TRIM5 is an innate immune sensor for the retrovirus capsid lattice

The cytoplasmic body component TRIM5α restricts HIV-1 infection in Old World monkeys

Stremlau, M. H., Owens, C. M., Perron, M. J., Kießling, M. K., Autissier, P., & Sodroski, J. (2004) · Nature · doi:10.1038/nature02343 · Cited by 1,810

Integration of murine leukemia virus DNA depends on mitosis.

Roe, T., Reynolds, T. C., Yu, G., & Brown, P. O. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb05858.x · Cited by 921

Specific recognition and accelerated uncoating of retroviral capsids by the TRIM5α restriction factor

Stremlau, M. H., Perron, M. J., Lee, M. N., Li, Y., Song, B., Javanbakht, H., Diaz‐Griffero, F., Anderson, D. J., Sundquist, W. I., & Sodroski, J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509996103 · Cited by 736

Assembly and Analysis of Conical Models for the HIV-1 Core

Ganser, B. K., Li, S., Klishko, V. Y., Finch, J. T., & Sundquist, W. I. (1999) · Science · doi:10.1126/science.283.5398.80 · Cited by 671

Cyclophilin A retrotransposition into TRIM5 explains owl monkey resistance to HIV-1

Sayah, D. M., Sokolskaja, E., Berthoux, L., & Luban, J. (2004) · Nature · doi:10.1038/nature02777 · Cited by 662

An Atomic Model of the Interferon-β Enhanceosome

Panne, D., Maniatis, T., & Harrison, S. C. (2007) · Cell · doi:10.1016/j.cell.2007.05.019 · Cited by 625

Reconstitution of the RIG-I Pathway Reveals a Signaling Role of Unanchored Polyubiquitin Chains in Innate Immunity

Zeng, W., Sun, L., Jiang, X., Chen, X., Hou, F., Adhikari, A., Xu, M., & Chen, Z. J. (2010) · Cell · doi:10.1016/j.cell.2010.03.029 · Cited by 613

Direct activation of protein kinases by unanchored polyubiquitin chains

Xia, Z.-P., Sun, L., Chen, X., Pineda, G., Jiang, X., Adhikari, A., Zeng, W., & Chen, Z. J. (2009) · Nature · doi:10.1038/nature08247 · Cited by 570

X-Ray Structures of the Hexameric Building Block of the HIV Capsid

Pornillos, O., Ganser-Pornillos, B. K., Kelly, B. N., Hua, Y., Whitby, F. G., Stout, C. D., Sundquist, W. I., Hill, C. P., & Yeager, M. (2009) · Cell · doi:10.1016/j.cell.2009.04.063 · Cited by 523

The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1

Yan, N., Regalado-Magdos, A. D., Stiggelbout, B., Lee‐Kirsch, M. A., & Lieberman, J. (2010) · Nature Immunology · doi:10.1038/ni.1941 · Cited by 522

Tripartite Motif 22 (TRIM22) protein restricts herpes simplex virus 1 by epigenetic silencing of viral immediate-early genes

Reddi, T. S., Merkl, P., Lim, S., Letvin, N. L., & Knipe, D. M. (2021) · PLoS Pathogens · doi:10.1371/journal.ppat.1009281 · Cited by 25

Host Cell Restriction Factors Blocking Efficient Vector Transduction: Challenges in Lentiviral and Adeno-Associated Vector Based Gene Therapies

Coroadinha, A. S. (2023) · Cells · doi:10.3390/cells12050732 · Cited by 26

TRIM5α and TRIM22 Are Differentially Regulated According to HIV-1 Infection Phase and Compartment

Singh, R., Patel, V. B., Mureithi, M., Naranbhai, V., Ramsuran, D., Tulsi, S., Hiramen, K., Werner, L., Mlisana, K. P., Altfeld, M. A., et al. (2014) · Journal of Virology · doi:10.1128/jvi.03603-13 · Cited by 25

TRIM5 and the Regulation of HIV-1 Infectivity

Luban, J. (2012) · Molecular Biology International · doi:10.1155/2012/426840 · Cited by 28

