The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
A sensing array of radically coupled genetic ‘biopixels’
Open accessAbstract
Although there has been considerable progress in the development of engineering principles for synthetic biology, a substantial challenge is the construction of robust circuits in a noisy cellular environment. Such an environment leads to considerable intercellular variability in circuit behaviour, which can hinder functionality at the colony level. Here we engineer the synchronization of thousands of oscillating colony ‘biopixels’ over centimetre-length scales through the use of synergistic intercellular coupling involving quorum sensing within a colony and gas-phase redox signalling between colonies. We use this platform to construct a liquid crystal display (LCD)-like macroscopic clock that can be used to sense arsenic via modulation of the oscillatory period. Given the repertoire of sensing capabilities of bacteria such as Escherichia coli, the ability to coordinate their behaviour over large length scales sets the stage for the construction of low cost genetic biosensors that are capable of detecting heavy metals and pathogens in the field.
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Cites
Stochastic Gene Expression in a Single Cell
Elowitz, M. B., Levine, A. J., Siggia, E. D., & Swain, P. S. (2002) · Science · doi:10.1126/science.1070919 · Cited by 5,441
Fridovich (1978) · doi:10.1126/science.210504 · Cited by 3,329
Foundations for engineering biology
Endy, D. (2005) · Nature · doi:10.1038/nature04342 · Cited by 1,511
Role of a peptide tagging system in degradation of proteins synthesized from damaged messenger RNA
Keiler, K. C., Waller, P. R. H., & Sauer, R. T. (1996) · Science · doi:10.1126/science.271.5251.990 · Cited by 1,125
Cited by
A brief history of synthetic biology
Cameron, D. E., Bashor, C. J., & Collins, J. J. (2014) · Nature Reviews Microbiology · doi:10.1038/nrmicro3239 · Cited by 933
Synchronized cycles of bacterial lysis for in vivo delivery
Din, M. O., Danino, T., Prindle, A., Skalak, M., Selimkhanov, J., Allen, K., Julio, E., Atolia, E., Tsimring, L. S., Bhatia, S. N., et al. (2016) · Nature · doi:10.1038/nature18930 · Cited by 784
Self-citationEngineered probiotics for local tumor delivery of checkpoint blockade nanobodies
Gurbatri, C. R., Lia, I., Vincent, R., Coker, C., Castro, S., Treuting, P. M., Hinchliffe, T. E., Arpaia, N., & Danino, T. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aax0876 · Cited by 647
Self-citationFan, J., Peng, M., Wang, H., Zheng, H., Liu, Z., Li, C., Wang, X., Liu, X., Cheng, S., & Zhang, X. (2019) · Advanced Materials · doi:10.1002/adma.201808278 · Cited by 363
Abrupt Desynchronization and Extensive Multistability in Globally Coupled Oscillator Simplexes
Skardal, P. S., & Arenas, A. (2019) · Physical Review Letters · doi:10.1103/physrevlett.122.248301 · Cited by 304
Metadata
- Authors
- Prindle, A., Samayoa, P., Razinkov, I., Danino, T., Tsimring, L. S., & Hasty, J.
- Venue
- Nature
- Published
- 2011-12-18
- Volume
- 481
- Issue
- 7379
- Pages
- 39-44
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2141564052
- Cited by
- 397
- References
- 4
- FWCI
- 11.52
- Type
- journal article
- Language
- en
- Open access
- green
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