Cited by 695Fatty Acid Research and HealthInflammatory mediators and NSAID effectsSphingolipid Metabolism and Signaling

The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.

Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis

Open access

Spite, Matthew, Norling, Lucy V., Summers, Lisa, Yang, Rong, Cooper, Dianne, Petasis, Nicos A., Flower, Roderick J., Perretti, Mauro, Serhan, Charles N.·2009·Nature

DOI 10.1038/nature08541PMC PMC2779525

Open this paper in CoChat — free account

Abstract

A growing body of evidence indicates that resolution of acute inflammation is an active process. Resolvins are a new family of lipid mediators enzymatically generated within resolution networks that possess unique and specific functions to orchestrate catabasis, the phase in which disease declines. Resolvin D2 (RvD2) was originally identified in resolving exudates, yet its individual contribution in resolution remained to be elucidated. Here, we establish RvD2's potent stereoselective actions in reducing excessive neutrophil trafficking to inflammatory loci. RvD2 decreased leukocyte-endothelial interactions in vivo by endothelial-dependent nitric oxide production, and by direct modulation of leukocyte adhesion receptor expression. In mice with microbial sepsis initiated by caecal ligation and puncture, RvD2 sharply decreased both local and systemic bacterial burden, excessive cytokine production and neutrophil recruitment, while increasing peritoneal mononuclear cells and macrophage phagocytosis. These multi-level pro-resolving actions of RvD2 translate to increased survival from sepsis induced by caecal ligation and puncture and surgery. Together, these results identify RvD2 as a potent endogenous regulator of excessive inflammatory responses that acts via multiple cellular targets to stimulate resolution and preserve immune vigilance.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/nature08541

Cites

33 of 33 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Exploring the full spectrum of macrophage activation
Mosser, D. M., & Edwards, J. P. (2008) · Nature Reviews Immunology · doi:10.1038/nri2448 · Cited by 9,144
The Pathophysiology and Treatment of Sepsis
Hotchkiss, R. S., & Karl, I. E. (2003) · New England Journal of Medicine · doi:10.1056/nejmra021333 · Cited by 4,134
Nitric oxide: an endogenous modulator of leukocyte adhesion.
Kubes, P., Suzuki, M., & Granger, D. N. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.11.4651 · Cited by 3,036
Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators
Serhan, C. N., Chiang, N., & Van Dyke, T. E. (2008) · Nature Reviews Immunology · doi:10.1038/nri2294 · Cited by 2,932
Self-citation
Immunodesign of experimental sepsis by cecal ligation and puncture
Rittirsch, D., Huber-Lang, M. S., Flierl, M. A., & Ward, P. A. (2009) · Nature Protocols · doi:10.1038/nprot.2008.214 · Cited by 2,209
Resolvins
Serhan, C. N., Hong, S., Gronert, K., Colgan, S. P., Devchand, P. R., Mirick, G., & Moussignac, R.-L. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20020760 · Cited by 1,650
Self-citation
Rapid increase in hospitalization and mortality rates for severe sepsis in the United States: A trend analysis from 1993 to 2003*
Dombrovskiy, V. Y., Martin, A. A., Sunderram, J., & Paz, H. L. (2007) · Critical Care Medicine · doi:10.1097/01.ccm.0000261890.41311.e9 · Cited by 1,253
Novel Docosatrienes and 17S-Resolvins Generated from Docosahexaenoic Acid in Murine Brain, Human Blood, and Glial Cells
Hong, S., Gronert, K., Devchand, P. R., Moussignac, R.-L., & Serhan, C. N. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300218200 · Cited by 1,000
Self-citation
The discovery of nitric oxide and its role in vascular biology
Moncada, S., & Higgs, E. A. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706458 · Cited by 863
Animal Models of sepsis: setting the stage
Buras, J. A., Holzmann, B., & Sitkovsky, M. V. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1854 · Cited by 838

