Adult haematopoietic stem cell niches

Cytokine-mediated regulation of CXCR4 expression in human neutrophils

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Mesenchymal and haematopoietic stem cells form a unique bone marrow niche

Méndez‐Ferrer, S., Michurina, T. V., Ferraro, F., Mazloom, A. R., MacArthur, B. D., Lira, S. A., Scadden, D. T., Ma’ayan, A., Enikolopov, G., & Frenette, P. S. (2010) · Nature · doi:10.1038/nature09262 · Cited by 3,381 · see citing works

SLAM Family Receptors Distinguish Hematopoietic Stem and Progenitor Cells and Reveal Endothelial Niches for Stem Cells

Kiel, M. J., Yilmaz, Ö. H., Iwashita, T., Yilmaz, O. H., Terhorst, C., & Morrison, S. J. (2005) · Cell · doi:10.1016/j.cell.2005.05.026 · Cited by 3,168 · see citing works

Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1

Ceradini, D. J., Kulkarni, A. R., Callaghan, M. J., Tepper, O. M., Bastidas, N., Kleinman, M. E., Capla, J. M., Galiano, R. D., Levine, J. P., & Gurtner, G. C. (2004) · Nature Medicine · doi:10.1038/nm1075 · Cited by 2,600 · see citing works

Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development

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The bone marrow niche for haematopoietic stem cells

Morrison, S. J., & Scadden, D. T. (2014) · Nature · doi:10.1038/nature12984 · Cited by 2,451 · see citing works

Maintenance of the Hematopoietic Stem Cell Pool by CXCL12-CXCR4 Chemokine Signaling in Bone Marrow Stromal Cell Niches

Sugiyama, T., Kohara, H., Noda, M., & Nagasawa, T. (2006) · Immunity · doi:10.1016/j.immuni.2006.10.016 · Cited by 2,419 · see citing works

Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1

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The relationship between the spleen colony-forming cell and the haemopoietic stem cell.

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Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment

Sacchetti, B., Funari, A., Michienzi, S., Di Cesare, S., Piersanti, S., Saggio, I., Tagliafico, E., Ferrari, S., Robey, P. G., Riminucci, M., et al. (2007) · Cell · doi:10.1016/j.cell.2007.08.025 · Cited by 2,226 · see citing works

Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone

Kusumbe, A. P., Ramasamy, S. K., & Adams, R. H. (2014) · Nature · doi:10.1038/nature13145 · Cited by 2,155 · see citing works

Stem Cells and Niches: Mechanisms That Promote Stem Cell Maintenance throughout Life

Morrison, S. J., & Spradling, A. C. (2008) · Cell · doi:10.1016/j.cell.2008.01.038 · Cited by 1,951 · see citing works

Endothelial and perivascular cells maintain haematopoietic stem cells

Ding, L., Saunders, T. L., Enikolopov, G., & Morrison, S. J. (2012) · Nature · doi:10.1038/nature10783 · Cited by 1,934 · see citing works

Hematopoietic Stem Cells Reversibly Switch from Dormancy to Self-Renewal during Homeostasis and Repair

Wilson, A., Laurenti, E., Oser, G., van der Wath, R. C., Blanco-Bose, W., Jaworski, M., Offner, S., Dunant, C. F., Eshkind, L., Bockamp, E., et al. (2008) · Cell · doi:10.1016/j.cell.2008.10.048 · Cited by 1,908 · see citing works

Definitive Hematopoiesis Is Autonomously Initiated by the AGM Region

Medvinsky, A., & Dzierzak, E. A. (1996) · Cell · doi:10.1016/s0092-8674(00)80165-8 · Cited by 1,548 · see citing works

Signals from the Sympathetic Nervous System Regulate Hematopoietic Stem Cell Egress from Bone Marrow

Katayama, Y., Battista, M., Kao, W.-M., Hidalgo, A., Peired, A. J., Thomas, S. A., & Frenette, P. S. (2006) · Cell · doi:10.1016/j.cell.2005.10.041 · Cited by 1,412 · see citing works

Stem cell factor is encoded at the SI locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor

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Leptin-Receptor-Expressing Mesenchymal Stromal Cells Represent the Main Source of Bone Formed by Adult Bone Marrow

Zhou, B. O., Yue, R., Murphy, M. M., Peyer, J. G., & Morrison, S. J. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2014.06.008 · Cited by 1,381 · see citing works

CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance

Greenbaum, A. M., Hsu, Y.-M. S., Day, R. B., Schuettpelz, L. G., Christopher, M. J., Borgerding, J. N., Nagasawa, T., & Link, D. C. (2013) · Nature · doi:10.1038/nature11926 · Cited by 1,372 · see citing works

