TRIM5 is an innate immune sensor for the retrovirus capsid lattice

Pertel, Thomas, Hausmann, Stéphane, Morger, Damien, Züger, Sara, Guerra, Jessica, Lascano, Josefina, Reinhard, Christian, Santoni, Federico A., Uchil, Pradeep D., Chatel, Laurence, Bisiaux, Aurélie, Albert, Matthew L., Strambio-De-Castillia, Caterina, Mothes, Walther, Pizzato, Massimo, Grütter, Markus G., Luban, Jeremy·2011·Nature
DOI 10.1038/nature09976

Cited by (648)

Items 501–600 of 648

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  8. Assemble, replicate, remodel and evade
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  9. Ebola Virus VP35 Interacts Non-Covalently with Ubiquitin Chains to Promote Viral Replication Creating New Therapeutic Opportunities
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  10. Capsid-dependent lentiviral restrictions
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  11. Alternative splicing broadens antiviral diversity at the human OAS2 locus
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  12. Compound delivery of eVLPs enhances prime editing for targeted genome engineering and high-throughput screening
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  13. Ubiquitination in viral entry and replication: Mechanisms and implications
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  14. Retrovirus Restriction Factor TRIM5α: The Mechanism of Action and Prospects for Use in Gene Therapy of HIV Infection
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  16. HIV capsids: orchestrators of innate immune evasion, pathogenesis and pandemicity
    Kate L. Morling, Mohamed ElGhazaly, Richard S. B. Milne, Greg J. Towers · 2025 · Journal of General Virology
  17. Review of basic science advances in HIV.
    Mario Stevenson · 2012 · Europe PMC (PubMed Central)
  18. Cellular Factors That Regulate Retrovirus Uncoating and Reverse Transcription
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  19. The Role of Lysine 63-Linked Ubiquitylation in Health and Disease
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  20. Enhanced Transduction of Macaca fascicularis Hematopoietic Cells with Chimeric Lentiviral Vectors
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  22. Realities of virus sensing
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  23. Suppressor of Cytokine Signaling 1 Counteracts Rhesus Macaque TRIM5α-Induced Inhibition of Human Immunodeficiency Virus Type-1 Production
    Sayaka Sukegawa, Ryuta Sakuma, Seiga Ohmine, Hiroaki Takeuchi, Yasuhiro Ikeda, Shoji Yamaoka · 2014 · PLoS ONE
  24. CryoEM Analysis of Capsid Assembly and Structural Changes Upon Interactions with a Host Restriction Factor, TRIM5α
    Gongpu Zhao, Peijun Zhang · 2013 · Methods in molecular biology
  25. Activation of NF-κB induced by TRIMCyp showing a discrepancy between owl monkey and northern pig-tailed macaque
    Jia-Wu Zhu, Dan Mu, Feng‐Liang Liu, Mengting Luo, Rong‐Hua Luo, Yong‐Tang Zheng · 2018 · Molecular Immunology
  26. Post-entry Restriction Factors of SIVcpz
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  27. HIV-1-induced cytokines deplete homeostatic ILCs and expand TCF7-dependent memory NK cells: Supplemental Figures and Tables
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  28. Trim-Away degrades lysine-less substrates without requiring ligase autoubiquitination
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  29. HIV-1 infection of human microglia activates inflammatory pathways associated with HIV-associated neurocognitive disorders (HAND)
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  30. TRIM5 as a promising diagnostic biomarker of hepatocellular carcinoma: integrated analysis and experimental validation
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  31. Alternative polyadenylation upon CPSF6 knock-out enhances HIV-1 infection in primary T cells
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  32. TRIM proteins as emerging regulators of immune pathways: potential therapeutic targets in immune-related disorders
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  33. Sensing Retroviruses
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  38. Delaying Reverse Transcription Does Not Increase Sensitivity of HIV-1 to Human TRIM5α
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  39. Lipopolysaccharide suppresses human immunodeficiency virus 1 reverse transcription in macrophages
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  40. Retroviral restriction: nature's own solution
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  46. Macrophage activation of cGAS and TRIM5 distinguish pandemic and non-pandemic HIV
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  50. INNATE, ADAPTIVE AND INTRINSIC IMMUNITY IN HUMAN IMMUNODEFICIENCY VIRUS INFECTION
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  51. TRIM5 moonlights as a pattern recognition receptor
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  52. Characterization of Resistance to Rhabdovirus and Retrovirus Infection in a Human Myeloid Cell Line
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  53. Closing the net on retroviruses
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  54. Genetic Variation in the Immune System of Old World Monkeys: Functional and Selective Effects
    Dagan A. Loisel, Jenny Tung · 2013 · Springer eBooks
  55. APOBECs and Their Role in Proviral DNA Synthesis
    John S. Albin, Reuben S. Harris · 2013 · Springer eBooks
  56. Vaginal epidermal dendritic cells: defense against HIV-1 or a safe haven?
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  57. Ubiquitination and SUMOylation in HIV Infection: Friends and Foes
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  59. Vesiculovirus G protein-based stable cell lines for continuous lentiviral vector production
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  60. TRIM34 acts with TRIM5 to restrict HIV and SIV capsids
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  61. Shielding the HIV-1 capsid
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  62. RIG-I and PKR, but not stress granules, mediate the pro-inflammatory response to Yellow fever virus
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  63. Faculty Opinions recommendation of Heteromeric interactions regulate butyrophilin (BTN) and BTN-like molecules governing γδ T cell biology.
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  64. TRIM5alpha
    Nadia Rahm · 2016 · Springer eBooks
  65. Primate TRIM34 is a broadly-acting, TRIM5-dependent lentiviral restriction factor
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  67. Genome-Wide Analyses of HIV-1 Host Genetics
    Kimberly Pelak · 2012 · DukeSpace (Duke University)
  68. Improving lentiviral vector-mediated gene transfer by understanding cellular barriers
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  69. Evolutionary and in silico analysis of the antiviral TRIM22 gene
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    Kavidha Reddy · 2014 · ResearchSpace (University of KwaZulu-Natal)
  71. Expression and interactions of the ubiquitin receptor ZNF216
    Joanna Strachan · 2012 · Nottingham ePrints (University of Nottingham)
  72. Expressão ex vivo de fatores antivirais em mães infectadas por HIV-1 e recém-natos.
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  73. Studies of Fv1 binding and restriction
    H. L. W. Li · 2015 · UCL Discovery (University College London)
  74. Identifying and characterizing the degradative pathway of the retroviral restriction factor rhTRIM5alpha
    Rachel S. Nelson · 2013
  75. Viral Infections of the Central Nervous System: Pathogenic and Protective Effects of Neuroinflammation
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  76. Lentiviral host restriction and viral countermeasures: The vif gene of maedi-visna virus
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  77. Reconsidering the Model of Trim5α Assembly: The Role of the Linker2 (l2) Region in Trim5α Assembly
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  78. On the function of the interferon-inducible p53 target gene TRIM22
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  79. TRIM5 moonlights as a pattern recognition receptor
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  80. Cell signalling and feline immunodeficiency virus growth and latency
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  82. Host Cell Factors in HIV-1 Replication Cycle
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  83. Sensors of Viral Infection
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  84. The primate TRIMCyp fusion genes and mechanism of restricting retroviruses replication
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  85. Mechanism of Ubiquitin Induced Activation of RIG-I Like Receptors in Antiviral Innate Immunity
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  86. Investigating the feasibility of incorporating Vpx into lentiviral gene therapy vectors: at a global and targeted scale
    Samantha McAllery · 2016 · The Sydney eScholarship Repository (The University of Sydney)
  87. TRIM Protein Family and Viral Restriction
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  88. Interactions Between HIV-2 and Host Restriction Factors
    Shmona Simpson, Sabelle Jallow · 2015 · Springer eBooks
  89. HIV-1 evasion of restriction factors: cyclophilin A and cell fusion provide a helping hand
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  90. Cellular Immune Responses to Retroviruses
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  91. Defects in assembly explain reduced antiviral activity of the G249D polymorphism in human TRIM5α
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  94. Molecular studies on the action of APOBEC3G against HIV-1 and development of an APOBEC-based anti-HIV approach
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  95. STING Engages Distinct Antiviral Mechanisms to Restrict RNA Virus and DNA Virus Replication
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  96. Multiple roles of the capsid protein in the early steps of HIV-1 infection
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  97. Modification of small ubiquitin‐related modifier 2 (SUMO2) by phosphoubiquitin in HEK293T cells
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  100. Faculty Opinions recommendation of Structural Basis for Target-Directed MicroRNA Degradation.
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