The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
NINJA connects the co-repressor TOPLESS to jasmonate signalling
Open accessAbstract
Jasmonoyl-isoleucine (JA-Ile) is a plant hormone that regulates a broad array of plant defence and developmental processes. JA-Ile-responsive gene expression is regulated by the transcriptional activator MYC2 that interacts physically with the jasmonate ZIM-domain (JAZ) repressor proteins. On perception of JA-Ile, JAZ proteins are degraded and JA-Ile-dependent gene expression is activated. The molecular mechanisms by which JAZ proteins repress gene expression remain unknown. Here we show that the Arabidopsis JAZ proteins recruit the Groucho/Tup1-type co-repressor TOPLESS (TPL) and TPL-related proteins (TPRs) through a previously uncharacterized adaptor protein, designated Novel Interactor of JAZ (NINJA). NINJA acts as a transcriptional repressor whose activity is mediated by a functional TPL-binding EAR repression motif. Accordingly, both NINJA and TPL proteins function as negative regulators of jasmonate responses. Our results point to TPL proteins as general co-repressors that affect multiple signalling pathways through the interaction with specific adaptor proteins. This new insight reveals how stress-related and growth-related signalling cascades use common molecular mechanisms to regulate gene expression in plants.
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Metadata
- Authors
- Pauwels, L., Barbero, G. F., Geerinck, J., Tilleman, S., Grunewald, W., Pérez, A. C., Chico, J. M., Bossche, R. V., Sewell, J., Gil, E., García-Casado, G., Witters, E., Inzé, D., Long, J. A., De Jaeger, G., Solano, R., & Goossens, A.
- Venue
- Nature
- Published
- 2010-04
- Volume
- 464
- Issue
- 7289
- Pages
- 788-791
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2119854546
- Cited by
- 1,018
- References
- 40
- FWCI
- 64.39
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Pauwels, L., Barbero, G. F., Geerinck, J., Tilleman, S., Grunewald, W., Pérez, A. C., Chico, J. M., Bossche, R. V., Sewell, J., Gil, E., García-Casado, G., Witters, E., Inzé, D., Long, J. A., De Jaeger, G., Solano, R., & Goossens, A. (2010). NINJA connects the co-repressor TOPLESS to jasmonate signalling. Nature. https://doi.org/10.1038/nature08854
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