Cell Membranes Resist Flow
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Abstract
The fluid-mosaic model posits a liquid-like plasma membrane, which can flow in response to tension gradients. It is widely assumed that membrane flow transmits local changes in membrane tension across the cell in milliseconds, mediating long-range signaling. Here, we show that propagation of membrane tension occurs quickly in cell-attached blebs but is largely suppressed in intact cells. The failure of tension to propagate in cells is explained by a fluid dynamical model that incorporates the flow resistance from cytoskeleton-bound transmembrane proteins. Perturbations to tension propagate diffusively, with a diffusion coefficient D σ ∼0.024 μm 2/s in HeLa cells. In primary endothelial cells, local increases in membrane tension lead only to local activation of mechanosensitive ion channels and to local vesicle fusion. Thus, membrane tension is not a mediator of long-range intracellular signaling, but local variations in tension mediate distinct processes in sub-cellular domains.
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A substantial spatial gradient of membrane tension is thought to persist due to attachment of cytoskeleton to the membrane.
“Indeed, a substantial spatial gradient of membrane tension is thought to persist due to attachment of cytoskeleton to the membrane28.”
From Membrane compression by synaptic vesicle exocytosis triggers ultrafast endocytosis (2023) · cites this paper as [28]
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- Authors
- Shi, Z., Graber, Z. T., Baumgart, T., Stone, H. A., & Cohen, A. E.
- Affiliations
- Howard Hughes Medical Institute (US)
- University of Pennsylvania (US)
- Princeton University (US)
- Corresponding author
- Cohen, Adam E.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2018-12
- Volume
- 175
- Issue
- 7
- Pages
- 1769-1779.e13
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC6541487
- OpenAlex
- W2795033146
- Cited by
- 355
- References
- 95
- Citations by year
- 2026: 32 · 2025: 48 · 2024: 43 · 2023: 41 · 2022: 56 · 2021: 38 · 2020: 49 · 2019: 41 · 2018: 6 · 2017: 1
- FWCI
- 18.56
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Gordon and Betty Moore Foundation
- Howard Hughes Medical Institute
- NIH (R01 GM 09755, U54CA193417)
- NSF (CBET-1509347, DMS 1614907)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Keywords
- membrane tension, cell membrane mechanics, mechanosensitive ion channels, vesicle fusion, endothelial cells, HeLa cells, intracellular signaling
- MeSH terms
- Animals, Cell Membrane, Cytoskeleton, Dogs, HeLa Cells, Humans, Ion Channels, Models, Biological, Signal Transduction, NIH 3T3 Cells, Mice, Rats, Madin Darby Canine Kidney Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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