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Functional mapping of single spines in cortical neurons in vivo.

Chen, Xiaowei, Leischner, Ulrich, Rochefort, Nathalie L., Nelken, Israel, Konnerth, Arthur·2011·Nature

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Abstract

The individual functional properties and spatial arrangement of afferent synaptic inputs on dendrites have a critical role in the processing of information by neurons in the mammalian brain. Although recent work has identified visually-evoked local dendritic calcium signals in the rodent visual cortex, sensory-evoked signalling on the level of dendritic spines, corresponding to individual afferent excitatory synapses, remains unexplored. Here we used a new variant of high-resolution two-photon imaging to detect sensory-evoked calcium transients in single dendritic spines of mouse cortical neurons in vivo. Calcium signals evoked by sound stimulation required the activation of NMDA (N-methyl-D-aspartate) receptors. Active spines are widely distributed on basal and apical dendrites and pure-tone stimulation at different frequencies revealed both narrowly and widely tuned spines. Notably, spines tuned for different frequencies were highly interspersed on the same dendrites: even neighbouring spines were mostly tuned to different frequencies. Thus, our results demonstrate that NMDA-receptor-dependent single-spine synaptic inputs to the same dendrite are highly heterogeneous. Furthermore, our study opens the way for in vivo mapping of functionally defined afferent sensory inputs with single-synapse resolution.

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Authors: Chen, X., Leischner, U., Rochefort, N. L., Nelken, I., & Konnerth, A.
Affiliations: Center for Integrated Protein Science Munich (DE)
Hebrew University of Jerusalem (IL)
Corresponding author: Konnerth, Arthur
ORCID: Chen, Xiaowei
Leischner, Ulrich
Rochefort, Nathalie L.
Nelken, Israel
Konnerth, Arthur
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2011-06-26
Volume: 475
Issue: 7357
Pages: 501-505
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature10193
OpenAlex: W1985450720
Cited by: 395
References: 43
Citations by year: 2026: 16 · 2025: 19 · 2024: 26 · 2023: 20 · 2022: 19 · 2021: 23 · 2020: 21 · 2019: 31 · 2018: 24 · 2017: 29 · 2016: 20 · 2015: 30 · 2014: 32 · 2013: 37 · 2012: 39
FWCI: 15.36
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: dendritic spines, auditory cortex, NMDA receptor, frequency tuning, dendritic integration, two-photon calcium imaging, mouse auditory cortex, in vivo imaging
MeSH terms: Acoustic Stimulation, Animals, Brain Mapping, Image Processing, Computer-Assisted, Mice, Inbred C57BL, Visual Cortex, Calcium Signaling, Microscopy, Fluorescence, Multiphoton, Dendritic Spines, Mice

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Functional mapping of single spines in cortical neurons in vivo.

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