Cited by 861Plant Molecular Biology ResearchDevelopmental Biology and Gene RegulationPlant nutrient uptake and metabolism

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Cell signalling by microRNA165/6 directs gene dose-dependent root cell fate

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Carlsbecker, Annelie, Lee, Ji-Young, Roberts, Christina J., Dettmer, Jan, Lehesranta, Satu, Zhou, Jing, Lindgren, Ove, Moreno-Risueno, Miguel A., Vatén, Anne, Thitamadee, Siripong, Campilho, Ana, Sebastian, Jose, Bowman, John L., Helariutta, Ykä, Benfey, Philip N.·2010·Nature

DOI 10.1038/nature08977PMC PMC2967782

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Abstract

A key question in developmental biology is how cells exchange positional information for proper patterning during organ development. In plant roots the radial tissue organization is highly conserved with a central vascular cylinder in which two water conducting cell types, protoxylem and metaxylem, are patterned centripetally. We show that this patterning occurs through crosstalk between the vascular cylinder and the surrounding endodermis mediated by cell-to-cell movement of a transcription factor in one direction and microRNAs in the other. SHORT ROOT, produced in the vascular cylinder, moves into the endodermis to activate SCARECROW. Together these transcription factors activate MIR165a and MIR166b. Endodermally produced microRNA165/6 then acts to degrade its target mRNAs encoding class III homeodomain-leucine zipper transcription factors in the endodermis and stele periphery. The resulting differential distribution of target mRNA in the vascular cylinder determines xylem cell types in a dosage-dependent manner.

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Floral dip: a simplified method for Agrobacterium ‐mediated transformation of Arabidopsis thaliana
Clough, S. J., & Bent, A. F. (1998) · The Plant Journal · doi:10.1046/j.1365-313x.1998.00343.x · Cited by 22,014
Anatomy of Seed Plants
Esau, K. (1960) · Soil Science · doi:10.1097/00010694-196008000-00031 · Cited by 2,092
Radial Patterning of Arabidopsis Shoots by Class III HD-ZIP and KANADI Genes
Emery, J. F., Floyd, S. K., Alvarez, J., Eshed, Y., Hawker, N. P., Izhaki, A., Baum, S. F., & Bowman, J. L. (2003) · Current Biology · doi:10.1016/j.cub.2003.09.035 · Cited by 1,143
Self-citation
The SCARECROW Gene Regulates an Asymmetric Cell Division That Is Essential for Generating the Radial Organization of the Arabidopsis Root
Di Laurenzio, L., Wysocka-Diller, J., Malamy, J. E., Pysh, L., Helariutta, Y., Freshour, G., Hahn, M. G., Feldmann, K. A., & Benfey, P. N. (1996) · Cell · doi:10.1016/s0092-8674(00)80115-4 · Cited by 1,124
Self-citation
The SHORT-ROOT Gene Controls Radial Patterning of the Arabidopsis Root through Radial Signaling
Helariutta, Y., Fukaki, H., Wysocka‐Diller, J. W., Nakajima, K., Jung, J. W., Sena, G., Hauser, M., & Benfey, P. N. (2000) · Cell · doi:10.1016/s0092-8674(00)80865-x · Cited by 1,123
Self-citation
Role of PHABULOSA and PHAVOLUTA in determining radial patterning in shoots
McConnell, J. R., Emery, J. F., Eshed, Y., Bao, N., Bowman, J. L., & Barton, M. K. (2001) · Nature · doi:10.1038/35079635 · Cited by 1,104
Self-citation
Animal MicroRNAs Confer Robustness to Gene Expression and Have a Significant Impact on 3′UTR Evolution
Stark, A., Brennecke, J., Bushati, N., Russell, R. B., & Cohen, S. M. (2005) · Cell · doi:10.1016/j.cell.2005.11.023 · Cited by 1,080
Intercellular movement of the putative transcription factor SHR in root patterning
Nakajima, K., Sena, G., Nawy, T., & Benfey, P. N. (2001) · Nature · doi:10.1038/35095061 · Cited by 870
Self-citation
Class III Homeodomain-Leucine Zipper Gene Family Members Have Overlapping, Antagonistic, and Distinct Roles in Arabidopsis Development
Prigge, M. J., Otsuga, D., Alonso, J. M., Ecker, J. R., Drews, G. N., & Clark, S. E. (2004) · The Plant Cell · doi:10.1105/tpc.104.026161 · Cited by 777
SCARECROW is involved in positioning the stem cell niche in the Arabidopsis root meristemPreprint
Sabatini, S., Heidstra, R., Wildwater, M., & Scheres, B. (2003) · Genes & Development · doi:10.1101/gad.252503 · Cited by 727

