Cited by 653T-cell and B-cell ImmunologyImmunodeficiency and Autoimmune DisordersImmune Response and Inflammation

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SAP-controlled T–B cell interactions underlie germinal centre formation

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Qi, Hai, Cannons, Jennifer L., Klauschen, Frederick, Schwartzberg, Pamela L., Germain, Ronald N.·2008·Nature

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Abstract

Generation of long-term antibody-mediated immunity depends on the germinal centre reaction, which requires cooperation between antigen-specific T and B lymphocytes. In human X-linked lymphoproliferative disease and its gene-targeted mouse model, loss-of-function mutations in signalling lymphocyte activation molecule-associated protein (SAP, encoded by SH2D1a) cause a profound defect in germinal centre formation by an as yet unknown mechanism. Here, using two-photon intravital imaging, we show that SAP deficiency selectively impairs the ability of CD4(+) T cells to stably interact with cognate B cells but not antigen-presenting dendritic cells. This selective defect results in a failure of antigen-specific B cells to receive adequate levels of contact-dependent T-cell help to expand normally, despite Sap(-/-) T cells exhibiting the known characteristics of otherwise competent helper T cells. Furthermore, the lack of stable interactions with B cells renders Sap(-/-) T cells unable to be efficiently recruited to and retained in a nascent germinal centre to sustain the germinal centre reaction. These results offer an explanation for the germinal centre defect due to SAP deficiency and provide new insights into the bi-directional communication between cognate T and B cells in vivo.

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Authors: Qi, H., Cannons, J. L., Klauschen, F., Schwartzberg, P. L., & Germain, R. N.
Affiliations: National Institutes of Health (US)
Corresponding author: Schwartzberg, Pamela L.
Germain, Ronald N.
ORCID: Qi, Hai
Cannons, Jennifer L.
Klauschen, Frederick
Schwartzberg, Pamela L.
Germain, Ronald N.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2008-10
Volume: 455
Issue: 7214
Pages: 764-769
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature07345
PMC: PMC2652134
OpenAlex: W1990297263
Cited by: 637
References: 45
Citations by year: 2026: 10 · 2025: 16 · 2024: 16 · 2023: 15 · 2022: 42 · 2021: 39 · 2020: 30 · 2019: 35 · 2018: 44 · 2017: 37 · 2016: 44 · 2015: 35 · 2014: 47 · 2013: 53 · 2012: 48
FWCI: 17.45
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: National Institutes of Health
National Institute of Allergy and Infectious Diseases (Z01AI000545)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immunodeficiency and Autoimmune Disorders
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: SH2D1A, X-linked lymphoproliferative disease, germinal center formation, T cell-B cell interaction, CD4+ T cell help, B cell activation, affinity maturation, intravital imaging
MeSH terms: Signaling Lymphocytic Activation Molecule Associated Protein, Animals, B-Lymphocytes, Cell Adhesion, Cell Communication, Cells, Cultured, Chimera, Dendritic Cells, Lymphocyte Activation, CD4-Positive T-Lymphocytes, Germinal Center, Intracellular Signaling Peptides and Proteins, Mice

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SAP-controlled T–B cell interactions underlie germinal centre formation

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