Cited by 861Plant Molecular Biology ResearchDevelopmental Biology and Gene RegulationPlant nutrient uptake and metabolism

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Cell signalling by microRNA165/6 directs gene dose-dependent root cell fate

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Carlsbecker, Annelie, Lee, Ji-Young, Roberts, Christina J., Dettmer, Jan, Lehesranta, Satu, Zhou, Jing, Lindgren, Ove, Moreno-Risueno, Miguel A., Vatén, Anne, Thitamadee, Siripong, Campilho, Ana, Sebastian, Jose, Bowman, John L., Helariutta, Ykä, Benfey, Philip N.·2010·Nature

DOI 10.1038/nature08977PMC PMC2967782

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Abstract

A key question in developmental biology is how cells exchange positional information for proper patterning during organ development. In plant roots the radial tissue organization is highly conserved with a central vascular cylinder in which two water conducting cell types, protoxylem and metaxylem, are patterned centripetally. We show that this patterning occurs through crosstalk between the vascular cylinder and the surrounding endodermis mediated by cell-to-cell movement of a transcription factor in one direction and microRNAs in the other. SHORT ROOT, produced in the vascular cylinder, moves into the endodermis to activate SCARECROW. Together these transcription factors activate MIR165a and MIR166b. Endodermally produced microRNA165/6 then acts to degrade its target mRNAs encoding class III homeodomain-leucine zipper transcription factors in the endodermis and stele periphery. The resulting differential distribution of target mRNA in the vascular cylinder determines xylem cell types in a dosage-dependent manner.

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Authors: Carlsbecker, A., Lee, J.-Y., Roberts, C. J., Dettmer, J., Lehesranta, S., Zhou, J., Lindgren, O., Moreno-Risueno, M. A., Vatén, A., Thitamadee, S., Campilho, A., Sebastian, J., Bowman, J. L., Helariutta, Y., & Benfey, P. N.
Affiliations: University of Helsinki (FI)
Cornell University (US)
Uppsala University (SE)
Monash University (AU)
Duke University (US)
Corresponding author: Helariutta, Ykä
Benfey, Philip N.
ORCID: Carlsbecker, Annelie
Lee, Ji-Young
Dettmer, Jan
Vatén, Anne
Thitamadee, Siripong
Campilho, Ana
Bowman, John L.
Helariutta, Ykä
Benfey, Philip N.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2010-04-21
Volume: 465
Issue: 7296
Pages: 316-321
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature08977
PMC: PMC2967782
OpenAlex: W2083540641
Cited by: 861
References: 42
Citations by year: 2026: 32 · 2025: 31 · 2024: 36 · 2023: 39 · 2022: 58 · 2021: 57 · 2020: 67 · 2019: 53 · 2018: 45 · 2017: 54 · 2016: 55 · 2015: 65 · 2014: 57 · 2013: 65 · 2012: 61
FWCI: 81.61
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
RePEc: Research Papers in Economics (submittedVersion)
ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
Funders: National Institute of General Medical Sciences (R01GM043778)
Topics: Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant nutrient uptake and metabolism
Keywords: SHORT-ROOT, scarecrow, protoxylem, metaxylem, endodermis, vascular cylinder, positional information, root development, Arabidopsis thaliana
MeSH terms: Cell Movement, Endoderm, Transcription Factors, Signal Transduction, Arabidopsis, Gene Expression Regulation, Plant, Plant Roots, Gene Dosage, RNA, Plant, Cell Lineage, Body Patterning, Arabidopsis Proteins, RNA Transport, MicroRNAs, Organogenesis, Xylem

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Cell signalling by microRNA165/6 directs gene dose-dependent root cell fate

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