The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Innate immunity and intestinal microbiota in the development of Type 1 diabetes
Open accessAbstract
Type 1 diabetes (T1D) is a debilitating autoimmune disease that results from T-cell-mediated destruction of insulin-producing beta-cells. Its incidence has increased during the past several decades in developed countries, suggesting that changes in the environment (including the human microbial environment) may influence disease pathogenesis. The incidence of spontaneous T1D in non-obese diabetic (NOD) mice can be affected by the microbial environment in the animal housing facility or by exposure to microbial stimuli, such as injection with mycobacteria or various microbial products. Here we show that specific pathogen-free NOD mice lacking MyD88 protein (an adaptor for multiple innate immune receptors that recognize microbial stimuli) do not develop T1D. The effect is dependent on commensal microbes because germ-free MyD88-negative NOD mice develop robust diabetes, whereas colonization of these germ-free MyD88-negative NOD mice with a defined microbial consortium (representing bacterial phyla normally present in human gut) attenuates T1D. We also find that MyD88 deficiency changes the composition of the distal gut microbiota, and that exposure to the microbiota of specific pathogen-free MyD88-negative NOD donors attenuates T1D in germ-free NOD recipients. Together, these findings indicate that interaction of the intestinal microbes with the innate immune system is a critical epigenetic factor modifying T1D predisposition.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Mice deficient in MyD88 display an altered microbiota composition.56”
From Interaction between microbiota and immunity in health and disease (2020) · cites this paper as [56]
In the citing paper
“TLR5 is of particular importance in shaping the gut microbiota,53–56 which might be confined to a critical time window during neonatal life.40”
From Interaction between microbiota and immunity in health and disease (2020) · cites this paper as [56]
In the citing paper
“GF non-obese diabetic mice lacking MyD88 signaling robustly develop T1D”
From Interaction between microbiota and immunity in health and disease (2020) · cites this paper as [56]
In the citing paper
“while microbial colonization of these mice attenuates the disease.56”
From Interaction between microbiota and immunity in health and disease (2020) · cites this paper as [56]
In the citing paper
“Changes in the proportions of specific taxa of gut microbiota have been observed in various disease states, including obesity68,69, inflammatory bowel disease70, type 1 and type 2 diabetes mellitus71,72, biliary disease73, and intestinal cancers74,75 among many others.”
From Dietary metabolism, the gut microbiome, and heart failure (2019) · cites this paper as [71]
In the citing paper
“there is evidence that particular population changes are associated with pathologies that confer an increased risk of developing PH and other vascular disease, including obesity[273–275], diabetes[276], and insulin resistance[277].”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [276]
In the citing paper
“Elevations in the Firmicutes:Bacteroidetes ratio have been associated with a high-fat diet and obesity[274,328,329], irritable bowel syndrome[330], hypertension[331], type 1 diabetes[276], and HIV[332].”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [276]
In the citing paper
“The Muc2-KO mouse possesses a distinct gut-associated bacterial community that is influenced by its altered genetic and immune states, as has been shown in other genetic knockout mouse models.4,53–55”
From Using Corticosteroids to Reshape the Gut Microbiome: Implications for Inflammatory Bowel Diseases (2015) · cites this paper as [55]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Naive Bayesian Classifier for Rapid Assignment of rRNA Sequences into the New Bacterial Taxonomy
Wang, Q., Garrity, G. M., Tiedje, J. M., & Cole, J. R. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.00062-07 · Cited by 20,145
An obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444
Self-citationPathogen Recognition and Innate Immunity
