.3390/biomedicines12092129 · Cited by 96
Ding, H., Zheng, S., Garcia-Ruiz, D., Hou, D., Wei, Z., Liao, Z., Li, L., Zhang, Y., Han, X., Zen, K., et al. (2016) · Nature Communications · doi:10.1038/ncomms11533 · Cited by 83
“Despite sharing the ability to accumulate triglycerides, the physiological roles of WAT and BAT are almost diametrically opposite 2 , which makes sense evolutionarily, because hunger and cold are two historical challenges during the development and evolution of mammals 15 .”
Rapamycin Blocks Induction of the Thermogenic Program in White Adipose Tissue
Tran, C. M., Mukherjee, S., Ye, L., Frederick, D. W., Kissig, M., Davis, J. G., Lamming, D. W., Seale, P., & Baur, J. A. (2016) · Diabetes · doi:10.2337/db15-0502 · Cited by 84
“Brown adipocyte-like cells termed “beige” or “brite” (brown in white) adipocytes are inducible in WAT and were shown via lineage tracing and transcriptional profiling to represent a third class of adipocytes that are distinct from the cells found in BAT (13,14).”
BackgroundInfluentialSelf-citationImaging of Brown Adipose Tissue: State of the Art
Sampath, S. C., Sampath, S. C., Bredella, M. A., Cypess, A. M., & Torriani, M. (2016) · Radiology · doi:10.1148/radiol.2016150390 · Cited by 83
PDGFRα controls the balance of stromal and adipogenic cells during adipose tissue organogenesis
Sun, C., Berry, W. L., & Olson, L. E. (2017) · Development · doi:10.1242/dev.135962 · Cited by 85
Tomaru, T., Steger, D. J., Lefterova, M. I., Schupp, M., & Lazar, M. A. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m808407200 · Cited by 81
Park, C. Y., Pierce, S. A., von Drehle, M., Ivey, K. N., Morgan, J. A., Blau, H. M., & Srivastava, D. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1013493107 · Cited by 85
“Recent studies showed that brown fat cells arise in vivo from the Myf5-positive myoblast lineage by the action of a PRDM16/EBP-b transcriptional complex (31, 32).”
BackgroundGrgurević, L., Christensen, G. L., Schulz, T. J., & Vukičević, S. (2015) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2015.12.009 · Cited by 84
Rzehak, P., Covic, M., Saffery, R., Reischl, E., Wahl, S., Grote, V., Weber, M., Xhonneux, A., Langhendries, J., Ferré, N., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-13099-4 · Cited by 82
The Role of AMPK Signaling in Brown Adipose Tissue Activation
van der Vaart, J. I., Boon, M. R., & Houtkooper, R. H. (2021) · Cells · doi:10.3390/cells10051122 · Cited by 90
Regulatory mechanisms of the early phase of white adipocyte differentiation: an overview
Audano, M., Pedretti, S., Caruso, D., Crestani, M., Fabiani, E. D., & Mitro, N. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04169-6 · Cited by 89
Tang, C., Wang, Y., Chen, D., Zhang, M., Xu, J., Chen, X., Liu, J., Kan, J., & Jin, C. (2023) · Food Research International · doi:10.1016/j.foodres.2023.113192 · Cited by 89
Zha, L., Li, F., Wu, R., Artinian, L. R., Rehder, V., Yu, L., Liang, H., Xue, B., & Shi, H. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.662650 · Cited by 80
Concise Review: Adipocyte Origins: Weighing the Possibilities
Majka, S. M., Barak, Y., & Klemm, D. J. (2011) · Stem Cells · doi:10.1002/stem.653 · Cited by 81
The significance of beige and brown fat in humans
Kiefer, F. W. (2017) · Endocrine Connections · doi:10.1530/ec-17-0037 · Cited by 82
Marrow Adipocytes: Origin, Structure, and Function
de Paula, F. J. A., & Rosen, C. J. (2019) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021119-034513 · Cited by 80
“On the other hand, brown adipocytes arise from cells expressing Myf5+, a muscle transcription factor that is not expressed in beige adipocytes (18, 21).”
BackgroundBrown adipose tissue: a potential target in the fight against obesity and the metabolic syndrome
Poekes, L., Lanthier, N., & Leclercq, I. A. (2015) · Clinical Science · doi:10.1042/cs20150339 · Cited by 83
Induction of thermogenic adipocytes: molecular targets and thermogenic small molecules
Song, N.-J., Chang, S., Li, D. Y., Villanueva, C. J., & Park, K. W. (2017) · Experimental & Molecular Medicine · doi:10.1038/emm.2017.70 · Cited by 81
Adiposity and Cognitive Decline: Underlying Mechanisms
Gustafson, D. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-120487 · Cited by 79
“It has been traditionally thought that most BAT disappears fairly quickly with aging, however, significant amounts of BAT are present in adults, particularly in paracervical and supraclavicular adipose tissue [34], as well as surrounding the kidney and along large blood vessels [37].”
BackgroundLiu, W., Liu, Y., Lai, X., & Kuang, S. (2011) · Developmental Biology · doi:10.1016/j.ydbio.2011.10.011 · Cited by 75
Self-citationThe role of adipose tissue in cancer-associated cachexia
Vaitkus, J. A., & Celi, F. S. (2016) · Experimental Biology and Medicine · doi:10.1177/1535370216683282 · Cited by 81
Cibi, D. M., Bi-Lin, K. W., Shekeran, S. G., Sandireddy, R., Tee, N., Singh, A., Wu, Y., Srinivasan, D. K., Kovalik, J., Ghosh, S., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108288 · Cited by 80
Self-citationThe adipocyte clock controls brown adipogenesis via TGF-β/BMP signaling pathway
Nam, D., Guo, B., Chatterjee, S., Chen, M.-H., Nelson, D. L., Yechoor, V. K., & Ma, K. (2015) · Journal of Cell Science · doi:10.1242/jcs.167643 · Cited by 80
Chen, W., Zhang, X., Birsoy, K., & Roeder, R. G. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005626107 · Cited by 79
Auffret, J., Viengchareun, S., Carré, N., Denis, R., Magnan, C., Marie, P., Muscat, A., Fève, B., Lombès, M., & Binart, N. (2012) · The FASEB Journal · doi:10.1096/fj.12-204958 · Cited by 81
Hoffmann, J. M., Grünberg, J. R., CHURCH, C. D., Elias, I., Pálsdóttir, V., Jansson, J., Bosch, F., Hammarstedt, A., Hedjazifar, S., & Smith, U. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.07.020 · Cited by 80
Depletion of Nsd2-mediated histone H3K36 methylation impairs adipose tissue development and function
Zhuang, L., Jang, Y., Park, Y.-K., Lee, J., Jain, S., Froimchuk, E., Broun, A., Liu, C., Gavrilova, O., & Ge, K. (2018) · Nature Communications · doi:10.1038/s41467-018-04127-6 · Cited by 82
Shapira, S. N., Lim, H., Rajakumari, S., Sakers, A. P., Ishibashi, J., Harms, M. J., Won, K., & Seale, P. (2017) · Genes & Development · doi:10.1101/gad.294405.116 · Cited by 79
“BAT and skeletal muscle descend from a related precursor population in the somitic mesoderm (Atit et al. 2006; Seale et al. 2008) and share many functional properties: abundant mitochondria, high levels of sympathetic innervation, and high thermogenic capacity(Forneret al. 2009).”
Self-citationDissecting Murine Muscle Stem Cell Aging through Regeneration Using Integrative Genomic Analysis
Shcherbina, A., Larouche, J., Fraczek, P., Yang, B. A., Brown, L. A., Markworth, J. F., Chung, C. H., Khaliq, M., de Silva, K., Choi, J. J., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107964 · Cited by 76
“Aged MuSCs were observed to increase the expression of Prdm16, which contributes to cell fate (An et al., 2017) decisions toward brown adipocytes (Seale et al., 2008), and downregulated Lsd1/ Kdm1a as well as E2F4 (An et al., 2017), both of which have been shown to prevent brown adipocyte…”
BackgroundActivin E controls energy homeostasis in both Brown and white adipose tissues as a hepatokine
Hashimoto, O., Funaba, M., Sekiyama, K., Doi, S., Shindo, D., Satoh, R., Itoi, H., Oiwa, H., Morita, M., Suzuki, C., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.10.008 · Cited by 77
Role of bile acids in the regulation of the metabolic pathways
Taoka, H., Yokoyama, Y., Morimoto, K., Kitamura, N., Tanigaki, T., Takashina, Y., Tsubota, K., & Watanabe, M. (2016) · World Journal of Diabetes · doi:10.4239/wjd.v7.i13.260 · Cited by 80
Brown fat thermogenesis and body weight regulation in mice: relevance to humans
Kozak, L. P., Koza, R. A., & Anunciado‐Koza, R. P. (2010) · International Journal of Obesity · doi:10.1038/ijo.2010.179 · Cited by 79
杉山, 拓., Benitez, C. M., Ghodasara, A., Liu, L., McLean, G. W., Lee, J., Blauwkamp, T. A., Nusse, R., Wright, C. V. E., Gu, G., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1304507110 · Cited by 76
“The accessibility of pancreatic progenitor cells to genetic manipulations and the authenticity of development in this system permitted an unprecedented short hairpin RNA (shRNA)-based genetic screen, as well as discovery of Prdm16 (20, 21) as a factor regulating in vivo islet cell differentiation and allocation.”
BackgroundASK1 signalling regulates brown and beige adipocyte function
Hattori, K., Naguro, I., Okabe, K., Funatsu, T., Furutani, S., Takeda, K., & Ichijo, H. (2016) · Nature Communications · doi:10.1038/ncomms11158 · Cited by 78
A MicroRNA Linking Human Positive Selection and Metabolic Disorders
Wang, L., Sinnott-Armstrong, N., Wagschal, A., Wark, A. R., Camporez, J. P., Perry, R. J., Ji, F., Sohn, Y., Oh, J. D., Wu, S., et al. (2020) · Cell · doi:10.1016/j.cell.2020.09.017 · Cited by 81
“Cell lineage tracing studies in vivo have revealed that brown adipocytes can derive from a Myf5-positive skeletal muscle precursor lineage (Sanchez-Gurmaches and Guertin, 2014; Seale et al., 2008).”
BackgroundThe developmental transition of ovine adipose tissue through early life
Pope, M., Budge, H., & Symonds, M. E. (2013) · Acta Physiologica · doi:10.1111/apha.12053 · Cited by 82
“Finally, several genes whose expression has been shown to be high during adipogenesis of both WAT and BAT were investigated, many of which are associated with lipid sequestration and include CCAAT-enhancer-binding protein b (C/EBPb), fatty acid-binding protein (FABP) 4. leptin, adiponectin, adipose differentiation–rel…”
BackgroundInfluentialAndrogen Effects on Adipose Tissue Architecture and Function in Nonhuman Primates
Varlamov, O., White, A. E., Carroll, J. M., Bethea, C. L., Reddy, A. P., Slayden, O. D., O’Rourke, R. W., & Roberts, C. T. (2012) · Endocrinology · doi:10.1210/en.2011-2111 · Cited by 74
Exercise-Induced Adaptations to Adipose Tissue Thermogenesis
Vidal, P., & Stanford, K. I. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00270 · Cited by 84
“However, while brown adipocytes arise from Pax7 and Myf5 positive cells (53, 54), beige adipocytes arise from Myf5 negative adipogenic stem cells within the adipose tissue (55, 56).”
BackgroundBrown Adipose Tissue Heterogeneity, Energy Metabolism, and Beyond
Shinde, A. B., Song, A., & Wang, Q. A. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.651763 · Cited by 82
Regulation of brown fat by AMP-activated protein kinase
van Dam, A. D., Kooijman, S., Schilperoort, M., Rensen, P. C. N., & Boon, M. R. (2015) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2015.07.003 · Cited by 79
Functional Brown Adipose Tissue is Related to Muscle Volume in Children and Adolescents
Gilsanz, V., Chung, S. A., Jackson, H. A., Dorey, F. J., & Hu, P. (2010) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2010.11.020 · Cited by 78
Morganstein, D. L., Wu, P., Mane, M. R., Fisk, N. M., White, R., & Parker, M. G. (2010) · Cell Research · doi:10.1038/cr.2010.11 · Cited by 77
“Recent work indicates that brown adipose tissue and skeletal muscle are derived from common Myf5 expressing progenitor cells and that the transcriptional regulator, PRDM16, controls a brown fat/skeletal muscle switch (Seale et al., 2008).”
BackgroundChen, L., Chen, Y.-H., Cheng, K., Chien, T.-Y., Chan, C.-H., Tsao, S., & Huang, H.-Y. (2017) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2017.11.004 · Cited by 75
CDK6 inhibits white to beige fat transition by suppressing RUNX1
Hou, X. S., Zhang, Y., Li, W., Hu, A. J., Luo, C., Zhou, W., Hu, J. K., Daniele, S. G., Wang, J., Sheng, J., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03451-1 · Cited by 74
Liu, P., Huang, S., Ling, S., Xu, S., Wang, F., Zhang, W., Zhou, R., He, L., Xia, X., Yao, Z., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-12988-8 · Cited by 75
Differential Computed Tomographic Attenuation of Metabolically Active and Inactive Adipose Tissues
Hu, P., Chung, S. A., Nayak, K. S., Jackson, H. A., & Gilsanz, V. (2011) · Journal of Computer Assisted Tomography · doi:10.1097/rct.0b013e3181fc2150 · Cited by 76
Biressi, S., Bjornson, C. R. R., Carlig, P. M. M., Nishijo, K., Keller, C., & Rando, T. A. (2013) · Developmental Biology · doi:10.1016/j.ydbio.2013.04.021 · Cited by 76
Pharmacological strategies for targeting BAT thermogenesis
Whittle, A. J., Relat, J., & Vidal‐Puig, A. (2013) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2013.04.004 · Cited by 82
Genetically modified cells in regenerative medicine and tissue engineering☆
Sheyn, D., Mizrahi, O., Benjamin, S., Gazit, Z., Pelled, G., & Gazit, D. (2010) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2010.01.002 · Cited by 77
Loss of MyoD Promotes Fate Transdifferentiation of Myoblasts Into Brown Adipocytes
Wang, C., Liu, W., Nie, Y., Qaher, M., Horton, H. E., Yue, F., Asakura, A., & Kuang, S. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.01.015 · Cited by 78
Self-citationShull, L. C., Sen, R., Menzel, J., Goyama, S., Kurokawa, M., & Artinger, K. (2020) · Developmental Biology · doi:10.1016/j.ydbio.2020.02.006 · Cited by 74
Transferrin Receptor 1 Regulates Thermogenic Capacity and Cell Fate in Brown/Beige Adipocytes
Li, J., Pan, X., Pan, G., Song, Z., He, Y., Zhang, S., Ye, X., Xiang, Y., Xie, E., Wang, X., et al. (2020) · Advanced Science · doi:10.1002/advs.201903366 · Cited by 74
van den Beukel, J. C., Grefhorst, A., Quarta, C., Steenbergen, J., Mastroberardino, P. G., Lombès, M., Delhanty, P. J. D., Mazza, R., Pagotto, U., van der Lely, A. J., et al. (2014) · The FASEB Journal · doi:10.1096/fj.14-254839 · Cited by 76
Thermogenic Ability of Uncoupling Protein 1 in Beige Adipocytes in Mice
Okamatsu‐Ogura, Y., Fukano, K., Tsubota, A., Uozumi, A., Terao, A., Kimura, K., & Saito, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0084229 · Cited by 81
Role of bone morphogenetic protein 4 in the differentiation of brown fat-like adipocytes
Xue, R., Wan, Y., Zhang, S., Zhang, Q., Ye, H., & Li, Y. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00119.2013 · Cited by 80
Uncoupling mechanism and redox regulation of mitochondrial uncoupling protein 1 (UCP1)
Ježek, P., Jabůrek, M., & Porter, R. K. (2018) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2018.11.007 · Cited by 73
“The myf5+ lineage (myogenic factor 5, myf5-dependent), which is also common for skeletal muscle, is determining in brown adipocytes, whereas a myf5− lineage is the precursor for beige adipocytes [99].”
BackgroundZhou, C., York, S. R., Chen, J. Y., Pondick, J. V., Motola, D., Chung, R. T., & Mullen, A. C. (2016) · Genome Medicine · doi:10.1186/s13073-016-0285-0 · Cited by 72
Jia, R., Luo, X.-Q., Wang, G., Lin, C. ‐., Qiao, H., Wang, N., Yao, T., Barclay, J. L., Whitehead, J. P., Luo, X., et al. (2016) · Acta Physiologica · doi:10.1111/apha.12688 · Cited by 71
“Constitutive or classical BAT (cBAT) is of embryonic origin and anatomically located in the interscapular region in rodents and has a musclelike Myf5+, En1+, Pax7+ cell lineage signature (Atit et al. 2006, Timmons et al. 2007, Seale et al. 2008, Lepper & Fan 2010).”
BackgroundPhytochemicals as potential candidates to combat obesity via adipose non-shivering thermogenesis
Li, H., Qi, J., & Li, L. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104393 · Cited by 76
Liu, K., Lin, L., Li, Q., Xue, Y., Zheng, F., Wang, G., Zheng, C., Du, L., Hu, M., Huang, Y., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1914553117 · Cited by 73
“By employing lineage-tracing mouse models, it has been revealed that progenitors of brown adipocytes reside in the dermomyotome (12).”
MethodBiferali, B., Bianconi, V., Fernández-Pérez, D., Pöhle‐Kronawitter, S., Marullo, F., Maggio, R., Santini, T., Polverino, F., Biagioni, S., Summa, V., et al. (2021) · Science Advances · doi:10.1126/sciadv.abd9371 · Cited by 73
Nuclear receptor regulation of stemness and stem cell differentiation
Jeong, Y., & Mangelsdorf, D. J. (2009) · Experimental & Molecular Medicine · doi:10.3858/emm.2009.41.8.091 · Cited by 74
“More interestingly, the physiological function of ERRβ has been recently demonstrated in the reprogramming of mouse fibroblasts to iPS cells, where ERRβ is coordinately involved in conjunction with Oct3/4 and Sox2 (Feng et al., 2009).”
BackgroundInfluentialCannon, B., & Nedergaard, J. (2008) · Nature · doi:10.1038/454947a · Cited by 73
Kissig, M., Ishibashi, J., Harms, M., Lim, H., Stine, R. R., Won, K., & Seale, P. (2017) · The EMBO Journal · doi:10.15252/embj.201695588 · Cited by 73
Self-citationMultifaceted Role of PRDM Proteins in Human Cancer
Casamassimi, A., Rienzo, M., Zazzo, E. D., Sorrentino, A., Fiore, D., Proto, M., Moncharmont, B., Gazzerro, P., Bifulco, M., & Abbondanza, C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072648 · Cited by 76
Nature's fat-burning machine: brown adipose tissue in a hibernating mammal
Ballinger, M. A., & Andrews, M. T. (2018) · Journal of Experimental Biology · doi:10.1242/jeb.162586 · Cited by 72
Lsd1 regulates skeletal muscle regeneration and directs the fate of satellite cells
Vukotić, M., Allen, A., Willmann, D., Lepper, C., Kim, J., Duteil, D., & Schüle, R. (2018) · Nature Communications · doi:10.1038/s41467-017-02740-5 · Cited by 72
Recruitment of Brown Adipose Tissue as a Therapy for Obesity-Associated Diseases
Boss, O., & Farmer, S. R. (2012) · Frontiers in Endocrinology · doi:10.3389/fendo.2012.00014 · Cited by 72
Mosaic Mutant Analysis Identifies PDGFRα/PDGFRβ as Negative Regulators of Adipogenesis
Sun, C., Sakashita, H., Kim, J. H., Tang, Z., Upchurch, G. M., Yao, L., Berry, W. L., Griffin, T. M., & Olson, L. E. (2020) · Cell stem cell · doi:10.1016/j.stem.2020.03.004 · Cited by 76
Los colores del tejido adiposo
Frigolet, M. E., & Gutiérrez‐Aguilar, R. (2020) · Gaceta Médica de México · doi:10.24875/gmm.20005541 · Cited by 96
Regulation of brown adipocyte metabolism by myostatin/follistatin signaling
Singh, R., Braga, M., & Pervin, S. (2014) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2014.00060 · Cited by 71
“Genetic fat-mapping experiments indicate that BAT in the interscapular region and skeletal muscle but not white adipose cells arise from Myf5+ precursor cells (Kajimura et al., 2010).”
BackgroundDeterminants of brown adipocyte development and thermogenesis
Richard, D., Carpentier, A. C., Doré, G., Ouellet, V., & Picard, F. (2010) · International Journal of Obesity · doi:10.1038/ijo.2010.241 · Cited by 71
Rossi, C. A., Pozzobon, M., Ditadi, A., Archacka, K., Gastaldello, A., Sanna, M., Franzin, C., Malerba, A., Milan, G., Cananzi, M., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0008523 · Cited by 71
“, leptin and perilipin expression cannot be found in myogenic cells. Moreover, differently to what previously demonstrated”
ResultDirect Evidence of Brown Adipocytes in Different Fat Depots in Children
Rockstroh, D., Landgraf, K., Wagner, I. V., Gesing, J. K., Tauscher, R., Lakowa, N., Kieß, W., Bühligen, U., Wojan, M., Till, H., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0117841 · Cited by 74
Prdm13 mediates the balance of inhibitory and excitatory neurons in somatosensory circuits
Chang, J. C., Meredith, D., Mayer, P. R., Borromeo, M. D., Lai, H., Ou, Y.-H., & Johnson, J. E. (2013) · Developmental Cell · doi:10.1016/j.devcel.2013.02.015 · Cited by 76
“For example, Prdm16 specifies brown fat fate while suppressing white fat or muscle (Kajimura et al., 2010; Seale et al., 2008).”
BackgroundNord, K. H., Magnusson, L., Isaksson, M., Nilsson, J., Lilljebjörn, H., Domanski, H. A., Kindblom, L., Mandahl, N., & Mertens, F. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1013512107 · Cited by 73
Epigenetic Regulation of Adipogenesis by PHF2 Histone Demethylase
Okuno, Y., Ohtake, F., Igarashi, K., Kanno, J., Μatsumoto, T., Takada, I., Kato, S., & Imai, Y. (2012) · Diabetes · doi:10.2337/db12-0628 · Cited by 71
“Recently, it was reported that brown adipocytes were differentiated from Myf5-positive precursor cells, which are more closely related to myoblasts rather than to the white preadipocytes (32).”
BackgroundNie, T., Zhao, S., Mao, L., Yang, Y., Sun, W., Lin, X., Liu, S., Li, K., Sun, Y., Li, P., et al. (2018) · British Journal of Pharmacology · doi:10.1111/bph.14139 · Cited by 69
MicroRNAs-Dependent Regulation of PPARs in Metabolic Diseases and Cancers
Portius, D., Sobolewski, C., & Foti, M. (2017) · PPAR Research · doi:10.1155/2017/7058424 · Cited by 72
“During brown adipogenesis, Prdm16 (PR domain-containing 16) instead of RXRα heterodimerizes with PPARγ2 andmediates brown adipocyte differentiation [115].”
BackgroundVanillic acid activates thermogenesis in brown and white adipose tissue
Han, X., Guo, J., You, Y., Yin, M., Liang, J. B., Ren, C., Zhan, J., & Huang, W. (2018) · Food & Function · doi:10.1039/c8fo00978c · Cited by 70
Zeng, Y.-Z., Ren, K., Zhu, X., Zheng, Z., & Yi, G. (2018) · Advances in clinical chemistry · doi:10.1016/bs.acc.2018.07.001 · Cited by 70
Kumar, A., Xie, L., Ta, C. M., Hinton, A. O., Jr., Gunasekar, S. K., Minerath, R. A., Shen, K. C., Maurer, J. M., Grueter, C. E., Abel, E. D., et al. (2020) · eLife · doi:10.7554/elife.58941 · Cited by 69
“Since Myf5 is also expressed in brown fat (Seale et al., 2008), it is possible that these metabolic phenotypes arise from LRRC8A-mediated effects in brown fat and consequent changes in systemic metabolism.”
BackgroundIntegrating Physiological Regulation with Stem Cell and Tissue Homeostasis
Nakada, D., Levi, B. P., & Morrison, S. J. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.011 · Cited by 78
Plasma Bile Acids Are Associated with Energy Expenditure and Thyroid Function in Humans
Ockenga, J., Valentini, L., Schuetz, T., Wohlgemuth, F., Glaeser, S., Omar, A., Kasim, E., DuPlessis, D., Featherstone, K., Davis, J. R., et al. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-2329 · Cited by 74
Regulation of brown and beige fat by microRNAs
Chen, Y., Pan, R., & Pfeifer, A. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.10.004 · Cited by 73
S100 proteins in obesity: liaisons dangereuses
Riuzzi, F., Chiappalupi, S., Arcuri, C., Giambanco, I., Sorci, G., & Donato, R. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03257-4 · Cited by 70
Genomic map of candidate human imprint control regions: the imprintome
Jima, D. D., Skaar, D. A., Planchart, A., Motsinger‐Reif, A. A., Cevik, S. E., Park, S. S., Cowley, M., Wright, F. A., House, J. S., Liu, A., et al. (2022) · Epigenetics · doi:10.1080/15592294.2022.2091815 · Cited by 75
Multiple symmetric lipomatosis: A rare disease and its possible links to brown adipose tissue
Enzi, G., Busetto, L., Sergi, G., Coin, A., İnelmen, E., Vindigni, V., Bassetto, F., & Cinti, S. (2015) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2015.01.010 · Cited by 72
Yes, even human brown fat is on fire!
Cannon, B., & Nedergaard, J. (2012) · Journal of Clinical Investigation · doi:10.1172/jci60941 · Cited by 67
Vestigial-like 3 is an inhibitor of adipocyte differentiation
Halperin, D. S., Pan, C., Lusis, A. J., & Tontonoz, P. (2012) · Journal of Lipid Research · doi:10.1194/jlr.m032755 · Cited by 69
Federico, L., Ren, H., Mueller, P. A., Wu, T., Liu, S., Popović, J., Blalock, E. M., Sunkara, M., Ovaa, H., Albers, H. M. H. G., et al. (2012) · Molecular Endocrinology · doi:10.1210/me.2011-1229 · Cited by 69
Martínez-López, N., Athonvarangkul, D., Sahu, S., Coletto, L., Zong, H., Bastie, C. C., Pessin, J. E., Schwartz, G. J., & Singh, R. (2013) · EMBO Reports · doi:10.1038/embor.2013.111 · Cited by 68
Metadata
- Authors
- Seale, P., Bjork, B., Yang, W., Kajimura, S., Chin, S., Kuang, S., Scimè, A., Devarakonda, S., Conroe, H. M., Erdjument-Bromage, H., Tempst, P., Rudnicki, M. A., Beier, D. R., & Spiegelman, B. M.
- Affiliations
- Harvard University (US)
- Brigham and Women's Hospital (US)
- Memorial Sloan Kettering Cancer Center (US)
- Corresponding author
- Spiegelman, Bruce M.
- ORCID
- Venue
- Nature
- Published
- 2008-08
- Volume
- 454
- Issue
- 7207
- Pages
- 961-967
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC2583329
- OpenAlex
- W2104827888
- Cited by
- 2,347
- References
- 44
- Citations by year
- 2026: 77 · 2025: 71 · 2024: 118 · 2023: 115 · 2022: 129 · 2021: 134 · 2020: 141 · 2019: 134 · 2018: 168 · 2017: 165 · 2016: 139 · 2015: 167 · 2014: 157 · 2013: 181 · 2012: 134
- FWCI
- 71.30
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- American Heart Association
- National Institute of Diabetes and Digestive and Kidney Diseases (R37DK031405)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR044031)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- PRDM16, brown adipose tissue, skeletal muscle, Myf5, brown adipogenesis, PPARγ, thermogenesis, myogenesis, energy expenditure, obesity
- MeSH terms
- Animals, Adipose Tissue, Brown, Cell Differentiation, Cell Line, Chlorocebus aethiops, DNA-Binding Proteins, Male, Transcription Factors, Muscle, Skeletal, Gene Expression Regulation, Developmental, COS Cells, Muscle Development, PPAR gamma, Mice, Myogenic Regulatory Factor 5, Adipocytes, Brown, Adipocytes, White
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