Flagged first, then by citations

Show all 33 references

Sorted by citations

Items 601–694 of 694

食用油を介した「食事－腸内細菌－宿主」ネットワークによる免疫制御
Saika, A., & 國澤, 純. (2018) · doi:10.11209/jim.32.167 · Cited by 1
Resolution phase of inflammation, resolvins and periodontitis: review
Непрелюк, О. А., Игоревич, Ж. С., Ирза, О. Л., & Kriventsov, M. A. (2024) · Clinical Dentistry (Russia) · doi:10.37988/1811-153x_2024_1_32 · Cited by 1
Pre-eclampsia with inflammatory and pro-resolving mediator fluctuations - contributions from hemolytic protozoan parasites
Roe, K. (2025) · Vascular Pharmacology · doi:10.1016/j.vph.2025.107552 · Cited by 1
Docosahexaenoic acid supplementation inhibits monocyte exhaustion memory formation during sepsis
Caldwell, B. A., Wu, Y., Ie, S., Lucas, A., Conacher, B., Zhang, Y., Razani, B., & Li, L. (2026) · Inflammation Research · doi:10.1007/s00011-026-02194-w · Cited by 1
Resolvin D1 requires TLR2-FPR2 crosstalk for inflammation resolution and protection during ocular bacterial infection
Singh, P. K., Singh, S., Kumar, A., Giri, S., & Kumar, A. (2026) · Communications Biology · doi:10.1038/s42003-026-09840-3 · Cited by 2
Médiateurs de l’inflammation au cours du sepsis
Cavaillon, J. (2011) · Springer eBooks · doi:10.1007/978-2-8178-0064-6_2 · Cited by 1
Docosahexaenoic acid Supplementation: A need or a commercial hype ?
Dogra, S., Gupta, M., Kumar, H., & Joshi, R. K. (2014) · International Journal of Basic & Clinical Pharmacology · doi:10.5455/2319-2003.ijbcp20140406 · Cited by 1
Neutrophils in Acute Bacterial Pneumonia
Gomez, J. C., Wang, Q., & Doerschuk, C. M. (2012) · Springer eBooks · doi:10.1007/978-1-4614-5326-0_4 · Cited by 1
Lipoxygenases and Cardiovascular Diseases
Laguna-Fernández, A., Petri, M. H., Thul, S., & Bäck, M. (2016) · Springer eBooks · doi:10.1007/978-3-319-27766-0_6 · Cited by 1
Novel Inflammatory and Immunomodulatory Mediators in Sepsis
Cen, C., Aziz, M., & Wang, P. (2016) · Springer eBooks · doi:10.1007/978-981-10-2425-2_14 · Cited by 1
Therapeutic Potential
Maru, Y. (2021) · Springer eBooks · doi:10.1007/978-981-16-1757-7_16 · Cited by 1
Fish Oils (Omega-3 Fatty Acids, Docosahexaenoic Acid, Eicosapentaenoic Acid, Dietary Fish, and Fish Oils)
Pizzorno, J. E., Paul, C. I., & Schauss, A. G. (2013) · Elsevier eBooks · doi:10.1016/b978-1-4377-2333-5.00091-2 · Cited by 1
Roles of Specialized Proresolving Lipid Mediators in Inflammation Resolution and Tissue Repair
Spite, M. R., & Serhan, C. N. (2017) · Wiley-VCH eBooks · doi:10.1002/9783527692156.ch57 · Cited by 1
Self-citation
Beneficial Effect of Omega-3 Fatty Acids on Immune and Reproductive Endometrial Function
Hidalgo, M. A., Ratto, M. H., & Burgos, R. A. (2020) · IntechOpen eBooks · doi:10.5772/intechopen.89351 · Cited by 2
Fish Oils and Omega-3 Fatty Acids
Nowicki, J., Paul, C. I., Schauss, A. G., & Pizzorno, J. E. (2020) · Elsevier eBooks · doi:10.1016/b978-0-323-43044-9.00080-7 · Cited by 1
EFEITO DA SUPLEMENTAÇÃO COM ÓLEO DE PEIXE NO MODELO EXPERIMENTAL DE SEPSE
Campos, R., Bortoti, A. A., Steclan, C. A., Pawlowytsch, P. W. D. M., Valério, M. C. J., Paluch, C. H., & Fernandes, L. C. (2020) · Revista Contexto & Saúde · doi:10.21527/2176-7114.2020.39.27-34 · Cited by 1
ApoE-Knockout Mice: What are New Achievements of this Model of Atherosclerosis?
Lorkowska-Zawicka, B., & Jawień, J. (2021) · Acta Scientific Pharmaceutical Sciences · doi:10.31080/asps.2021.05.0737
Possible Protective Effect of Each of Omega-3 PUFA and Leptin on Indomethacin-Induced Gastric Ulcer in Rats with type II DM
Motawee, M., Hassan, F., Damanhory, A. A., Mohie, P. M., Khalifa, M. M., & Elbastawisy, Y. M. (2022) · Bulletin of Egyptian Society for Physiological Sciences · doi:10.21608/besps.2022.121674.1119 · Cited by 1