Akira, S., Uematsu, S., & Takeuchi, O. (2006) · Cell · doi:10.1016/j.cell.2006.02.015 · Cited by 12,401
16S ribosomal DNA amplification for phylogenetic study
Weisburg, W. G., Barns, S. M., Pelletier, D. A., & Lane, D. J. (1991) · Journal of Bacteriology · doi:10.1128/jb.173.2.697-703.1991 · Cited by 11,970
Human gut microbes associated with obesity
Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. (2006) · Nature · doi:10.1038/4441022a · Cited by 8,785
Self-citationUniFrac: a New Phylogenetic Method for Comparing Microbial Communities
Lozupone, C., & Knight, R. (2005) · Applied and Environmental Microbiology · doi:10.1128/aem.71.12.8228-8235.2005 · Cited by 8,227
ARB: a software environment for sequence data
Ludwig, W. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh293 · Cited by 6,714
Obesity alters gut microbial ecology
Ley, R. E., Bäckhed, F., Turnbaugh, P., Lozupone, C. A., Knight, R. D., & Gordon, J. I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504978102 · Cited by 6,176
Self-citationRecognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis
Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S., & Medzhitov, R. (2004) · Cell · doi:10.1016/j.cell.2004.07.002 · Cited by 4,251
Approaching the asymptote? Evolution and revolution in immunology.Preprint
Janeway, C. (1989) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1989.054.01.003 · Cited by 3,396
Flagged first, then by citations
Research works printed but not linked: 1
- Funda, D. P., Fundova, P. & Harrison, L. C. Microflora-dependency of selected diabetes-preventive diets: germ-free and ex-germ-free monocolonized NOD mice as models for studying environmental factors in type 1 diabetes. Proc. 13th Int. Congr. Immunol. MS-11.4 16 (Brazilian Society for Immunology, Rio de Janeiro, 2007)
Cited by
Sorted by citations
Items 901–1,000 of 1,002
Favero, C., Carriazo, S. M., Cuarental, L., Fernández-Prado, R., Gomá-Garcés, E., Pérez-Gómez, M. V., Ortíz, A., Fernández‐Fernández, B., & Sánchez-Niño, M. D. (2021) · Nutrients · doi:10.3390/nu13041273 · Cited by 42
Land Cover of Early-Life Environment Modulates the Risk of Type 1 Diabetes
Nurminen, N., Cerrone, D., Lehtonen, J., Parajuli, A., Roslund, M. I., Lönnrot, M., Ilonen, J., Toppari, J., Veijola, R., Knip, M., et al. (2021) · Diabetes Care · doi:10.2337/dc20-1719 · Cited by 46
Gut microbiota dysbiosis in Chinese children with type 1 diabetes mellitus: An observational study
Liu, X., Cheng, Y., Shao, L., Sun, S., Wu, J., Song, Q., Hong-sheng, Z., & Ling, Z. (2021) · World Journal of Gastroenterology · doi:10.3748/wjg.v27.i19.2394 · Cited by 42
The gut–brain connection: triggering of brain autoimmune disease by commensal gut bacteria
Wekerle, H. (2016) · Rheumatology · doi:10.1093/rheumatology/kew353 · Cited by 41
The gut microbiome and the immune system
Choden, T., & Cohen, N. A. (2022) · Exploration of Medicine · doi:10.37349/emed.2022.00087 · Cited by 41
Intestinal Microbiota in Animal Models of Inflammatory Diseases
Hörmannsperger, G., Schaubeck, M., & Haller, D. (2015) · ILAR Journal · doi:10.1093/ilar/ilv019 · Cited by 42
Prevention or acceleration of type 1 diabetes by viruses
Ghazarian, L., Diana, J., Simoni, Y., Beaudoin, L., & Lehuen, A. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1042-1 · Cited by 40
Equine Fecal Microbiota Changes Associated With Anthelmintic Administration
Kunz, I. G. Z., Reed, K. J., Metcalf, J. L., Hassel, D. M., Coleman, R., Hess, T. M., & Coleman, S. J. (2019) · Journal of Equine Veterinary Science · doi:10.1016/j.jevs.2019.01.018 · Cited by 44
Urinary metabolite signature in bipolar disorder patients during depressive episode
Chen, J., Xie, J., Zeng, L., Zhou, C., Zheng, P., & Xie, P. (2019) · Aging · doi:10.18632/aging.101805 · Cited by 40
Wei, H., Li, X., Tang, L., Yao, H., Ren, Z., Wang, C., Mu, C., Shi, C., & Wang, H. (2020) · Chemosphere · doi:10.1016/j.chemosphere.2020.126891 · Cited by 40
Guo, J., Song, C., Liu, Y., Wu, X., Dong, W., Zhu, H., Xiang, Z., & Qin, C. (2022) · Animal Models and Experimental Medicine · doi:10.1002/ame2.12257 · Cited by 42
Microbial–immune cross‐talk and regulation of the immune system
Cahenzli, J., Balmer, M. L., & McCoy, K. D. (2012) · Immunology · doi:10.1111/j.1365-2567.2012.03624.x · Cited by 44
Bugs & us: the role of the gut in autoimmunity.
