Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes

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Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2

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Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus

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A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome

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DNA Methylation-Related Chromatin Remodeling in Activity-Dependent Bdnf Gene Regulation

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Subregion- and Cell Type–Restricted Gene Knockout in Mouse Brain

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Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice

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The Story of Rett Syndrome: From Clinic to Neurobiology

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Derepression of BDNF Transcription Involves Calcium-Dependent Phosphorylation of MeCP2

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Safety and efficacy of genetic MECP2 supplementation in the R294X mouse model of Rett syndrome

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Neuronal Dystroglycan regulates postnatal development of CCK/cannabinoid receptor-1 interneurons

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Defining the nature of human pluripotent stem cell-derived interneurons via single-cell analysis

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Cerebellar contribution to autism-relevant behaviors in fragile X syndrome models

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Towards a comprehensive model of stereotypy: Integrating operant and neurobiological interpretations

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Synaptic Plasticity in Mouse Models of Autism Spectrum Disorders

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Enhanced postsynaptic inhibitory strength in hippocampal principal cells in high-performing aged rats

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Promoter‐like sequences regulating transcriptional activity in neurexin and neuroligin genes

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Acute and crucial requirement for MeCP2 function upon transition from early to late adult stages of brain maturation

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An Astrocytic Influence on Impaired Tonic Inhibition in Hippocampal CA1 Pyramidal Neurons in a Mouse Model of Rett Syndrome

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Increasing astrogenesis in the developing hippocampus induces autistic‐like behavior in mice via enhancing inhibitory synaptic transmission

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Metabolomic Fingerprint of Mecp2-Deficient Mouse Cortex: Evidence for a Pronounced Multi-Facetted Metabolic Component in Rett Syndrome

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MeCP2 and transcriptional control of eukaryotic gene expression

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Rescue of Methyl-CpG Binding Protein 2 Dysfunction-induced Defects in Newborn Neurons by Pentobarbital

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Time-dependent modulation of GABAA-ergic synaptic transmission by allopregnanolone in locus coeruleus neurons of Mecp2-null mice

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Modulation of parvalbumin interneuron number by developmentally transient neocortical vasopressin receptor 1a (V1aR)

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Pharmacological interference with the glucocorticoid system influences symptoms and lifespan in a mouse model of Rett syndrome

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Structural and functional differences in the barrel cortex of Mecp2 null mice

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Noise Exposure Alters Glutamatergic and GABAergic Synaptic Connectivity in the Hippocampus and Its Relevance to Tinnitus

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No balance between glutamate+glutamine and GABA+ in visual or motor cortices of the human brain: A magnetic resonance spectroscopy study

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Inter‐α‐inhibitor deficiency in the mouse is associated with alterations in anxiety‐like behavior, exploration and social approach

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Microglia in animal models of autism spectrum disorders

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Loss of MeCP2 Function Across Several Neuronal Populations Impairs Breathing Response to Acute Hypoxia

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Translational research

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Mecp2 Truncation in Male Mice Promotes Affiliative Social Behavior

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Disruption of the NF-κB/IκBα Autoinhibitory Loop Improves Cognitive Performance and Promotes Hyperexcitability of Hippocampal Neurons

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Scn1a dysfunction alters behavior but not the effect of stress on seizure response

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mGluR1 and mGluR5 Synergistically Control Cholinergic Synaptic Transmission in the Thalamic Reticular Nucleus

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Hypoxia regulates the level of glutamic acid decarboxylase enzymes and interrupts inhibitory synapse stability in primary cultured neurons

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Rescue of Inhibitory Synapse Strength following Developmental Hearing Loss

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Early‐life single‐episode sevoflurane exposure impairs social behavior and cognition later in life

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Mature Hippocampal Neurons Require LIS1 for Synaptic Integrity: Implications for Cognition

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Pre-clinical Investigation of Rett Syndrome Using Human Stem Cell-Based Disease Models

Haase, F., Coorey, B., Riley, L. G., Cantrill, L. C., Tam, P., & Gold, W. A. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.698812 · Cited by 22

Rett Syndrome and Fragile X Syndrome: Different Etiology With Common Molecular Dysfunctions

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Modestly increasing systemic interleukin-6 perinatally disturbs secondary germinal zone neurogenesis and gliogenesis and produces sociability deficits

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Exploratory evidence for differences in GABAergic regulation of auditory processing in autism spectrum disorder

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Increased number of excitatory synapsis and decreased number of inhibitory synapsis in the prefrontal cortex in autism

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Methyl-CpG binding-protein 2 function in cholinergic neurons mediates cardiac arrhythmogenesis

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Decreased Number and Expression of nNOS-Positive Interneurons in Basolateral Amygdala in Two Mouse Models of Autism

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Mecp2Deletion from Cholinergic Neurons Selectively Impairs Recognition Memory and Disrupts Cholinergic Modulation of the Perirhinal Cortex

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Temporal Dynamics of GABA and Glx in the Visual Cortex

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Reviewing Evidence for the Relationship of EEG Abnormalities and RTT Phenotype Paralleled by Insights from Animal Studies

