Biomarkers for early diagnosis of pancreatic cancer

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Cancer statistics, 2014

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Projecting Cancer Incidence and Deaths to 2030: The Unexpected Burden of Thyroid, Liver, and Pancreas Cancers in the United States

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Isolation of rare circulating tumour cells in cancer patients by microchip technology

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Towards Complete and Accurate Reporting of Studies of Diagnostic Accuracy: The STARD Initiative

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Cell-free nucleic acids as biomarkers in cancer patients

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A Randomized Trial of Chemoradiotherapy and Chemotherapy after Resection of Pancreatic Cancer

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Tumor cells circulate in the peripheral blood of all major carcinomas but not in healthy subjects or patients with nonmalignant diseases

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Distant metastasis occurs late during the genetic evolution of pancreatic cancer

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An ultrasensitive method for quantitating circulating tumor DNA with broad patient coverage

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EMT and Dissemination Precede Pancreatic Tumor Formation

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European Prospective Investigation into Cancer and Nutrition (EPIC): study populations and data collection

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ASCO 2006 Update of Recommendations for the Use of Tumor Markers in Gastrointestinal Cancer

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Detection of microRNA Expression in Human Peripheral Blood Microvesicles

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Adjuvant Chemotherapy With Fluorouracil Plus Folinic Acid vs Gemcitabine Following Pancreatic Cancer Resection

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The patterns and dynamics of genomic instability in metastatic pancreatic cancer

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Dissecting the metastatic cascade

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Systemic Spread Is an Early Step in Breast Cancer

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MicroRNA Expression Patterns to Differentiate Pancreatic Adenocarcinoma From Normal Pancreas and Chronic Pancreatitis

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Expression profiling identifies microRNA signature in pancreatic cancer

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Sensitivity and specificity of multimodal and ultrasound screening for ovarian cancer, and stage distribution of detected cancers: results of the prevalence screen of the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS)

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Phase III Randomized Comparison of Gemcitabine Versus Gemcitabine Plus Capecitabine in Patients With Advanced Pancreatic Cancer

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Advanced pancreatic carcinoma: current treatment and future challenges

Stathis, A., & Moore, M. J. (2010) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2009.236 · Cited by 791 · see citing works

Pancreatic cancer: a report of treatment and survival trends for 100,313 patients diagnosed from 1985–1995, using the National Cancer Database11No competing interests declared.

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Variations of oral microbiota are associated with pancreatic diseases including pancreatic cancer

Farrell, J. J., Zhang, L., Zhou, H., Chia, D., Elashoff, D., Akin, D., Paster, B. J., Joshipura, K., & Wong, D. T. W. (2012) · Gut · doi:10.1136/gutjnl-2011-300784 · Cited by 662 · see citing works

MicroRNA expression alterations are linked to tumorigenesis and non-neoplastic processes in pancreatic ductal adenocarcinoma

Szafranska, A. E., Davison, T. S., John, J., Cannon, T., Sipos, B., Maghnouj, A., Labourier, E., & Hahn, S. A. (2007) · Oncogene · doi:10.1038/sj.onc.1210228 · Cited by 660 · see citing works

Prevalence and Clinical Profile of Pancreatic Cancer–Associated Diabetes Mellitus

Pannala, R., Leirness, J. B., Bamlet, W. R., Basu, A., Petersen, G. M., & Chari, S. T. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.01.039 · Cited by 621 · see citing works

MicroRNA-21 in Pancreatic Cancer: Correlation with Clinical Outcome and Pharmacologic Aspects Underlying Its Role in the Modulation of Gemcitabine Activity

Giovannetti, E., Funel, N., Peters, G. J., Chiaro, M. D., Erozenci, L. A., Vasile, E., León, L. G., Pollina, L. E., Groen, A., Falcone, A., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-4467 · Cited by 453 · see citing works

Serum microRNAs as non-invasive biomarkers for cancer

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Salivary Transcriptomic Biomarkers for Detection of Resectable Pancreatic Cancer

Zhang, L., Farrell, J. J., Zhou, H., Elashoff, D. A., Akin, D., Park, N., Chia, D., & Wong, D. T. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.11.010 · Cited by 342 · see citing works

Fluid biopsy in patients with metastatic prostate, pancreatic and breast cancers

Marrinucci, D. C., Bethel, K. J., Kolatkar, A. R., Luttgen, M. S., Malchiodi, M., Baehring, F., Voigt, K., Lazar, D. C., Nieva, J. J., Bazhenova, L. A., et al. (2012) · Physical Biology · doi:10.1088/1478-3975/9/1/016003 · Cited by 303 · see citing works

MicroRNA miR-155 is a biomarker of early pancreatic neoplasia

Habbe, N., Koorstra, J.-B. M., Mendell, J. T., Offerhaus, G. J. A., Ryu, J. K., Feldmann, G., Mullendore, M. E., Goggins, M., Hong, S., & Maitra, A. (2009) · Cancer Biology & Therapy · doi:10.4161/cbt.8.4.7338 · Cited by 296 · see citing works

