The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment
Open accessAbstract
Osteoblasts and endothelium constitute functional niches that support haematopoietic stem cells in mammalian bone marrow. Adult bone marrow also contains adipocytes, the number of which correlates inversely with the haematopoietic activity of the marrow. Fatty infiltration of haematopoietic red marrow follows irradiation or chemotherapy and is a diagnostic feature in biopsies from patients with marrow aplasia. To explore whether adipocytes influence haematopoiesis or simply fill marrow space, we compared the haematopoietic activity of distinct regions of the mouse skeleton that differ in adiposity. Here we show, by flow cytometry, colony-forming activity and competitive repopulation assay, that haematopoietic stem cells and short-term progenitors are reduced in frequency in the adipocyte-rich vertebrae of the mouse tail relative to the adipocyte-free vertebrae of the thorax. In lipoatrophic A-ZIP/F1 'fatless' mice, which are genetically incapable of forming adipocytes, and in mice treated with the peroxisome proliferator-activated receptor-gamma inhibitor bisphenol A diglycidyl ether, which inhibits adipogenesis, marrow engraftment after irradiation is accelerated relative to wild-type or untreated mice. These data implicate adipocytes as predominantly negative regulators of the bone-marrow microenvironment, and indicate that antagonizing marrow adipogenesis may enhance haematopoietic recovery in clinical bone-marrow transplantation.
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“A similar fatty deterioration of the bone marrow microenvironment occurs (41)”
From Causes, consequences, and reversal of immune system aging (2013) · cites this paper as [41]
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“Moreover, adipocytes have been described to secrete mediators suppressing hematopoiesis and upholding a proinflammatory environment such as TNF-a.51”
From Inflammatory bone marrow microenvironment (2019) · cites this paper as [51]
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Cites
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What we talk about when we talk about fat
Rosen, E. D., & Spiegelman, B. M. (2014) · Cell · doi:10.1016/j.cell.2013.12.012 · Cited by 2,373
“There is an inverse relationship between the number of fat cells and the number of hematopoietic precursors, and elimination of marrow fat by genetic or pharmacologic means enhances the rate of engraftment following radioablation (Naveiras et al., 2009).”
Adipogenesis and metabolic health
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Arteriolar niches maintain haematopoietic stem cell quiescence
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“Unlike long bones which are mostly occupied by adipocytes in adult humans 29 , the sternum exhibits rich hematopoietic activity in both species.”
Multipotent mesenchymal stromal cells and the innate immune system
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Haematopoietic stem cell activity and interactions with the niche
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Metadata
- Authors
- Naveiras, O., Nardi, V., Wenzel, P. L., Hauschka, P. V., Fahey, F., & Daley, G. Q.
- Affiliations
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Boston Children's Hospital (US)
- Corresponding author
- Daley, George Q.
- Venue
- Nature
- Published
- 2009-06-10
- Volume
- 460
- Issue
- 7252
- Pages
- 259-263
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC2831539
- OpenAlex
- W2100140007
- Cited by
- 1,129
- References
- 31
- Citations by year
- 2026: 22 · 2025: 49 · 2024: 64 · 2023: 68 · 2022: 62 · 2021: 84 · 2020: 96 · 2019: 71 · 2018: 71 · 2017: 94 · 2016: 69 · 2015: 65 · 2014: 59 · 2013: 69 · 2012: 67
- FWCI
- 39.67
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health (DP1OD000256)
- National Heart, Lung, and Blood Institute (T32HL007623)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK059279, R01DK070055)
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Keywords
- bone marrow adipocytes, hematopoiesis, hematopoietic stem cells, hematopoietic progenitor cells, adipogenesis, bone marrow transplantation, hematopoietic recovery, DGEBA, PPARγ
- MeSH terms
- Bisphenol A Compounds, Animals, Benzhydryl Compounds, Bone Marrow Cells, Cell Line, Epoxy Compounds, Femur, Hematopoiesis, Hematopoietic Stem Cells, Homeostasis, Mice, Inbred C57BL, Osteogenesis, Spine, Tail, Thorax, Tibia, Bone Marrow Transplantation, Stromal Cells, Adipocytes, Adiposity, Adipogenesis, Mice
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