Cited by 308Developmental Biology and Gene RegulationNeurobiology and Insect Physiology ResearchGenomics and Chromatin Dynamics

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Genome-wide analysis of Notch signalling in Drosophila by transgenic RNAi

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Mummery-Widmer, Jennifer L., Yamazaki, Masakazu, Stoeger, Thomas, Novatchkova, Maria, Bhalerao, Sheetal, Chen, Doris, Dietzl, Georg, Dickson, Barry J., Knoblich, Juergen A.·2009·Nature

DOI 10.1038/nature07936PMC PMC2988197

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Abstract

Genome-wide RNA interference (RNAi) screens have identified near-complete sets of genes involved in cellular processes. However, this methodology has not yet been used to study complex developmental processes in a tissue-specific manner. Here we report the use of a library of Drosophila strains expressing inducible hairpin RNAi constructs to study the Notch signalling pathway during external sensory organ development. We assigned putative loss-of-function phenotypes to 21.2% of the protein-coding Drosophila genes. Using secondary assays, we identified 6 new genes involved in asymmetric cell division and 23 novel genes regulating the Notch signalling pathway. By integrating our phenotypic results with protein interaction data, we constructed a genome-wide, functionally validated interaction network governing Notch signalling and asymmetric cell division. We used clustering algorithms to identify nuclear import pathways and the COP9 signallosome as Notch regulators. Our results show that complex developmental processes can be analysed on a genome-wide level and provide a unique resource for functional annotation of the Drosophila genome.

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Authors: Mummery-Widmer, J. L., Yamazaki, M., Stoeger, T., Novatchkova, M., Bhalerao, S., Chen, D., Dietzl, G., Dickson, B. J., & Knoblich, J. A.
Affiliations: Institute of Molecular Biotechnology (AT)
Max Perutz Labs (AT)
Research Institute of Molecular Pathology (AT)
Corresponding author: Knoblich, Juergen A.
ORCID: Yamazaki, Masakazu
Stoeger, Thomas
Novatchkova, Maria
Chen, Doris
Dickson, Barry J.
Knoblich, Juergen A.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2009-04
Volume: 458
Issue: 7241
Pages: 987-992
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature07936
PMC: PMC2988197
OpenAlex: W2118810801
Cited by: 305
References: 54
Citations by year: 2026: 7 · 2025: 7 · 2024: 5 · 2023: 10 · 2022: 13 · 2021: 15 · 2020: 14 · 2019: 11 · 2018: 16 · 2017: 16 · 2016: 24 · 2015: 24 · 2014: 29 · 2013: 30 · 2012: 24
FWCI: 10.50
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords: Notch signaling, Drosophila, genome-wide RNAi screen, asymmetric cell division, protein-protein interaction network, COP9 signalosome, loss-of-function phenotypes
MeSH terms: Animals, Cell Division, Drosophila melanogaster, Phenotype, Quality Control, Signal Transduction, Active Transport, Cell Nucleus, Drosophila Proteins, Animals, Genetically Modified, RNA Interference, Genome, Insect, Receptors, Notch

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Genome-wide analysis of Notch signalling in Drosophila by transgenic RNAi

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