The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Genetic history of an archaic hominin group from Denisova Cave in Siberia
Open accessAbstract
Using DNA extracted from a finger bone found in Denisova Cave in southern Siberia, we have sequenced the genome of an archaic hominin to about 1.9-fold coverage. This individual is from a group that shares a common origin with Neanderthals. This population was not involved in the putative gene flow from Neanderthals into Eurasians; however, the data suggest that it contributed 4–6% of its genetic material to the genomes of present-day Melanesians. We designate this hominin population ‘Denisovans’ and suggest that it may have been widespread in Asia during the Late Pleistocene epoch. A tooth found in Denisova Cave carries a mitochondrial genome highly similar to that of the finger bone. This tooth shares no derived morphological features with Neanderthals or modern humans, further indicating that Denisovans have an evolutionary history distinct from Neanderthals and modern humans. Anatomically modern humans were in Africa from some point after 200,000 years ago and reached Eurasia rather later. Meanwhile, archaic hominins — including the Neanderthals — had been in Eurasia from at least 230,000 years ago and disappear from the fossil record only about 30,000 years ago. The genome of a female archaic hominin from Denisova Cave in southern Siberia has now been sequenced from DNA extracted from a finger bone. The group to which this 'Denisovan' individual belonged shares a common origin with Neanderthals and, although it was not involved in the putative gene flow from Neanderthals into Eurasians, it contributed 4–6% of the genomes of present-day Melanesians. In addition, the morphology of a tooth with a mitochondrial genome very similar to that of the finger bone suggests that these hominins are evolutionarily distinct from both Neanderthals and modern humans. Using DNA from a finger bone, the genome of an archaic hominin from southern Siberia has been sequenced to about 1.9-fold coverage. The group to which this individual belonged shares a common origin with Neanderthals, and although it was not involved in the putative gene flow from Neanderthals into Eurasians, it contributed 4–6% of its genetic material to the genomes of present-day Melanesians. A tooth whose mitochondrial genome is very similar to that of the finger bone further suggests that these hominins are evolutionarily distinct from Neanderthals and modern humans.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source doesn’t support the claim as written.
In the citing paper
“There is evidence for superarchaic gene flow into Denisovans 13,21,22 , into Neanderthal-Denisovan ancestors 27 , and into Africans 4 .”
From The Genetic Legacy of Introgression from Two Deeply Divergent Lineages in the Genus Homo (2026) · cites this paper as [27]
Checked by a reasoning model — may be wrong.
Experimental — accuracy not yet measuredThe cited source doesn’t support the claim as written.
In the citing paper
“EAS populations also show evidence of introgression from Denisovans [18, 19, 31].”
From Denisovan and Neanderthal archaic introgression differentially impacted the genetics of complex traits in modern populations (2022) · cites this paper as [31]
Checked by a reasoning model — may be wrong.
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“These results solve a puzzle: under model αβγδ 27 (Fig. 1), successive methodological improvements led to less and less plausible estimates of the separation time, T XY , between modern west Africans and Europeans.”
From The Genetic Legacy of Introgression from Two Deeply Divergent Lineages in the Genus Homo (2026) · cites this paper as [27]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Methods for quality control, calling ancestral alleles, and calibrating the molecular clock are as described by Rogers et al. 27 .”
From The Genetic Legacy of Introgression from Two Deeply Divergent Lineages in the Genus Homo (2026) · cites this paper as [27]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“nearly all Eurasians have ~2% Neanderthal ancestry resulting from interbreeding events that occurred shortly after their ancestors left Africa1,2.”
From Quantifying the contribution of Neanderthal introgression to the heritability of complex traits (2021) · cites this paper as [2]
Experimental — accuracy not yet measured
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“In some cases, these past introgression events likely resulted in adaptive introgression (Bustamante and Henn 2010; Green et al. 2010; Reich et al. 2010)—selection favoring archaic variants to facilitate adaptation to novel environments in modern humans (Racimo et al. 2015).”
From The Impact of Modern Admixture on Archaic Human Ancestry in Human Populations (2023) · cites this paper as Reich et al. 2010
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“For example, we now have evidence that archaic and modern humans interbred, and that numerous population replacement and admixture events occurred across Eurasia in the past, resulting in the transmission of genes between previously geographically separated populations (Bustamante and Henn 2010; Green et al. 2010; Reich et al. 2010).”