Pediatric and Adult High-Grade Glioma Stem Cell Culture Models Are Permissive to Lytic Infection with Parvovirus H-1

Josupeit, R., Bender, S., Kern, S., Leuchs, B., Hielscher, T., Herold‐Mende, C. C., Schlehofer, J. R., Dinsart, C., Witt, O., Rommelaere, J., et al. (2016) · Viruses · doi:10.3390/v8050138 · Cited by 25

Lv4 Is a Capsid-Specific Antiviral Activity in Human Blood Cells That Restricts Viruses of the SIVMAC/SIVSM/HIV-2 Lineage Prior to Integration

Pizzato, M., McCauley, S. M., Neagu, M. R., Pertel, T., Firrito, C., Ziglio, S., Dauphin, A., Zufferey, M., Berthoux, L., & Luban, J. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1005050 · Cited by 23

Identification of a TRIM32 from Penaeus monodon is involved in autophagy and innate immunity during white spot syndrome virus infection

Peng, C., Zhao, C., Wang, P., Yan, L. E., Fan, S., & Qiu, L. (2021) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2021.104169 · Cited by 24

A finTRIM Family Protein Acquires RNA-Binding Activity and E3 Ligase Activity to Shape the IFN Response in Fish

Qu, Z.-L., Li, Y., Gong, X.-Y., Zhao, X., Sun, H.-Y., Dan, C., Gui, J., & Zhang, Y.-B. (2022) · The Journal of Immunology · doi:10.4049/jimmunol.2200343 · Cited by 24

IP6‐stabilised HIV capsids evade cGAS/STING‐mediated host immune sensing

Papa, G., Albecka, A., Mallery, D. L., Vaysburd, M., Renner, N., & James, L. C. (2023) · EMBO Reports · doi:10.15252/embr.202256275 · Cited by 26

TRIM5α Restriction Affects Clinical Outcome and Disease Progression in Simian Immunodeficiency Virus-Infected Rhesus Macaques

Wu, F., Ourmanov, I., Riddick, N. E., Matsuda, K., Whitted, S., Plishka, R. J., Buckler-White, A. J., Starost, M. F., & Hirsch, V. M. (2014) · Journal of Virology · doi:10.1128/jvi.02978-14 · Cited by 24

Structure–Activity Relationships of a Novel Capsid Targeted Inhibitor of HIV-1 Replication

Kortagere, S., Xu, J. P., Mankowski, M. K., Ptak, R. G., & Cocklin, S. (2014) · Journal of Chemical Information and Modeling · doi:10.1021/ci500437r · Cited by 24

Relationship of TRIM5 and TRIM22 polymorphisms with liver disease and HCV clearance after antiviral therapy in HIV/HCV coinfected patients

Medrano, L. M., Rallón, N. I., Berenguer, J., Jiménez‐Sousa, M. Á., Soriano, V., Aldámiz‐Echevarría, T., Fernández‐Rodríguez, A., García, M., Tejerina, F., Martínez, I., et al. (2016) · Journal of Translational Medicine · doi:10.1186/s12967-016-1005-7 · Cited by 24

Prospects in Innate Immune Responses as Potential Control Strategies against Non-Primate Lentiviruses

de Pablo-Maiso, L., Doménech, A., Echeverría, I., Gómez-Arrebola, C., de Andrés, D., Rosati, S., Gómez‐Lucía, E., & Reina, R. (2018) · Viruses · doi:10.3390/v10080435 · Cited by 25

Preclinical Assessment of Mutant Human TRIM5α as an Anti-HIV-1 Transgene

Jung, U., Urak, K., Veillette, M., Nepveu-Traversy, M.-É., Pham, Q. T., Hamel, S., Rossi, J. J., & Berthoux, L. (2015) · Human Gene Therapy · doi:10.1089/hum.2015.059 · Cited by 23

Viral and cellular mechanisms of the innate immune sensing of HIV

Lahaye, X., & Manel, N. (2015) · Current Opinion in Virology · doi:10.1016/j.coviro.2015.01.013 · Cited by 26

Evolution of the rodent Trim5 cluster is marked by divergent paralogous expansions and independent acquisitions of TrimCyp fusions

Boso, G., Shaffer, E., Liu, Q., Cavanna, K., Buckler-White, A. J., & Kozak, C. A. (2019) · Scientific Reports · doi:10.1038/s41598-019-47720-5 · Cited by 23

The role of TRIM proteins in PRR signaling pathways and immune-related diseases

Jin, Z., & Zhu, Z. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.107813 · Cited by 23

Regulation of Viral Restriction by Post-Translational Modifications

Chamontin, C., Bossis, G., Nisole, S., Arhel, N. J., & Maarifi, G. (2021) · Viruses · doi:10.3390/v13112197 · Cited by 25

Toll-Like Receptor (TLR) Signaling Enables Cyclic GMP-AMP Synthase (cGAS) Sensing of HIV-1 Infection in Macrophages

Siddiqui, M. A., & Yamashita, M. (2021) · mBio · doi:10.1128/mbio.02817-21 · Cited by 23

Functional Evidence for the Involvement of Microtubules and Dynein Motor Complexes in TRIM5α-Mediated Restriction of Retroviruses

Pawlica, P., Sage, V. L., Poccardi, N., Tremblay, M. J., Mouland, A. J., & Berthoux, L. (2014) · Journal of Virology · doi:10.1128/jvi.03717-13 · Cited by 23

Virus-Specific Effects of TRIM5α rh RING Domain Functions on Restriction of Retroviruses

Li, X., Kim, J., Song, B., Finzi, A., Pacheco, B., & Sodroski, J. (2013) · Journal of Virology · doi:10.1128/jvi.00620-13 · Cited by 23

In Silico Analysis of Functional Single Nucleotide Polymorphisms in the Human TRIM22 Gene

Kelly, J. N., & Barr, S. D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0101436 · Cited by 23

Uev1A-Ubc13 catalyzes K63-linked ubiquitination of RHBDF2 to promote TACE maturation

Zhang, Y., Li, Y., Yang, X. S., Wang, J., Wang, R., Qian, X., Zhang, W., & Xiao, W. (2017) · Cellular Signalling · doi:10.1016/j.cellsig.2017.10.013 · Cited by 23

Investigating genetic drivers of dermatomyositis pathogenesis using meta-analysis

Aljabban, J., Syed, S. A., Syed, S., Rohr, M., Weisleder, N. L., McElhanon, K. E., Hasan, L. K., Safeer, L. Z., Hoffman, K. P., Aljabban, N., et al. (2020) · Heliyon · doi:10.1016/j.heliyon.2020.e04866 · Cited by 23

The catcher in the RIG-I

Weber, F. (2015) · Cytokine · doi:10.1016/j.cyto.2015.07.002 · Cited by 24

An overview of intracellular interactions between immunodeficiency viruses and their hosts

Bieniasz, P. D. (2012) · AIDS · doi:10.1097/qad.0b013e328353bd04 · Cited by 22

Evidence for selection at HIV host susceptibility genes in a West Central African human population

Zhao, K. X., Ishida, Y., Oleksyk, T. K., Winkler, C. A., & Roca, A. L. (2012) · BMC Evolutionary Biology · doi:10.1186/1471-2148-12-237 · Cited by 22

Impact of TRIM5α in vivo

Nakayama, E. E., & Shioda, T. (2015) · AIDS · doi:10.1097/qad.0000000000000812 · Cited by 24

Gene expression profiling of the TRIM protein family reveals potential biomarkers for indicating tuberculosis status

Chen, Y., Cao, S., Sun, Y., & Li, C. (2017) · Microbial Pathogenesis · doi:10.1016/j.micpath.2017.12.008 · Cited by 22

Review: Unchained maladie – a reassessment of the role of Ubb+1‐capped polyubiquitin chains in Alzheimer's disease

Chadwick, L., Gentle, L., Strachan, J., & Layfield, R. (2011) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2011.01236.x · Cited by 22

Hepatitis B Virus Nucleocapsid but Not Free Core Antigen Controls Viral Clearance in Mice

Lin, Y., Wu, H., Chen, D., & Chen, P. (2012) · Journal of Virology · doi:10.1128/jvi.00608-12 · Cited by 22

Tripartite Motif-Containing Protein 22 Interacts with Class II Transactivator and Orchestrates Its Recruitment in Nuclear Bodies Containing TRIM19/PML and Cyclin T1

Forlani, G., Tosi, G., Turrini, F., Poli, G., Vicenzi, E., & Accolla, R. S. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00564 · Cited by 22

Role of Human TRIM5α in Intrinsic Immunity

Nakayama, E. E., & Shioda, T. (2012) · Frontiers in Microbiology · doi:10.3389/fmicb.2012.00097 · Cited by 22

SERINC proteins potentiate antiviral type I IFN production and proinflammatory signaling pathways

Zeng, C., Waheed, A. A., Li, T., Yu, J., Zheng, Y.-M., Yount, J. S., Wen, H., Freed, E. O., & Liu, S. (2021) · Science Signaling · doi:10.1126/scisignal.abc7611 · Cited by 25

The conserved sumoylation consensus site in TRIM5α modulates its immune activation functions

Nepveu-Traversy, M.-É., & Berthoux, L. (2014) · Virus Research · doi:10.1016/j.virusres.2014.02.013 · Cited by 21

Retrovirus Restriction by TRIM5 Proteins Requires Recognition of Only a Small Fraction of Viral Capsid Subunits

Shi, J., Friedman, D. B., & Aiken, C. (2013) · Journal of Virology · doi:10.1128/jvi.00713-13 · Cited by 21

Differential Expression of Tripartite Motif-Containing Family in Normal Human Dermal Fibroblasts in Response to Porcine Endogenous Retrovirus Infection

Kimsa, M. W., Strzałka‐Mrozik, B., Kimsa, M. C., Mazurek, U. M., Kruszniewska‐Rajs, C., Gola, J. M., Adamska, J., & Twardoch, M. (2014) · Folia Biologica · doi:10.14712/fb2014060030144 · Cited by 21

Whole genome sequencing of extreme phenotypes identifies variants in CD101 and UBE2V1 associated with increased risk of sexually acquired HIV-1

Mackelprang, R. D., Bamshad, M. J., Chong, J. X., Hou, X., Buckingham, K. J., Shively, K. M., de Bruyn, G., Mugo, N., Mullins, J. I., McElrath, M. J., et al. (2017) · PLoS Pathogens · doi:10.1371/journal.ppat.1006703 · Cited by 21

TRIM39R, but not TRIM39B, regulates type I interferon response

Kurata, R., Tajima, A., Yonezawa, T., & Inoko, H. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.05.064 · Cited by 21

Gammaretroviral pol sequences act in cis to direct polysome loading and NXF1/NXT-dependent protein production by gag -encoded RNA

Bartels, H., & Luban, J. (2014) · Retrovirology · doi:10.1186/preaccept-8755229871261499 · Cited by 22

Unconventional posttranslational modification in innate immunity

Chen, J., Qi, D., Hu, H., Wang, X., & Lin, W. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-024-05319-8 · Cited by 21

Lentiviral Gene Therapy Against Human Immunodeficiency Virus Type 1, Using a Novel Human TRIM21-Cyclophilin A Restriction Factor

Chan, E., Schaller, T., Eddaoudi, A., Zhan, H., Tan, C. P., Jacobsen, M. C., Thrasher, A. J., Towers, G. J., & Qasim, W. (2012) · Human Gene Therapy · doi:10.1089/hum.2012.083 · Cited by 20

Cyclophilins and nucleoporins are required for infection mediated by capsids from circulating HIV-2 primary isolates

Mamede, J. I., Damond, F., de Bernardo, A., Matheron, S., Descamps, D., Battini, J., Sitbon, M., & Courgnaud, V. (2017) · Scientific Reports · doi:10.1038/srep45214 · Cited by 22

The role of human endogenous retroviruses (HERVs) in Multiple Sclerosis and the plausible interplay between HERVs, Epstein–Barr virus infection, and vitamin D

Latifi, T., Zebardast, A., & Marashi, S. M. (2021) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2021.103318 · Cited by 20

Tripartite Motif Protein Family in Central Nervous System Diseases

Pan, M., Li, X., Xu, G., Tian, X., Li, Y., & Fang, W. (2023) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-023-01337-5 · Cited by 19

High level of susceptibility to human TRIM5α conferred by HIV-2 capsid sequences

Takeuchi, J. S., Perche, B., Migraine, J., Mercier‐Delarue, S., Ponscarme, D., Simon, F., Clavel, F., & Labrosse, B. (2013) · Retrovirology · doi:10.1186/1742-4690-10-50 · Cited by 20

A Cell Internalizing Antibody Targeting Capsid Protein (p24) Inhibits the Replication of HIV-1 in T Cells Lines and PBMCs: A Proof of Concept Study

Ali, S. A., Teow, S., Omar, M. T. C., Khoo, A. S. B., Choon, T. S., & Yusoff, N. M. (2016) · PLoS ONE · doi:10.1371/journal.pone.0145986 · Cited by 20

Coadministration of a Plasmid Encoding HIV-1 Gag Enhances the Efficacy of Cancer DNA Vaccines

Lambricht, L., Vanvarenberg, K., Beuckelaer, A. D., Hoecke, L. V., Grooten, J., Učakar, B., Lipnik, P., Sanders, N. N., Lienenklaus, S., Véronique Préat, A., et al. (2016) · Molecular Therapy · doi:10.1038/mt.2016.122 · Cited by 21

The Human Immunodeficiency Virus Capsid Is More Than Just a Genome Package

James, L. C., & Jacques, D. A. (2018) · Annual Review of Virology · doi:10.1146/annurev-virology-092917-043430 · Cited by 18

Multiple Pathways To Avoid Beta Interferon Sensitivity of HIV-1 by Mutations in Capsid

Sultana, T., Mamede, J. I., Saito, A., Ode, H., Nohata, K., Cohen, R., Nakayama, E. E., Iwatani, Y., Yamashita, M., Hope, T. J., et al. (2019) · Journal of Virology · doi:10.1128/jvi.00986-19 · Cited by 20

Tripartite Motif-Containing Protein 30 Modulates TCR-Activated Proliferation and Effector Functions in CD4+ T Cells

Choi, U. Y., Hur, J. Y., Lee, M. S., Zhang, Q., Choi, W. Y., Kim, L. K., Lee, W., Oh, G. T., & Kim, Y.-J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0095805 · Cited by 20

Macropinocytosis and TAK1 mediate anti-inflammatory to pro-inflammatory macrophage differentiation by HIV-1 Nef

Hashimoto, M., Nasser, H., Chihara, T., & Suzu, S. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.233 · Cited by 20

Anti-HIV-1 activity of Trim 37

Tabah, A. A., Tardif, K. D., & Mansky, L. M. (2013) · Journal of General Virology · doi:10.1099/vir.0.057653-0 · Cited by 19

Morphogenesis of the Infectious HIV-1 Virion

Sakuragi, J.-I. (2011) · Frontiers in Microbiology · doi:10.3389/fmicb.2011.00242 · Cited by 21

Ubiquitination and SUMOylation in HIV Infection: Friends and Foes

Colomer-Lluch, M., Castro‐Gonzalez, S., & Serra-Moreno, R. (2019) · Current Issues in Molecular Biology · doi:10.21775/cimb.035.159 · Cited by 21

Herpesvirus-mediated stabilization of ICP0 expression neutralizes restriction by TRIM23

Liu, X., Acharya, D., Krawczyk, E., Kangas, C., Gack, M. U., & He, B. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2113060118 · Cited by 19

A new chromosome-scale duck genome shows a major histocompatibility complex with several expanded multigene families

Hu, J.-X., Song, L., Ning, M., Niu, X., Han, M., Gao, C.-Z., Feng, X., Cai, H., Li, T., Li, F., et al. (2024) · BMC Biology · doi:10.1186/s12915-024-01817-0 · Cited by 15

Study of Sylvilagusrabbit TRIM5α species-specific domain: how ancient endoviruses could have shaped the antiviral repertoire in Lagomorpha

de Matos, A. L., van der Loo, W., Areal, H., Lanning, D. K., & Esteves, P. J. (2011) · BMC Evolutionary Biology · doi:10.1186/1471-2148-11-294 · Cited by 19