G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4

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Haematopoietic stem cell release is regulated by circadian oscillations

Méndez‐Ferrer, S., Lucas, D., Battista, M., & Frenette, P. S. (2008) · Nature · doi:10.1038/nature06685 · Cited by 1,310 · see citing works

Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches

Ding, L., & Morrison, S. J. (2013) · Nature · doi:10.1038/nature11885 · Cited by 1,286 · see citing works

Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand

de Sauvage, F. J., Hass, P. E., Spencer, S. D., Malloy, B. E., Gurney, A. L., Spencer, S. A., Darbonne, W. C., Henzel, W. J., Wong, S. C., Kuang, W.-J., et al. (1994) · Nature · doi:10.1038/369533a0 · Cited by 1,259 · see citing works

Arteriolar niches maintain haematopoietic stem cell quiescence

Kunisaki, Y., Bruns, I., Scheiermann, C., Ahmed, J. U., Pinho, S., Zhang, D., Mizoguchi, T., Wei, Q., Lucas, D., Ito, K., et al. (2013) · Nature · doi:10.1038/nature12612 · Cited by 1,236 · see citing works

Direct measurement of local oxygen concentration in the bone marrow of live animals

Spencer, J. A., Ferraro, F., Roussakis, E., Klein, A., Wu, J., Runnels, J. M., Zaher, W., Mortensen, L. J., Alt, C., Turcotte, R., et al. (2014) · Nature · doi:10.1038/nature13034 · Cited by 1,167 · see citing works

The hematopoietic growth factor KL is encoded by the SI locus and is the ligand of the c-kit receptor, the gene product of the W locus

Huang, E. J., Nocka, K. H., Beier, D. R., Chu, T.-Y., Buck, J., Lahm, H., Wellner, D., Leder, P., & Besmer, P. (1990) · Cell · doi:10.1016/0092-8674(90)90303-v · Cited by 1,149 · see citing works

Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment

Naveiras, O., Nardi, V., Wenzel, P. L., Hauschka, P. V., Fahey, F., & Daley, G. Q. (2009) · Nature · doi:10.1038/nature08099 · Cited by 1,129 · see citing works

Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia

Raaijmakers, M. H. G. P., Mukherjee, S., Guo, S., Zhang, S., Kobayashi, T., Schoonmaker, J. A., Ebert, B. L., Al-Shahrour, F., Hasserjian, R. P., Scadden, E. O., et al. (2010) · Nature · doi:10.1038/nature08851 · Cited by 1,115 · see citing works

Haematopoietic stem cells derive directly from aortic endothelium during development

Bertrand, J. Y., Chi, N. C., Santoso, B., Teng, S., Stainier, D. Y. R., & Traver, D. J. (2010) · Nature · doi:10.1038/nature08738 · Cited by 1,053 · see citing works

Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin

Kaushansky, K., Lok, S., Holly, R. D., Broudy, V. C., Lin, N. L., Bailey, M. C., Forstrom, J. W., Buddle, M. M., Oort, P. J., Hagen, F. S., et al. (1994) · Nature · doi:10.1038/369568a0 · Cited by 1,024 · see citing works

Expression of Cre recombinase in the developing mouse limb bud driven by a Prxl enhancer

Logan, M., Martin, J. F., Nagy, A., Lobe, C., Olson, E., & Tabin, C. (2002) · Genesis · doi:10.1002/gene.10092 · Cited by 1,022 · see citing works

Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter

Chen, M. J., Yokomizo, T., Zeigler, B. M., Dzierzak, E. A., & Speck, N. A. (2009) · Nature · doi:10.1038/nature07619 · Cited by 1,016 · see citing works

Granulocyte colony-stimulating factor and its receptor

Demetri, G. D., & Griffin, J. (1991) · Blood · doi:10.1182/blood.v78.11.2791.2791 · Cited by 978 · see citing works

Blood stem cells emerge from aortic endothelium by a novel type of cell transition

Kissa, K., & Herbomel, P. (2010) · Nature · doi:10.1038/nature08761 · Cited by 961 · see citing works

Osteoblast Precursors, but Not Mature Osteoblasts, Move into Developing and Fractured Bones along with Invading Blood Vessels

Maes, C., Kobayashi, T., Selig, M. K., Torrekens, S., Roth, S. I., Mackem, S., Carmeliet, G., & Kronenberg, H. M. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.07.010 · Cited by 940 · see citing works

Physiological Migration of Hematopoietic Stem and Progenitor Cells

Wright, D. E., Wagers, A. J., Gulati, A. P., Johnson, F. L., & Weissman, I. L. (2001) · Science · doi:10.1126/science.1064081 · Cited by 933 · see citing works