Circulating miR-210 as a Novel Hypoxia Marker in Pancreatic Cancer

Ho, A. S., Huang, X., Cao, H., Christman-Skieller, C., Bennewith, K. L., Le, Q., & Koong, A. C. (2010) · Translational Oncology · doi:10.1593/tlo.09256 · Cited by 286 · see citing works

Pancreatic Cancers Epigenetically Silence SIP1 and Hypomethylate and Overexpress miR-200a/200b in Association with Elevated Circulating miR-200a and miR-200b Levels

Li, A., Omura, N., Hong, S., Vincent, A., Walter, K., Griffith, M., Borges, M. W., & Goggins, M. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-4227 · Cited by 272 · see citing works

Capture, release and culture of circulating tumor cells from pancreatic cancer patients using an enhanced mixing chip

Sheng, W., Ogunwobi, O. O., Chen, T., Zhang, J., George, T. J., Liu, C., & Fan, Z. H. (2013) · Lab on a Chip · doi:10.1039/c3lc51017d · Cited by 257 · see citing works

A pilot study to explore circulating tumour cells in pancreatic cancer as a novel biomarker

Khoja, L., Backen, A. C., Sloane, R. A. S., Menasce, L. P., Ryder, W. D. J., Krebs, M., R Board, Clack, G., Hughes, A. M., Blackhall, F. H., et al. (2011) · British Journal of Cancer · doi:10.1038/bjc.2011.545 · Cited by 256 · see citing works

Role of Pancreatic Cancer-derived Exosomes in Salivary Biomarker Development

Lau, C., Kim, Y., Chia, D., Spielmann, N., Eibl, G., Elashoff, D., Wei, F., Lin, Y.-L., Moro, A., Grogan, T., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.452458 · Cited by 256 · see citing works

A Mouse to Human Search for Plasma Proteome Changes Associated with Pancreatic Tumor Development

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Novel diagnostic value of circulating miR-18a in plasma of patients with pancreatic cancer

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Serum Biomarker Panels for the Detection of Pancreatic Cancer

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The quality of diagnostic accuracy studies since the STARD statement

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K-ras Mutations in DNA Extracted From the Plasma of Patients With Pancreatic Carcinoma: Diagnostic Utility and Prognostic Significance

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Early Diagnosis of Pancreatic Cancer: Challenges and New Developments

Kaur, S., Baine, M. J., Jain, M., Sasson, A. R., & Batra, S. K. (2012) · Biomarkers in Medicine · doi:10.2217/bmm.12.69 · Cited by 221 · see citing works

MicroRNA-21 Is Induced Early in Pancreatic Ductal Adenocarcinoma Precursor Lesions

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MicroRNA Alterations of Pancreatic Intraepithelial Neoplasias

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Adjuvant 5-fluorouracil and folinic acid vs observation for pancreatic cancer: composite data from the ESPAC-1 and -3(v1) trials

for the European Study Group of Pancreatic Cancer, Neoptolemos, J. P., Stocken, D. D., et al. (2009) · British Journal of Cancer · doi:10.1038/sj.bjc.6604838 · Cited by 204 · see citing works

Sources of Bias in Specimens for Research About Molecular Markers for Cancer

Ransohoff, D. F., & Gourlay, M. L. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2009.25.6065 · Cited by 200 · see citing works

New biomarkers and targets in pancreatic cancer and their application to treatment

Costello, E., Greenhalf, W., & Neoptolemos, J. P. (2012) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2012.119 · Cited by 192 · see citing works

Understanding Metastasis in Pancreatic Cancer: A Call for New Clinical Approaches

Tuveson, D. A., & Neoptolemos, J. P. (2012) · Cell · doi:10.1016/j.cell.2011.12.021 · Cited by 188 · see citing works

Detection and isolation of circulating tumor cells: Principles and methods

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Mutant TP53 in Duodenal Samples of Pancreatic Juice From Patients With Pancreatic Cancer or High-Grade Dysplasia

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Proteomic Analysis of Chronic Pancreatitis and Pancreatic Adenocarcinoma

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Mutant GNAS detected in duodenal collections of secretin-stimulated pancreatic juice indicates the presence or emergence of pancreatic cysts

Kanda, M., Knight, S., Topazian, M. D., Syngal, S., Farrell, J. J., Lee, J. D., Kamel, I. R., Lennon, A. M., Borges, M. W., Young, A., et al. (2012) · Gut · doi:10.1136/gutjnl-2012-302823 · Cited by 170 · see citing works

Pancreatic Adenocarcinoma: Treating a Systemic Disease With Systemic Therapy

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How to improve reliability and efficiency of research about molecular markers: roles of phases, guidelines, and study design