Specialized Pro‐Resolving Lipid Derived Fatty Acid Mediators: Wiring the Circuitry of Effector Immune Homeostasis
Fredman, G., & Serhan, C. N. (2012) · Wiley eBooks · doi:10.1002/9781118704509.ch4 · Cited by 1
Self-citation
Production and impaired regulation of neutrophil extracellular traps following severe thermal injury, implications for sepsis and multiple organ failure
Dinsdale, R. J. (2017) · University of Birmingham Institutional Research Archive (University of Birmingham) · Cited by 1
Therapeutic Potential
Maru, Y. (2016) · Springer eBooks · doi:10.1007/978-4-431-56024-1_16 · Cited by 1
The Mucosal Immune System and Gastrointestinal Inflammation
Cominelli, F., Arseneau, K. O., Hamilton, M. J., & Blumberg, R. S. (2015) · Wiley eBooks · doi:10.1002/9781118512074.ch17 · Cited by 1
Efeitos citotóxicos de resolvinas da série D em glioma murino
Corrêa, L. T. (2015) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
Inflammation-resolving lipid mediators promote revascularization to enhance wound healing.
Zhang, M. (2014) · ThinkIR: The University of Louisville's Institutional Repository (University of Louisville) · doi:10.18297/etd/1643
Efeito da infusão pré-operatória de emulsão lipídica parenteral de óleo de peixe sobre a resposta imunológica pós-operatória e a evolução clínica imediata de pacientes com câncer gastrintestinal
Torrinhas, R. S. M. M. (2012) · doi:10.11606/t.5.2012.tde-14012013-102454
The effects of dietary fish oil on the induction and resolution of antigen-induced inflammation
Tómasdóttir, V. (2014) · Skemman
EVALUACION DEL EFECTO GASTROPROTECTOR DEL DHA (ACIDO DOCOSAHEXAENOICO) EN EL DANO GASTRICO INDUCIDO POR INDOMETACINA
Pena, P., & Pineda‐Peña, E. A. (2013) · REMERI - Red Mexicana de Repositorios Institucionales
Cytokine storm barrier
Haas, M. J. (2010) · Science-Business eXchange · doi:10.1038/scibx.2010.395
Recent advances in periodontology
Aurer, A. (2012) · University of Zagreb University Computing Centre (SRCE)
O papel da maresina 1, um mediador lipídico derivado do ácido graxo poliinsaturado omega-3, na colite experimental em camundongos
Marcon, R. (2013) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
Effects of dietary fatty acids on the immune system
Svahn, S. L. (2015) · Gothenburg University Publications Electronic Archive (Gothenburg University)
Omega-3 polyunsaturated fatty acids and cardiovascular disease: an emphasis on omega-3-acid ethyl esters 90 for the treatment of
Tatsuno, I. (2014)
Emerging Roles for Lipids in the Hepatic Innate Immune
Kremer, M., Sanderlin, E. J., & Hines, I. N. (2013)
Acute Inflammation: A Protective Host Response that May Turn into Harm
Recchiuti, A. (2014)
InflammationShifts in Immunity and
Kominsky, D. J., & Campbell, E. L. (2010)
Atividade de mediadores lipídicos derivados de ácidos graxos poli-insaturados sobre alterações comportamentais e bioquímicas em um modelo de fibromialgia em camundongos
Klein, C. P. (2014) · Americanae (AECID Library)
Study of role of ribosomal protein L13a in resolving inflammation
Poddar, D. (2014) · EngagedScholarship @ Cleveland State University (Cleveland State University)
Chemoselective reactions and their applications in metabolite isolation and analysis.
Gori, S. S. (2016) · doi:10.18297/etd/2476
Linoleic acid and leukocyte inflammatory markers in periparturient dairy cows
Raphael, W. (2014) · Michigan State University Libraries · doi:10.25335/m5ch79
Specialized Pro-resolving Mediators Act on the Innate Immune System to Attenuate Pulmonary Inflammation
Croasdell, A., Phipps, R. P., & Sime, P. J. (2016) · UR Research (University of Rochester)
Expression and Function of the P2y14 Receptor in Murine Peritoneal Macrophages
