The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter
Open accessAbstract
Haematopoietic stem cells (HSCs) are the founder cells of the adult haematopoietic system, and thus knowledge of the molecular program directing their generation during development is important for regenerative haematopoietic strategies. Runx1 is a pivotal transcription factor required for HSC generation in the vascular regions of the mouse conceptus—the aorta, vitelline and umbilical arteries, yolk sac and placenta. It is thought that HSCs emerge from vascular endothelial cells through the formation of intra-arterial clusters and that Runx1 functions during the transition from ‘haemogenic endothelium’ to HSCs. Here we show by conditional deletion that Runx1 activity in vascular-endothelial-cadherin-positive endothelial cells is indeed essential for intra-arterial cluster, haematopoietic progenitor and HSC formation in mice. In contrast, Runx1 is not required in cells expressing Vav1, one of the first pan-haematopoietic genes expressed in HSCs. Collectively these data show that Runx1 function is essential in endothelial cells for haematopoietic progenitor and HSC formation from the vasculature, but its requirement ends once or before Vav is expressed.
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Self-citationCbfa2 is required for the formation of intra-aortic hematopoietic clusters
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Self-citationIchikawa, M., Asai, T., Saito, T., Yamamoto, G., Seo, S., Yamazaki, I., Yamagata, T., Mitani, K., Chiba, S., Hirai, H., et al. (2004) · Nature Medicine · doi:10.1038/nm997 · Cited by 596
Loss of Runx1 perturbs adult hematopoiesis and is associated with a myeloproliferative phenotype
Growney, J. D., Shigematsu, H., Li, Z., Lee, B. H., Adelsperger, J., Rowan, R., Curley, D. P., Kutok, J. L., Akashi, K., Williams, I. R., et al. (2005) · Blood · doi:10.1182/blood-2004-08-3280 · Cited by 462
Self-citationRequirement of Runx1/AML1/PEBP2αB for the generation of haematopoietic cells from endothelial cells
Yokomizo, T., Ogawa, M., Osato, M., Kanno, T., Yoshida, H., Fujimoto, T., Fraser, S., Nishikawa, S., Okada, H., Satake, M., et al. (2001) · Genes to Cells · doi:10.1046/j.1365-2443.2001.00393.x · Cited by 176
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Ginhoux, F., & Guilliams, M. (2016) · Immunity · doi:10.1016/j.immuni.2016.02.024 · Cited by 1,884
Haematopoietic stem cells derive directly from aortic endothelium during development
Bertrand, J. Y., Chi, N. C., Santoso, B., Teng, S., Stainier, D. Y. R., & Traver, D. (2010) · Nature · doi:10.1038/nature08738 · Cited by 1,025
In vivo imaging of haematopoietic cells emerging from the mouse aortic endothelium
Boisset, J.-C., van Cappellen, W., Andrieu-Soler, C., Galjart, N., Dzierzak, E., & Robin, C. (2010) · Nature · doi:10.1038/nature08764 · Cited by 917
Self-citationForcing cells to change lineages
Graf, T., & Enver, T. (2009) · Nature · doi:10.1038/nature08533 · Cited by 899
Adult haematopoietic stem cell niches
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Metadata
- Authors
- Chen, M. J., Yokomizo, T., Zeigler, B. M., Dzierzak, E., & Speck, N. A.
- Venue
- Nature
- Published
- 2009-02-01
- Volume
- 457
- Issue
- 7231
- Pages
- 887-891
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2110918588
- Cited by
- 1,013
- References
- 5
- FWCI
- 40.41
- Type
- journal article
- Language
- en
- Open access
- green
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- Chen, M. J., Yokomizo, T., Zeigler, B. M., Dzierzak, E., & Speck, N. A. (2009). Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter. Nature. https://doi.org/10.1038/nature07619
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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