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miRNA Biomarkers in Cyst Fluid Augment the Diagnosis and Management of Pancreatic Cysts

Matthaei, H., Wylie, D., Lloyd, M. B., Molin, M. D., Kemppainen, J., Mayo, S. C., Wolfgang, C. L., Schulick, R. D., Langfield, L., Andruss, B. F., et al. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-0035 · Cited by 157 · see citing works

Recruitment to multicentre trials—lessons from UKCTOCS: descriptive study

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Detection of circulating tumor cells in patients with pancreatic cancer: a preliminary result

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Circulating U2 small nuclear RNA fragments as a novel diagnostic biomarker for pancreatic and colorectal adenocarcinoma

Baraniskin, A., Nöpel‐Dünnebacke, S., Ahrens, M., Jensen, S. G., Zöllner, H., Maghnouj, A., Wos, A., Mayerle, J. V., Munding, J. B., Kost, D., et al. (2012) · International Journal of Cancer · doi:10.1002/ijc.27791 · Cited by 143 · see citing works

Early detection of pancreatic carcinoma

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Aberrant MicroRNA-155 Expression Is an Early Event in the Multistep Progression of Pancreatic Adenocarcinoma

Ryu, J. K., Hong, S., Karikari, C. A., Hruban, R. H., Goggins, M., & Maitra, A. (2010) · Pancreatology · doi:10.1159/000231984 · Cited by 140 · see citing works

Diagnostic value of serum carbohydrate antigen 19-9 in pancreatic cancer: a meta-analysis

Huang, Z., & Liu, F. (2014) · Tumor Biology · doi:10.1007/s13277-014-1995-9 · Cited by 130 · see citing works

Glycoprotein biomarker panel for pancreatic cancer discovered by quantitative proteomics analysis

Nie, S., Lo, A., Wu, J., Zhu, J., Tan, Z., Simeone, D. M., Anderson, M. A., Shedden, K. A., Ruffin, M. T., & Lubman, D. M. (2014) · Journal of Proteome Research · doi:10.1021/pr400967x · Cited by 128 · see citing works

Circulating Autoantibodies to Phosphorylated α-Enolase are a Hallmark of Pancreatic Cancer

Tomaino, B., Cappello, P., Capello, M., Fredolini, C., Sperduti, I., Migliorini, P., Salacone, P., Novarino, A., Giacobino, A., Ciuffreda, L., et al. (2010) · Journal of Proteome Research · doi:10.1021/pr100213b · Cited by 124 · see citing works

Reporting quality of diagnostic accuracy studies: a systematic review and meta-analysis of investigations on adherence to STARD

Korevaar, D. A., van Enst, W. A., Spijker, R., Bossuyt, P. M. M., & Hooft, L. (2014) · Evidence Based Medicine · doi:10.1136/eb-2013-101637 · Cited by 119 · see citing works

Molecular Analysis to Detect Pancreatic Ductal Adenocarcinoma in High-Risk Groups

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Multimarker Gene Analysis of Circulating Tumor Cells in Pancreatic Cancer Patients: A Feasibility Study

de Albuquerque, A., Kubisch, I., Breier, G., Stamminger, G., Fersis, N., Eichler, A., Kaul, S., & Stölzel, U. (2012) · Oncology · doi:10.1159/000335479 · Cited by 112 · see citing works

Biomarkers for pancreatic cancer: promising new markers and options beyond CA 19-9

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The Clinical Utility and Limitations of Serum Carbohydrate Antigen (CA19-9) as a Diagnostic Tool for Pancreatic Cancer and Cholangiocarcinoma

Singh, S., Tang, S., Sreenarasimhaiah, J., Lara, L. F., & Siddiqui, A. A. (2011) · Digestive Diseases and Sciences · doi:10.1007/s10620-011-1709-8 · Cited by 106 · see citing works

Diagnosing Pancreatic Cancer Using Methylation Specific PCR Analysis

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Global microRNA expression profiling of microdissected tissues identifiesmiR‐135bas a novel biomarker for pancreatic ductal adenocarcinoma

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Multiplex Targeted Proteomic Assay for Biomarker Detection in Plasma: A Pancreatic Cancer Biomarker Case Study

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Serum CA19-9 Decline Compared to Radiographic Response as a Surrogate for Clinical Outcomes in Patients With Metastatic Pancreatic Cancer Receiving Chemotherapy

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Modelling the benefits of early diagnosis of pancreatic cancer using a biomarker signature

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Detection of mutations of p53 tumor suppressor gene in pancreatic juice and its application to diagnosis of patients with pancreatic cancer: comparison with K-ras mutation.

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Serum cytokine biomarker panels for discriminating pancreatic cancer from benign pancreatic disease

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Claudin-4-targeted optical imaging detects pancreatic cancer and its precursor lesions

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