Kudo, F., Nishiguchi, N., Ito, K., Nakano, M., & Ito, K. (2012) · Hirosaki University Repository for Academic Resources (Hirosaki University)
Preoperative Optimization and Enhanced Recovery Protocols in Ventral Hernia Repair
Orenstein, S. B., & Martindale, R. G. (2017) · Springer eBooks · doi:10.1007/978-3-319-43045-4_27
Molecular Targets for Therapy
Kalil, A. C., & Opal, S. M. (2017) · Respiratory medicine · doi:10.1007/978-3-319-48470-9_6
Characterization of the Immune Response to Lipopolysaccharide in Early Pregnant Ewes as a Model to Study Bacterial Infection Induced Embryonic Loss
Hadfield, J. M. (2017) · The Research Repository @ WVU (West Virginia University) · doi:10.33915/etd.5731
Advance in Therapies for Rheumatoid Arthritis
Amaral, F. A., Oliveira, T. H., Calderaro, D. C., Ferreira, G. A., & Teixeira, M. M. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803302-9.00002-6
Novel Targets for Drug Development
Cross, A. S., & Opal, S. M. (2017) · Wiley-VCH eBooks · doi:10.1002/9783527692156.ch63
Medio de cultivo convencional enriquecido con extractos de quinoa, amaranto y chía promueve el crecimiento de Staphylococcus aureus.
Proaño-Pérez, E., Manjarres-Raza, I., Carvajal-Tapia, C., & Wilber, R.-F. (2017) · DOAJ (DOAJ: Directory of Open Access Journals)
The Effect of Docosahexaenoic Acid in a Mouse Model of Neuroinflammation
Orr, S. K. (2012) · TSpace (University of Toronto)
Mechanistic Insight Into the Role of FABP7 in Malignant Glioma
Beaulieu, M. J. (2012) · ERA: Education and Research Archive (University of Alberta) · doi:10.7939/r3rt33
Preoperative Optimization and Enhanced Recovery After Surgery Protocols in Ventral Hernia Repair
Orenstein, S. B., & Martindale, R. G. (2018) · Springer eBooks · doi:10.1007/978-3-319-90737-6_3
Pro-resolution of Inflammation: New Hints to Manage Sepsis?
Liu, Y., Yu, H., Bhandari, S., & Jin, S. (2019) · Springer eBooks · doi:10.1007/978-981-13-3353-8_8
Dinâmica da incorporação plasmática, leucocitária e hepática de ácidos graxos poli-insaturados após infusão parenteral de diferentes emulsões lipídicas contendo óleo de peixe
de Morais, A. T. (2019) · doi:10.11606/d.5.2019.tde-07052019-124349
Avaliações sequenciais do perfil de ácidos graxos poliinsaturados leucocitários, plasmáticos e hepáticos após infusão parenteral de emulsão lipídica contendo óleo de peixe em rat
Antunes, M. D. S. (2020) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.5.2020.tde-01022021-130259
Experimental studies of lipid mediator modulation of airway responsiveness
Abma, W. (2021) · Figshare
Mechanisms for chlorinated lipids in sepsis
Yu, H. (2020) · doi:10.32469/10355/83793
Regenerative Capacity Of Resolvin D2 On Stem Cells Of Apical Papilla
Ranjan, M. (2021) · International Journal of Dentistry and Oral Science · doi:10.19070/2377-8075-21000516
Leveraging omics to understand the molecular basis of acute-on-chronic liver failure
Clària, J. (2021) · Advances in Laboratory Medicine / Avances en Medicina de Laboratorio · doi:10.1515/almed-2021-0023 · Cited by 2
La aplicación de las ómicas para comprender la base molecular de la insuficiencia hepática aguda sobre crónica
Clària, J. (2021) · Advances in Laboratory Medicine / Avances en Medicina de Laboratorio · doi:10.1515/almed-2021-0068 · Cited by 1
Hot Topic: The U.S. Communities Government Purchasing Alliance: A Money-Saving Purchasing Source Available to Tennessee Cities
Finane, J. (2003)
Faculty Opinions recommendation of Infection regulates pro-resolving mediators that lower antibiotic requirements.
Kurilla, M. G. (2012) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.714597897.790202830
Faculty Opinions recommendation of Activation of GPR37 in macrophages confers protection against infection-induced sepsis and pain-like behaviour in mice.
Bradley, S. J. (2021) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.739756652.793585309
Faculty Opinions recommendation of Myeloperoxidase-derived 2-chlorofatty acids contribute to human sepsis mortality via acute respiratory distress syndrome.
Zimmerman, G. A. (2018) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.733096801.793545237
Changes of LipoxinA 4 Levels Following Early Hospital Management of Patients with Non-Severe COVID-19: A Pilot StudyPreprint
Jamali, F., Shahrami, B., Mojtahedzadeh, A., Najmeddin, F., Arabzadeh, A., Hadadi, A., Sharifzadeh, M. S., & Mojtahedzadeh, M. (2022) · medRxiv · doi:10.1101/2022.04.18.22273880
The authors reply
Osthoff, M. F., Sidler, J. A., & Widmer, A. F. (2016) · Critical Care Medicine · doi:10.1097/ccm.0000000000001897
脂質メディエーターに着目した外科侵襲後の生体反応
明久, 松., 正夫, 宮., 真吏奈, 山., 智司, 松., 櫻澤信行, 陽一, 川., 関口久美子, 松谷, 毅., 岳史, 山., & 英二, 内. (2017) · The Japanese Journal of SURGICAL METABOLISM and NUTRITION · doi:10.11638/jssmn.51.4_157
Repair and recovery mechanisms following critical illness
Bellingan, G. J., & Patel, B. V. (2016) · doi:10.1093/med/9780199600830.003.0309
Omega-3 Fatty Acids
Mayer, K. (2012) · Springer eBooks · doi:10.1007/978-3-642-00418-6_739
Neutrophils
Borregaard, N. (2015) · Wiley eBooks · doi:10.1002/9780470015902.a0001219.pub2 · Cited by 1
Effects of Nutrition on Neutrophil Function in Preclinical Studies
Kohama, K., Kotani, J., & Nakao, A. (2015) · Springer eBooks · doi:10.1007/978-1-4614-7836-2_144
223 Single cell–level pro-resolving actions of Resolvin D1 and D2 on Staphylococcus aureus lung infection and inflammation in cystic fibrosis
Mattoscio, D., Ferri, G., Mucci, M., Romano, M., & Recchiuti, A. (2023) · Journal of Cystic Fibrosis · doi:10.1016/s1569-1993(23)01153-0
222 Signaling mechanisms driving CFTR-independent chloride secretion in Calu-3 cells
Abazari, S. M., Masarweh, G., Gammons, J. W., Sarthi, J. B., & Sellers, Z. M. (2023) · Journal of Cystic Fibrosis · doi:10.1016/s1569-1993(23)01152-9
Nanoparticles Treat Ischemic Stroke by Responding to Stroke Microenvironment
Cao, D., Chen, W., Ma, A., Cheng, M., & Wu, B. (2023) · BioNanoScience · doi:10.1007/s12668-023-01247-2
Desvendando o papel biológico de LsfA, uma 1-Cys Prx envolvida na virulência de Pseudomonas aeruginosa
Silva, R. L. A. (2023) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.41.2023.tde-23012024-200930
Metabolic routes for fatty acids
Lembke, P. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-29114-2.00023-4
Additional file 1 of N-Oleoyl dopamine induces IL-10 via central nervous system TRPV1 and improves endotoxemia and sepsis outcomes
Joffre, J., Wong, E., Lawton, S., Lloyd, E., Nguyen, N., Xu, F., Sempio, C., Kobzik, L., Zlatanova, I., Schumacher, M. A., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19863062
Additional file 1 of Low-dose pro-resolving mediators temporally reset the resolution response to microbial inflammation
Serhan, C. N., Chiang, N., & Nshimiyimana, R. (2024) · Figshare · doi:10.6084/m9.figshare.27059132
Self-citation
GPR18 Deletion in Mice Inversely Affects Vasoactive Signaling and Passive Biomechanical Properties of the Thoracic Aorta and Femoral Artery
Moudt, S. D., Herzine, A., Rodrigues, M.-D. L., Collin, M., Bäck, M., Yen, F. T., & Mercier, N. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27020841
New Vistas in Pharmaconutrition: Potential Role of Specialized Pro-Resolving Molecules (SPMs) in Medical Nutrition—The Marine Background
Télessy, I. G., Buttar, H. S., Wilson, D. W., & Jaglan, P. (2026) · MarineMedicine · doi:10.64187/mm.2026.v2.i1.002
Rôle de GILZ (Glucocorticoid-induced leucine zipper) dans l’apoptose du polynucléaire neutrophile et la résolution de l’inflammation
Espinasse, M. (2014) · theses.fr (ABES) · doi:10.70675/9a999a1dzf723z45d7z993dz46f6da46f94d
Caractérisation de métabolites oxygénés dérivés des acides arachidonique et docosahexaénoïque dans le cerveau de rat
Jouvene, C. C. (2016) · theses.fr (ABES) · doi:10.70675/48490179zca84z4fb2z8a6dzbc32351d6d47
Impact de la qualité des protéines et des lipides du régime de renutrition sur la composition en acides gras, la réponse hépatique à l'insuline, la régulation de l'homéostasie énergétique et l'inflammation, chez les rats âgés Wistar souffrant de malnutrition
Hamouda, H. O. (2015) · theses.fr (ABES) · doi:10.70675/50f93b3ez0942z4f48z890dzc84fea4bd38a
Effet protecteur des acides gras polyinsaturés n-3 sur la neuroinflammation : implication des dérivés lipidiques
Rey, C. (2017) · theses.fr (ABES) · doi:10.70675/db74a518z73a9z4ed6zbf40zd3bd564302e5
Leveraging whole blood based functional assays for pre-clinical research in the context of rheumatoid arthritis
García, C. C. (2023) · theses.fr (ABES) · doi:10.70675/6ea195a8zbbc3z4188z9a08zbe738e998182
Resolvin D2 attenuates platelet activation and thrombosis via the GPR18 receptor
Ji, Y., Wang, M., Sun, P., Zhao, Q., & Cai, S. (2026) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2026.153805
The Emerging Parkinson's Disease Oxylipin‐Ome
Kelliher, J. C., & Fanning, S. (2026) · Advanced Science · doi:10.1002/advs.202522997
Neutrophil efferocytosis in chronic inflammatory gastrointestinal diseases: mechanistic insights and therapeutic potential
Ye, S.-Y., Qu, Y., Zhang, J.-H., Wang, X.-H., Wang, J., Xue, Y., & Liu, J.-D. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1835168
Targeted Delivery of Specialized Pro-Resolving Mediators (SPMs) for Improved Treatments of Inflammatory Diseases and Cancer
Aminu, A., & Wang, Z. (2026) · Pharmaceutics · doi:10.3390/pharmaceutics18091048
The Determınant Effect of Novel Inflammatory Markers on Pressure Ulcer Formatıon and Progressıon of Its Stages
Güngör, M. E., Durmaz, A., Ozdemir, Ç., & Kurtoğlu, Y. K. (2026) · Uluborlu Mesleki Bilimler Dergisi · doi:10.71445/umbd.1899067
Resolution of inflammation: A novel therapeutic paradigm for rheumatoid arthritis and its comorbidities
Yazdi, R. F., Tan, S. I., Bu, W., FRANCO, B. B., Ng, A. J. K., Peh, H. Y., & Chen, J. (2026) · Pharmacological Research · doi:10.1016/j.phrs.2026.109655
Resolution Medicine: Steps to Uncovering the Specialized Pro-resolving Mediator Superfamily and Their Potent Functions in Resolving Inflammation
Serhan, C. N. (2026) · Current topics in microbiology and immunology · doi:10.1007/82_2026_354
Self-citation
Transcriptional regulation and function of GPR18 in macrophage subtype specification
Mena, H. A., Patsalos, A., Altomare, J., Davidsson, F., Nagy, G., Berger, W. K., Wong, B. C. K., Rahtes, A., Fredman, G., Nagy, L., et al. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2612173123
Self-citation
Synthetic analogs of specialized proresolving mediators: From chemical design to therapeutic prospects in atherosclerosis
Kotlyarov, S. (2026) · Studies in natural products chemistry · doi:10.1016/b978-0-443-51068-7.00014-3
BindingDB Entry 50020962: Potent, Selective Agonists for the Cannabinoid-like Orphan G Protein-Coupled Receptor GPR18: A Promising Drug Target for Cancer and Immunity.
BindingDB (2025) · UC San Diego · doi:10.7270/q24t6q03
Disrupted Resolution Mechanisms in the Onset and Progression of Chronic Liver Disease
Clãria, J., Romero-Grimaldo, B., Contreras, B. J., Sánchez-Rodríguez, M. B., Rojano, C., Titos, E., & López‐Vicario, C. (2026) · Current topics in microbiology and immunology · doi:10.1007/82_2026_365