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Neuroanatomical Alterations in the CNTNAP2 Mouse Model of Autism Spectrum Disorder

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MeCP2 in cholinergic interneurons of nucleus accumbens regulates fear learning

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Disrupting cortical astrocyte Ca 2+ signaling in developing brain induces social deficits and depressive‐like behaviors

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Children with Autism Spectrum Disorder and Abnormalities of Clinical EEG: A Qualitative Review

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iPSC-derived models of PACS1 syndrome reveal transcriptional and functional deficits in neuron activity

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Potential translational targets revealed by linking mouse grooming behavioral phenotypes to gene expression using public databases

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Over-Expression of Either MECP2_e1 or MECP2_e2 in Neuronally Differentiated Cells Results in Different Patterns of Gene Expression

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Present and future of developmental neuropsychopharmacology

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Selection of multiple agonist antibodies from intracellular combinatorial libraries reveals that cellular receptors are functionally pleiotropic

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GRK5 Regulates Social Behavior Via Suppression of mTORC1 Signaling in Medial Prefrontal Cortex

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Dysbindin Deficiency Modifies the Expression of GABA Neuron and Ion Permeation Transcripts in the Developing Hippocampus

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Synaptopathology in autism spectrum disorders: Complex effects of synaptic genes on neural circuits

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Autaptic cultures of human induced neurons as a versatile platform for studying synaptic function and neuronal morphology

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From Cannabinoids and Neurosteroids to Statins and the Ketogenic Diet: New Therapeutic Avenues in Rett Syndrome?

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Sensory evoked potentials in patients with Rett syndrome through the lens of animal studies: Systematic review

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Differential modulation of excitatory and inhibitory populations of superficial dorsal horn neurons in lumbar spinal cord by Aβ-fiber electrical stimulation

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Inhibitory neuron‐specific Cre‐dependent red fluorescent labeling using VGAT BAC‐based transgenic mouse lines with identified transgene integration sites

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Sleep problems in Rett syndrome animal models: A systematic review

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Electrophysiological and Behavioral Evidence for Hyper- and Hyposensitivity in Rare Genetic Syndromes Associated with Autism

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Ketamine administration in early postnatal life as a tool for mimicking Autism Spectrum Disorders core symptoms

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What’s in the pipeline? Drugs in development for autism spectrum disorder

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Early life seizures in female rats lead to anxiety-related behavior and abnormal social behavior characterized by reduced motivation to novelty and deficit in social discrimination

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Aberrant Dendritic Excitability: A Common Pathophysiology in CNS Disorders Affecting Memory?

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Analysis of Extracellular Nucleotide Metabolism in Adult Zebrafish After Embryological Exposure to Valproic Acid

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Selective preservation of cholinergic MeCP2 rescues specific Rett-syndrome-like phenotypes in MeCP2stop mice

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Autism spectrum in patients with schizophrenia: correlations with real-life functioning, resilience, and coping styles

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Clonazepam attenuates neurobehavioral abnormalities in offspring exposed to maternal immune activation by enhancing GABAergic neurotransmission

Yang, Y., Wang, B., Zhong, Z., Chen, H., Ding, W., & Hoi, M. P. M. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114711 · Cited by 21

Imbalance of Functional Connectivity and Temporal Entropy in Resting-State Networks in Autism Spectrum Disorder: A Machine Learning Approach

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Evaluation of a mechanical lung model to test small animal whole body plethysmography

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Hair Trace Elements and Mineral Content in Moroccan Children with Autism Spectrum Disorder: a Case–Control Study

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Embryonic exposure to environmental factors drives transmitter switching in the neonatal mouse cortex causing autistic-like adult behavior

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Disruption of AT-hook 1 domain in MeCP2 protein caused behavioral abnormality in mice

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MeCP2 Dysfunction in Rett Syndrome and Neuropsychiatric Disorders

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Hyperactive MEK1 Signaling in Cortical GABAergic Neurons Promotes Embryonic Parvalbumin Neuron Loss and Defects in Behavioral Inhibition

Holter, M. C., Hewitt, L. T., Nishimura, K. J., Knowles, S. J., Bjorklund, G. R., Shah, S., Fry, N., Rees, K. P., Gupta, T. A., Daniels, C. W., et al. (2020) · Cerebral Cortex · doi:10.1093/cercor/bhaa413 · Cited by 22

Multimodal Neuroimaging in Rett Syndrome With MECP2 Mutation

Kong, Y., Li, Q.-B., Zhao-hong, Y., Jiang, X., Zhang, G.-Q., Cheng, N., & Dang, N. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.838206 · Cited by 21

Role of medial hypothalamic orexin system in panic, phobia and hypertension

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A single low dose of valproic acid in late prenatal life alters postnatal behavior and glutamic acid decarboxylase levels in the mouse

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Binocular rivalry dynamics associated with high levels of self-reported autistic traits suggest an imbalance of cortical excitation and inhibition

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Autism, Mitochondria and Polybrominated Diphenyl Ether Exposure

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