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Ramachandran, P., Augstein, F., Nguyen, V. C., & Carlsbecker, A. (2020) · Frontiers in Plant Science · doi:10.3389/fpls.2020.00570 · Cited by 51
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Maize microRNA166 Inactivation Confers Plant Development and Abiotic Stress Resistance
Li, N., Yang, T., Guo, Z., Wang, Q., Chai, M., Wu, M., Li, X., Li, W., Li, G., Tang, J., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249506 · Cited by 51
Surfing along the root ground tissue gene network
Pauluzzi, G. C., Divol, F., Puig, J., Guiderdoni, E., Diévart, A., & Périn, C. (2012) · Developmental Biology · doi:10.1016/j.ydbio.2012.02.007 · Cited by 51
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Azpeitia, E. M., Weinstein, N., Benítez, M., Mendoza, L., & Alvarez-Buylla, E. R. (2013) · Frontiers in Plant Science · doi:10.3389/fpls.2013.00110 · Cited by 50
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Huen, A., Rodriguez‐Medina, C., Ho, A. Y. Y., Atkins, C. A., & Smith, P. M. C. (2017) · Plant Biology · doi:10.1111/plb.12568 · Cited by 51
Parsimonious Model of Vascular Patterning Links Transverse Hormone Fluxes to Lateral Root Initiation: Auxin Leads the Way, while Cytokinin Levels Out
El‐Showk, S., Help, H., Blomster, T., Riccardo, S., Marée, A. F. M., Mähönen, A. P., & Grieneisen, V. A. (2015) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1004450 · Cited by 49
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Alabdallah, O., Ahou, A., Mancuso, N., Pompili, V., Macone, A., Pashkoulov, D., Stano, P., Cona, A., Angelini, R., & Tavladoraki, P. (2016) · Journal of Experimental Botany · doi:10.1093/jxb/erw510 · Cited by 49
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Fan, P., Aguilar, E., Bradai, M., Xue, H., Wang, H., Rosas‐Díaz, T., Tang, W., Wolf, S., Zhang, H., Xu, L., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2022547118 · Cited by 48
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Li, Z., Li, S., Zhang, L., Han, S., Li, W.-F., Xu, H., Yang, W., Liu, Y., Fan, Y., & Qi, L. (2016) · Plant Cell Tissue and Organ Culture (PCTOC) · doi:10.1007/s11240-016-1071-9 · Cited by 47
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Magnani, E., & Barton, M. K. (2011) · The Plant Cell · doi:10.1105/tpc.110.080754 · Cited by 46
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Ormancey, M., Ru, A. L., Duboé, C., Jin, H., Thuleau, P., Plaza, S., & Combier, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072266 · Cited by 34
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Omics and modelling approaches for understanding regulation of asymmetric cell divisions in arabidopsis and other angiosperm plants
Kajala, K., Ramakrishna, P., Fisher, A., Bergmann, D. C., Smet, I. D., Sozzani, R., Weijers, D., & Brady, S. M. (2014) · Annals of Botany · doi:10.1093/aob/mcu065 · Cited by 34
Small but thick enough – the Arabidopsis hypocotyl as a model to study secondary growth
Ragni, L., & Hardtke, C. S. (2013) · Physiologia Plantarum · doi:10.1111/ppl.12118 · Cited by 34
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Pagliarani, C., & Gambino, G. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20174306 · Cited by 34
The regulatory role of abscisic acid on cadmium uptake, accumulation and translocation in plants
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Feng, X., Liu, W., Dai, H., Qiu, Y., Zhang, G., Chen, Z., & Wu, F. (2020) · Journal of Experimental Botany · doi:10.1093/jxb/eraa290 · Cited by 32
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A SCARECROW-based regulatory circuit controls Arabidopsis thaliana meristem size from the root endodermis
Moubayidin, L., Salvi, E., Giustini, L., Terpstra, I. R., Heidstra, R., Costantino, P., & Sabatini, S. (2016) · Planta · doi:10.1007/s00425-016-2471-0 · Cited by 31
Differential spatial distribution of miR165/6 determines variability in plant root anatomy
Ruocco, G. D., Bertolotti, G., Pacifici, E., Polverari, L., Tsiantis, M., Sabatini, S., Costantino, P., & Ioio, R. D. (2017) · Development · doi:10.1242/dev.153858 · Cited by 32
Micropropagation of Plants
Singh, A. (2015) · Springer eBooks · doi:10.1007/978-81-322-2283-5_16 · Cited by 31
FDF-PAGE: a powerful technique revealing previously undetected small RNAs sequestered by complementary transcripts
Harris, C. J., Molnár, A., Müller, S., & Baulcombe, D. C. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv604 · Cited by 30
Water-deficit responsive microRNAs in the primary root growth zone of maize
Seeve, C. M., Sunkar, R., Zheng, Y., Liu, L., Liu, Z., McMullen, M. D., Nelson, S. K., Sharp, R. E., & Oliver, M. J. (2019) · BMC Plant Biology · doi:10.1186/s12870-019-2037-y · Cited by 31
Specification and regulation of vascular tissue identity in the Arabidopsis embryo
Smit, M. E., Llavata‐Peris, C. I., Roosjen, M., van Beijnum, H., Novikova, D. D., Levitsky, V. G., Sevilem, I., Roszak, P., Slane, D., Jürgens, G., et al. (2020) · Development · doi:10.1242/dev.186130 · Cited by 31

Authors: Carlsbecker, A., Lee, J.-Y., Roberts, C. J., Dettmer, J., Lehesranta, S., Zhou, J., Lindgren, O., Moreno-Risueno, M. A., Vatén, A., Thitamadee, S., Campilho, A., Sebastian, J., Bowman, J. L., Helariutta, Y., & Benfey, P. N.
Affiliations: University of Helsinki (FI)
Cornell University (US)
Uppsala University (SE)
Monash University (AU)
Duke University (US)
Corresponding author: Helariutta, Ykä
Benfey, Philip N.
ORCID: Carlsbecker, Annelie
Lee, Ji-Young
Dettmer, Jan
Vatén, Anne
Thitamadee, Siripong
Campilho, Ana
Bowman, John L.
Helariutta, Ykä
Benfey, Philip N.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2010-04-21
Volume: 465
Issue: 7296
Pages: 316-321
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature08977
PMC: PMC2967782
OpenAlex: W2083540641
Cited by: 861
References: 42
Citations by year: 2026: 32 · 2025: 31 · 2024: 36 · 2023: 39 · 2022: 58 · 2021: 57 · 2020: 67 · 2019: 53 · 2018: 45 · 2017: 54 · 2016: 55 · 2015: 65 · 2014: 57 · 2013: 65 · 2012: 61
FWCI: 81.61
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
RePEc: Research Papers in Economics (submittedVersion)
ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
Funders: National Institute of General Medical Sciences (R01GM043778)
Topics: Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant nutrient uptake and metabolism
Keywords: SHORT-ROOT, scarecrow, protoxylem, metaxylem, endodermis, vascular cylinder, positional information, root development, Arabidopsis thaliana
MeSH terms: Cell Movement, Endoderm, Transcription Factors, Signal Transduction, Arabidopsis, Gene Expression Regulation, Plant, Plant Roots, Gene Dosage, RNA, Plant, Cell Lineage, Body Patterning, Arabidopsis Proteins, RNA Transport, MicroRNAs, Organogenesis, Xylem

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Cell signalling by microRNA165/6 directs gene dose-dependent root cell fate

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