From The Impact of Modern Admixture on Archaic Human Ancestry in Human Populations (2023) · cites this paper as Reich et al. 2010
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“It has been shown that Papuans and Indigenous Australians carry the largest amount of Denisovan introgression (∼1% to 5%), followed by East and South Asians (∼0.06% to 0.5%), and Indigenous Americans (∼0.05% to 0.4%) (Reich et al. 2010; Racimo et al. 2015; Mallick et al. 2016; Sankararaman et al. 2016; Browning et al. 2018).”
From The Human Accelerated Region HAR202 Controls NPAS3 Expression in the Developing Forebrain Displaying Differential Enhancer Activity Between Modern and Archaic Human Sequences (2024) · cites this paper as Reich et al. 2010
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Sequencing of Neanderthal genomes has revealed that ~2% of the DNA of modern humans (MHs) outside of Africa is more similar to DNA from Neanderthals (NEs) than it is to DNA from sub-Saharan African populations (1, 2).”
From Past human expansions shaped the spatial pattern of Neanderthal ancestry (2023) · cites this paper as [2]
The cited source says what the claim attributes to it.
In the citing paper
“Model-averaged parameter estimates (Fig. 4) are in general agreement with previous work 27 , but there are a few exceptions.”
From The Genetic Legacy of Introgression from Two Deeply Divergent Lineages in the Genus Homo (2026) · cites this paper as [27]
The cited source says what the claim attributes to it.
In the citing paper
“Many modern humans also show evidence of introgression, or the incorporation of alleles from archaic humans like Neanderthals and Denisovans (Green et al. 2010; Reich et al. 2010).”
From The Impact of Modern Admixture on Archaic Human Ancestry in Human Populations (2023) · cites this paper as Reich et al. 2010
The cited source says what the claim attributes to it.
In the citing paper
“Admixture with extinct hominins (Neanderthals and Denisovans) resulted in the introgression of archaic alleles into the human gene pool51–53.”
From Distinct selective forces and Neanderthal introgression shaped genetic diversity at genes involved in neurodevelopmental disorders (2017) · cites this paper as [53]
The cited source says what the claim attributes to it.
In the citing paper
“Recent palaeo-genetic studies666768 have already hinted at a more explicit and active degree of social interaction between hominin species than was previously thought possible.”
From Assessing the calorific significance of episodes of human cannibalism in the Palaeolithic (2017) · cites this paper as [66]
The check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“We proposed 27 that this second wave interbred with the Eurasian descendants of the first, during what we refer to as the δ episode of admixture.”
From The Genetic Legacy of Introgression from Two Deeply Divergent Lineages in the Genus Homo (2026) · cites this paper as [27]
Experimental — accuracy not yet measuredIn the citing paper
“Analyses of DNA from the archaic humans showed strong evidence of a small amount of gene flow to modern humans, giving rise to a ‘leaky replacement’ model.”
From Ancient DNA and the rewriting of human history: be sparing with Occam’s razor (2016) · cites this paper as [10]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Fast and accurate short read alignment with Burrows-Wheeler transform
Li, H., & Durbin, R. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp324 · Cited by 58,607
Self-citationA draft sequence of the Neandertal genome
Green, R. E., Krause, J., Briggs, A. W., Maricic, T., Stenzel, U., Kircher, M., Patterson, N., Li, H., Zhai, W., Fritz, M. H.-Y., et al. (2010) · Science · doi:10.1126/science.1188021 · Cited by 4,318
Self-citationIllumina Sequencing Library Preparation for Highly Multiplexed Target Capture and SequencingPreprint
Meyer, M., & Kircher, M. (2010) · Cold Spring Harbor Protocols · doi:10.1101/pdb.prot5448 · Cited by 2,233
Self-citationWorldwide Human Relationships Inferred from Genome-Wide Patterns of Variation
Li, J. Z., Absher, D. M., Tang, H., Southwick, A. M., Casto, A. M., Ramachandran, S., Cann, H. M., Barsh, G. S., Feldman, M. W., Cavalli-Sforza, L. L., et al. (2008) · Science · doi:10.1126/science.1153717 · Cited by 1,915
A new small-bodied hominin from the Late Pleistocene of Flores, Indonesia.
Brown, P., Sutikna, T., Morwood, M. J., Soejono, R. P., Jatmiko, Wayhu Saptomo, E., & Awe Due, R. (2004) · Nature · doi:10.1038/nature02999 · Cited by 1,075
Patterns of damage in genomic DNA sequences from a neandertal
Briggs, A. W., Stenzel, U., Johnson, P. L. F., Green, R. E., Kelso, J., Prüfer, K., Meyer, M., Krause, J., Ronan, M. T., Lachmann, M., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704665104 · Cited by 981
Self-citationAncient human genome sequence of an extinct Palaeo-Eskimo
Rasmussen, M., Li, Y., Lindgreen, S., Pedersen, J. S., Albrechtsen, A., Moltke, I., Metspalu, M., Metspalu, E., Kivisild, T., Gupta, R., et al. (2010) · Nature · doi:10.1038/nature08835 · Cited by 849
The complete mitochondrial DNA genome of an unknown hominin from southern Siberia
Krause, J., Fu, Q., Good, J. M., Viola, B., Shunkov, M. V., Derevianko, A. P., & Pääbo, S. (2010) · Nature · doi:10.1038/nature08976 · Cited by 818
Self-citationMetagenomics to Paleogenomics: Large-Scale Sequencing of Mammoth DNA
Poinar, H. N., Schwarz, C., Qi, J., Shapiro, B., MacPhee, R. D. E., Buigues, B., Tikhonov, A., Huson, D. H., Tomsho, L. P., Auch, A. F., et al. (2005) · Science · doi:10.1126/science.1123360 · Cited by 638
A Complete Neandertal Mitochondrial Genome Sequence Determined by High-Throughput Sequencing
Green, R. E., Malaspinas, A., Krause, J., Briggs, A. W., Johnson, P. L. F., Uhler, C., Meyer, M., Good, J. M., Maričić, T., Stenzel, U., et al. (2008) · Cell · doi:10.1016/j.cell.2008.06.021 · Cited by 608
Self-citation
Research works printed but not linked: 2
- Wu, X. & Poirier, F. E. Human Evolution in Asia (Oxford Univ. Press, 1995)
- Derevianko, A. P. et al. Paleoenvironment and Paleolithic Human Occupation of Gorny Altai [in Russian] (Institute of Archeology and Ethnography SB RAS Press, 2003)
Cited by
Sorted by citations
Items 601–700 of 1,005
Origins and Evolution of the Primate Hepatitis B Virus
LOCARNINI, S. A., Littlejohn, M., & Yuen, L. K. W. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.653684 · Cited by 32
Hoover, K. C., Gökçümen, Ö., Qureshy, Z., Bruguera, E. S., Savangsuksa, A., Cobb, M. A., & Matsunami, H. (2015) · Chemical Senses · doi:10.1093/chemse/bjv030 · Cited by 31
Unconstrained cranial evolution in Neandertals and modern humans compared to common chimpanzees
Weaver, T. D., & Stringer, C. B. (2015) · Proceedings of the Royal Society B: Biological Sciences · doi:10.1098/rspb.2015.1519 · Cited by 31
The Impact of Evolutionary Driving Forces on Human Complex Diseases: A Population Genetics Approach
Saeb, A. T. M., & Alnaqeb, D. (2016) · Scientifica · doi:10.1155/2016/2079704 · Cited by 31
Glinsky, G. V. (2015) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/022913 · Cited by 31
Genomics of a complete butterfly continentPreprint
Zhang, J., Cong, Q., Shen, J., Opler, P. A., & Grishin, N. V. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/829887 · Cited by 34
A test for ancient selective sweeps and an application to candidate sites in modern humans
Racimo, F., Kuhlwilm, M., & Slatkin, M. (2014) · Molecular Biology and Evolution · doi:10.1093/molbev/msu255 · Cited by 30
Self-citationWhat aDNA can (and cannot) tell us about the emergence of language and speech
DeSalle, R., & Tattersall, I. (2017) · Journal of Language Evolution · doi:10.1093/jole/lzx018 · Cited by 29
Neandertal and Denisovan retroviruses
Agoni, L., Golden, A., Guha, C., & Lenz, J. (2012) · Current Biology · doi:10.1016/j.cub.2012.04.049 · Cited by 30
The Capital Economy in Hominin Evolution
Wells, J. C. K. (2012) · Current Anthropology · doi:10.1086/667606 · Cited by 30
The Ahmarian in the Context of the Earlier Upper Palaeolithic in the Near East
Goring‐Morris, A. N., & Belfer‐Cohen, A. (2017) · Springer eBooks · doi:10.1007/978-981-10-6826-3_7 · Cited by 30
Martinón‐Torres, M., de Castro, J. M. B., de Pinillos, M. M., Modesto‐Mata, M., Xing, S., Martín‐Francés, L., García‐Campos, C., Wu, X., & Liu, W. (2019) · Journal of Human Evolution · doi:10.1016/j.jhevol.2018.12.001 · Cited by 31
The Impact of Modern Admixture on Archaic Human Ancestry in Human Populations
Witt, K. E., Funk, A., Añorve-Garibay, V., Fang, L. L., & Huerta-Sánchez, E. (2023) · Genome Biology and Evolution · doi:10.1093/gbe/evad066 · Cited by 25
Zhang, X., Kim, B., Singh, A., Sankararaman, S., Durvasula, A., & Lohmueller, K. E. (2023) · Molecular Biology and Evolution · doi:10.1093/molbev/msad001 · Cited by 29
Zilhão, J., d’Errico, F., Banks, W. E., & Teyssandier, N. (2024) · Quaternary Environments and Humans · doi:10.1016/j.qeh.2024.100037 · Cited by 32
Gökçümen, Ö., Zhu, Q., Mulder, L. C. F., Iskow, R. C., Austermann, C., Scharer, C. D., Raj, T., Boss, J. M., Sunyaev, S. R., Price, A. L., et al. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003404 · Cited by 29
Forni, D., Cagliani, R., Pozzoli, U., Colleoni, M., Riva, S., Biasin, M., Filippi, G., GIOIA, L. D., Gnudi, F., Comi, G. P., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.04.008 · Cited by 29
Ancient DNA in the Study of Ancient Disease
Stone, A. C., & Ozga, A. T. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-809738-0.00008-9 · Cited by 30
A mobile laboratory for ancient DNA analysis
Utge, J., Sévêque, N., Lartigot‐Campin, A., Testu, A., Moigne, A., Vézian, R., Maksud, F., Bégouën, R., Verna, C., Soriano, S., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0230496 · Cited by 29
Lbova, L. (2020) · Quaternary International · doi:10.1016/j.quaint.2020.05.035 · Cited by 29
Extremely Rare Interbreeding Events Can Explain Neanderthal DNA in Living Humans
Neves, A., & Serva, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047076 · Cited by 33
Smith, F. H. (2013) · Journal of Anthropological Research · doi:10.3998/jar.0521004.0069.202 · Cited by 28
Functional primate genomics—leveraging the medical potential
Enard, W. (2012) · Journal of Molecular Medicine · doi:10.1007/s00109-012-0901-4 · Cited by 30
The Mitonuclear Dimension of Neanderthal and Denisovan Ancestry in Modern Human Genomes
Sharbrough, J., Havird, J. C., Noe, G. R., Warren, J. M., & Sloan, D. B. (2017) · Genome Biology and Evolution · doi:10.1093/gbe/evx114 · Cited by 27
Human Evolution: Multiregional Origins
Wolpoff, M. H. (2020) · Springer eBooks · doi:10.1007/978-3-030-30018-0_672 · Cited by 29
Recent Advances in the Genetics of Vocal Learning
Condro, M. C., & White, S. A. (2014) · Comparative Cognition & Behavior Reviews · doi:10.3819/ccbr.2014.90003 · Cited by 27
A “source and sink” model for East Asia? Preliminary approach through the dental evidence
Martinón‐Torres, M., Xing, S., Liu, W., & de Castro, J. M. B. (2016) · Comptes Rendus Palevol · doi:10.1016/j.crpv.2015.09.011 · Cited by 27
Disparate Stone Age Technological Evolution in North China
Li, F., Kuhn, S. L., Olsen, J. W., Chen, F., & Gao, X. (2014) · Journal of Anthropological Research · doi:10.3998/jar.0521004.0070.103 · Cited by 28
Puhl, H. L., Won, Y., Lu, V. B., & Ikeda, S. R. (2015) · Scientific Reports · doi:10.1038/srep12880 · Cited by 27
Comprehensive analysis of microorganisms accompanying human archaeological remains
Philips, A., Stolarek, I., Kuczkowska, B., Juras, A., Handschuh, L., Piontek, J., Kozłowski, P., & Figlerowicz, M. (2017) · GigaScience · doi:10.1093/gigascience/gix044 · Cited by 29
The deep population history in Africa
Hollfelder, N., Breton, G., Sjödin, P., & Jakobsson, M. (2021) · Human Molecular Genetics · doi:10.1093/hmg/ddab005 · Cited by 28
Krajcarz, M. T., Kot, M., Pavlenok, K., Fedorowicz, S., Krajcarz, M., Lazarev, S. Y., Mroczek, P., Radzhabov, A., Shnaider, S., Szymanek, M., et al. (2015) · Quaternary International · doi:10.1016/j.quaint.2015.07.051 · Cited by 31
Archaic admixture in human history
Wall, J. D., & Brandt, D. Y. C. (2016) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2016.07.002 · Cited by 29
Characterising private and shared signatures of positive selection in 37 Asian populations
Liu, X., Lu, D., Saw, W., Shaw, P. J., Wangkumhang, P., Ngamphiw, C., Fucharoen, S., Lert-itthiporn, W., Chin-inmanu, K., Chau, T. N. B., et al. (2017) · European Journal of Human Genetics · doi:10.1038/ejhg.2016.181 · Cited by 28
Climate, clothing, and agriculture in prehistory linking evidence, causes, and effects
Gilligan, I. (2019) · Cited by 27
Koller, D., Wendt, F. R., Pathak, G. A., De Lillo, A., De Angelis, F., Cabrera-Mendoza, B., Tucci, S., & Polimanti, R. (2022) · BMC Biology · doi:10.1186/s12915-022-01449-2 · Cited by 27
“EAS populations also show evidence of introgression from Denisovans [18, 19, 31].”
BackgroundEvolution, systematics, and the unnatural history of mitochondrial DNA
Schwartz, J. H. (2021) · Mitochondrial DNA Part A · doi:10.1080/24701394.2021.1899165 · Cited by 29
A structured coalescent model reveals deep ancestral structure shared by all modern humans
Cousins, T., Scally, A., & Durbin, R. (2025) · Nature Genetics · doi:10.1038/s41588-025-02117-1 · Cited by 27
Genomic Correlates of Atherosclerosis in Ancient Humans
Zink, A., Wann, L. S., Thompson, R. C., Keller, A., Maixner, F., Allam, A. H., Finch, C. E., Frøhlich, B., Kaplan, H. S., Lombardi, G. P., et al. (2014) · Global Heart · doi:10.1016/j.gheart.2014.03.2453 · Cited by 29
Self-citationConceptualizing the Tibetan Plateau: Environmental constraints on the peopling of the “Third Pole”
Madsen, D. B. (2016) · Archaeological Research in Asia · doi:10.1016/j.ara.2016.01.002 · Cited by 28
The Essentials of Computational Molecular Evolution
Aris‐Brosou, S., & Rodrigue, N. (2012) · Methods in molecular biology · doi:10.1007/978-1-61779-582-4_4 · Cited by 25
Inferences of African evolutionary history from genomic data
Beltrame, M. H., Rubel, M., & Tishkoff, S. A. (2016) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2016.10.002 · Cited by 26
Wang, Y., Zou, X., Wang, M., Yuan, D., Yang, L., Zeng, Y., Cheng, F., Tang, R., & He, G. (2022) · Molecular Genetics and Genomics · doi:10.1007/s00438-021-01837-3 · Cited by 27
Disotell, T. R. (2012) · American Journal of Physical Anthropology · doi:10.1002/ajpa.22159 · Cited by 30
Bias in estimators of archaic admixture
Rogers, A. R., & Bohlender, R. J. (2015) · Theoretical Population Biology · doi:10.1016/j.tpb.2014.12.006 · Cited by 28
Analysis of Ancient DNA in Microbial Ecology
Gorgé, O., Bennett, E. A., Massilani, D., Daligault, J., Pruvost, M., Geigl, E.-M., & Grange, T. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-3369-3_17 · Cited by 31
The potential and pitfalls of de‐extinction
Richmond, D. J., Sinding, M. S., & Gilbert, M. T. P. (2016) · Zoologica Scripta · doi:10.1111/zsc.12212 · Cited by 28
Inferring Human Demographic Histories of Non-African Populations from Patterns of Allele Sharing
Wall, J. D. (2017) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2017.04.002 · Cited by 27
Solomonova, M. Y., Blinnikov, M. S., Silantyeva, М. М., & Speranskaja, N. Y. (2019) · Frontiers in Ecology and Evolution · doi:10.3389/fevo.2019.00002 · Cited by 27
Re-inventing ancient human DNA
Knapp, M., Lalueza‐Fox, C., & Hofreiter, M. (2015) · Investigative Genetics · doi:10.1186/s13323-015-0020-4 · Cited by 30
Middle and Upper Paleolithic Levallois technology in eastern Central Asia
Rybin, E. P., & Khatsenovich, A. M. (2018) · Quaternary International · doi:10.1016/j.quaint.2018.10.042 · Cited by 28
Miao, Y., Song, Y., Li, Y., Yang, S., Li, Y., Zhao, Y., & Zeng, M. (2020) · Palaeogeography Palaeoclimatology Palaeoecology · doi:10.1016/j.palaeo.2020.109700 · Cited by 28
Minirmd: accurate and fast duplicate removal tool for short reads via multiple minimizers
Liu, Y., Zhang, X., Zou, Q., & Zeng, X. (2020) · Bioinformatics · doi:10.1093/bioinformatics/btaa915 · Cited by 26
Fault Lines: A primer on race, science and society
(2020) · African Sun Media eBooks · doi:10.18820/9781928480495 · Cited by 28
Northern gene flow into southeastern East Asians inferred from genome‐wide array genotyping
He, G., Li, Y., Zou, X., Yeh, H., Tang, R., Wang, P., Bai, J., Yang, X., Wang, Z., Guo, J., et al. (2022) · Journal of Systematics and Evolution · doi:10.1111/jse.12826 · Cited by 23
Rong, S., Neil, C. R., Welch, A., Duan, C., Maguire, S., Meremikwu, I. C., Meyerson, M., Evans, B. J., & Fairbrother, W. G. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2218308120 · Cited by 25
Genetic analysis of hair samples attributed to yeti, bigfoot and other anomalous primates
Sykes, B. C., Mullis, R. A., Hagenmuller, C., Melton, T. W., & Sartori, M. (2014) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2014.0161 · Cited by 26
Ancient human genomics: the methodology behind reconstructing evolutionary pathways
Marciniak, S., Klunk, J., Devault, A. M., Enk, J. M., & Poinar, H. N. (2015) · Journal of Human Evolution · doi:10.1016/j.jhevol.2014.11.003 · Cited by 30
Bai, H., Guo, X., Zhang, D., Narisu, N., Bu, J., Jirimutu, J., Liang, F., Zhao, X., Xing, Y., Wang, D.-Z., et al. (2014) · Genome Biology and Evolution · doi:10.1093/gbe/evu242 · Cited by 26
Out of Africa, the Nile Valley and the Northern Route
Wurz, S., & Peer, P. V. (2012) · The South African Archaeological Bulletin · Cited by 26
On the Pleistocene Population History in the Japanese Archipelago
Nakazawa, Y. (2017) · Current Anthropology · doi:10.1086/694447 · Cited by 26
da Fonseca, R. R., Ureña, I., Afonso, S., Pires, A. E., Jørsboe, E., Chikhi, L., & Ginja, C. (2019) · BMC Genomics · doi:10.1186/s12864-019-5685-2 · Cited by 26
Sharma, V., Jani, K., Khosla, P., Butler, E., Siegel, D., & Wurmbach, E. (2019) · Electrophoresis · doi:10.1002/elps.201800344 · Cited by 24
A phylogeny for the Drosophila montium species group: A model clade for comparative analyses
Conner, W. R., Delaney, E., Bronski, M. J., Ginsberg, P., Wheeler, T. B., Richardson, K. M., Peckenpaugh, B., Kim, K. J., Watada, M., Hoffmann, A. A., et al. (2020) · Molecular Phylogenetics and Evolution · doi:10.1016/j.ympev.2020.107061 · Cited by 27
Robust and accurate Bayesian inference of genome-wide genealogies for hundreds of genomes
Deng, Y. K., Nielsen, R., & Song, Y. S. (2025) · Nature Genetics · doi:10.1038/s41588-025-02317-9 · Cited by 71
Distribution of HLA haplotypes across Japanese Archipelago: similarity, difference and admixture
Nakaoka, H., & Inoue, I. (2015) · Journal of Human Genetics · doi:10.1038/jhg.2015.90 · Cited by 25
The role of gene regulatory factors in the evolutionary history of humans
Perdomo-Sabogal, Á., Kanton, S., Walter, M. B. C., & Nowick, K. (2014) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2014.08.007 · Cited by 25
Hochreiter, S. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt1013 · Cited by 25
Identification of Putative Target Genes of the Transcription Factor RUNX2
Kuhlwilm, M., Davierwala, A. P., & Pääbo, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0083218 · Cited by 25
Self-citationKrause, J., & Pääbo, S. (2016) · Genetics · doi:10.1534/genetics.116.187856 · Cited by 25
Self-citationCarriers of human mitochondrial DNA macrohaplogroup M colonized India from southeastern Asia
Marrero, P., Abu‐Amero, K. K., Larruga, J. M., & Cabrera, V. M. (2016) · BMC Evolutionary Biology · doi:10.1186/s12862-016-0816-8 · Cited by 27
Triangulating Neanderthal cognition: A tale of not seeing the forest for the trees
Breyl, M. (2020) · Wiley Interdisciplinary Reviews Cognitive Science · doi:10.1002/wcs.1545 · Cited by 25
Gunz, P., & Bulygina, E. D. (2012) · American Journal of Physical Anthropology · doi:10.1002/ajpa.22133 · Cited by 27
Chromosomal Rearrangements as Barriers to Genetic Homogenization between Archaic and Modern Humans
Rogers, R. L. (2015) · Molecular Biology and Evolution · doi:10.1093/molbev/msv204 · Cited by 27
Climate, Clothing, and Agriculture in Prehistory
Gilligan, I. (2018) · Cambridge University Press eBooks · doi:10.1017/9781108555883 · Cited by 27
Irwin, J. A., Just, R. S., Scheible, M. K. R., & Loreille, O. M. (2011) · Forensic science international. Genetics supplement series · doi:10.1016/j.fsigss.2011.09.085 · Cited by 25
Bordes, L., Fullagar, R., Prinsloo, L. C., Hayes, E. H., Kozlikin, M. B., Shunkov, M. V., Derevianko, A. P., & Roberts, R. G. (2018) · Journal of Archaeological Science · doi:10.1016/j.jas.2018.05.001 · Cited by 25
Self-citationAboriginal genome analysis comes to grips with ethics
Callaway, E. (2011) · Nature · doi:10.1038/477522a · Cited by 27
Paleogenomics of the prehistory of Europe: human migrations, domestication and disease
Serrano, J. G., Ordóñez, A. C., & Fregel, R. (2021) · Annals of Human Biology · doi:10.1080/03014460.2021.1942205 · Cited by 23
Holliday, T. W., Gautney, J. R., & Friedl, L. (2014) · Current Anthropology · doi:10.1086/679068 · Cited by 24
Novel Denisovan and Neanderthal Retroviruses
Lee, A. F., Huntley, D. M., Aiewsakun, P., Kanda, R. K., Lynn, C., & Tristem, M. (2014) · Journal of Virology · doi:10.1128/jvi.01825-14 · Cited by 22
Risso, D. S., Behrens, M., Sainz, E., Meyerhof, W., & Drayna, D. T. (2017) · Molecular Biology and Evolution · doi:10.1093/molbev/msx097 · Cited by 25
Identifying Bird Remains Using Ancient DNA Barcoding
Dalén, L., Lagerholm, V. K., Nylander, J. A. A., Barton, N., Bocheński, Z. M., Tomek, T., Rudling, D., Ericson, P. G. P., Irestedt, M., & Stewart, J. R. (2017) · Genes · doi:10.3390/genes8060169 · Cited by 24
Lavretsky, P., Wilson, R. E., Talbot, S. L., & Sonsthagen, S. A. (2021) · Molecular Phylogenetics and Evolution · doi:10.1016/j.ympev.2021.107164 · Cited by 24
Predicting Archaic Hominin Phenotypes from Genomic Data
Brand, C. M., Colbran, L. L., & Capra, J. A. (2022) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev-genom-111521-121903 · Cited by 24
Novo, M., Riesgo, A., Fernàndez-Guerra, A., & Giribet, G. (2013) · Molecular Biology and Evolution · doi:10.1093/molbev/mst074 · Cited by 24
Pimenoff, V. N., Houldcroft, C. J., Rifkin, R. F., & Underdown, S. (2018) · Genes · doi:10.3390/genes9070317 · Cited by 23
Detecting introgression despite phylogenetic uncertainty: The case of the South American siskins
Beckman, E. J., Benham, P. M., Cheviron, Z. A., & Witt, C. C. (2018) · Molecular Ecology · doi:10.1111/mec.14795 · Cited by 25
Modern Human Origins in Central Europe
Ahern, J. C. M., Janković, I., Voisin, J., & Smith, F. H. (2013) · Wiley eBooks · doi:10.1002/9781118659991.ch5 · Cited by 24
Bednarik, R. G. (2020) · Encyclopedia · doi:10.3390/encyclopedia3030067 · Cited by 25
Recovering signals of ghost archaic introgression in African populationsPreprint
Durvasula, A., & Sankararaman, S. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/285734 · Cited by 26
Neanderthal and Denisova tooth protein variants in present-day humans
Zanolli, C., Hourset, M., Esclassan, R., & Mollereau, C. (2017) · PLoS ONE · doi:10.1371/journal.pone.0183802 · Cited by 24
A Genomic View of the Pleistocene Population History of Asia
Sikora, M. (2017) · Current Anthropology · doi:10.1086/694422 · Cited by 24
Glauberman, P., Gasparyan, B., Wilkinson, K., Frahm, E., Nahapetyan, S., Arakelyan, D., Raczynski-Henk, Y., Haydosyan, H., & Adler, D. S. (2020) · Journal of Paleolithic Archaeology · doi:10.1007/s41982-020-00071-4 · Cited by 23
Microbiome-associated human genetic variants impact phenome-wide disease risk
Markowitz, R. H. G., LaBella, A. L., Shi, M., Rokas, A., Capra, J. A., Ferguson, J. F., Mosley, J. D., & Bordenstein, S. R. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2200551119 · Cited by 21
Carr, S. M., Duggan, A. T., Stenson, G. B., & Marshall, H. D. (2015) · PLoS ONE · doi:10.1371/journal.pone.0134207 · Cited by 23
Vázquez‐Moreno, M. A., Zeng, H., Locia‐Morales, D., Peralta‐Romero, J., Asif, H., Maharaj, A., Tam, V., Romero-Figueroa, M. D. S., Sosa-Bustamante, G. P., Méndez‐Martínez, S., et al. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgz276 · Cited by 23
Premo, L. S. (2015) · Springer eBooks · doi:10.1007/978-4-431-55363-2_5 · Cited by 23
Fregel, R., Cabrera, V. M., Larruga, J. M., Abu‐Amero, K. K., & González, A. M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0129839 · Cited by 22
Analyzing asymmetries and praxis in aDNA research: A bioanthropological critique
Argüelles, J. M., Fuentes, A., & Fuentes, A. (2022) · American Anthropologist · doi:10.1111/aman.13692 · Cited by 28
Metadata
- Authors
- Reich, D., Green, R. E., Kircher, M., Krause, J., Patterson, N., Durand, E. Y., Viola, B., Briggs, A. W., Stenzel, U., Johnson, P. L. F., Maricic, T., Good, J. M., Marques-Bonet, T., Alkan, C., Fu, Q., Mallick, S., Li, H., Meyer, M., Eichler, E. E., Stoneking, M., Richards, M., Talamo, S., Shunkov, M. V., Derevianko, A. P., Hublin, J.-J., Kelso, J., Slatkin, M., & Pääbo, S.
- Affiliations
- Harvard University (US)
- Max Planck Society (DE)
- Broad Institute (US)
- University of California, Berkeley (US)
- Emory University (US)
- Howard Hughes Medical Institute (US)
- University of British Columbia (CA)
- Russian Academy of Sciences (RU)
- Corresponding author
- Reich, David
- Viola, Bence
- Pääbo, Svante
- ORCID
- Reich, David
- Green, Richard E.
- Kircher, Martin
- Krause, Johannes
- Patterson, Nick
- Viola, Bence
- Briggs, Adrian W.
- Good, Jeffrey M.
- Alkan, Can
- Fu, Qiaomei
- Mallick, Swapan
- Li, Heng
- Meyer, Matthias
- Eichler, Evan E.
- Stoneking, Mark
- Richards, Michael
- Talamo, Sahra
- Shunkov, Michael V.
- Hublin, Jean-Jacques
- Kelso, Janet
- Slatkin, Montgomery
- Pääbo, Svante
- Venue
- Nature
- Published
- 2010-12
- Volume
- 468
- Issue
- 7327
- Pages
- 1053-1060
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC4306417
- OpenAlex
- W1994263888
- Cited by
- 1,991
- References
- 37
- Citations by year
- 2026: 72 · 2025: 126 · 2024: 119 · 2023: 132 · 2022: 134 · 2021: 148 · 2020: 89 · 2019: 115 · 2018: 123 · 2017: 129 · 2016: 127 · 2015: 126 · 2014: 161 · 2013: 153 · 2012: 134
- FWCI
- 530.94
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Nature (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- RECERCAT (Consorci de Serveis Universitaris de Catalunya) (publishedVersion, other-oa)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Digital Commons - University of South Florida (University of South Florida) (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
- RePEc: Research Papers in Economics (submittedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- Max Planck Digital Library (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Repositori digital de la UPF (Universitat Pompeu Fabra) (submittedVersion, cc-by-nc-sa)
- Funders
- National Science Foundation (0754461, 1032255)
- Max-Planck-Gesellschaft
- Max-Planck-Institut für Evolutionäre Anthropologie
- National Institutes of Health
- National Institute of General Medical Sciences (R01GM040282)
- Office of International Science and Engineering
- Topics
- Social Sciences › Anthropology › Pleistocene-Era Hominins and Archaeology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Forensic and Genetic Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Keywords
- Denisovans, Denisova Cave, archaic humans, Neanderthals, mitochondrial genome, human evolution, Neanderthal introgression, hominin phylogeny
- MeSH terms
- Animals, Asia, DNA, Mitochondrial, Europe, Fossils, Humans, Melanesia, Molecular Sequence Data, Phylogeny, Siberia, Tooth, Hominidae, Genome, Finger Phalanges, Gene Flow
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
