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Cited by 500

The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.

Pten in stromal fibroblasts suppresses mammary epithelial tumours

Open access
Trimboli, Anthony J., Cantemir-Stone, Carmen Z., Li, Fu, Wallace, Julie A., Merchant, Anand, Creasap, Nicholas, Thompson, John C., Caserta, Enrico, Wang, Hui, Chong, Jean-Leon, Naidu, Shan, Wei, Guo, Sharma, Sudarshana M., Stephens, Julie A., Fernandez, Soledad A., Gurcan, Metin N., Weinstein, Michael B., Barsky, Sanford H., Yee, Lisa, Rosol, Thomas J., Stromberg, Paul C., Robinson, Michael L., Pepin, Francois, Hallett, Michael, Park, Morag, Ostrowski, Michael C., Leone, Gustavo·2009·Nature
DOI 10.1038/nature08486
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Abstract

The tumour stroma is believed to contribute to some of the most malignant characteristics of epithelial tumours. However, signalling between stromal and tumour cells is complex and remains poorly understood. Here we show that the genetic inactivation of Pten in stromal fibroblasts of mouse mammary glands accelerated the initiation, progression and malignant transformation of mammary epithelial tumours. This was associated with the massive remodelling of the extracellular matrix (ECM), innate immune cell infiltration and increased angiogenesis. Loss of Pten in stromal fibroblasts led to increased expression, phosphorylation (T72) and recruitment of Ets2 to target promoters known to be involved in these processes. Remarkably, Ets2 inactivation in Pten stroma-deleted tumours ameliorated disruption of the tumour microenvironment and was sufficient to decrease tumour growth and progression. Global gene expression profiling of mammary stromal cells identified a Pten-specific signature that was highly represented in the tumour stroma of patients with breast cancer. These findings identify the Pten–Ets2 axis as a critical stroma-specific signalling pathway that suppresses mammary epithelial tumours.

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Metadata

Authors
Trimboli, A. J., Cantemir-Stone, C. Z., Li, F., Wallace, J. A., Merchant, A., Creasap, N., Thompson, J. C., Caserta, E., Wang, H., Chong, J.-L., Naidu, S., Wei, G., Sharma, S. M., Stephens, J. A., Fernandez, S. A., Gurcan, M. N., Weinstein, M. B., Barsky, S. H., Yee, L., Rosol, T. J., Stromberg, P. C., Robinson, M. L., Pepin, F., Hallett, M., Park, M., Ostrowski, M. C., & Leone, G.
Venue
Nature
Publisher
Springer Science and Business Media LLC
Published
2009-10
Volume
461
Issue
7267
Pages
1084-1091
ISSN
  • 0028-0836 (ISSN-L)
  • 1476-4687
DOI
10.1038/nature08486
OpenAlex
W2168649860
Cited by
500
References
8
FWCI
20.89
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Pten in stromal fibroblasts suppresses mammary epithelial tumours. https://app.cochat.ai/papers/10.1038/nature08486
The paper
Trimboli, A. J., Cantemir-Stone, C. Z., Li, F., Wallace, J. A., Merchant, A., Creasap, N., Thompson, J. C., Caserta, E., Wang, H., Chong, J.-L., Naidu, S., Wei, G., Sharma, S. M., Stephens, J. A., Fernandez, S. A., Gurcan, M. N., Weinstein, M. B., Barsky, S. H., Yee, L., . . . Leone, G. (2009). Pten in stromal fibroblasts suppresses mammary epithelial tumours. Nature. https://doi.org/10.1038/nature08486

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.