Knoblich, Juergen A.

Cerebral organoids model human brain development and microcephaly

Lancaster, M. A., Renner, M., Martin, C.-A., Wenzel, D., Bicknell, L. S., Hurles, M. E., Homfray, T., Penninger, J. M., Jackson, A. P., & Knoblich, J. A. (2013) · Nature

Neurogenesis and neuroplasticity mechanismsPluripotent Stem Cells Research

Cited by 5,372

Organogenesis in a dish: Modeling development and disease using organoid technologies

Lancaster, M. A., & Knoblich, J. A. (2014) · Science

Pluripotent Stem Cells Research3D Printing in Biomedical Research

Cited by 2,931

Human organoids: model systems for human biology and medicine

Kim, J., Koo, B.-K., & Knoblich, J. A. (2020) · Nature Reviews Molecular Cell Biology

Pluripotent Stem Cells Research3D Printing in Biomedical Research

Cited by 2,187

Human cerebral organoids recapitulate gene expression programs of fetal neocortex development

Camp, J. G., Badsha, F., Florio, M., Kanton, S., Gerber, T., Wilsch-Bräuninger, M., Lewitus, E., Sykes, A., Hevers, W., Lancaster, M., et al. (2015) · Proceedings of the National Academy of Sciences

Neurogenesis and neuroplasticity mechanismsSingle-cell and spatial transcriptomics

Cited by 1,130

Human blood vessel organoids as a model of diabetic vasculopathy

Wimmer, R. A., Leopoldi, A., Aichinger, M., Wick, N., Hantusch, B., Novatchkova, M., Taubenschmid, J., Hämmerle, M., Esk, C., Bagley, J. A., et al. (2019) · Nature

Angiogenesis and VEGF in CancerBarrier Structure and Function Studies

Cited by 803

Fused cerebral organoids model interactions between brain regions

Bagley, J. A., Reumann, D., Bian, S., Lévi-Strauss, J., & Knoblich, J. A. (2017) · Nature Methods

Neurogenesis and neuroplasticity mechanismsPluripotent Stem Cells Research

Cited by 790

Guided self-organization and cortical plate formation in human brain organoids

Lancaster, M. A., Corsini, N. S., Wolfinger, S., Gustafson, E. H., Phillips, A. W., Burkard, T. R., Otani, T., Livesey, F. J., & Knoblich, J. A. (2017) · Nature Biotechnology

Neurogenesis and neuroplasticity mechanisms3D Printing in Biomedical Research

Cited by 783

Drosophila neuroblasts: a model for stem cell biology

Homem, C. C. F., & Knoblich, J. A. (2012) · Development

Developmental Biology and Gene RegulationNeurogenesis and neuroplasticity mechanisms

Cited by 476

The Tumor Suppressors Brat and Numb Regulate Transit-Amplifying Neuroblast Lineages in Drosophila

Bowman, S. K., Rolland, V., Betschinger, J., Kinsey, K. A., Emery, G., & Knoblich, J. A. (2008) · Developmental Cell

Developmental Biology and Gene RegulationNeurogenesis and neuroplasticity mechanisms

Cited by 444

Induction of Expansion and Folding in Human Cerebral Organoids

Li, Y., Muffat, J., Omer, A., Bosch, I., Lancaster, M. A., Sur, M., Gehrke, L., Knoblich, J. A., & Jaenisch, R. (2017) · Cell Stem Cell

Neurogenesis and neuroplasticity mechanismsFetal and Pediatric Neurological Disorders

Cited by 436

The hope and the hype of organoid research

Huch, M., Knoblich, J. A., Lutolf, M. P., & Martinez-Arias, A. (2017) · Development

3D Printing in Biomedical ResearchPluripotent Stem Cells Research

Cited by 409

Self‐organized developmental patterning and differentiation in cerebral organoids

Renner, M., Lancaster, M. A., Bian, S., Choi, H., Ku, T., Peer, A., Chung, K., & Knoblich, J. A. (2017) · The EMBO Journal

Neurogenesis and neuroplasticity mechanismsPluripotent Stem Cells Research

Cited by 389

Cerebral Organoids Recapitulate Epigenomic Signatures of the Human Fetal Brain

Luo, C., Lancaster, M. A., Castanon, R., Nery, J. R., Knoblich, J. A., & Ecker, J. R. (2016) · Cell Reports

Epigenetics and DNA MethylationPluripotent Stem Cells Research

Cited by 370

Human tissues in a dish: The research and ethical implications of organoid technology

Bredenoord, A. L., Clevers, H., & Knoblich, J. A. (2017) · Science

Biomedical Ethics and RegulationPluripotent Stem Cells Research

Cited by 334

Genome-wide analysis of Notch signalling in Drosophila by transgenic RNAi

Mummery-Widmer, J. L., Yamazaki, M., Stoeger, T., Novatchkova, M., Bhalerao, S., Chen, D., Dietzl, G., Dickson, B. J., & Knoblich, J. A. (2009) · Nature

Developmental Biology and Gene RegulationNeurobiology and Insect Physiology Research

Cited by 305

Single-cell brain organoid screening identifies developmental defects in autism

Li, C., Fleck, J. S., Martins-Costa, C., Burkard, T. R., Themann, J., Stuempflen, M., Peer, A. M., Vertesy, Á., Littleboy, J. B., Esk, C., et al. (2023) · Nature

Pluripotent Stem Cells ResearchGenetics and Neurodevelopmental Disorders

Cited by 283

Ecdysone and Mediator Change Energy Metabolism to Terminate Proliferation in Drosophila Neural Stem Cells

Homem, C. C. F., Steinmann, V., Burkard, T. R., Jais, A., Esterbauer, H., & Knoblich, J. A. (2014) · Cell

Developmental Biology and Gene RegulationNeurogenesis and neuroplasticity mechanisms

Cited by 243

The organoid cell atlas

the Human Cell Atlas ‘Biological Network’ Organoids, Bock, C., Boutros, M., Camp, J. G., Clarke, L., Clevers, H., Knoblich, J. A., Liberali, P., Regev, A., Rios, A. C., et al. (2021) · Nature Biotechnology

Single-cell and spatial transcriptomicsPluripotent Stem Cells Research

Cited by 171

Mechanisms of asymmetric cell division during animal development

Knoblich, J. A. (1997) · Current Opinion in Cell Biology

Developmental Biology and Gene RegulationMicrotubule and mitosis dynamics

Cited by 87