Identification of a ligand for the c-kit proto-oncogene

Williams, D. E., Eisenman, J. R., Baird, A. M., Rauch, C. T., Ness, K. V., March, C. J., Park, L. S., Martin, U., Mochizukl, D. Y., Boswell, H. S., et al. (1990) · Cell · doi:10.1016/0092-8674(90)90297-r · Cited by 911 · see citing works

In vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftment

Sipkins, D. A., Wei, X., Wu, J. W., Runnels, J. M., Côté, D. C., Means, T. K., Luster, A. D., Scadden, D. T., & Lin, C. P. (2005) · Nature · doi:10.1038/nature03703 · Cited by 880 · see citing works

Quiescent haematopoietic stem cells are activated by IFN-γ in response to chronic infection

Baldridge, M. T., King, K. Y., Boles, N. C., Weksberg, D. C., & Goodell, M. A. (2010) · Nature · doi:10.1038/nature09135 · Cited by 877 · see citing works

Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia

Parmar, K., Mauch, P., Vergilio, J.-A., Sackstein, R., & Down, J. D. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701152104 · Cited by 867 · see citing works

Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche

Chow, A. T., Lucas, D., Hidalgo, A., Méndez‐Ferrer, S., Hashimoto, D., Scheiermann, C., Battista, M., Leboeuf, M., Prophete, C., van Rooijen, N., et al. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20101688 · Cited by 866 · see citing works

The Essential Functions of Adipo-osteogenic Progenitors as the Hematopoietic Stem and Progenitor Cell Niche

Omatsu, Y., Sugiyama, T., Kohara, H., Kondoh, G., Fujii, N., Kohno, K., & Nagasawa, T. (2010) · Immunity · doi:10.1016/j.immuni.2010.08.017 · Cited by 849 · see citing works

Molecular cloning of mast cell growth factor, a hematopoietin that is active in both membrane bound and soluble forms

Anderson, D. M., Lyman, S. D., Baird, A. M., Wignall, J. M., Eisenman, J. R., Rauch, C. T., March, C. J., Boswell, H. S., Gimpel, S. D., Cosman, D. J., et al. (1990) · Cell · doi:10.1016/0092-8674(90)90304-w · Cited by 827 · see citing works

Granulocyte colony-stimulating factor and its receptor

Demetri, G. D., & Griffin, J. (1991) · Blood · doi:10.1182/blood.v78.11.2791.bloodjournal78112791 · Cited by 825 · see citing works

Molecular cloning and structure of a pre-B-cell growth-stimulating factor.

Nagasawa, T., Kikutani, H., & Kishimoto, T. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.6.2305 · Cited by 817 · see citing works

Thrombopoietin/MPL Signaling Regulates Hematopoietic Stem Cell Quiescence and Interaction with the Osteoblastic Niche

Yoshihara, H., Arai, F., Hosokawa, K., Hagiwara, T., Takubo, K., Nakamura, Y., Gomei, Y., Iwasaki, H., Matsuoka, S., Miyamoto, K., et al. (2007) · Cell stem cell · doi:10.1016/j.stem.2007.10.020 · Cited by 816 · see citing works

Hematopoiesis is severely altered in mice with an induced osteoblast deficiency

Višnjić, D., Kalajzić, Ž., Rowe, D. W., Katavić, V., Lorenzo, J., & Aguila, H. L. (2004) · Blood · doi:10.1182/blood-2003-11-4011 · Cited by 804 · see citing works

Clonal dynamics of native haematopoiesis

Sun, J., Ramos, A., Chapman, B., Johnnidis, J. B., Le, L., Ho, Y.-J., Klein, A. M., Hofmann, O., & Camargo, F. D. (2014) · Nature · doi:10.1038/nature13824 · Cited by 803 · see citing works

Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs

Winkler, I. G., Sims, N. A., Pettit, A. R., Barbier, V., Nowlan, B., Helwani, F., Poulton, I. J., van Rooijen, N., Alexander, K. A., Raggatt, L. J., et al. (2010) · Blood · doi:10.1182/blood-2009-11-253534 · Cited by 801 · see citing works

Nonmyelinating Schwann Cells Maintain Hematopoietic Stem Cell Hibernation in the Bone Marrow Niche

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Cellular Niches Controlling B Lymphocyte Behavior within Bone Marrow during Development

Tokoyoda, K., Egawa, T., Sugiyama, T., Choi, B.-I., & Nagasawa, T. (2004) · Immunity · doi:10.1016/j.immuni.2004.05.001 · Cited by 796 · see citing works