Authors: Spite, M., Norling, L. V., Summers, L., Yang, R., Cooper, D., Petasis, N. A., Flower, R. J., Perretti, M., & Serhan, C. N.
Affiliations: Brigham and Women's Hospital (US)
Queen Mary University of London (GB)
University of Southern California (US)
Corresponding author: Serhan, Charles N.
ORCID: Spite, Matthew
Norling, Lucy V.
Yang, Rong
Cooper, Dianne
Petasis, Nicos A.
Perretti, Mauro
Serhan, Charles N.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2009-10
Volume: 461
Issue: 7268
Pages: 1287-1291
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature08541
PMC: PMC2779525
OpenAlex: W1974226247
Cited by: 695
References: 33
Citations by year: 2026: 21 · 2025: 19 · 2024: 35 · 2023: 34 · 2022: 42 · 2021: 49 · 2020: 61 · 2019: 40 · 2018: 40 · 2017: 44 · 2016: 54 · 2015: 45 · 2014: 39 · 2013: 50 · 2012: 48
FWCI: 38.72
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Queen Mary Research Online (Queen Mary University of London) (submittedVersion)
Funders: Wellcome Trust (086867/Z/08/Z, 085903/Z/08)
Versus Arthritis (18445, 18103)
National Institutes of Health (4r37gm038765-19)
National Heart, Lung, and Blood Institute (HL087526, F32HL087526)
National Institute of General Medical Sciences (GM 38765, R01GM038765, R37-GM038765)
National Institute of Dental and Craniofacial Research (P50DE016191)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Health Sciences › Medicine › Pharmacology (medical) › Inflammatory mediators and NSAID effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sphingolipid Metabolism and Signaling
Keywords: resolvin D2, inflammation resolution, neutrophil trafficking, leukocyte-endothelium interaction, nitric oxide, leukocyte adhesion molecules, cecal ligation and puncture, bacterial load, macrophage phagocytosis, anti-inflammatory agents, host defense
MeSH terms: Animals, Docosahexaenoic Acids, Escherichia coli, Humans, Inflammation, Leukocytes, Macrophages, Male, Mice, Inbred C57BL, Nitric Oxide, Peritoneal Cavity, Peritonitis, Phagocytosis, Reactive Oxygen Species, Sepsis, Endothelial Cells, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks