Cited by 1,317Cancer Genomics and DiagnosticsPancreatic and Hepatic Oncology ResearchChromatin Remodeling and Cancer

The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.

The patterns and dynamics of genomic instability in metastatic pancreatic cancer

Open access

Campbell, Peter J., Yachida, Shinichi, Mudie, Laura J., Stephens, Philip J., Pleasance, Erin D., Stebbings, Lucy A., Morsberger, Laura A., Latimer, Calli, McLaren, Stuart, Lin, Meng-Lay, McBride, David J., Varela, Ignacio, Nik-Zainal, Serena A., Leroy, Catherine, Jia, Mingming, Menzies, Andrew, Butler, Adam P., Teague, Jon W., Griffin, Constance A., Burton, John, Swerdlow, Harold, Quail, Michael A., Stratton, Michael R., Iacobuzio-Donahue, Christine, Futreal, P. Andrew·2010·Nature

DOI 10.1038/nature09460PMC PMC3137369

Open this paper in CoChat — free account

Abstract

Pancreatic cancer is an aggressive malignancy with a five-year mortality of 97-98%, usually due to widespread metastatic disease. Previous studies indicate that this disease has a complex genomic landscape, with frequent copy number changes and point mutations, but genomic rearrangements have not been characterized in detail. Despite the clinical importance of metastasis, there remain fundamental questions about the clonal structures of metastatic tumours, including phylogenetic relationships among metastases, the scale of ongoing parallel evolution in metastatic and primary sites, and how the tumour disseminates. Here we harness advances in DNA sequencing to annotate genomic rearrangements in 13 patients with pancreatic cancer and explore clonal relationships among metastases. We find that pancreatic cancer acquires rearrangements indicative of telomere dysfunction and abnormal cell-cycle control, namely dysregulated G1-to-S-phase transition with intact G2-M checkpoint. These initiate amplification of cancer genes and occur predominantly in early cancer development rather than the later stages of the disease. Genomic instability frequently persists after cancer dissemination, resulting in ongoing, parallel and even convergent evolution among different metastases. We find evidence that there is genetic heterogeneity among metastasis-initiating cells, that seeding metastasis may require driver mutations beyond those required for primary tumours, and that phylogenetic trees across metastases show organ-specific branches. These data attest to the richness of genetic variation in cancer, brought about by the tandem forces of genomic instability and evolutionary selection.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/nature09460

Cites

30 of 30 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses
Jones, S., Zhang, X., Parsons, D. W., Lin, J. C.-H., Leary, R. J., Angenendt, P., Mankoo, P., Carter, H., Kamiyama, H., Jimeno, A., et al. (2008) · Science · doi:10.1126/science.1164368 · Cited by 3,969
Self-citation
Mapping short DNA sequencing reads and calling variants using mapping quality scores
Li, H., Ruan, J., & Durbin, R. (2008) · Genome Research · doi:10.1101/gr.078212.108 · Cited by 2,638
Recurring mutations found by sequencing an acute myeloid leukemia genome
Mardis, E. R., Ding, L., Dooling, D. J., Larson, D. E., McLellan, M. D., Chen, K., Koboldt, D. C., Fulton, R. S., Delehaunty, K. D., McGrath, S. D., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0903840 · Cited by 2,219
A comprehensive catalogue of somatic mutations from a human cancer genome
Pleasance, E. D., Cheetham, R. K., Stephens, P. J., McBride, D. J., Humphray, S. J., Greenman, C. D., Varela, I., Lin, M.-L., Ordóñez, G. R., Bignell, G. R., et al. (2010) · Nature · doi:10.1038/nature08658 · Cited by 1,696
Self-citation
THE STABILITY OF BROKEN ENDS OF CHROMOSOMES IN ZEA MAYS
McClintock, B. (1941) · Genetics · doi:10.1093/genetics/26.2.234 · Cited by 1,605
Pancreatic cancer biology and genetics
Bardeesy, N. M., & DePinho, R. A. (2002) · Nature reviews. Cancer · doi:10.1038/nrc949 · Cited by 1,175
Parallel progression of primary tumours and metastases
Klein, C. A. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2627 · Cited by 1,161
Genome remodelling in a basal-like breast cancer metastasis and xenograft
Ding, L., Ellis, M. J., Li, S., Larson, D. E., Chen, K., Wallis, J. W., Harris, C. C., McLellan, M. D., Fulton, R. S., Fulton, L., et al. (2010) · Nature · doi:10.1038/nature08989 · Cited by 1,144
A small-cell lung cancer genome with complex signatures of tobacco exposure
Pleasance, E., Stephens, P. J., O’Meara, S., McBride, D. J., Meynert, A. M., Jones, D., Lin, M., Beare, D. M., Lau, K. W., Greenman, C., et al. (2009) · Nature · doi:10.1038/nature08629 · Cited by 1,076
Self-citation
Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution
Shah, S. P., Morin, R. D., Khattra, J. S., Prentice, L., Pugh, T. J., Burleigh, A., Delaney, A. D., Gelmon, K. A., Guliany, R., Senz, J., et al. (2009) · Nature · doi:10.1038/nature08489 · Cited by 1,063

Flagged first, then by citations

Show all 30 references

Sorted by citations

Items 501–600 of 1,000

Exome sequencing and digital PCR analyses reveal novel mutated genes related to the metastasis of pancreatic ductal adenocarcinoma
Zhou, B., Irwanto, A. K., Guo, Y., Bei, J., Wu, Q., Chen, G., Zhang, T.-P., Lei, J.-J., Feng, Q.-S., Chen, L.-Z., et al. (2012) · Cancer Biology & Therapy · doi:10.4161/cbt.20839 · Cited by 46
Stem cells as the root of pancreatic ductal adenocarcinoma
Balic, A., Dorado, J., Alonso-Gómez, M., & Heeschen, C. (2011) · Experimental Cell Research · doi:10.1016/j.yexcr.2011.11.007 · Cited by 49
Zebrafish as a model to assess cancer heterogeneity, progression and relapse
Blackburn, J. S., & Langenau, D. M. (2014) · Disease Models & Mechanisms · doi:10.1242/dmm.015842 · Cited by 52
Allele-Specific Quantification of Structural Variations in Cancer Genomes
Li, Y., Zhou, S., Schwartz, D. C., & Ma, J. (2016) · Cell Systems · doi:10.1016/j.cels.2016.05.007 · Cited by 46
Heterogeneity of metastatic pancreatic adenocarcinoma: Lung metastasis show better prognosis than liver metastasis—a case control study
Decoster, C., Gilabert, M., Autret, A., Turrini, O., Oziel-Taïeb, S., Poizat, F., Giovannini, M. F., Viens, P., Iovanna, J., & Raoul, J. (2016) · Oncotarget · doi:10.18632/oncotarget.9861 · Cited by 46
Liquid Biopsy: The Unique Test for Chasing the Genetics of Solid Tumors
Aghamir, S. M. K., Heshmat, R., Ebrahimi, M., & Khatami, F. (2020) · Epigenetics Insights · doi:10.1177/2516865720904052 · Cited by 47
Exploiting the Complexities of Glioblastoma Stem Cells: Insights for Cancer Initiation and Therapeutic Targeting
de Castro, J. V., Gonçalves, C. S., Hormigo, A., & Costa, B. M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21155278 · Cited by 47
SMAD4 represses FOSL1 expression and pancreatic cancer metastatic colonization
Dai, C., Rennhack, J. P., Arnoff, T. E., Thaker, M., Younger, S. T., Doench, J. G., Huang, A. Y., Yang, A., Aguirre, A. J., Wang, B. L., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109443 · Cited by 45
From complexity to clarity: unravelling tumor heterogeneity through the lens of tumor microenvironment for innovative cancer therapy
Imodoye, S. O., Adedokun, K. A., & Bello, I. O. (2024) · Histochemistry and Cell Biology · doi:10.1007/s00418-023-02258-6 · Cited by 47
Nestin Delineates Pancreatic Cancer Stem Cells in Metastatic Foci of NOD/Shi-scid IL2Rγnull (NOG) Mice
Matsuda, Y., Yoshimura, H., Ueda, J., Naito, Z., Korc, M., & Ishiwata, T. (2014) · American Journal Of Pathology · doi:10.1016/j.ajpath.2013.11.014 · Cited by 45
Dynamics of cancer cell subpopulations in primary and metastatic colorectal tumors
Goranova, T., Ohue, M., Shimoharu, Y., & Kato, K. (2011) · Clinical & Experimental Metastasis · doi:10.1007/s10585-011-9381-0 · Cited by 45
MicroRNAs as emerging biomarkers and therapeutic targets for pancreatic cancer
Gayral, M. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i32.11199 · Cited by 45
Metastatic mechanisms in follicular cell-derived thyroid cancer
Phay, J. E., & Ringel, M. D. (2013) · Endocrine Related Cancer · doi:10.1530/erc-13-0187 · Cited by 45
Cancer pharmacogenomics, challenges in implementation, and patient-focused perspectives
Patel, J. N. (2016) · Pharmacogenomics and Personalized Medicine · doi:10.2147/pgpm.s62918 · Cited by 50
Targeting DNA repair: the genome as a potential biomarker
Nesic, K., Wakefield, M. J., Kondrashova, O., Scott, C. L., & McNeish, I. A. (2017) · The Journal of Pathology · doi:10.1002/path.5025 · Cited by 47
Synergistic therapeutic effect of combined PDGFR and SGK1 inhibition in metastasis-initiating cells of breast cancer
Yang, L., Li, N., Xue, Z., Liu, L.-R., Li, J., Huang, X., Xie, X., Zou, Y., Tang, H., & Xie, X. (2020) · Cell Death and Differentiation · doi:10.1038/s41418-019-0485-4 · Cited by 45
Multi‐omics analysis of intra‐tumoural and inter‐tumoural heterogeneity in pancreatic ductal adenocarcinoma
Liu, X., Wang, W., Liu, X., Zhang, Z., Yu, L., Li, R., Guo, D., Cai, W., Quan, X., Wu, H., et al. (2022) · Clinical and Translational Medicine · doi:10.1002/ctm2.670 · Cited by 45
Lysosomal protein transmembrane 5 promotes lung-specific metastasis by regulating BMPR1A lysosomal degradation
Jiang, B., Zhao, X., Chen, W., Diao, W., Ding, M., Qin, H., Li, B., Cao, W., Chen, W., Fu, Y. S., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-31783-6 · Cited by 45
Improving pancreatic cancer diagnosis using circulating tumor cells: prospects for staging and single-cell analysis
Court, C. M., Ankeny, J. S., Hou, S., Tseng, H., & Tomlinson, J. S. (2015) · Expert Review of Molecular Diagnostics · doi:10.1586/14737159.2015.1091311 · Cited by 44
Dielectrophoretic Capture and Genetic Analysis of Single Neuroblastoma Tumor Cells
Carpenter, E. L., Rader, J., Ruden, J. B., Rappaport, E. F., Hunter, K. N., Hallberg, P. L., Krytska, K., Oâ€TMDwyer, P. J., & Mossé, Y. P. (2014) · Frontiers in Oncology · doi:10.3389/fonc.2014.00201 · Cited by 45
Signaling for lymphangiogenesis via VEGFR-3 is required for the early events of metastasis
Matsumoto, M., Roufail, S., Inder, R., Caesar, C., Karnezis, T., Shayan, R., Farnsworth, R. H., Sato, T., Achen, M. G., Mann, G. B., et al. (2013) · Clinical & Experimental Metastasis · doi:10.1007/s10585-013-9581-x · Cited by 44
Identification of Molecular Tumor Markers in Renal Cell Carcinomas with TFE3 Protein Expression by RNA Sequencing
Pflueger, D., Sboner, A., Storz, M., Roth, J., Compérat, É., Bruder, E., Rubin, M. A., Schraml, P., & Moch, H. (2013) · Neoplasia · doi:10.1593/neo.131544 · Cited by 42
Adapting Clinical Paradigms to the Challenges of Cancer Clonal Evolution
Murugaesu, N., Chew, S. K., & Swanton, C. (2013) · American Journal Of Pathology · doi:10.1016/j.ajpath.2013.02.026 · Cited by 42
Molecular Pathology of Pancreatic Cancer: From Bench-to-Bedside Translation
Corbo, V., Tortora, G., & Scarpa, A. (2012) · Current Drug Targets · doi:10.2174/138945012800564103 · Cited by 44
Natural and chemotherapy-induced clonal evolution of tumors
Ibragimova, M. K., Tsyganov, M. M., & Литвяков, Н. В. (2017) · Biochemistry (Moscow) · doi:10.1134/s0006297917040022 · Cited by 44
Succession of transiently active tumor‐initiating cell clones in human pancreatic cancer xenografts
Ball, C. R., Oppel, F., Ehrenberg, K. R., Dubash, T. D., Dieter, S. M., Hoffmann, C. M., Abel, U. R., Herbst, F., Koch, M., Werner, J., et al. (2017) · EMBO Molecular Medicine · doi:10.15252/emmm.201607354 · Cited by 43
Time of Metastasis and Outcome in Colorectal Cancer
Rahbari, N. N., Carr, P. R., Jansen, L., Chang-Claude, J. C., Weitz, J., Hoffmeister, M., & Brenner, H. (2017) · Annals of Surgery · doi:10.1097/sla.0000000000002564 · Cited by 44
Biomarkers for early diagnosis of pancreatic cancer
Jenkinson, C., Earl, J., Ghaneh, P., Halloran, C., Carrato, A., Greenhalf, W., Neoptolemos, J., & Costello, E. (2015) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/17474124.2015.965145 · Cited by 42
Recent advances in drug delivery and targeting for the treatment of pancreatic cancer
Pramanik, N., Gupta, A. K., Ghanwatkar, Y., & Mahato, R. I. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.12.053 · Cited by 42
Applying next-generation sequencing to pancreatic cancer treatment
Mardis, E. R. (2012) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2012.126 · Cited by 43
Genomic Sequencing for Cancer Diagnosis and Therapy
Wang, L., & Wheeler, D. A. (2013) · Annual Review of Medicine · doi:10.1146/annurev-med-120811-171056 · Cited by 44
Single Nucleotide Polymorphism Array Analysis of Uveal Melanomas Reveals That Amplification of CNKSR3 Is Correlated With Improved Patient Survival
Lake, S. L., Damato, B. E., Kalirai, H., Dodson, A. R., Taktak, A. F. G., Lloyd, B. H., & Coupland, S. E. (2013) · American Journal Of Pathology · doi:10.1016/j.ajpath.2012.11.036 · Cited by 43
Modeling Tumor Clonal Evolution for Drug Combinations Design
Zhao, B., Hemann, M. T., & Lauffenburger, D. A. (2016) · Trends in cancer · doi:10.1016/j.trecan.2016.02.001 · Cited by 42
Determinants of Organotropic Metastasis
Smith, H. A., & Kang, Y. (2016) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-041916-064715 · Cited by 47
T-Cell Immunity in Pancreatic Cancer
Ajina, R., & Weiner, L. M. (2020) · Pancreas · doi:10.1097/mpa.0000000000001621 · Cited by 46
Triptolide Cooperates With Cisplatin to Induce Apoptosis in Gemcitabine-Resistant Pancreatic Cancer
Zhu, W., Li, J., Wu, S., Li, S., Le, L., Su, X., Qiu, P., Hu, H., & Yan, G. (2012) · Pancreas · doi:10.1097/mpa.0b013e31824abdc0 · Cited by 43
A MEK/PI3K/HDAC inhibitor combination therapy for KRAS mutant pancreatic cancer cells
Ischenko, I., Petrenko, O., & Hayman, M. J. (2015) · Oncotarget · doi:10.18632/oncotarget.4538 · Cited by 42
Whole-genome sequencing of matched primary and metastatic hepatocellular carcinomas
Ouyang, L., Lee, J., Park, C.-K., Mao, M., Shi, Y., Gong, Z., Zheng, H., Li, Y., Zhao, Y., Wang, G., et al. (2014) · BMC Medical Genomics · doi:10.1186/1755-8794-7-2 · Cited by 42
A Robust Method to Analyze Copy Number Alterations of Less than 100 kb in Single Cells Using Oligonucleotide Array CGH
Möhlendick, B., Bartenhagen, C., Behrens, B., Honisch, E., Raba, K., Knoefel, W. T., & Stoecklein, N. H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067031 · Cited by 42
Intra-tumor heterogeneity: lessons from microbial evolution and clinical implications
de Bruin, E. C., Taylor, T., & Swanton, C. (2013) · Genome Medicine · doi:10.1186/gm505 · Cited by 44
Inherent variability of cancer-specific aneuploidy generates metastases
Bloomfield, M., & DUESBERG, P. H. (2016) · Molecular Cytogenetics · doi:10.1186/s13039-016-0297-x · Cited by 42
Pancreatic Cancer Diagnosis and Management: Has the Time Come to Prick the Bubble?
Moutinho-Ribeiro, P., Macedo, G., & Melo, S. A. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00779 · Cited by 43
Chimeric Antigen Receptor T Cell Therapy for Solid Tumors: Current Status, Obstacles and Future Strategies
Heyman, B. M., & Yang, Y. (2019) · Cancers · doi:10.3390/cancers11020191 · Cited by 43
The Influence of Immune Heterogeneity on the Effectiveness of Immune Checkpoint Inhibitors in Multifocal Hepatocellular Carcinomas
Huang, M., He, M., Guo, Y., Li, H., Shen, S., Xie, Y., Li, X., Xiao, H., Fang, L., Li, D., et al. (2020) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-19-3840 · Cited by 42
Patterns of structural variation in human cancerPreprint
Li, Y.-L., Roberts, N. D., Weischenfeldt, J., Wala, J., Shapira, O., Schumacher, S., Khurana, E., Korbel, J., Imieliński, M., Beroukhim, R., et al. (2017) · bioRxiv · doi:10.1101/181339 · Cited by 48
Self-citation
Progress on diagnostic and prognostic markers of pancreatic cancer
YANG, H., Li, W., Ren, L., Yang, Y., Zhang, Y., Ge, B., Li, S., Zheng, X., Liu, J., Zhang, S., et al. (2023) · Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics · doi:10.32604/or.2023.028905 · Cited by 43
Single-cell transcriptome analysis reveals subtype-specific clonal evolution and microenvironmental changes in liver metastasis of pancreatic adenocarcinoma and their clinical implications
Park, J. K., Jeong, H., Kim, H. M., Choi, J. H., Lee, E. M., Kim, S., Jang, J., Choi, D. W.-Y., Lee, S., Kim, K. M., et al. (2024) · Molecular Cancer · doi:10.1186/s12943-024-02003-0 · Cited by 43
Pancreatic cancer stem cells – insights and perspectives
Hermann, P. C., Mueller, M.-T., & Heeschen, C. (2009) · Expert Opinion on Biological Therapy · doi:10.1517/14712590903246362 · Cited by 41
Transfer of malignant trait to BRCA1 deficient human fibroblasts following exposure to serum of cancer patients
Hamam, D., Abdouh, M., Gao, Z., Arena, V., Arena, M., & Arena, G. O. (2016) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-016-0360-9 · Cited by 42
Maskless fabrication of cell-laden microfluidic chips with localized surface functionalization for the co-culture of cancer cells
Hamid, Q., Wang, C., Snyder, J., Williams, S., Liu, Y., & Sun, W. (2015) · Biofabrication · doi:10.1088/1758-5090/7/1/015012 · Cited by 42
Molecular markers in pancreatic cancer diagnosis
Herreros‐Villanueva, M., Gironella, M., Castells, A., & Bujanda, L. (2013) · Clinica Chimica Acta · doi:10.1016/j.cca.2012.12.025 · Cited by 41
A biomimetic tumor model of heterogeneous invasion in pancreatic ductal adenocarcinoma
Bradney, M. J., Venis, S. M., Yang, Y., Konieczny, S. F., & Han, B. (2020) · Small · doi:10.1002/smll.201905500 · Cited by 38
High-grade serous ovarian cancer: the clone wars
Salomon‐Perzyński, A., Salomon-Perzyńska, M., Michalski, B., & Skrzypulec‐Plinta, V. (2017) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-017-4292-1 · Cited by 43
Pathway Instability Is an Effective New Mutation-Based Type of Cancer Biomarkers
Zolotovskaia, M., Sorokin, M., Roumiantsev, S. A., Borisov, N., & Buzdin, A. A. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2018.00658 · Cited by 40
Impact of cancer evolution on immune surveillance and checkpoint inhibitor response
Wu, Y., Biswas, D., & Swanton, C. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.02.013 · Cited by 43
Quantitative and qualitative mutational impact of ionizing radiation on normal cells
Youk, J., Kwon, H. W., Lim, J., Kim, E., Kim, T., Kim, R., Park, S., Yi, K., Nam, C. H., Jeon, S., et al. (2024) · Cell Genomics · doi:10.1016/j.xgen.2024.100499 · Cited by 46
Next-generation sequencing applied to molecular diagnostics
Natrajan, R., & Reis-Filho, J. S. (2011) · Expert Review of Molecular Diagnostics · doi:10.1586/erm.11.18 · Cited by 41
NGS catalog: A database of next generation sequencing studies in humans
Xia, J., Wang, Q., Jia, P., Wang, B., Pao, W. J., & Zhao, Z. (2012) · Human Mutation · doi:10.1002/humu.22096 · Cited by 39
Energy sources identify metabolic phenotypes in pancreatic cancer
Liang, C., Qin, Y., Zhang, B., Ji, S., Shi, S., Xu, W., Liu, J., Xiang, J., Liang, D., Hu, Q., et al. (2016) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmw097 · Cited by 37
Pathological nodal disease defines survival outcomes in patients with lung cancer with tumour major pathological response following neoadjuvant chemotherapy
Corsini, E. M., Weissferdt, A., Pataer, A., Zhou, N., Antonoff, M. B., Hofstetter, W. L., Mehran, R. J., Rajaram, R., Rice, D. C., Roth, J. A., et al. (2020) · European Journal of Cardio-Thoracic Surgery · doi:10.1093/ejcts/ezaa290 · Cited by 41
Identification and validation of heterotypic cell-in-cell structure as an adverse prognostic predictor for young patients of resectable pancreatic ductal adenocarcinoma
Huang, H., He, M., Zhang, Y., Zhang, B., Niu, Z., Zheng, Y., Li, W., Cui, P., Wang, X., & Sun, Q. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00346-w · Cited by 39
LINC01094 promotes pancreatic cancer progression by sponging miR-577 to regulate LIN28B expression and the PI3K/AKT pathway
Luo, C. H., Kang, L., Hu, C., Zhu, X., Zhu, J., & Zhu, Z. (2021) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2021.08.024 · Cited by 39
PhyloOncology: Understanding cancer through phylogenetic analysis
Somarelli, J. A., Ware, K. E., Kostadinov, R. L., Robinson, J. M., Amri, H., Abu-Asab, M. S., Fourie, N. H., Diogo, R., Swofford, D. L., & Townsend, J. P. (2016) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2016.10.006 · Cited by 39
The biological role of metabolic reprogramming in pancreatic cancer
Suzuki, T., Otsuka, M., Seimiya, T., Iwata, T., Kishikawa, T., & Koike, K. (2020) · MedComm · doi:10.1002/mco2.37 · Cited by 38
Targeting the Retinoic Acid Pathway to Eradicate Cancer Stem Cells
Brown, G. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032373 · Cited by 40
Artificial intelligence CT radiomics to predict early recurrence of intrahepatic cholangiocarcinoma: a multicenter study
Song, Y., Zhou, G., Zhou, Y., Xu, Y., Zhang, J., Zhang, K., He, P., Chen, M., Liu, Y., Sun, J., et al. (2023) · Hepatology International · doi:10.1007/s12072-023-10487-z · Cited by 38
Biological characteristics of pancreatic ductal adenocarcinoma: Initiation to malignancy, intracellular to extracellular
Li, O., Li, L., Sheng, Y., Ke, K., Wu, J., Mou, Y., Liu, M., & Jin, W. (2023) · Cancer Letters · doi:10.1016/j.canlet.2023.216391 · Cited by 38
A Distinct Class of Chromoanagenesis Events Characterized by Focal Copy Number Gains
Masset, H., Hestand, M. S., Esch, H. V., Kleinfinger, P., Plaisancié, J., Afenjar, A., Molignier, R., Schluth‐Bolard, C., Sanlaville, D., & Vermeesch, J. R. (2016) · Human Mutation · doi:10.1002/humu.22984 · Cited by 38
How should clinicians address intratumour heterogeneity in clear cell renal cell carcinoma?
Soultati, A. S., Stares, M., Swanton, C., Larkin, J., & Turajlic, S. (2015) · Current Opinion in Urology · doi:10.1097/mou.0000000000000204 · Cited by 37
Mutation patterns in small cell and non-small cell lung cancer patients suggest a different level of heterogeneity between primary and metastatic tumors
Saber, A., Hiltermann, T. J. N., Kok, K., Terpstra, M. M., de Lange, K., Timens, W., Groen, H. J. M., & van den Berg, A. (2016) · Carcinogenesis · doi:10.1093/carcin/bgw128 · Cited by 39
Behind the Wheel of Epithelial Plasticity in KRAS-Driven Cancers
Arner, E. N., Du, W., & Brekken, R. A. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.01049 · Cited by 40
Advances in pancreatic cancer
Kim, E. J.-H., & Simeone, D. M. (2011) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e328349e31f · Cited by 37
Protease‐activated receptor‐2 induces migration of pancreatic cancer cells in an extracellular ATP‐dependent manner
Shi, K., Queiroz, K. C. S., Stap, J., Richel, D. J., & Spek, C. A. (2013) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.12361 · Cited by 38
Spatial and temporal cancer evolution: causes and consequences of tumour diversity
Hiley, C. T., & Swanton, C. (2014) · Clinical Medicine · doi:10.7861/clinmedicine.14-6-s33 · Cited by 39
Integrated Genomic Analysis of Pancreatic Ductal Adenocarcinomas Reveals Genomic Rearrangement Events as Significant Drivers of Disease
Murphy, S. J., Hart, S. N., Halling, G. C., Johnson, S. H., Smadbeck, J. B., Drucker, T., Lima, J. F., Rohakhtar, F. R., Harris, F. R., Kosari, F., et al. (2015) · Cancer Research · doi:10.1158/0008-5472.can-15-2198 · Cited by 37
Deciphering the link between PI3K and PAK: An opportunity to target key pathways in pancreatic cancer?
Thillai, K., Lam, H., Sarker, D., & Wells, C. M. (2016) · Oncotarget · doi:10.18632/oncotarget.13309 · Cited by 37
Pancreatic stellate cells increase pancreatic cancer cells invasion through the hepatocyte growth factor /c-Met/survivin regulated by P53/P21
Yang, X., Liu, S., Xu, J., Cao, S.-G., Li, Y., & Zhou, Y. (2017) · Experimental Cell Research · doi:10.1016/j.yexcr.2017.04.027 · Cited by 37
Long non-coding RNA ZFAS1 promotes pancreatic cancer proliferation and metastasis by sponging miR-497-5p to regulate HMGA2 expression
Rao, M., Xu, S., Zhang, Y., Liu, Y., Luan, W., & Zhou, J. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-04123-7 · Cited by 37
GSVD Comparison of Patient-Matched Normal and Tumor aCGH Profiles Reveals Global Copy-Number Alterations Predicting Glioblastoma Multiforme Survival
Lee, C. H., Alpert, B. O., Sankaranarayanan, P., & Alter, O. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030098 · Cited by 36
Copy Number Variations in Pancreatic Cancer: From Biological Significance to Clinical Utility
Oketch, D. J. A., Giulietti, M., & Piva, F. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms25010391 · Cited by 36
miRNA in clinical practice: Pancreatic cancer
Humeau, M., Torrisani, J., & Cordelier, P. (2013) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2013.03.019 · Cited by 36
Identification of pY654-β-catenin as a critical co-factor in hypoxia-inducible factor-1α signaling and tumor responses to hypoxia
Xi, Y., Wei, Y., Sennino, B., Ulsamer, A., Kwan, I., Brumwell, A. L., Tan, K., Aghi, M. K., McDonald, D. M., Jablons, D. M., et al. (2012) · Oncogene · doi:10.1038/onc.2012.530 · Cited by 36
An integrated transcriptome and epigenome analysis identifies a novel candidate gene for pancreatic cancer
Jia, J., Parikh, H. M., Xiao, W., Hoskins, J. W., Pflicke, H., Liu, X., Collins, I. J., Zhou, W., Wang, Z., Powell, J. I., et al. (2013) · BMC Medical Genomics · doi:10.1186/1755-8794-6-33 · Cited by 38
RETRACTED ARTICLE: Long non-coding RNA LINC01133 silencing exerts antioncogenic effect in pancreatic cancer through the methylation of DKK1 promoter and the activation of Wnt signaling pathway
Weng, Y., Ma, J., Zhang, J., & Wang, J. (2018) · Cancer Biology & Therapy · doi:10.1080/15384047.2018.1529110 · Cited by 36
Retracted
The METABANK score: A clinical tool to predict survival after stereotactic radiotherapy for oligometastatic disease
den Begin, R. V., Engels, B., Collen, C., de Vin, T., Defauw, A., Dubaere, E., Barbé, K., & Ridder, M. D. (2019) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2019.01.001 · Cited by 34
Screening of MSI detection loci and their heterogeneity in East Asian colorectal cancer patients
Bai, W., Ma, J., Liu, Y., Liang, J., Wu, Y., Yang, X., Xu, E., Li, Y., & Xi, Y. (2019) · Cancer Medicine · doi:10.1002/cam4.2111 · Cited by 35
Characterization of DLL3-positive circulating tumor cells (CTCs) in patients with small cell lung cancer (SCLC) and evaluation of their clinical relevance during front-line treatment
Messaritakis, I., Nikolaou, M., Koinis, F., Politaki, E., Koutsopoulos, A. V., Lagoudaki, E. D., Vetsika, E., Georgoulias, V., & Kotsakis, A. P. (2019) · Lung Cancer · doi:10.1016/j.lungcan.2019.06.025 · Cited by 36
Companion animal models of neurological disease
Partridge, B. R., & Rossmeisl, J. H. (2019) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2019.108484 · Cited by 36
Genetic and Epigenetic Modulation of Drug Resistance in Cancer: Challenges and Opportunities
Shah, K., & Rawal, R. (2020) · Current Drug Metabolism · doi:10.2174/1389200221666200103111539 · Cited by 36
Delving into Early-onset Pancreatic Ductal Adenocarcinoma: How Does Age Fit In?
Tsang, E. S., Topham, J. T., Karasinska, J. M., Lee, M. K. C., Williamson, L., Mendis, S. R., Denroche, R. E., Jang, G. H., Kalloger, S. E., Moore, R. A., et al. (2020) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-20-1042 · Cited by 37
Transitional dynamics of cancer stem cells in invasion and metastasis
Richard, V., Kumar, T. R. S., & Pillai, R. M. (2020) · Translational Oncology · doi:10.1016/j.tranon.2020.100909 · Cited by 34
Pathology and genetics of uveal melanoma
Griewank, K., & Murali, R. (2012) · Pathology · doi:10.1097/pat.0b013e32835c6505 · Cited by 36
Cancer evolution: the final frontier of precision medicine?
Swanton, C. (2014) · Annals of Oncology · doi:10.1093/annonc/mdu005 · Cited by 38
Pentose conversions support the tumorigenesis of pancreatic cancer distant metastases
Bechard, M. E., Word, A. E., Tran, A. V., Liu, X., Locasale, J. W., & McDonald, O. G. (2018) · Oncogene · doi:10.1038/s41388-018-0346-5 · Cited by 35
Pancreatic cancers suppress negative feedback of glucose transport to reprogram chromatin for metastasis
Bechard, M. E., Smalling, R., Hayashi, A., Zhong, Y., Word, A. E., Campbell, S. L., Tran, A. V., Weiss, V. L., Iacobuzio-Donahue, C., Wellen, K. E., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17839-5 · Cited by 33
Self-citation
Cancer Stem Cells, EMT, and Developmental Pathway Activation in Pancreatic Tumors
Hindriksen, S., & Bijlsma, M. F. (2012) · Cancers · doi:10.3390/cancers4040989 · Cited by 35
Intratumor heterogeneity and clonal evolution in an aggressive papillary thyroid cancer and matched metastases
Pennec, S. L., Konopka, T., Gacquer, D., Fimereli, D., Tarabichi, M., Tomás, G., Savagner, F., Decaussin‐Petrucci, M., Trésallet, C., Andry, G., et al. (2015) · Endocrine Related Cancer · doi:10.1530/erc-14-0351 · Cited by 35
Immunomodulation in cancer
Hegmans, J. P., & Aerts, J. G. J. V. (2014) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2014.06.007 · Cited by 35
α-Amanitin Restrains Cancer Relapse from Drug-Tolerant Cell Subpopulations via TAF15
Kume, K., Ikeda, M., Miura, S., Ito, K., Sato, K. A., Ohmori, Y., Endo, F., Katagiri, H., Ishida, K., Ito, C., et al. (2016) · Scientific Reports · doi:10.1038/srep25895 · Cited by 35
Genetic heterogeneity within collective invasion packs drives leader and follower cell phenotypes
Zoeller, E. L., Pedro, B. A., Konen, J. M., Dwivedi, B., Rupji, M., Sundararaman, N., Wang, L., Horton, J. R., Zhong, C., Barwick, B. G., et al. (2019) · Journal of Cell Science · doi:10.1242/jcs.231514 · Cited by 35

Authors: Campbell, P. J., Yachida, S., Mudie, L. J., Stephens, P. J., Pleasance, E. D., Stebbings, L. A., Morsberger, L. A., Latimer, C., McLaren, S., Lin, M.-L., McBride, D. J., Varela, I., Nik-Zainal, S. A., Leroy, C., Jia, M., Menzies, A., Butler, A. P., Teague, J. W., Griffin, C. A., Burton, J., Swerdlow, H., Quail, M. A., Stratton, M. R., Iacobuzio-Donahue, C., & Futreal, P. A.
Affiliations: University of Cambridge (GB)
Johns Hopkins University (US)
Wellcome Sanger Institute (GB)
Institute of Cancer Research (GB)
Corresponding author: Futreal, P. Andrew
ORCID: Campbell, Peter J.
Yachida, Shinichi
Pleasance, Erin D.
Latimer, Calli
McLaren, Stuart
McBride, David J.
Varela, Ignacio
Jia, Mingming
Menzies, Andrew
Teague, Jon W.
Swerdlow, Harold
Quail, Michael A.
Stratton, Michael R.
Futreal, P. Andrew
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2010-10
Volume: 467
Issue: 7319
Pages: 1109-1113
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature09460
PMC: PMC3137369
OpenAlex: W2066254965
Cited by: 1,317
References: 30
Citations by year: 2026: 10 · 2025: 31 · 2024: 33 · 2023: 51 · 2022: 47 · 2021: 86 · 2020: 69 · 2019: 72 · 2018: 75 · 2017: 117 · 2016: 104 · 2015: 119 · 2014: 153 · 2013: 109 · 2012: 135
FWCI: 34.92
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: Skip Viragh Foundation
Uehara Memorial Foundation
Wellcome Trust (077012/Z/05/Z, 088340, 093867, WT088340MA)
National Institutes of Health
National Cancer Institute (R01CA140599, K08CA106610, CA140599, CA106610)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
Keywords: pancreatic cancer, metastasis, genomic instability, chromosomal rearrangements, clonal evolution, telomere dysfunction, G1/S checkpoint, copy number alterations, tumor progression, early detection, therapeutic target, interpatient heterogeneity, tumour dissemination, somatic mutations, GATA4, GATA3
MeSH terms: Adenocarcinoma, Cell Cycle, Clone Cells, DNA Mutational Analysis, Humans, Liver Neoplasms, Lung Neoplasms, Neoplasm Metastasis, Organ Specificity, Pancreatic Neoplasms, Mutagenesis, Telomere, Disease Progression, Cell Lineage, Evolution, Molecular, Genomic Instability, Genes, Neoplasm

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The patterns and dynamics of genomic instability in metastatic pancreatic cancer

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks