TRIM5 is an innate immune sensor for the retrovirus capsid lattice

The cytoplasmic body component TRIM5α restricts HIV-1 infection in Old World monkeys

Stremlau, M. H., Owens, C. M., Perron, M. J., Kießling, M. K., Autissier, P., & Sodroski, J. (2004) · Nature · doi:10.1038/nature02343 · Cited by 1,810

Integration of murine leukemia virus DNA depends on mitosis.

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Specific recognition and accelerated uncoating of retroviral capsids by the TRIM5α restriction factor

Stremlau, M. H., Perron, M. J., Lee, M. N., Li, Y., Song, B., Javanbakht, H., Diaz‐Griffero, F., Anderson, D. J., Sundquist, W. I., & Sodroski, J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509996103 · Cited by 736

Assembly and Analysis of Conical Models for the HIV-1 Core

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Cyclophilin A retrotransposition into TRIM5 explains owl monkey resistance to HIV-1

Sayah, D. M., Sokolskaja, E., Berthoux, L., & Luban, J. (2004) · Nature · doi:10.1038/nature02777 · Cited by 662

An Atomic Model of the Interferon-β Enhanceosome

Panne, D., Maniatis, T., & Harrison, S. C. (2007) · Cell · doi:10.1016/j.cell.2007.05.019 · Cited by 625

Reconstitution of the RIG-I Pathway Reveals a Signaling Role of Unanchored Polyubiquitin Chains in Innate Immunity

Zeng, W., Sun, L., Jiang, X., Chen, X., Hou, F., Adhikari, A., Xu, M., & Chen, Z. J. (2010) · Cell · doi:10.1016/j.cell.2010.03.029 · Cited by 613

Direct activation of protein kinases by unanchored polyubiquitin chains

Xia, Z.-P., Sun, L., Chen, X., Pineda, G., Jiang, X., Adhikari, A., Zeng, W., & Chen, Z. J. (2009) · Nature · doi:10.1038/nature08247 · Cited by 570

X-Ray Structures of the Hexameric Building Block of the HIV Capsid

Pornillos, O., Ganser-Pornillos, B. K., Kelly, B. N., Hua, Y., Whitby, F. G., Stout, C. D., Sundquist, W. I., Hill, C. P., & Yeager, M. (2009) · Cell · doi:10.1016/j.cell.2009.04.063 · Cited by 523

The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1

Yan, N., Regalado-Magdos, A. D., Stiggelbout, B., Lee‐Kirsch, M. A., & Lieberman, J. (2010) · Nature Immunology · doi:10.1038/ni.1941 · Cited by 522

TRIM69 Inhibits Vesicular Stomatitis Indiana Virus

Rihn, S. J., Aziz, M. A., Stewart, D. G., Hughes, J., Turnbull, M. L., Varela, M., Sugrue, E., Herd, C. S., Stanifer, M. L., Sinkins, S. P., et al. (2019) · Journal of Virology · doi:10.1128/jvi.00951-19 · Cited by 44

Birth, decay, and reconstruction of an ancient TRIMCyp gene fusion in primate genomes

Malfavon-Borja, R., Wu, L. I., Emerman, M., & Malik, H. S. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1216542110 · Cited by 43

TRIM5α Does Not Affect Simian Immunodeficiency Virus SIV mac251 Replication in Vaccinated or Unvaccinated Indian Rhesus Macaques following Intrarectal Challenge Exposure

Fenizia, C., Keele, B. F., Nichols, D., Cornara, S., Binello, N., Vaccari, M., Pegu, P., Robert-Guroff, M., Ma, Z.-M., Miller, C. J., et al. (2011) · Journal of Virology · doi:10.1128/jvi.05707-11 · Cited by 43

TRIM21-Dependent Intracellular Antibody Neutralization of Virus Infection

McEwan, W. A., & James, L. C. (2014) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2014.10.006 · Cited by 43

TRIM5α restricts poxviruses and is antagonized by CypA and the viral protein C6

Zhao, Y., Lu, Y., Richardson, S., Sreekumar, M., Albarnaz, J. D., & Smith, G. L. (2023) · Nature · doi:10.1038/s41586-023-06401-0 · Cited by 42

TRIM17 contributes to autophagy of midbodies while actively sparing other targets from degradation

Mandell, M. A., Jain, A., Kumar, S. G., Castleman, M. J., Anwar, T., Eskelinen, E., Johansen, T., Prekeris, R., & Deretic, V. P. (2016) · Journal of Cell Science · doi:10.1242/jcs.190017 · Cited by 45

Mutational resilience of antiviral restriction favors primate TRIM5α in host-virus evolutionary arms races

Tenthorey, J. L., Young, C., Sodeinde, A., Emerman, M., & Malik, H. S. (2020) · eLife · doi:10.7554/elife.59988 · Cited by 41

Protein phosphatase 1 abrogates IRF7‐mediated type I IFN response in antiviral immunity

Wang, L., Zhao, J., Ren, J., Hall, K. H., Moorman, J. P., Yao, Z. Q., & Ning, S. (2016) · European Journal of Immunology · doi:10.1002/eji.201646491 · Cited by 41

Truncated CPSF6 Forms Higher-Order Complexes That Bind and Disrupt HIV-1 Capsid

Ning, J., Zhong, Z., Fischer, D. K., Harris, G., Watkins, S. C., Ambrose, Z., & Zhang, P. (2018) · Journal of Virology · doi:10.1128/jvi.00368-18 · Cited by 41

Physiological Stress Response by Selective Autophagy

Sánchez‐Martín, P., & Komatsu, M. (2019) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.06.013 · Cited by 41

Emerging Roles of Tripartite Motif-Containing Family Proteins (TRIMs) in Eliminating Misfolded Proteins

Zhang, L., Afolabi, L. O., Wan, X., Li, Y., & Chen, L. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00802 · Cited by 41

Reshaping of the Dendritic Cell Chromatin Landscape and Interferon Pathways during HIV Infection

Johnson, J. S., Lucas, S. Y., Amon, L. M., Skelton, S., Nazitto, R., Carbonetti, S., Sather, D. N., Littman, D. R., & Aderem, A. A. (2018) · Cell Host & Microbe · doi:10.1016/j.chom.2018.01.012 · Cited by 42

TRIM5 alpha Drives SIVsmm Evolution in Rhesus Macaques

Wu, F., Kirmaier, A., Goeken, R. M., Ourmanov, I., Hall, L. R., Morgan, J. S., Matsuda, K., Buckler-White, A. J., Tomioka, K., Plishka, R. J., et al. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003577 · Cited by 40

Endogenous TRIM5α Function Is Regulated by SUMOylation and Nuclear Sequestration for Efficient Innate Sensing in Dendritic Cells

Portilho, D. M., Fernandez, J., Ringeard, M., Machado, A. K., Boulay, A., Mayer, M., Müller-Trutwin, M. C., Beignon, A., Kirchhoff, F., Nisole, S., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.12.039 · Cited by 44

FTR83, a Member of the Large Fish-Specific finTRIM Family, Triggers IFN Pathway and Counters Viral Infection

Langevin, C., Aleksejeva, E., Houël, A., Briolat, V., Torhy, C., Lunazzi, A., Levraud, J., & Boudinot, P. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00617 · Cited by 39

HIV-1 protease cleaves the serine-threonine kinases RIPK1 and RIPK2

Wagner, R. N., Reed, J. C., & Chanda, S. K. (2015) · Retrovirology · doi:10.1186/s12977-015-0200-6 · Cited by 41

Primate Lentiviruses Modulate NF-κB Activity by Multiple Mechanisms to Fine-Tune Viral and Cellular Gene Expression

Heusinger, E., & Kirchhoff, F. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.00198 · Cited by 40

Structure and catalytic activation of the TRIM23 RING E3 ubiquitin ligase

Dawidziak, D. M., Sanchez, J. G., Wagner, J. M., Ganser‐Pornillos, B. K., & Pornillos, O. (2017) · Proteins Structure Function and Bioinformatics · doi:10.1002/prot.25348 · Cited by 38

HIV-1 Activation of Innate Immunity Depends Strongly on the Intracellular Level of TREX1 and Sensing of Incomplete Reverse Transcription Products

Kumar, S., Morrison, J. H., Dingli, D., & Poeschla, E. M. (2018) · Journal of Virology · doi:10.1128/jvi.00001-18 · Cited by 39