Luckey, D. H., Gomez, A. M., Murray, J. A., White, B. A., & Taneja, V. (2013) · Europe PMC (PubMed Central) · Cited by 40
Animal Models of EnterohemorrhagicEscherichia coliInfection
Ritchie, J. M. (2014) · Microbiology Spectrum · doi:10.1128/microbiolspec.ehec-0022-2013 · Cited by 41
Can we vaccinate against depression?
Rook, G. A. W., Raison, C. L., & Lowry, C. A. (2012) · Drug Discovery Today · doi:10.1016/j.drudis.2012.03.018 · Cited by 39
Interaction of Intestinal Microorganisms with the Human Host in the Framework of Autoimmune Diseases
Sánchez, B., Hevia, A., González, S., & Margollés, A. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00594 · Cited by 39
Gill, R. G., Pagni, P. P., Kupfer, T., Wasserfall, C. H., Deng, S., Posgai, A. L., Manenkova, Y., Hani, A. B., Straub, L., Bernstein, P., et al. (2015) · Diabetes · doi:10.2337/db15-0492 · Cited by 41
The hundred most-cited publications in microbiota of diabetes research
Tian, J., Li, M., Lian, F., & Tong, X. (2017) · Medicine · doi:10.1097/md.0000000000007338 · Cited by 39
Schuster, C., Jonas, F., Zhao, F., & Kissler, S. (2018) · European Journal of Immunology · doi:10.1002/eji.201847498 · Cited by 40
Common ground: shared risk factors for type 1 diabetes and celiac disease
Verdu, E. F., & Danska, J. S. (2018) · Nature Immunology · doi:10.1038/s41590-018-0130-2 · Cited by 39
Ceccarelli, F., Orrù, G., Pilloni, A., Bartosiewicz, I., Perricone, C., Martino, E., Lucchetti, R., Fais, S., Vomero, M., Olivieri, M., et al. (2018) · Clinical & Experimental Immunology · doi:10.1111/cei.13184 · Cited by 39
Arrazuria, R., Pérez, V. P., Molina, E., Juste, R. A., Khafipour, E., & Elguezábal, N. (2018) · Scientific Reports · doi:10.1038/s41598-018-32484-1 · Cited by 41
Fan, C., Lei, X., Guo, L., & Zhang, A. (2018) · Neurocomputing · doi:10.1016/j.neucom.2018.09.054 · Cited by 39
Gut Dysbiosis in Pancreatic Diseases: A Causative Factor and a Novel Therapeutic Target
Zhang, T., Gao, G., Sakandar, H. A., Kwok, L., & Sun, Z. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.814269 · Cited by 39
Xiong, X., Zhou, J. W., Fu, Q., Xu, X., Wei, S., Yang, S., & Chen, B. (2022) · Lipids in Health and Disease · doi:10.1186/s12944-022-01673-3 · Cited by 41
Regulation of multi-organ inflammation in the regulatory T cell-deficient scurfy mice
Sharma, R., Sung, S. J., Fu, S. M., & Ju, S. (2009) · Journal of Biomedical Science · doi:10.1186/1423-0127-16-20 · Cited by 39
Culp, D. J., Robinson, B., Parkkila, S., Pan, P., Cash, M. N., Truong, H. N., Hussey, T. W., & Gullett, S. L. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.09.006 · Cited by 38
Visser, J. T. J., Bos, N. A., Harthoorn, L. F., Stellaard, F., Beijer‐Liefers, S., Rozing, J., & van Tol, E. A. F. (2012) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2311 · Cited by 38
Epigenetic regulation of Toll-like receptors and its roles in type 1 diabetes
Xie, Z., Huang, G., Wang, Z., Luo, S., Zheng, P., & Zhou, Z. (2018) · Journal of Molecular Medicine · doi:10.1007/s00109-018-1660-7 · Cited by 38
STAT3 dictates β-cell apoptosis by modulating PTEN in streptozocin-induced hyperglycemia
Weng, Q., Zhao, M., Zheng, J., Yang, L., Xu, Z., Zhang, Z., Wang, J., Wang, J., Yang, B., Lu, Q. R., et al. (2019) · Cell Death and Differentiation · doi:10.1038/s41418-019-0344-3 · Cited by 38
Liu, Y., Wang, S., Zhang, J., Zhang, W., Zhou, S., & Wen, L. (2020) · IEEE Transactions on Computational Biology and Bioinformatics · doi:10.1109/tcbb.2020.3018138 · Cited by 38
Self-citationBlake, S. J., James, J., Ryan, F. J., Caparros-Martin, J. A., Eden, G. L., Tee, Y. C., Salamon, J., Benson, S. C., Tumes, D. J., Sribnaia, A., et al. (2021) · Cell Reports Medicine · doi:10.1016/j.xcrm.2021.100464 · Cited by 38
Wu, J., Zou, J., Hu, E.-D., Chen, D., Chen, L., Lu, F., Xu, L., Zheng, M., Li, H., Huang, Y., et al. (2017) · Immunology Letters · doi:10.1016/j.imlet.2017.08.005 · Cited by 38
Metabolomics in childhood diabetes
Frohnert, B. I., & Rewers, M. (2015) · Pediatric Diabetes · doi:10.1111/pedi.12323 · Cited by 38
The influence of the microbiota on the immune response to transplantation
Bartman, C., Chong, A. S., & Alegre, M. (2015) · Current Opinion in Organ Transplantation · doi:10.1097/mot.0000000000000150 · Cited by 39
Evolutionary and ecological forces that shape the bacterial communities of the human gut
Messer, J. S., Liechty, E. R., Vogel, O. A., & Chang, E. B. (2017) · Mucosal Immunology · doi:10.1038/mi.2016.138 · Cited by 41
Early-Life Nutritional Factors and Mucosal Immunity in the Development of Autoimmune Diabetes
Xiao, L., Land, B. V., van de Worp, W. R. P. H., Stahl, B., Folkerts, G., & Garssen, J. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01219 · Cited by 37
Potential roles of chromium on inflammatory biomarkers in diabetes: A Systematic
Moradi, F., Maleki, V., Saleh‐Ghadimi, S., Kooshki, F., & Gargari, B. P. (2019) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.13144 · Cited by 37
The composition and stability of the faecal microbiota of Merino sheep
Mamun, M., Sandeman, M. R., Rayment, P., Brook-Carter, P., Scholes, E., Kasinadhuni, N., Piedrafita, D. M., & Greenhill, A. R. (2019) · Journal of Applied Microbiology · doi:10.1111/jam.14468 · Cited by 38
Xin, G.-Y., Li, W., Suman, T. Y., Jia, P., Ma, Y., & Pei, D. (2020) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2020.08.018 · Cited by 37
Conte, M. L., Cencicchio, M. A., Ulaszewska, M., Nobili, A., Cosorich, I., Ferrarese, R., Massimino, L., Andolfo, A., Ungaro, F., Mancini, N., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1089987 · Cited by 38
Asano, K., Yoshimura, S., & Nakane, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0075008 · Cited by 36
Raine, T., Liu, J. Z., Anderson, C. A., Parkes, M., & Kaser, A. (2014) · Gut · doi:10.1136/gutjnl-2013-306657 · Cited by 36
Mamantopoulos, M., Ronchi, F., McCoy, K. D., & Wullaert, A. (2018) · Gut Microbes · doi:10.1080/19490976.2017.1421888 · Cited by 37
Carrero, J. A., Benshoff, N. D., Nalley, K., & Unanue, E. R. (2018) · Diabetes · doi:10.2337/db18-0331 · Cited by 36
Host innate and adaptive immunity shapes the gut microbiota biogeography
Gu, M., Samuelson, D. R., de la Rúa, N. M., Charles, T. P., Taylor, C. M., Luo, M., Siggins, R. W., Shellito, J. E., & Welsh, D. A. (2022) · Microbiology and Immunology · doi:10.1111/1348-0421.12963 · Cited by 36
Zhou, X., Zhang, X., Niu, D., Zhang, S., Wang, H., Zhang, X., Nan, F., Jiang, S., & Wang, B. (2023) · Scientific Reports · doi:10.1038/s41598-023-33806-8 · Cited by 39
Epidemiologic Clues to Inflammatory Bowel Disease
Bernstein, C. N. (2010) · Current Gastroenterology Reports · doi:10.1007/s11894-010-0144-x · Cited by 36
Effects of ammonia on intestinal microflora and productive performance of laying ducks
Tao, Z., Xu, W., Zhu, C., Zhang, S., Shi, Z., Song, W., Liu, H., & Li, H. (2019) · Poultry Science · doi:10.3382/ps/pey578 · Cited by 36
Therapeutic Advances in Diabetes, Autoimmune, and Neurological Diseases
Liu, J., Ting, J. P., Al-Azzam, S., Ding, Y., & Afshar, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22062805 · Cited by 37
Antigen-Based Immune Therapeutics for Type 1 Diabetes: Magic Bullets or Ordinary Blanks?
Čulina, S., Boîtard, C., & Mallone, R. (2011) · Clinical and Developmental Immunology · doi:10.1155/2011/286248 · Cited by 38
Protective effects of bifidobacteria against enteropathogens
Aw, W., & Fukuda, S. (2019) · Microbial Biotechnology · doi:10.1111/1751-7915.13460 · Cited by 35
Czaja, A. J. (2019) · World Journal of Gastroenterology · doi:10.3748/wjg.v25.i45.6579 · Cited by 35
Approaches in type 1 diabetes research: A status report
Rao, V., Raha, O., Chowdhury, S., Dasgupta, S., Raychaudhuri, P., Sarkar, B., & Raju, P. (2009) · International Journal of Diabetes in Developing Countries · doi:10.4103/0973-3930.53126 · Cited by 36
Role of Innate Immunity in Diabetes and Metabolism: Recent Progress in the Study of Inflammasomes
Lee, M. (2011) · Immune Network · doi:10.4110/in.2011.11.2.95 · Cited by 35
Disruption of the Gut Microbiota With Antibiotics Exacerbates Acute Vascular Rejection
Rey, K., Manku, S., Enns, W., Rossum, T. V., Bushell, K. R., Morin, R. D., Brinkman, F. S. L., & Choy, J. C. (2018) · Transplantation · doi:10.1097/tp.0000000000002169 · Cited by 35
Discovery of a Kojibiose Phosphorylase in Escherichia coli K-12
Mukherjee, K., Narindoshvili, T., & Raushel, F. M. (2018) · Biochemistry · doi:10.1021/acs.biochem.8b00392 · Cited by 35
Sofi, M. H., Johnson, B. M., Gudi, R. R., Jolly, A., Gaudreau, M., & Vasu, C. (2019) · Diabetes · doi:10.2337/db19-0211 · Cited by 35
Microbiome and pregnancy: focus on microbial dysbiosis coupled with maternal obesity
Beckers, K. F., Flanagan, J. P., & Sones, J. L. (2023) · International Journal of Obesity · doi:10.1038/s41366-023-01438-7 · Cited by 35
Short-chain fatty acids: key antiviral mediators of gut microbiota
Xu, Z., Wang, T., Wang, Y., Li, Y., Sun, Y., & Qiu, H. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1614879 · Cited by 37
Advances in comparative genetics: influence of genetics on obesity
Mathes, W. F., Kelly, S. A., & Pomp, D. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114511001905 · Cited by 35
Edwards, M. R., Dai, R., Heid, B., Cecere, T. E., Khan, D., Mu, Q., Cowan, C., Luo, X., & Ahmed, S. A. (2017) · International Immunology · doi:10.1093/intimm/dxx033 · Cited by 35
Choe, U., Li, Y., Gao, B., Yu, L., Wang, T. T. Y., Sun, J., Chen, P. C., Liu, J., & Yu, L. L. (2018) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b03343 · Cited by 36
The Emerging Role of Gut Dysbiosis in Cardio-metabolic Risk Factors for Heart Failure
Sata, Y., Marques, F. Z., & Kaye, D. M. (2020) · Current Hypertension Reports · doi:10.1007/s11906-020-01046-0 · Cited by 34
Wang, H., Liu, L., Rao, X., Zeng, B., Yu, Y., Zhou, C., Zeng, L., Zheng, P., Pu, J., Xu, S., et al. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-01024-9 · Cited by 34
Can we prevent childhood Leukaemia?
Greaves, M. F., Cazzaniga, V., & Ford, A. M. (2021) · Leukemia · doi:10.1038/s41375-021-01211-7 · Cited by 36
Inhibition of TLR4 signaling prolongs Treg-dependent murine islet allograft survival
Zhang, N., Krüger, B., Lal, G., Luan, Y., Yadav, A., Zang, W., Grimm, M. R., Waaga-Gasser, A. M., Murphy, B. T., Bromberg, J. S., et al. (2009) · Immunology Letters · doi:10.1016/j.imlet.2009.10.004 · Cited by 35
Garagnani, P., Pirazzini, C., Giuliani, C., Candela, M., Brigidi, P., Sevini, F., Luiselli, D., Bacalini, M. G., Salvioli, S., Capri, M., et al. (2014) · BioMed Research International · doi:10.1155/2014/560340 · Cited by 38
The human metagenome: our other genome?
Brüls, T., & Weissenbach, J. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr353 · Cited by 34
Prostaglandin E2 Produced by the Lung Augments the Effector Phase of Allergic Inflammation
Church, R. J., Jania, L. A., & Koller, B. H. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1101873 · Cited by 34
Association of Gut Microbial Dysbiosis and Hypertension: A Systematic Review
Naik, S. S., Ramphall, S., Rijal, S., Prakash, V., Ekladios, H., Saju, J. M., Mandal, N., Kham, N. I., Shahid, R., & Venugopal, S. (2022) · Cureus · doi:10.7759/cureus.29927 · Cited by 33
Mutual modulation of gut microbiota and the immune system in type 1 diabetes models
Rosell‐Mases, E., Santiago, A., Corral-Pujol, M., Yáñez, F., Varela, E., Egia‐Mendikute, L., Arpa, B., Cosovanu, C., Panosa, A., Serrano-Gómez, G., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-43652-x · Cited by 33
Sorini, C., & Falcone, M. (2013) · Europe PMC (PubMed Central) · Cited by 33
A Review of Applied Aspects of Dealing with Gut Microbiota Impact on Rodent Models
Hansen, A. K., Krych, Ł., Nielsen, D. S., & Hansen, C. H. F. (2015) · ILAR Journal · doi:10.1093/ilar/ilv010 · Cited by 34
Hansen, C. H. F., Metzdorff, S. B., & Hansen, A. K. (2013) · Gut Microbes · doi:10.4161/gmic.23999 · Cited by 34
Singh, H., Yu, Y., Suh, M., Torralba, M., Stenzel, R. D., Tovchigrechko, A., Thovarai, V., Harkins, D. M., Rajagopala, S. V., Osborne, W., et al. (2017) · Theranostics · doi:10.7150/thno.19679 · Cited by 33
Gut Microbiome and Inflammation: A Study of Diabetic Inflammasome-Knockout Mice
Pahwa, R., Balderas, M. A., Jialal, I., Chen, X., Luna, R. A., & Devaraj, S. (2017) · Journal of Diabetes Research · doi:10.1155/2017/6519785 · Cited by 33
Therapies to Suppress β Cell Autoimmunity in Type 1 Diabetes
Kroger, C. J., Clark, M., Qi, K., & Tisch, R. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01891 · Cited by 35
Gut Microbiota, Probiotics, and Sport
Pane, M., Amoruso, A., Deidda, F., Graziano, T., Allesina, S., & Mogna, L. (2018) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000001058 · Cited by 36
The Role of Epigenetics in Type 1 Diabetes
Xie, Z., Chang, C., Huang, G., & Zhou, Z. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-981-15-3449-2_9 · Cited by 36
Huang, J., Tan, Q., Tai, N., Pearson, J. A., Li, Y., Chao, C., Zhang, L., Peng, J., Xing, Y., Zhang, L., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.702955 · Cited by 33
Self-citationCabrera, S. M., Coren, A. T., Pant, T., Ciecko, A. E., Jia, S., Roethle, M. F., Simpson, P. M., Atkinson, S. N., Salzman, N. H., Chen, Y., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-07203-6 · Cited by 34
New insights into MAIT cells in autoimmune diseases
Fan, Q., Nan, H., Li, Z., Li, B., Zhang, F., & Bi, L. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114250 · Cited by 33
Bäckhed, F. (2010) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2010.04123.x · Cited by 33
Study Insights into Gastrointestinal Cancer through the Gut Microbiota
Kong, F., & Cai, Y. (2019) · BioMed Research International · doi:10.1155/2019/8721503 · Cited by 33
The effect of microbial colonization on the host proteome varies by gastrointestinal location
Lichtman, J. S., Alsentzer, E., Jaffe, M., Sprockett, D., Masutani, E., Ikwa, E., Fragiadakis, G. K., Clifford, D., Huang, B. E., Sonnenburg, J. L., et al. (2016) · The ISME Journal · doi:10.1038/ismej.2015.187 · Cited by 32
Therapeutic Potentials of Microalgae and Their Bioactive Compounds on Diabetes Mellitus
Tamel Selvan, K., Goon, J. A., Makpol, S., & Tan, J. K. (2023) · Marine Drugs · doi:10.3390/md21090462 · Cited by 32
Recent advances in understanding type 1 diabetes
Christoffersson, G., Rodriguez-Calvo, T., & von Herrath, M. (2016) · F1000Research · doi:10.12688/f1000research.7356.1 · Cited by 32
Zhang, Y., Qin, K., & Liu, C. (2024) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2024.133459 · Cited by 32
Targeting innate immunity to downmodulate adaptive immunity and reverse type 1 diabetes
Itoh, A., & Ridgway, W. M. (2017) · ImmunoTargets and Therapy · doi:10.2147/itt.s117264 · Cited by 32
The molecular basis of immune regulation in autoimmunity
Yang, S., Gao, C., Li, L., Chang, C., Leung, P. S. C., Gershwin, M. E., & Lian, Z. (2018) · Clinical Science · doi:10.1042/cs20171154 · Cited by 34
Li, H., Wang, Y., Jiang, J., Zhao, H., Feng, X., Zhao, B., & Wang, L. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00676 · Cited by 32
Antidiabetic effect of an engineered bacterium Lactobacillus plantarum-pMG36e -GLP-1 in monkey model
Luo, J., Zhang, H., Lu, J., Ma, C., & Chen, T. (2021) · Synthetic and Systems Biotechnology · doi:10.1016/j.synbio.2021.09.009 · Cited by 33
Galleri, L., Sebastiani, G., Vendrame, F., Grieco, F. A., Spagnuolo, I., & Dotta, F. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-5441-0_20 · Cited by 32
Immunomodulation with microbial vaccines to prevent type 1 diabetes mellitus
Petrovsky, N. (2010) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2009.273 · Cited by 32
Inflammasome activation and metabolic disease progression
Li, H., Jin, C., Chen, Y., & Flavell, R. A. (2014) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2014.07.020 · Cited by 32
Innate receptors and microbes in induction of autoimmunity
Chervonsky, A. V. (2009) · Current Opinion in Immunology · doi:10.1016/j.coi.2009.08.003 · Cited by 32
Self-citationAltered Phenotype of Peripheral Blood Dendritic Cells in Pediatric Type 1 Diabetes
Nieminen, J. K., Vakkila, J., Salo, H. M., Ekström, N., Härkönen, T., Ilonen, J., Knip, M., & Vaarala, O. (2012) · Diabetes Care · doi:10.2337/dc11-2460 · Cited by 32
Extrusion of barley and oat influence the fecal microbiota and SCFA profile of growing pigs
Moen, B., Berget, I., Rud, I., Hole, A. S., Kjos, N. P., & Sahlstrøm, S. (2016) · Food & Function · doi:10.1039/c5fo01452b · Cited by 34
Gut microbiota, immunity, and bile acid metabolism: decoding metabolic disease interactions
Zhao, Q., Wu, J., Ding, Y., Pang, Y., & Jiang, C. (2023) · Life Metabolism · doi:10.1093/lifemeta/load032 · Cited by 31
Metadata
- Authors
- Wen, L., Ley, R. E., Volchkov, P. Y., Stranges, P. B., Avanesyan, L., Stonebraker, A. C., Hu, C., Wong, F. S., Szot, G. L., Bluestone, J. A., Gordon, J. I., & Chervonsky, A. V.
- Affiliations
- Washington University in St. Louis (US)
- University of Chicago (US)
- Jackson Laboratory (US)
- Yale University (US)
- University of Bristol (GB)
- University of California, San Francisco (US)
- Corresponding author
- Chervonsky, Alexander V.
- ORCID
- Venue
- Nature
- Published
- 2008-09-21
- Volume
- 455
- Issue
- 7216
- Pages
- 1109-1113
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC2574766
- OpenAlex
- W2148067809
- Cited by
- 1,921
- References
- 39
- Citations by year
- 2026: 23 · 2025: 49 · 2024: 75 · 2023: 69 · 2022: 105 · 2021: 86 · 2020: 112 · 2019: 137 · 2018: 134 · 2017: 128 · 2016: 141 · 2015: 137 · 2014: 138 · 2013: 119 · 2012: 132
- FWCI
- 62.63
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Explore Bristol Research (publishedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
- Bristol Research (University of Bristol) (submittedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (R37AI046643)
- National Institute of Diabetes and Digestive and Kidney Diseases (R37DK030292, DK-30292, DK 45735, DK063452, R21DK063452, DK 70977, DK42086, R01DK070977, P30DK063720, P30DK042086, P30DK056341, R01DK030292, P30DK045735)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- type 1 diabetes, innate immunity, gut microbiota, MyD88, Toll-like receptors, NOD mice, germ-free mice, commensal bacteria, autoimmune disease susceptibility, microbial products, mycobacteria, disease prevention, beta cell destruction, host-microbe interactions
- MeSH terms
- Animals, Bacteria, Diabetes Mellitus, Type 1, Female, Immunity, Innate, Interferon-gamma, Intestines, Islets of Langerhans, Male, Molecular Sequence Data, Phylogeny, Specific Pathogen-Free Organisms, Time Factors, Mice, SCID, Mice, Inbred NOD, Mice, Knockout, CD8-Positive T-Lymphocytes, Mice, Myeloid Differentiation Factor 88
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
