CoChat
Sign Up
Cited by 653T-cell and B-cell ImmunologyImmunodeficiency and Autoimmune DisordersImmune Response and Inflammation

The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.

SAP-controlled T–B cell interactions underlie germinal centre formation

Open access
Qi, Hai, Cannons, Jennifer L., Klauschen, Frederick, Schwartzberg, Pamela L., Germain, Ronald N.·2008·Nature
DOI 10.1038/nature07345PMC PMC2652134
Open this paper in CoChat — free account

Abstract

Generation of long-term antibody-mediated immunity depends on the germinal centre reaction, which requires cooperation between antigen-specific T and B lymphocytes. In human X-linked lymphoproliferative disease and its gene-targeted mouse model, loss-of-function mutations in signalling lymphocyte activation molecule-associated protein (SAP, encoded by SH2D1a) cause a profound defect in germinal centre formation by an as yet unknown mechanism. Here, using two-photon intravital imaging, we show that SAP deficiency selectively impairs the ability of CD4(+) T cells to stably interact with cognate B cells but not antigen-presenting dendritic cells. This selective defect results in a failure of antigen-specific B cells to receive adequate levels of contact-dependent T-cell help to expand normally, despite Sap(-/-) T cells exhibiting the known characteristics of otherwise competent helper T cells. Furthermore, the lack of stable interactions with B cells renders Sap(-/-) T cells unable to be efficiently recruited to and retained in a nascent germinal centre to sustain the germinal centre reaction. These results offer an explanation for the germinal centre defect due to SAP deficiency and provide new insights into the bi-directional communication between cognate T and B cells in vivo.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1038/nature07345

Cites

45 of 45 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 45 references

Cited by

Sorted by citations

Items 601–653 of 653

Related

See all

Metadata

Authors
Qi, H., Cannons, J. L., Klauschen, F., Schwartzberg, P. L., & Germain, R. N.
Affiliations
National Institutes of Health (US)
Corresponding author
  • Schwartzberg, Pamela L.
  • Germain, Ronald N.
ORCID
Venue
Nature
Publisher
Springer Science and Business Media LLC
Published
2008-10
Volume
455
Issue
7214
Pages
764-769
ISSN
  • 0028-0836 (ISSN-L)
  • 1476-4687
DOI
10.1038/nature07345
PMC
PMC2652134
OpenAlex
W1990297263
Cited by
637
References
45
Citations by year
2026: 10 · 2025: 16 · 2024: 16 · 2023: 15 · 2022: 42 · 2021: 39 · 2020: 30 · 2019: 35 · 2018: 44 · 2017: 37 · 2016: 44 · 2015: 35 · 2014: 47 · 2013: 53 · 2012: 48
FWCI
17.45
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (tdm)
Locations
  • Nature (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
Funders
  • National Institutes of Health
  • National Institute of Allergy and Infectious Diseases (Z01AI000545)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Immunology › Immunodeficiency and Autoimmune Disorders
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords
SH2D1A, X-linked lymphoproliferative disease, germinal center formation, T cell-B cell interaction, CD4+ T cell help, B cell activation, affinity maturation, intravital imaging
MeSH terms
Signaling Lymphocytic Activation Molecule Associated Protein, Animals, B-Lymphocytes, Cell Adhesion, Cell Communication, Cells, Cultured, Chimera, Dendritic Cells, Lymphocyte Activation, CD4-Positive T-Lymphocytes, Germinal Center, Intracellular Signaling Peptides and Proteins, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review