Interplay between Intrinsic and Innate Immunity during HIV Infection

Bergantz, L., Subra, F., Deprez, E., Delelis, O., & Richetta, C. (2019) · Cells · doi:10.3390/cells8080922 · Cited by 42

The RNA helicase DHX16 recognizes specific viral RNA to trigger RIG-I-dependent innate antiviral immunity

Hage, A., Bharaj, P., van Tol, S., Giraldo, M. I., González-Orozco, M., Valerdi, K. M., Warren, A. N., Aguilera-Aguirre, L., Xie, X., Widen, S. G., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110434 · Cited by 37

Canonical and Non-Canonical Autophagy in HIV-1 Replication Cycle

Leymarie, O., Lepont, L., & Berlioz‐Torrent, C. (2017) · Viruses · doi:10.3390/v9100270 · Cited by 37

Human TRIM5α senses and restricts LINE-1 elements

Volkmann, B., Wittmann, S., Lagisquet, J., Deutschmann, J., Eissmann, K., Ross, J. J., Biesinger, B., & Gramberg, T. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1922366117 · Cited by 41

Dendritic Cell-Lymphocyte Cross Talk Downregulates Host Restriction Factor SAMHD1 and Stimulates HIV-1 Replication in Dendritic Cells

Su, B., Biedma, M. E., Lederle, A., Peressin, M., Lambotin, M., Proust, A. M., Decoville, T., Schmidt, S., Laumond, G., & Moog, C. (2014) · Journal of Virology · doi:10.1128/jvi.03057-13 · Cited by 41

Combinatorial anti-HIV gene therapy: using a multipronged approach to reach beyond HAART

Peterson, C. W., Younan, P. M., Jerome, K. R., & Kiem, H.-P. (2013) · Gene Therapy · doi:10.1038/gt.2012.98 · Cited by 37

Cellular Innate Immunity and Restriction of Viral Infection: Implications for Lentiviral Gene Therapy in Human Hematopoietic Cells

Kajaste‐Rudnitski, A., & Naldini, L. (2015) · Human Gene Therapy · doi:10.1089/hum.2015.036 · Cited by 37

Tripartite Motif (TRIM) 12c, a Mouse Homolog of TRIM5, Is a Ubiquitin Ligase That Stimulates Type I IFN and NF-κB Pathways along with TNFR-Associated Factor 6

Chang, T.-H., Yoshimi, R., & Ozato, K. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1402064 · Cited by 36

Upregulation of IFN-stimulated genes persists beyond the transitory broad immunologic changes of acute HIV-1 infection

Mackelprang, R. D., Filali-Mouhim, A., Richardson, B., Lefebvre, F., Katabira, E. T., Ronald, A., Gray, G., Cohen, K. W., Klatt, N. R., Pecor, T., et al. (2023) · iScience · doi:10.1016/j.isci.2023.106454 · Cited by 35

PNMA2 forms immunogenic non-enveloped virus-like capsids associated with paraneoplastic neurological syndrome

Xu, J., Erlendsson, S., Singh, M., Holling, G. A., Regier, M., Ibiricu, I., Einstein, J., Hantak, M. P., Day, G. S., Piquet, A. L., et al. (2024) · Cell · doi:10.1016/j.cell.2024.01.009 · Cited by 38

Insights into the Molecular Composition of Endogenous Unanchored Polyubiquitin Chains

Strachan, J., Roach, L. V., Sokratous, K., Tooth, D., Long, J., Garner, T. P., Searle, M. S., Oldham, N. J., & Layfield, R. (2012) · Journal of Proteome Research · doi:10.1021/pr201167n · Cited by 36

Gene Expression Profiling of the Response to Interferon Beta in Epstein-Barr-Transformed and Primary B Cells of Patients with Multiple Sclerosis

Khsheibun, R., Paperna, T., Volkowich, A., Lejbkowicz, I., Avidan, N., & Miller, A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0102331 · Cited by 34

14-3-3 proteins sequester a pool of soluble TRIM32 ubiquitin ligase to repress autoubiquitination and cytoplasmic body formation

Ichimura, T., Taoka, M., Shoji, I., Kato, H., Sato, T. Z., Hatakeyama, S., Isobe, T., & Hachiya, N. (2013) · Journal of Cell Science · doi:10.1242/jcs.122069 · Cited by 35

Retroviral Restriction Factors and Their Viral Targets: Restriction Strategies and Evolutionary Adaptations

Boso, G., & Kozak, C. A. (2020) · Microorganisms · doi:10.3390/microorganisms8121965 · Cited by 37

TRIMming Type I Interferon-Mediated Innate Immune Response in Antiviral and Antitumor Defense

Wang, L., & Ning, S. (2021) · Viruses · doi:10.3390/v13020279 · Cited by 34

Stabilized Human TRIM5α Protects Human T Cells From HIV-1 Infection

Richardson, M. W., Guo, L., Xin, F., Yang, X., & Riley, J. L. (2014) · Molecular Therapy · doi:10.1038/mt.2014.52 · Cited by 39

Type I Interferon at the Interface of Antiviral Immunity and Immune Regulation: The Curious Case of HIV-1

Boasso, A. (2013) · Scientifica · doi:10.1155/2013/580968 · Cited by 37

Vpr Promotes Macrophage-Dependent HIV-1 Infection of CD4+ T Lymphocytes

Collins, D. R., Lubow, J., Lukic, Z., Mashiba, M., & Collins, K. L. (2015) · PLOS Pathogens · doi:10.1371/journal.ppat.1005054 · Cited by 34

Complex roles of members of the ADP-ribosyl transferase super family in immune defences: Looking beyond PARP1

Welsby, I., Hutin, D., & Léo, O. (2012) · Biochemical Pharmacology · doi:10.1016/j.bcp.2012.02.016 · Cited by 34

Innate signaling in HIV-1 infection of dendritic cells

van der Vlist, M., van der Aar, A. M. G., Gringhuis, S. I., & Geijtenbeek, T. B. H. (2011) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0b013e328349a2d1 · Cited by 34

Interferons and beyond: Induction of antiretroviral restriction factors

Hotter, D., & Kirchhoff, F. (2017) · Journal of Leukocyte Biology · doi:10.1002/jlb.3mr0717-307r · Cited by 36

Unanchored Ubiquitin Chains, Revisited

Blount, J. R., Johnson, S. L., & Todi, S. V. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.582361 · Cited by 36

Expression Analysis of LEDGF/p75, APOBEC3G, TRIM5alpha, and Tetherin in a Senegalese Cohort of HIV-1-Exposed Seronegative Individuals

Mous, K., Jennes, W., Camara, M., Seydi, M., Daneau, G., Mboup, S., Kestens, L., & Ostade, X. V. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033934 · Cited by 35

Gene Therapy Strategies to Exploit TRIM Derived Restriction Factors against HIV-1

Chan, E., Towers, G. J., & Qasim, W. (2014) · Viruses · doi:10.3390/v6010243 · Cited by 36

A Structural Model for the Generation of Continuous Curvature on the Surface of a Retroviral Capsid

Bailey, G. D., Hyun, J.-K., Mitra, A. K., & Kingston, R. L. (2012) · Journal of Molecular Biology · doi:10.1016/j.jmb.2012.01.014 · Cited by 33

HIV replication

Sauter, D., & Kirchhoff, F. (2015) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0000000000000233 · Cited by 35

Antiviral immunity and nucleic acid sensing in haematopoietic stem cell gene engineering

Piras, F., & Kajaste‐Rudnitski, A. (2020) · Gene Therapy · doi:10.1038/s41434-020-0175-3 · Cited by 32

Vpu-Deficient HIV Strains Stimulate Innate Immune Signaling Responses in Target Cells

Doehle, B., Chang, K., Ballweber-Fleming, L., McNevin, J. P., Hladik, F., McElrath, M. J., & Gale, M. (2012) · Journal of Virology · doi:10.1128/jvi.00424-12 · Cited by 34

Cyclin F/FBXO1 Interacts with HIV-1 Viral Infectivity Factor (Vif) and Restricts Progeny Virion Infectivity by Ubiquitination and Proteasomal Degradation of Vif Protein through SCFcyclin F E3 Ligase Machinery

Augustine, T., Chaudhary, P., Gupta, K., Islam, S., Ghosh, P., Santra, M. K., & Mitra, D. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.765842 · Cited by 36

Regulation of the innate immune system by ubiquitin and ubiquitin-like modifiers

Oudshoorn, D., Versteeg, G. A., & Kikkert, M. (2012) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2012.08.003 · Cited by 33

A Unique Spumavirus Gag N-terminal Domain with Functional Properties of Orthoretroviral Matrix and Capsid

Goldstone, D. C., Flower, T. G., Ball, N. J., Sanz-Ramos, M., Yap, M. W., Ogrodowicz, R. W., Stanke, N., Reh, J., Lindemann, D., Stoye, J. P., et al. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003376 · Cited by 32

TRIM19/PML Restricts HIV Infection in a Cell Type-Dependent Manner

Kahle, T., Volkmann, B., Eissmann, K., Herrmann, A., Schmitt, S., Wittmann, S., Merkel, L., Reuter, N., Stamminger, T., & Gramberg, T. (2015) · Viruses · doi:10.3390/v8010002 · Cited by 35

Binding of the rhesus TRIM5α PRYSPRY domain to capsid is necessary but not sufficient for HIV-1 restriction

Yang, Y., Brandariz-Núñez, A., Fricke, T., Ivanov, D. N., Sarnak, Z., & Diaz‐Griffero, F. (2013) · Virology · doi:10.1016/j.virol.2013.10.012 · Cited by 32

Antiretroviral restriction factors

Hatziioannou, T., & Bieniasz, P. D. (2011) · Current Opinion in Virology · doi:10.1016/j.coviro.2011.10.007 · Cited by 33

Promising new therapeutic targets for regulation of inflammation and immunity: RING-type E3 ubiquitin ligases

Bulatov, E., Valiullina, A., Sayarova, R., & Rizvanov, A. A. (2018) · Immunology Letters · doi:10.1016/j.imlet.2018.08.001 · Cited by 32

Macrocycle-based PROTACs selectively degrade cyclophilin A and inhibit HIV-1 and HCV

Newton, L. S., Gathmann, C., Ridewood, S., Smith, R. J., Wijaya, A. J., Hornsby, T. W., Morling, K. L., Davison, D., Chiozzi, R. Z., Reuschl, A., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-56317-8 · Cited by 34

SAMHD1 Degradation Enhances Active Suppression of Dendritic Cell Maturation by HIV-1

Hertoghs, N., van der Aar, A. M. G., Setiawan, L. C., Kootstra, N. A., Gringhuis, S. I., & Geijtenbeek, T. B. H. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1403016 · Cited by 34

The interferon-induced antiviral protein PML (TRIM19) promotes the restriction and transcriptional silencing of lentiviruses in a context-specific, isoform-specific fashion

Masroori, N., Mérindol, N., & Berthoux, L. (2016) · Retrovirology · doi:10.1186/s12977-016-0253-1 · Cited by 32

Tripartite-motif protein 21 knockdown extenuates LPS-triggered neurotoxicity by inhibiting microglial M1 polarization via suppressing NF-κB-mediated NLRP3 inflammasome activation

Xiao, T., Wan, J., Qu, H., & Li, Y. (2021) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2021.108918 · Cited by 33

Inhibition of Retroviral Replication by Members of the TRIM Protein Family

Fletcher, A. J., & Towers, G. J. (2013) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-37765-5_2 · Cited by 32

Trim-Away ubiquitinates and degrades lysine-less and N-terminally acetylated substrates

Kiss, L., Rhinesmith, T., Lupták, J., Dickson, C. F., Weidenhausen, J., Smyly, S., Yang, J., Maslen, S., Sinning, I., Neuhaus, D., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-37504-x · Cited by 31

Sensing of HIV-1 Infection in Tzm-bl Cells with Reconstituted Expression of STING

Trotard, M., Tsopoulidis, N., Tibroni, N., Willemsen, J., Binder, M., Ruggieri, A., & Fackler, O. (2015) · Journal of Virology · doi:10.1128/jvi.02966-15 · Cited by 30

IFIH1 (MDA5) is required for innate immune detection of intron-containing RNA expressed from the HIV-1 provirus

Guney, M. H., Nagalekshmi, K., McCauley, S. M., Carbone, C., Aydemir, Ö., & Luban, J. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2404349121 · Cited by 28

Heterogeneous susceptibility of circulating SIV isolate capsids to HIV-interacting factors

Mamede, J. I., Sitbon, M., Battini, J., & Courgnaud, V. (2013) · Retrovirology · doi:10.1186/1742-4690-10-77 · Cited by 32

Are Evolution and the Intracellular Innate Immune System Key Determinants in HIV Transmission?

Sumner, R. P., Thorne, L., Fink, D., Khan, H., Milne, R. S. B., & Towers, G. J. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01246 · Cited by 28

The molecular mechanisms that drive intracellular neutralization by the antibody-receptor and RING E3 ligase TRIM21

Kiss, L., & James, L. C. (2021) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2021.11.005 · Cited by 29

Type I IFN – A blunt spear in fighting HIV-1 infection

Acchioni, C., Marsili, G., Perrotti, E., Remoli, A. L., Sgarbanti, M., & Battistini, A. (2014) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2014.10.004 · Cited by 33

Editing of the human TRIM5 gene to introduce mutations with the potential to inhibit HIV-1

Dufour, C., Claudel, A., Joubarne, N., Mérindol, N., Maisonnet, T., Masroori, N., Plourde, M. B., & Berthoux, L. (2018) · PLoS ONE · doi:10.1371/journal.pone.0191709 · Cited by 32

BCA2/Rabring7 Interferes with HIV-1 Proviral Transcription by Enhancing the SUMOylation of IκBα

Colomer-Lluch, M., & Serra-Moreno, R. (2017) · Journal of Virology · doi:10.1128/jvi.02098-16 · Cited by 30

HIV-1 Vpr Induces Widespread Transcriptomic Changes in CD4 + T Cells Early Postinfection

Bauby, H., Ward, C. C., Hugh-White, R., Swanson, C. M., Schulz, R., Goujon, C., & Malim, M. H. (2021) · mBio · doi:10.1128/mbio.01369-21 · Cited by 32

HIV-1 Vpr and p21 restrict LINE-1 mobility

Kawano, K., Doucet, A. J., Ueno, M., Kariya, R., An, W., Marzetta, F., Kuroki, M., Turelli, P., Sukegawa, S., Okada, S., et al. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky688 · Cited by 28

TRIM5 allelic polymorphism in macaque species/populations of different geographic origins: its impact on SIV vaccine studies

de Groot, N. G., Heijmans, C. M. C., Koopman, G., Verschoor, E. J., Bogers, W. M. J. M., & Bontrop, R. E. (2011) · Tissue Antigens · doi:10.1111/j.1399-0039.2011.01768.x · Cited by 28

Fish species-specific TRIM gene FTRCA1 negatively regulates interferon response through attenuating IRF7 transcription

Wu, M., Dan, C., Gui, J., & Zhang, Y.-B. (2019) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2019.04.297 · Cited by 28

The SARS-CoV-2 protein ORF3c is a mitochondrial modulator of innate immunity

Stewart, H., Lu, Y., O’Keefe, S. M., Valpadashi, A., Cruz‐Zaragoza, L. D., Michel, H. A., Nguyen, S. K., Carnell, G., Lukhovitskaya, N. I., Milligan, R., et al. (2023) · iScience · doi:10.1016/j.isci.2023.108080 · Cited by 28

Lentiviral vector interactions with the host cell

Borsotti, C., Borroni, E., & Follenzi, A. (2016) · Current Opinion in Virology · doi:10.1016/j.coviro.2016.08.016 · Cited by 29

HIV-1 capsids from B27/B57+ elite controllers escape Mx2 but are targeted by TRIM5α, leading to the induction of an antiviral state

Mérindol, N., Far, M. E., Sylla, M., Masroori, N., Dufour, C., Li, J., Cherry, P., Plourde, M. B., Tremblay, C. L., & Berthoux, L. (2018) · PLoS Pathogens · doi:10.1371/journal.ppat.1007398 · Cited by 28

TRIM41-Mediated Ubiquitination of Nucleoprotein Limits Vesicular Stomatitis Virus Infection

Patil, G., Xu, L., Wu, Y., Song, K., Hao, W., Hua, F., Wang, L., & Li, S. (2020) · Viruses · doi:10.3390/v12020131 · Cited by 28

Microglial immunometabolism endophenotypes contribute to sex difference in Alzheimer's disease

Hou, Y., Caldwell, J., Lathia, J. D., Leverenz, J. B., Pieper, A. A., Cummings, J. L., & Cheng, F. (2023) · Alzheimer s & Dementia · doi:10.1002/alz.13546 · Cited by 29

A bacterial immunity protein directly senses two disparate phage proteins

Zhang, T., Čepauskas, A., Nadieina, A., Thureau, A., Wallant, K. C. ’., Martens, C., Lim, D., García-Pino, A., & Laub, M. T. (2024) · Nature · doi:10.1038/s41586-024-08039-y · Cited by 29

Endogenous Retrovirus-K and Nervous System Diseases

Manghera, M., Ferguson, J., & Douville, R. N. (2014) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-014-0488-y · Cited by 27

Gain-of-Sensitivity Mutations in a Trim5-Resistant Primary Isolate of Pathogenic SIV Identify Two Independent Conserved Determinants of Trim5α Specificity

McCarthy, K. R., Schmidt, A. G., Kirmaier, A., Wyand, A. L., Newman, R. M., & Johnson, W. E. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003352 · Cited by 27

Characterisation of assembly and ubiquitylation by the RBCC motif of Trim5α

Keown, J. R., Yang, J. X., Douglas, J., & Goldstone, D. C. (2016) · Scientific Reports · doi:10.1038/srep26837 · Cited by 27

General Model for Retroviral Capsid Pattern Recognition by TRIM5 Proteins

Wagner, J. M., Christensen, D. E., Bhattacharya, A., Dawidziak, D. M., Roganowicz, M., Wan, Y., Pumroy, R. A., Demeler, B., Ivanov, D. N., Ganser‐Pornillos, B. K., et al. (2017) · Journal of Virology · doi:10.1128/jvi.01563-17 · Cited by 27

Role of the Ubiquitin Proteasome System (UPS) in the HIV-1 Life Cycle

Rojas, V. K., & Park, I.-W. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20122984 · Cited by 29

Restriction Genes for Retroviruses Influence the Risk of Multiple Sclerosis

Nexø, B. A., Hansen, B. D., Nissen, K. K., Gundestrup, L., Terkelsen, T., Villesen, P., Bahrami, S., Petersen, T., Pedersen, F. S., & Laska, M. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074063 · Cited by 27

Role of SUMO-1 and SUMO interacting motifs in rhesus TRIM5α-mediated restriction

Lukic, Z., Goff, S. P., Campbell, E. M., & Arriagada, G. (2013) · Retrovirology · doi:10.1186/1742-4690-10-10 · Cited by 27

TRIM15 is a focal adhesion protein that regulates focal adhesion disassembly

Uchil, P. D., Pawliczek, T., Reynolds, T. D., Ding, S., Hinz, A., Munro, J. B., Huang, F., Floyd, R. W., Yang, H., Hamilton, W., et al. (2014) · Journal of Cell Science · doi:10.1242/jcs.143537 · Cited by 27

Antiviral Protection via RdRP-Mediated Stable Activation of Innate Immunity

Painter, M. M., Morrison, J. H., Zoecklein, L. J., Rinkoski, T. A., Watzlawik, J. O., Papke, L. M., Warrington, A. E., Bieber, A. J., Matchett, W. E., Turkowski, K. L., et al. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1005311 · Cited by 26

The Three-Fold Axis of the HIV-1 Capsid Lattice Is the Species-Specific Binding Interface for TRIM5α

Morger, D., Zosel, F., Bühlmann, M., Züger, S., Mittelviefhaus, M., Schuler, B., Luban, J., & Grütter, M. G. (2017) · Journal of Virology · doi:10.1128/jvi.01541-17 · Cited by 28

Endogenous retroviruses and multiple sclerosis–new pieces to the puzzle

Nissen, K. K., Laska, M. J., Hansen, B. D., Terkelsen, T., Villesen, P., Bahrami, S., Petersen, T., Pedersen, F. S., & Nexø, B. A. (2013) · BMC Neurology · doi:10.1186/1471-2377-13-111 · Cited by 27

Protein Nanoparticles Made of Recombinant Viral Antigens: A Promising Biomaterial for Oral Delivery of Fish Prophylactics

Thwaite, R., Ji, J., Torrealba, D., Coll, J. M., Sabés, M., Villaverde, A., & Roher, N. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01652 · Cited by 26

Host Restriction Factors and Human Immunodeficiency Virus (HIV-1): A Dynamic Interplay Involving All Phases of the Viral Life Cycle

D’Urbano, V., Crignis, E. D., & Re, M. C. (2018) · Current HIV Research · doi:10.2174/1570162x16666180817115830 · Cited by 31

Retinoic Acid Inducible Gene I and Protein Kinase R, but Not Stress Granules, Mediate the Proinflammatory Response to Yellow Fever Virus

Beauclair, G., Streicher, F., Chazal, M., Bruni, D., Lesage, S., Gracias, S., Bourgeau, S., Sinigaglia, L., Fujita, T., MEURS, E. F., et al. (2020) · Journal of Virology · doi:10.1128/jvi.00403-20 · Cited by 26

Human TRIM5α: Autophagy Connects Cell-Intrinsic HIV-1 Restriction and Innate Immune Sensor Functioning

Cloherty, A. P. M., Rader, A. G., Compeer, B., & Ribeiro, C. M. S. (2021) · Viruses · doi:10.3390/v13020320 · Cited by 28

TRIMs: selective recruitment at different steps of the NF-κB pathway—determinant of activation or resolution of inflammation

Roy, M., & Singh, R. K. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-03900-z · Cited by 27

Pressure from TRIM5α Contributes to Control of HIV-1 Replication by Individuals Expressing Protective HLA-B Alleles

Granier, C., Battivelli, E., Lécuroux, C., Venet, A., Lambotte, O., Schmitt-Boulanger, M., Delaugerre, C., Molina, J., Chakrabarti, L. A., Clavel, F., et al. (2013) · Journal of Virology · doi:10.1128/jvi.01313-13 · Cited by 26

Macaques as model hosts for studies of HIV-1 infection

Misra, A., Thippeshappa, R., & Kimata, J. T. (2013) · Frontiers in Microbiology · doi:10.3389/fmicb.2013.00176 · Cited by 27

Mechanisms of HIV-1 Control

Soliman, M., Srikrishna, G., & Balagopal, A. (2017) · Current HIV/AIDS Reports · doi:10.1007/s11904-017-0357-9 · Cited by 28

Ligand-Blocking and Membrane-Proximal Domain Targeting Anti-OX40 Antibodies Mediate Potent T Cell-Stimulatory and Anti-Tumor Activity

Zhang, P., Tu, G. H., Wei, J., Santiago, P., Larrabee, L., Liao-Chan, S., Mistry, T., Chu, M. L.-H., Sai, T., Lindquist, K. C., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.05.027 · Cited by 26

The Restrictome of Flaviviruses

Berthoux, L. (2020) · Virologica Sinica · doi:10.1007/s12250-020-00208-3 · Cited by 27

TRIM5α SPRY/coiled-coil interactions optimize avid retroviral capsid recognition

Roganowicz, M., Keceli, S. K., Mukherjee, S., Plewka, J., Alam, S. L., Skorupka, K. A., Wan, Y., Dawidowski, D., Cafiso, D. S., Ganser‐Pornillos, B. K., et al. (2017) · PLoS Pathogens · doi:10.1371/journal.ppat.1006686 · Cited by 25

TRIM5 structure, HIV-1 capsid recognition, and innate immune signaling

Grütter, M. G., & Luban, J. (2012) · Current Opinion in Virology · doi:10.1016/j.coviro.2012.02.003 · Cited by 137

TRIM5 does double duty

Aiken, C., & Joyce, S. (2011) · Nature · doi:10.1038/472305a · Cited by 9

TRIM5 Acts as More Than a Retroviral Restriction Factor

de Silva, S., & Wu, L. J. (2011) · Viruses · doi:10.3390/v3071204 · Cited by 14

TRIM5 and the Regulation of HIV-1 Infectivity

Luban, J. (2012) · Molecular Biology International · doi:10.1155/2012/426840 · Cited by 28

Review Article

Luban, J. (2012)