Structure of a Spumaretrovirus Gag Central Domain Reveals an Ancient Retroviral Capsid

Ball, N. J., Nicastro, G., Dutta, M., Pollard, D. J., Goldstone, D. C., Sanz-Ramos, M., Ramos, A., Müllers, E., Stirnnagel, K., Stanke, N., et al. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1005981 · Cited by 19

TRIM5α Promotes Ubiquitination of Rta from Epstein–Barr Virus to Attenuate Lytic Progression

Huang, H.-H., Chen, C.-S., Wang, W., Hsu, S.-W., Tsai, H., Liu, S., & Chang, L.-K. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.02129 · Cited by 19

TBK1 is ubiquitinated by TRIM5α to assemble mitophagy machinery

Saha, B., Olsvik, H. L., Williams, G. L., Oh, S., Evjen, G., Sjøttem, E., & Mandell, M. A. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114294 · Cited by 20

Anti-HIV Factors: Targeting Each Step of HIV's Replication Cycle

Colomer-Lluch, M., Gollahon, L., & Serra-Moreno, R. (2016) · Current HIV Research · doi:10.2174/1570162x14999160224094621 · Cited by 17

TRIM7 Restricts Coxsackievirus and Norovirus Infection by Detecting the C-Terminal Glutamine Generated by 3C Protease Processing

Lupták, J., Mallery, D. L., Jahun, A. S., Albecka, A., Clift, D., Ather, O., Slodkowicz, G., Goodfellow, I., & James, L. C. (2022) · Viruses · doi:10.3390/v14081610 · Cited by 18

Spatiotemporal binding of cyclophilin A and CPSF6 to capsid regulates HIV-1 nuclear entry and integration

Ingram, Z., Kline, C. E., Hughson, A. K., Singh, P. K., Fischer, H. L., Radhakrishnan, R., Sowd, G. A., dos Santos, N. F. B., Ganser‐Pornillos, B. K., Watkins, S. C., et al. (2025) · mBio · doi:10.1128/mbio.00169-25 · Cited by 16

The role of tripartite motif family members in mediating susceptibility to HIV-1 infection

Rahm, N., & Telenti, A. (2012) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0b013e32835048e1 · Cited by 20

Cellular and Biochemical Mechanisms of the Retroviral Restriction Factor SAMHD1

Wu, L. J. (2013) · ISRN Biochemistry · doi:10.1155/2013/728392 · Cited by 19

Interactomic analysis reveals a homeostatic role for the HIV restriction factor TRIM5α in mitophagy

Saha, B., Salemi, M., Williams, G. L., Oh, S., Paffett, M. L., Phinney, B. S., & Mandell, M. A. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110797 · Cited by 18

Independent Birth of a Novel TRIMCyp in Tupaia belangeri with a Divergent Function from Its Paralog TRIM5

Mu, D., Yang, H., Zhu, J.-W., Liu, F., Tian, R., Zheng, H., Han, J.-B., Shi, P., & Zheng, Y. (2014) · Molecular Biology and Evolution · doi:10.1093/molbev/msu238 · Cited by 18

A Potent Postentry Restriction to Primate Lentiviruses in a Yinpterochiropteran Bat

Morrison, J. H., Miller, C. M., Bankers, L., Crameri, G. S., Wang, L., & Poeschla, E. M. (2020) · mBio · doi:10.1128/mbio.01854-20 · Cited by 20

Delayed disease progression in HIV-2: the importance of TRIM5α and the retroviral capsid

Boswell, M. T., & Rowland‐Jones, S. (2019) · Clinical & Experimental Immunology · doi:10.1111/cei.13280 · Cited by 18

Nef, the shuttling molecular adaptor of HIV, influences the cytokine network

Percario, Z. A., Ali, M., Mangino, G., & Affabris, E. (2014) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2014.11.010 · Cited by 17

Friend retrovirus drives cytotoxic effectors through Toll-like receptor 3

Sutter, K., Francois, S., Sigmund, A. M., Harper, M. S., Barrett, B. S., Kirchning, C. J., Lu, M., Santiago, M. L., & Dittmer, U. (2014) · Retrovirology · doi:10.1186/s12977-014-0126-4 · Cited by 17

Positive Regulation of TRAF6-Dependent Innate Immune Responses by Protein Phosphatase PP1-γ

Opaluch, A. M., Schneider, M., Chiang, C.-Y., Nguyen, Q., Maestre, A. M., Mulder, L. C. F., Secundino, I., Jesus, P. D. D., König, R., Simon, V. R., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0089284 · Cited by 17

HIV‐1, ubiquitin and ubiquitin‐like proteins: the dialectic interactions of a virus with a sophisticated network of post‐translational modifications

Biard‐Piechaczyk, M., Borel, S., Espert, L., de Bettignies, G., & Coux, O. (2011) · Biology of the Cell · doi:10.1111/boc.201100112 · Cited by 18

The novel gene TRIM44L from orange-spotted grouper negatively regulates the interferon response

Zheng, J., Ya, Z., Zhi, L., Lv, S., Xiao, L., Huang, X., Huang, Y., & Qin, Q. (2019) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2019.06.062 · Cited by 17

Lentiviral Effector Pathways of TRIM Proteins

Turrini, F., Pietro, A. D., & Vicenzi, E. (2014) · DNA and Cell Biology · doi:10.1089/dna.2014.2374 · Cited by 17

A non-canonical role for the autophagy machinery in anti-retroviral signaling mediated by TRIM5α

Saha, B., Chisholm, D., Kell, A. M., & Mandell, M. A. (2020) · PLOS Pathogens · doi:10.1371/journal.ppat.1009017 · Cited by 16

Cell-free assays reveal that the HIV-1 capsid protects reverse transcripts from cGAS immune sensing

Scott, T. M., Arnold, L. M., Powers, J. A., McCann, D., Rowe, A. B., Christensen, D. E., Pereira, M. J. B., Zhou, W., Torrez, R. M., Iwasa, J., et al. (2025) · PLoS Pathogens · doi:10.1371/journal.ppat.1012206 · Cited by 16

Recognize Yourself—Innate Sensing of Non-LTR Retrotransposons

Lagisquet, J., Zuber, K., & Gramberg, T. (2021) · Viruses · doi:10.3390/v13010094 · Cited by 17

Cellular Restriction Factors of Feline Immunodeficiency Virus

Zielonka, J., & Münk, C. (2011) · Viruses · doi:10.3390/v3101986 · Cited by 16

Pattern Recognition Receptors in HIV Transmission

Mesman, A. W., & Geijtenbeek, T. B. H. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00059 · Cited by 17

Nonhuman TRIM5 Variants Enhance Recognition of HIV-1-Infected Cells by CD8 + T Cells

Jiménez‐Moyano, E., Ruiz, A., Kløverpris, H. N., Rodriguez-Plata, M. T., Peña, R., Blondeau, C., Selwood, D. L., Izquierdo‐Useros, N., Moris, A., Clotet, B., et al. (2016) · Journal of Virology · doi:10.1128/jvi.00819-16 · Cited by 16

Exploring Coronary Artery Disease GWAs Targets With Functional Links to Immunometabolism

Hughes, M., Lenighan, Y. M., Godson, C., & Roche, H. M. (2018) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2018.00148 · Cited by 16

The Cell Biology of TRIM5α

Lukic, Z., & Campbell, E. M. (2011) · Current HIV/AIDS Reports · doi:10.1007/s11904-011-0102-8 · Cited by 16

Opposite transcriptional regulation of integrated vs unintegrated HIV genomes by the NF-κB pathway

Thierry, S., Thierry, E., Subra, F., Deprez, E., Leh, H., Bury‐Moné, S., & Delelis, O. (2016) · Scientific Reports · doi:10.1038/srep25678 · Cited by 16

Characterization of porcine tripartite motif genes as host restriction factors against PRRSV and PEDV infection

Wei, Y., Zou, C., Zeng, S., Xue, C., & Cao, Y. (2019) · Virus Research · doi:10.1016/j.virusres.2019.197647 · Cited by 16

SERINC5 Can Enhance Proinflammatory Cytokine Production by Primary Human Myeloid Cells in Response to Challenge with HIV-1 Particles

Pierini, V., Gallucci, L., Stürzel, C. M., Kirchhoff, F., & Fackler, O. (2021) · Journal of Virology · doi:10.1128/jvi.02372-20 · Cited by 16

TRIM5α recruits HDAC1 to p50 and Sp1 and promotes H3K9 deacetylation at the HIV-1 LTR

Ran, X.-H., Zhu, J.-W., Ni, R.-Z., Zheng, Y., Chen, Y.-Y., Zheng, W.-H., & Mu, D. (2023) · Nature Communications · doi:10.1038/s41467-023-39056-6 · Cited by 16

K63-Linked Ubiquitin Is Required for Restriction of HIV-1 Reverse Transcription and Capsid Destabilization by Rhesus TRIM5α

Imam, S., Keceli, S. K., Mattick, J., Selyutina, A., Talley, S., Eddins, A., Diaz‐Griffero, F., & Campbell, E. M. (2019) · Journal of Virology · doi:10.1128/jvi.00558-19 · Cited by 16

Heroin use is associated with lower levels of restriction factors and type I interferon expression and facilitates HIV-1 replication

Zhu, J.-W., Liu, F., Mu, D., Deng, D., & Zheng, Y. (2017) · Microbes and Infection · doi:10.1016/j.micinf.2017.01.002 · Cited by 15

Human Primary Macrophages Derived In Vitro from Circulating Monocytes Comprise Adherent and Non-Adherent Subsets with Differential Expression of Siglec-1 and CD4 and Permissiveness to HIV-1 Infection

Jobe, O., Kim, J., Tycksen, E., Onkar, S., Michael, N. L., Alving, C. R., & Rao, M. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01352 · Cited by 15

E2 conjugating enzymes: A silent but crucial player in ubiquitin biology

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It’s a TRIM-endous view from the top: the varied roles of TRIpartite Motif proteins in brain development and disease

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Ebola virus VP35 interacts non-covalently with ubiquitin chains to promote viral replication

Rodríguez-Salazar, C. A., van Tol, S., Mailhot, O., González-Orozco, M., Galdino, G. T., Warren, A. N., Teruel, N., Behera, P., Afreen, K. S., Zhang, L., et al. (2024) · PLoS Biology · doi:10.1371/journal.pbio.3002544 · Cited by 16

Ancient and Recent Adaptive Evolution in the AntiviralTRIM22Gene: Identification of a Single-Nucleotide Polymorphism That Impacts TRIM22 Function

Kelly, J. N., Woods, M. W., Xhiku, S., & Barr, S. D. (2014) · Human Mutation · doi:10.1002/humu.22595 · Cited by 14

Macaque-tropic human immunodeficiency virus type 1: breaking out of the host restriction factors

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A putative SUMO interacting motif in the B30.2/SPRY domain of rhesus macaque TRIM5α important for NF-κB/AP-1 signaling and HIV-1 restriction

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Interplay between HIV-1 innate sensing and restriction in mucosal dendritic cells: balancing defense and viral transmission

Hertoghs, N., Geijtenbeek, T. B. H., & Ribeiro, C. M. S. (2017) · Current Opinion in Virology · doi:10.1016/j.coviro.2017.01.001 · Cited by 15

Cyclophilins A and B oppositely regulate renal tubular epithelial cell phenotype

Sarró, E., Durán, M., Rico, A., Bou‐Teen, D., Fernández‐Majada, V., Croatt, A. J., Nath, K. A., Salcedo, M. T., Gundelach, J. H., BATLLE, D. C., et al. (2020) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjaa005 · Cited by 14

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TRIM5 structure, HIV-1 capsid recognition, and innate immune signaling

Grütter, M. G., & Luban, J. (2012) · Current Opinion in Virology · doi:10.1016/j.coviro.2012.02.003 · Cited by 137

TRIM5 does double duty

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TRIM5 Acts as More Than a Retroviral Restriction Factor

de Silva, S., & Wu, L. J. (2011) · Viruses · doi:10.3390/v3071204 · Cited by 14

TRIM5 and the Regulation of HIV-1 Infectivity

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Review Article

Luban, J. (2012)