The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Expansion of the eukaryotic proteome by alternative splicing
Open accessAbstract
The collection of components required to carry out the intricate processes involved in generating and maintaining a living, breathing and, sometimes, thinking organism is staggeringly complex. Where do all of the parts come from? Early estimates stated that about 100,000 genes would be required to make up a mammal; however, the actual number is less than one-quarter of that, barely four times the number of genes in budding yeast. It is now clear that the 'missing' information is in large part provided by alternative splicing, the process by which multiple different functional messenger RNAs, and therefore proteins, can be synthesized from a single gene.
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Cites
Alternative isoform regulation in human tissue transcriptomes
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Listening to silence and understanding nonsense: exonic mutations that affect splicing
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Chromatin organization marks exon-intron structure
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Differential Control of the Releasable Vesicle Pools by SNAP-25 Splice Variants and SNAP-23
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Control of alternative splicing through siRNA-mediated transcriptional gene silencing
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Interferon-stimulated genes: A complex web of host defenses
Schneider, W. M., Chevillotte, M. D., & Rice, C. M. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120231 · Cited by 3,067
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The Noncoding RNA Revolution—Trashing Old Rules to Forge New Ones
Cech, T. R., & Steitz, J. A. (2014) · Cell · doi:10.1016/j.cell.2014.03.008 · Cited by 2,524
RNA sequencing: advances, challenges and opportunities
Ozsolak, F., & Milos, P. M. (2011) · Nature Reviews Genetics · doi:10.1038/nrg2934 · Cited by 2,135
“Characterization of alternative splicing patterns Given the importance of alternative splicing patterns in development and the fact that 15–60% of known disease-causing mutations affect splicin”
BackgroundNuclear m6A Reader YTHDC1 Regulates mRNA Splicing
Xiao, W., Adhikari, S., Dahal, U., Chen, Y.-S., Hao, Y.-J., Sun, B.-F., Sun, H.-Y., Li, A., Ping, X.-L., Lai, W.-Y., et al. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.01.012 · Cited by 2,054
Metadata
- Authors
- Nilsen, T. W., & Graveley, B. R.
- Venue
- Nature
- Published
- 2010-01
- Volume
- 463
- Issue
- 7280
- Pages
- 457-463
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2063530272
- Cited by
- 2,197
- References
- 11
- FWCI
- 54.35
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
