Seale, Patrick

PRDM16 controls a brown fat/skeletal muscle switch

Seale, P., Bjork, B., Yang, W., Kajimura, S., Chin, S., Kuang, S., Scimè, A., Devarakonda, S., Conroe, H. M., Erdjument-Bromage, H., et al. (2008) · Nature

Adipose Tissue and MetabolismPeroxisome Proliferator-Activated Receptors

Cited by 2,347

Brown and beige fat: Development, function and therapeutic potential

Harms, M., & Seale, P. (2013) · Nature Medicine

Adipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic Diseases

Cited by 2,328

Transcriptional Control of Brown Fat Determination by PRDM16

Seale, P., Kajimura, S., Yang, W., Chin, S., Rohas, L. M., Uldry, M., Tavernier, G., Langin, D., & Spiegelman, B. M. (2007) · Cell Metabolism

Adipose Tissue and MetabolismPeroxisome Proliferator-Activated Receptors

Cited by 1,174

Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity

Brestoff, J. R., Kim, B. S., Saenz, S. A., Stine, R. R., Monticelli, L. A., Sonnenberg, G. F., Thome, J. J., Farber, D. L., Lutfy, K., Seale, P., et al. (2015) · Nature

IL-33, ST2, and ILC PathwaysAdipokines, Inflammation, and Metabolic Diseases

Cited by 968

Initiation of myoblast to brown fat switch by a PRDM16–C/EBP-β transcriptional complex

Kajimura, S., Seale, P., Kubota, K., Lunsford, E., Frangioni, J. V., Gygi, S. P., & Spiegelman, B. M. (2009) · Nature

Adipose Tissue and MetabolismPeroxisome Proliferator-Activated Receptors

Cited by 703

Identification of a mesenchymal progenitor cell hierarchy in adipose tissue

Merrick, D., Sakers, A., Irgebay, Z., Okada, C., Calvert, C., Morley, M. P., Percec, I., & Seale, P. (2019) · Science

Adipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic Diseases

Cited by 664

Regeneration of fat cells from myofibroblasts during wound healing

Plikus, M. V., Guerrero-Juarez, C. F., Ito, M., Li, Y. R., Dedhia, P. H., Zheng, Y., Shao, M., Gay, D. L., Ramos, R., Hsi, T.-C., et al. (2017) · Science

Wound Healing and TreatmentsHair Growth and Disorders

Cited by 584

Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex

Kajimura, S., Seale, P., Tomaru, T., Erdjument-Bromage, H., Cooper, M. P., Ruas, J. L., Chin, S., Tempst, P., Lazar, M. A., & Spiegelman, B. M. (2008) · Genes & Development

Adipose Tissue and MetabolismPeroxisome Proliferator-Activated Receptors

Cited by 468

MicroRNA-133 Controls Brown Adipose Determination in Skeletal Muscle Satellite Cells by Targeting Prdm16

Yin, H., Pasut, A., Soleimani, V. D., Bentzinger, C. F., Antoun, G., Thorn, S., Seale, P., Fernando, P., van IJcken, W., Grosveld, F., et al. (2013) · Cell Metabolism

Adipose Tissue and MetabolismMuscle Physiology and Disorders

Cited by 293

Microphysiological Engineering of Self-Assembled and Perfusable Microvascular Beds for the Production of Vascularized Three-Dimensional Human Microtissues

Paek, J., Park, S. E., Lu, Q., Park, K.-T., Cho, M., Oh, J. M., Kwon, K. W., Yi, Y.-S., Song, J. W., Edelstein, H. I., et al. (2019) · ACS Nano

3D Printing in Biomedical ResearchTissue Engineering and Regenerative Medicine

Cited by 238

Antibody blockade of activin type II receptors preserves skeletal muscle mass and enhances fat loss during GLP-1 receptor agonism

Nunn, E., Jaiswal, N., Gavin, M., Uehara, K., Stefkovich, M., Drareni, K., Calhoun, R., Lee, M., Holman, C. D., Baur, J. A., et al. (2024) · Molecular Metabolism

Muscle Physiology and DisordersNutrition and Health in Aging

Cited by 126

Aging impairs cold-induced beige adipogenesis and adipocyte metabolic reprogramming

Holman, C. D., Sakers, A. P., Calhoun, R. P., Cheng, L., Fein, E. C., Jacobs, C., Tsai, L., Rosen, E. D., & Seale, P. (2024) · eLife

Adipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic Diseases

Cited by 8