Identification, purification, and biological characterization of hematopoietic stem cell factor from buffalo rat liver-conditioned medium

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Stem cell engraftment at the endosteal niche is specified by the calcium-sensing receptor

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Osteoclasts degrade endosteal components and promote mobilization of hematopoietic progenitor cells

Kollet, Ó., Dar, A., Shivtiel, S., Kalinkovich, A., Lapid, K., Sztainberg, Y., Tesio, M., Samstein, R. M., Goichberg, P., Spiegel, A., et al. (2006) · Nature Medicine · doi:10.1038/nm1417 · Cited by 774 · see citing works

The kit ligand: A cell surface molecule altered in steel mutant fibroblasts

Flanagan, J. G., & Leder, P. (1990) · Cell · doi:10.1016/0092-8674(90)90299-t · Cited by 770 · see citing works

Fundamental properties of unperturbed haematopoiesis from stem cells in vivo

Busch, K., Klapproth, K., Barile, M., Flossdorf, M., Holland-Letz, T., Schlenner, S. M., Reth, M., Höfer, T., & Rodewald, H.-R. (2015) · Nature · doi:10.1038/nature14242 · Cited by 769 · see citing works

Identification and Specification of the Mouse Skeletal Stem Cell

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Rhythmic Modulation of the Hematopoietic Niche through Neutrophil Clearance

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Expression and function of c-kit in hemopoietic progenitor cells.

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Primary structure and functional expression of rat and human stem cell factor DNAs

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Osteopontin is a hematopoietic stem cell niche component that negatively regulates stem cell pool size

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Distinct bone marrow blood vessels differentially regulate haematopoiesis

Itkin, T., Gur‐Cohen, S., Spencer, J. A., Schajnovitz, A., Ramasamy, S. K., Kusumbe, A. P., Ledergor, G., Jung, Y., Milo, I., Poulos, M. G., et al. (2016) · Nature · doi:10.1038/nature17624 · Cited by 709 · see citing works

Deep imaging of bone marrow shows non-dividing stem cells are mainly perisinusoidal

Acar, M., Kocherlakota, K. S., Murphy, M. M., Peyer, J. G., Oguro, H., Inra, C. N., Jaiyeola, C., Zhao, Z., Luby‐Phelps, K., & Morrison, S. J. (2015) · Nature · doi:10.1038/nature15250 · Cited by 702 · see citing works

Fate tracing reveals the endothelial origin of hematopoietic stem cells

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Endothelial Cells Are Essential for the Self-Renewal and Repopulation of Notch-Dependent Hematopoietic Stem Cells

Butler, J. M., Nolan, D. J., Vertes, E. L., Varnum‐Finney, B., Kobayashi, H., Hooper, A. T., Seandel, M., Shido, K., White, I. A., Kobayashi, M., et al. (2010) · Cell stem cell · doi:10.1016/j.stem.2010.02.001 · Cited by 678 · see citing works

The Placenta Is a Niche for Hematopoietic Stem Cells

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SLAM Family Markers Resolve Functionally Distinct Subpopulations of Hematopoietic Stem Cells and Multipotent Progenitors

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Origin of monocytes and macrophages in a committed progenitor

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Engraftment and Reconstitution of Hematopoiesis Is Dependent on VEGFR2-Mediated Regeneration of Sinusoidal Endothelial Cells

Hooper, A. T., Butler, J. M., Nolan, D. J., Kranz, A., Iida, K., Kobayashi, M., Kopp, H., Shido, K., Petit, I., Yanger, K., et al. (2009) · Cell stem cell · doi:10.1016/j.stem.2009.01.006 · Cited by 641 · see citing works

Evidence that hematopoietic stem cells express mouse c-kit but do not depend on steel factor for their generation.

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Gremlin 1 Identifies a Skeletal Stem Cell with Bone, Cartilage, and Reticular Stromal Potential

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Endogenous Bone Marrow MSCs Are Dynamic, Fate-Restricted Participants in Bone Maintenance and Regeneration

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Megakaryocytes regulate hematopoietic stem cell quiescence through CXCL4 secretion

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Bone Marrow Transplantation for Sickle Cell Disease

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Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells

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Definitive hematopoietic stem cells first develop within the major arterial regions of the mouse embryo

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Myeloproliferative neoplasia remodels the endosteal bone marrow niche into a self-reinforcing leukemic niche

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The purification and characterization of fetal liver hematopoietic stem cells

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Mast cell growth factor maps near the steel locus on mouse chromosome 10 and is deleted in a number of steel alleles

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Megakaryocytes maintain homeostatic quiescence and promote post-injury regeneration of hematopoietic stem cells

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