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Emerging roles for lipids in shaping membrane-protein function
Open accessAbstract
Studies of membrane proteins have revealed a direct link between the lipid environment and the structure and function of some of these proteins. Although some of these effects involve specific chemical interactions between lipids and protein residues, many can be understood in terms of protein-induced perturbations to the membrane shape. The free-energy cost of such perturbations can be estimated quantitatively, and measurements of channel gating in model systems of membrane proteins with their lipid partners are now confirming predictions of simple models.
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Cites
Molecular anatomy of a trafficking organelle
Takamori, S., Holt, M., Stenius, K., Lemke, E. A., Grønborg, M., Riedel, D., Urlaub, H., Schenck, S., Brügger, B., Ringler, P., et al. (2006) · Cell · doi:10.1016/j.cell.2006.10.030 · Cited by 2,373
Macromolecular crowding: obvious but underappreciated
Ellis, R. J. (2001) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(01)01938-7 · Cited by 2,309
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Structure of the mechanically activated ion channel Piezo1
Saotome, K., Murthy, S. E., Kefauver, J. M., Whitwam, T., Patapoutian, A., & Ward, A. B. (2018) · Nature · doi:10.1038/nature25453 · Cited by 649
The Mechanical World of Bacteria
Persat, A., Nadell, C. D., Kim, M. K., Ingremeau, F., Siryaporn, A., Drescher, K., Wingreen, N. S., Bassler, B. L., Gitai, Z., & Stone, H. A. (2015) · Cell · doi:10.1016/j.cell.2015.05.005 · Cited by 615
Homeoviscous Adaptation and the Regulation of Membrane Lipids
Ernst, R., Ejsing, C. S., & Antonny, B. (2016) · Journal of Molecular Biology · doi:10.1016/j.jmb.2016.08.013 · Cited by 506
Emerging Diversity in Lipid–Protein Interactions
Corradi, V., Sejdiu, B. I., Mesa-Galloso, H., Abdizadeh, H., Noskov, S. Y., Marrink, S. J., & Tieleman, D. P. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00451 · Cited by 459
Shi, Z., Graber, Z. T., Baumgart, T., Stone, H. A., & Cohen, A. E. (2018) · Cell · doi:10.1016/j.cell.2018.09.054 · Cited by 355
Metadata
- Authors
- Phillips, R., Ursell, T., Wiggins, P., & Sens, P.
- Venue
- Nature
- Published
- 2009-05
- Volume
- 459
- Issue
- 7245
- Pages
- 379-385
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2054342311
- Cited by
- 984
- References
- 2
- FWCI
- 21.96
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Phillips, R., Ursell, T., Wiggins, P., & Sens, P. (2009). Emerging roles for lipids in shaping membrane-protein function. Nature. https://doi.org/10.1038/nature08147
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