The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity
Open accessAbstract
Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome and the leading cause of chronic liver disease in the Western world. Twenty per cent of NAFLD individuals develop chronic hepatic inflammation (non-alcoholic steatohepatitis, NASH) associated with cirrhosis, portal hypertension and hepatocellular carcinoma, yet the causes of progression from NAFLD to NASH remain obscure. Here, we show that the NLRP6 and NLRP3 inflammasomes and the effector protein IL-18 negatively regulate NAFLD/NASH progression, as well as multiple aspects of metabolic syndrome via modulation of the gut microbiota. Different mouse models reveal that inflammasome-deficiency-associated changes in the configuration of the gut microbiota are associated with exacerbated hepatic steatosis and inflammation through influx of TLR4 and TLR9 agonists into the portal circulation, leading to enhanced hepatic tumour-necrosis factor (TNF)-α expression that drives NASH progression. Furthermore, co-housing of inflammasome-deficient mice with wild-type mice results in exacerbation of hepatic steatosis and obesity. Thus, altered interactions between the gut microbiota and the host, produced by defective NLRP3 and NLRP6 inflammasome sensing, may govern the rate of progression of multiple metabolic syndrome-associated abnormalities, highlighting the central role of the microbiota in the pathogenesis of heretofore seemingly unrelated systemic auto-inflammatory and metabolic disorders.
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In the citing paper
“Either in patients with NASH or animal models, the expression of inflammasome components was increased, indicating the potential role in the pathogenesis of liver injury [226,227,288,289,290,291].”
From Gut-pancreas-liver Axis as a target for treatment of NAFLD/NASH (2020) · cites this paper as [226]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“LPS-mediated activation of KCs via TLR4 leading to MyD88-dependent activation of NF-kB, production of proinflammatory cytokines and subsequent liver injury have also been demonstrated for both MASH(214) and ASH(215).”
From The liver as a central "hub" of the immune system: pathophysiological implications (2025) · cites this paper as [214]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Animal studies have demonstrated a direct role of altered intestinal microbiota in steatosis,15 NASH(16), fibrosis17 and liver cancer.18”
From Intestinal B cells license metabolic T-cell activation in NASH microbiota/antigen-independently and contribute to fibrosis by IgA-FcR signalling (2023) · cites this paper as [16]
In the citing paper
“In NAFLD models, lack of inflammasomes has been demonstrated to select a pathogenetic microbiota which was associated with a more severe degree of liver injury [226].”
From Gut-pancreas-liver Axis as a target for treatment of NAFLD/NASH (2020) · cites this paper as [226]
In the citing paper
“These results indicate that complex interactions between the diet, the innate immunity, bacteria and intestinal function occurs in the development of NASH [226,227], and similar observations were obtained in experimental models of HCC development [285,286,287].”
From Gut-pancreas-liver Axis as a target for treatment of NAFLD/NASH (2020) · cites this paper as [226]
In the citing paper
“Co-housing wildtype mice with mice prone to MASH led to increased disease severity in wildtype mice, presumably due to a transfer of fecal microbiota (204).”
From Found in translation—Fibrosis in metabolic dysfunction–associated steatohepatitis (MASH) (2023) · cites this paper as [204]
In the citing paper
“In the MCD diet model, the microbiota has a key role in NASH exacerbation as demonstrated by experiments, in which co-housing transmitted NASH risk and antibiotics reduced NASH risk65.”
From The gut microbiome and liver cancer: mechanisms and clinical translation (2017) · cites this paper as [65]
In the citing paper
“Functional studies utilizing co-housing and faecal transplantation have provided evidence that dysbiosis is a transmissible driver of liver disease development and progression 65,89.”
From The gut microbiome and liver cancer: mechanisms and clinical translation (2017) · cites this paper as [65]
In the citing paper
“Similarly, dysbiosis represented a transmissible risk factor in a genetic NASH model in which NASH was triggered by inflammasome deficiency; co-housing of dysbiotic inflammasome-deficient mice with control mice resulted in the development of NASH in control mice65.”
From The gut microbiome and liver cancer: mechanisms and clinical translation (2017) · cites this paper as [65]
In the citing paper
“Association of bacterial composition with many diseases has been observed, including immune, inflammatory, and metabolic phenotypes.”
From The Gut Microbiome Contributes to a Substantial Proportion of the Variation in Blood Lipids (2015) · cites this paper as [5]
In the citing paper
“Disruption of the murine inflammasomes (see box 1) is associated with an increase in Bacteroidetes and reduction in Firmicutes and results in severe hepatic steatosis and inflammation.41”
From The gut microbiota and host health: a new clinical frontier (2016) · cites this paper as [41]
In the citing paper
“the NLRP6 and NLRP3 inflammasomes may exert protective effects against NAFLD/NASH through modulation of the gut microbiota.181”
From Interaction between microbiota and immunity in health and disease (2020) · cites this paper as [181]
In the citing paper
“Dysbiosis has been observed in mice deficient for inflammasomes components, including NLRP6, ASC, caspase-1, and IL-18 [131,132,133,134].”
From Gut Microbiota and Cancer: From Pathogenesis to Therapy (2019) · cites this paper as [134]
In the citing paper
“The Muc2-KO mouse possesses a distinct gut-associated bacterial community that is influenced by its altered genetic and immune states, as has been shown in other genetic knockout mouse models.4,53–55”
From Using Corticosteroids to Reshape the Gut Microbiome: Implications for Inflammatory Bowel Diseases (2015) · cites this paper as [54]
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Citations
Cites
QIIME allows analysis of high-throughput community sequencing data
Caporaso, J. G., Kuczynski, J., Stombaugh, J., Bittinger, K., Bushman, F. D., Costello, E. K., Fierer, N., Peña, A. G., Goodrich, J. K., Gordon, J. I., et al. (2010) · Nature Methods · doi:10.1038/nmeth.f.303 · Cited by 34,887
Self-citationDesign and validation of a histological scoring system for nonalcoholic fatty liver disease†
Kleiner, D. E., Brunt, E. M., Van Natta, M., Behling, C., Contos, M. J., Cummings, O. W., Ferrell, L. D., Liu, Y., Torbenson, M. S., Unalp‐Arida, A., et al. (2005) · Hepatology · doi:10.1002/hep.20701 · Cited by 10,791
A Toll-like receptor recognizes bacterial DNA
Hemmi, H., Takeuchi, O., Kawai, T., Kaisho, T., Sato, S., Sanjo, H., Matsumoto, M., Hoshino, K., Wagner, H., Takeda, K., et al. (2000) · Nature · doi:10.1038/35047123 · Cited by 6,491 · cited 1×
“Tlr9 –/– mice have been described in another repor”
BackgroundMartinon, F., Burns, K., & Tschopp, J. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00599-3 · Cited by 6,066
A role for mitochondria in nlrp3 inflammasome activation
Zhou, R., Yazdi, A. S., Menu, P., & Tschopp, J. (2011) · Nature · doi:10.1038/nature09663 · Cited by 5,602
Steatohepatitis: A tale of two “hits”?
Day, C. P., & James, O. F. W. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70599-2 · Cited by 4,285
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
Duewell, P., Kono, H., Rayner, K. J., Sirois, C. M., Vladimer, G., Bauernfeind, F. G., Abela, G. S., Franchi, L., Nuñez, G., Schnurr, M., et al. (2010) · Nature · doi:10.1038/nature08938 · Cited by 4,026
Ludwig, J., Viggiano, T. R., McGill, D. B., & Ott, B. J. (1980) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(24)00530-5 · Cited by 2,903
Nonalcoholic Fatty Liver, Steatohepatitis, and the Metabolic Syndrome
Marchesini, G., Bugianesi, E., Forlani, G., Cerrelli, F., Lenzi, M., Manini, R., Natale, S., Vanni, E., Villanova, N., Melchionda, N., et al. (2003) · Hepatology · doi:10.1053/jhep.2003.50161 · Cited by 2,728
Thioredoxin-interacting protein links oxidative stress to inflammasome activation
Zhou, R., Tardivel, A., Thorens, B., Choi, I., & Tschopp, J. (2010) · Nature Immunology · doi:10.1038/ni.1831 · Cited by 2,708
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Human intestinal metagenomics: state of the art and future
Blottière, H. M., de Vos, W. M., Ehrlich, S. D., & Dore, J. M. (2013) · Current Opinion in Microbiology · doi:10.1016/j.mib.2013.06.006 · Cited by 78
Burz, S. D., Monnoye, M., Philippe, C., Farin, W., Ratziu, V., Strozzi, F., Paillarse, J.-M., Chêne, L., Blottière, H. M., & Gérard, P. (2021) · Microorganisms · doi:10.3390/microorganisms9010199 · Cited by 75
Peiseler, M., & Tacke, F. (2021) · Cancers · doi:10.3390/cancers13040730 · Cited by 77
Gut Microbiota Affects Sensitivity to Acute DSS-induced Colitis Independently of Host Genotype
Brinkman, B. M. N., Becker, A. A. M. J., Ayiseh, R. B., Hildebrand, F., Raes, J., Huys, G. R. B., & Vandenabeele, P. (2013) · Inflammatory Bowel Diseases · doi:10.1097/mib.0b013e3182a8759a · Cited by 74
MiRNA-194 Regulates Palmitic Acid-Induced Toll-Like Receptor 4 Inflammatory Responses in THP-1 Cells
Tian, H., Liu, C., Zou, X., Wu, W., Zhang, C., & Yuan, D. (2015) · Nutrients · doi:10.3390/nu7053483 · Cited by 71
Nicolson, G. L., & Ash, M. E. (2017) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2017.04.013 · Cited by 75
What are the effects of proton pump inhibitors on the small intestine?
Fujimori, S. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i22.6817 · Cited by 70
Torok, N. J., Dranoff, J. A., Schuppan, D., & Friedman, S. L. (2015) · Hepatology · doi:10.1002/hep.27720 · Cited by 71
Probiotics in valorization of innate immunity across various animal models
Patel, S. V., Shukla, R., & Goyal, A. (2015) · Journal of Functional Foods · doi:10.1016/j.jff.2015.02.022 · Cited by 70
Grayson, M. H., Camarda, L. E., Hussain, S.-R. A., Zemple, S. J., Hayward, M., Lam, V., Hunter, D., Santoro, J. L., Rohlfing, M. M., Cheung, D. S., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01587 · Cited by 71
Chong, C. Y. L., Orr, D. W., Plank, L. D., Vatanen, T., O'Sullivan, J. M., & Murphy, R. (2020) · Nutrients · doi:10.3390/nu12040937 · Cited by 70
Ning, K., Lu, K., Chen, Q., Guo, Z., Du, X., Riaz, F., Feng, L., Fu, Y., Yin, C., Zhang, F., et al. (2020) · ACS Omega · doi:10.1021/acsomega.0c01689 · Cited by 70
Identification of an ASC oligomerization inhibitor for the treatment of inflammatory diseases
Soriano‐Teruel, P. M., García‐Laínez, G., Marco-Salvador, M., Pardo, J., Arias, M. A., DeFord, C., Merfort, I., Vicent, M. J., Pelegrı́n, P., Sancho, M., et al. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-04420-1 · Cited by 70
NLRPs , microbiota, and gut homeostasis: unravelling the connection
Zambetti, L. P., & Mortellaro, A. (2014) · The Journal of Pathology · doi:10.1002/path.4357 · Cited by 73
Mohamed, F. E. Z. A., Al-Jehani, R. M., Minogue, S., Andreola, F., Winstanley, A. M., Damink, S. W. M. O., Habtesion, A., Malagó, M., Davies, N. A., Luong, T. V., et al. (2014) · Liver International · doi:10.1111/liv.12626 · Cited by 70
Chen, K., Ma, J., Jia, X., Ai, W., Ma, Z., & Pan, Q. (2018) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2018.11.005 · Cited by 72
Concise review: Coarse cereals exert multiple beneficial effects on human health
Fu, J., Zhang, Y., Hu, Y., Zhao, G., Tang, Y., & Zou, L. (2020) · Food Chemistry · doi:10.1016/j.foodchem.2020.126761 · Cited by 70
Combined alcoholic and non-alcoholic steatohepatitis
Wandji, L. C. N., Gnemmi, V., Mathurin, P., & Louvet, A. (2020) · JHEP Reports · doi:10.1016/j.jhepr.2020.100101 · Cited by 70
Fever control in septic shock: beneficial or harmful?
Su, F., Nguyen, N. D., Wang, Z., Cai, Y., Rogiers, P., & Vincent, J. (2005) · PubMed · doi:10.1097/01.shk.0000161390.46688.da · Cited by 73
Bridging immunity and lipid metabolism by gut microbiota
Greer, R. L., Morgun, A., & Shulzhenko, N. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.06.025 · Cited by 69
Acute graft-versus-host disease is regulated by an IL-17–sensitive microbiome
Varelias, A., Ormerod, K. L., Bunting, M. D., Koyama, M., Gartlan, K. H., Kuns, R. D., Lachner, N., Locke, K. R., Lim, C. Y. H., Henden, A. S., et al. (2017) · Blood · doi:10.1182/blood-2016-08-732628 · Cited by 69
Free Fatty Acid Receptors as Mediators and Therapeutic Targets in Liver Disease
Secor, J. D., Fligor, S. C., Tsikis, S. T., Yu, L. J., & Puder, M. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.656441 · Cited by 73
Liver Injury and the Activation of the Hepatic Myofibroblasts
Jiang, J. X., & Torok, N. J. (2013) · Current Pathobiology Reports · doi:10.1007/s40139-013-0019-6 · Cited by 70
Role of the microbiome in non-gastrointestinal cancers
Pevsner‐Fischer, M., Tuganbaev, T., Meijer, M. T., Zhang, S., Zeng, Z., Chen, M., & Elinav, E. (2016) · World Journal of Clinical Oncology · doi:10.5306/wjco.v7.i2.200 · Cited by 72
Self-citationMalondialdehyde epitopes are sterile mediators of hepatic inflammation in hypercholesterolemic mice
Busch, C. J., Hendrikx, T., Weismann, D., Jäckel, S., Walenbergh, S. M. A., Rendeiro, A. F., Weißer, J., Puhm, F., Hladik, A., Göderle, L., et al. (2016) · Hepatology · doi:10.1002/hep.28970 · Cited by 69
Circulating microbiota-derived metabolites: a “liquid biopsy?
Aragonès, G., Colom‐Pellicer, M., Aguilar, C., Guiu‐Jurado, E., Martínez, S., Sabench, F., Porras, J. A., Riesco, D., Castillo, D. D., Richart, C., et al. (2019) · International Journal of Obesity · doi:10.1038/s41366-019-0430-0 · Cited by 73
Publisher Correction: The gut–liver axis and the intersection with the microbiome
Tripathi, A., Debelius, J., Brenner, D. A., Karin, M., Loomba, R., Schnabl, B., & Knight, R. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0031-8 · Cited by 70
Pan, X., Kaminga, A. C., Liu, A., Wen, S. W., Luo, M., & Luo, J. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.683743 · Cited by 68
Anatomical localization of commensal bacteria in immune cell homeostasis and disease
Fung, T. C., Artis, D., & Sonnenberg, G. F. (2014) · Immunological Reviews · doi:10.1111/imr.12186 · Cited by 75
Role of gut microbiota: Obesity and NAFLD
Gangarapu, V., Yıldız, K., İnce, A. T., & Baysal, B. (2014) · The Turkish Journal of Gastroenterology · doi:10.5152/tjg.2014.7886 · Cited by 68
Lee, H. J. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i45.12787 · Cited by 68
McCaughey, L. C., Ritchie, N. D., Douce, G. R., Evans, T. J., & Walker, D. (2016) · Scientific Reports · doi:10.1038/srep30201 · Cited by 68
Bifari, F., Ruocco, C., Decimo, I., Fumagalli, G. F., Valerio, A., & Nisoli, E. (2017) · Genes & Nutrition · doi:10.1186/s12263-017-0582-2 · Cited by 70
Microbial Regulation of Glucose Metabolism and Insulin Resistance
Crommen, S., & Simon, M. (2017) · Genes · doi:10.3390/genes9010010 · Cited by 69
Aissa, A. F., Tryndyak, V., de Conti, A., Melnyk, S., Gomes, T. D. U. H., Bianchi, M. L. P., James, S. J., Beland, F. A., Antunes, L. M. G., & Pogribny, I. P. (2014) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201300726 · Cited by 67
Resident commensals shaping immunity
Ertürk-Hasdemir, D., & Kasper, D. L. (2013) · Current Opinion in Immunology · doi:10.1016/j.coi.2013.06.001 · Cited by 68
Xiao, J., Wang, J., Xing, F., Han, T., Jiao, R., Liong, E. C., Fung, M., So, K., & Tipoe, G. L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0095214 · Cited by 67
Fatty Liver Disease and Gut Microbiota: A Comprehensive Update
Campo, L., Eiseler, S., Apfel, T., & Pyrsopoulos, N. (2018) · Journal of Clinical and Translational Hepatology · doi:10.14218/jcth.2018.00008 · Cited by 68
Chen, J., Liu, J., Yan, C., Zhang, C., Pan, W., Zhang, W., Lu, Y., Chen, L., & Chen, Y. (2020) · Food & Function · doi:10.1039/c9fo00963a · Cited by 67
Gut-pancreas-liver Axis as a target for treatment of NAFLD/NASH
Svegliati-Baroni, G., Patrício, B., Lioci, G., Macedo, M. P., & Gastaldelli, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21165820 · Cited by 66
Adipose Tissue Inflammation Induces B Cell Inflammation and Decreases B Cell Function in Aging
Frasca, D., & Blomberg, B. B. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01003 · Cited by 66
Inflammatory Diseases and Vitamin E—What Do We Know and Where Do We Go?
Wallert, M., Börmel, L., & Lorkowski, S. (2020) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202000097 · Cited by 68
Astaxanthin-Shifted Gut Microbiota Is Associated with Inflammation and Metabolic Homeostasis in Mice
Wu, L., Lyu, Y., Ramkumar, S., Wu, J., Ojo, B. A., Tang, M., El-Rassi, G. D., Metzinger, K., Smith, B. J., Lucas, E. A., et al. (2020) · Journal of Nutrition · doi:10.1093/jn/nxaa222 · Cited by 66
Chen, S., Chen, L., Qi, Y., Xu, J., Ge, Q., Fan, Y., Chen, D., Zhang, Y., Wang, L., Hou, T., et al. (2021) · Nature Aging · doi:10.1038/s43587-021-00129-0 · Cited by 69
The IL-1 cytokine family as custodians of barrier immunity
Matarazzo, L., Hernandez-Santana, Y., Walsh, P. T., & Fallon, P. G. (2022) · Cytokine · doi:10.1016/j.cyto.2022.155890 · Cited by 67
Gut mycobiome and metabolic diseases: The known, the unknown, and the future
Wang, L., Zhang, K., Zeng, Y., Luo, Y., Peng, J., Zhang, J., Kuang, T., & Fan, G. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106807 · Cited by 67
Niu, B., Pan, T., Xiao, Y., Wang, H., Zhu, J., Tian, F., Lu, W., & Chen, W. (2024) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2023.2299744 · Cited by 66
Yu, W., Sun, S., Yan, Y., Zhou, H., Liu, Z., & Fu, Q. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1519925 · Cited by 70
The potential of silymarin for the treatment of hepatic disorders
Hellerbrand, C., Schattenberg, J. M., Peterburs, P., Lechner, A., & Brignoli, R. (2016) · Clinical Phytoscience · doi:10.1186/s40816-016-0019-2 · Cited by 67
Guo, Y. H., Liu, C., Shan, C., Chen, Y., Li, H., Huang, Z., & Zou, D. (2016) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2857 · Cited by 67
Yuan, Y., Wu, X., Zhang, X., Hong, Y., & Yan, H. (2019) · Food and Chemical Toxicology · doi:10.1016/j.fct.2019.01.007 · Cited by 66
Does a prenatal bacterial microbiota exist?
Hornef, M. W., & Penders, J. (2017) · Mucosal Immunology · doi:10.1038/mi.2016.141 · Cited by 68
The Interplay Between Tissue Niche and Macrophage Cellular Metabolism in Obesity
Daemen, S., & Schilling, J. D. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2019.03133 · Cited by 68
Wang, F., Park, J.-S., Ma, Y., Ma, H., Lee, Y.-J., Lee, G., Yoo, H., Hong, J. T., & Roh, Y. (2021) · Nutrients · doi:10.3390/nu13030856 · Cited by 67
The Intestinal Microbiota in Chronic Liver Disease
Henao‐Mejia, J., Elinav, E., Thaiss, C. A., & Flavell, R. A. (2013) · Advances in immunology · doi:10.1016/b978-0-12-410524-9.00003-7 · Cited by 70
Self-citationThe Dimension of Time in Host-Microbiome Interactions
Uhr, G. T., Dohnalová, L., & Thaiss, C. A. (2019) · mSystems · doi:10.1128/msystems.00216-18 · Cited by 70
Self-citationBourrie, B. C. T., Cotter, P. D., & Willing, B. P. (2018) · Journal of Functional Foods · doi:10.1016/j.jff.2018.04.039 · Cited by 64
A “systems medicine” approach to the study of non-alcoholic fatty liver disease
Petta, S., Valenti, L. V. C., Bugianesi, E., Targher, G., Bellentani, S., Bonino, F., Ferrannini, E., Loguercio, C., Lonardo, A., Marra, F., et al. (2015) · Digestive and Liver Disease · doi:10.1016/j.dld.2015.10.027 · Cited by 66
Role of Bile Acids in Dysbiosis and Treatment of Nonalcoholic Fatty Liver Disease
Wang, C., Zhu, C., Shao, L., Ye, J., Shen, Y., & Ren, Y. (2019) · Mediators of Inflammation · doi:10.1155/2019/7659509 · Cited by 67
Interleukin-17 in Liver Disease Pathogenesis
Li, N., Yamamoto, G., Fuji, H., & Kisseleva, T. (2021) · Seminars in Liver Disease · doi:10.1055/s-0041-1730926 · Cited by 64
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Fukui, H. (2015) · Microorganisms · doi:10.3390/microorganisms3040759 · Cited by 64
Cannito, S., Morello, E., Bocca, C., Foglia, B., Benetti, E., Novo, E., Chiazza, F., Rogazzo, M., Fantozzi, R., Povero, D., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0172575 · Cited by 65
NLRP3 Inflammasome and IL-33: Novel Players in Sterile Liver Inflammation
Neumann, K., Schiller, B., & Tiegs, G. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19092732 · Cited by 64
Cardiovascular and Metabolic Protection by Vitamin E: A Matter of Treatment Strategy?
Ziegler, M., Wallert, M., Lorkowski, S., & Peter, K. (2020) · Antioxidants · doi:10.3390/antiox9100935 · Cited by 66
Two-signal requirement for growth-promoting function of Yap in hepatocytes
Su, T., Bondar, T., Zhou, X., Zhang, C., He, H., & Medzhitov, R. (2015) · eLife · doi:10.7554/elife.02948 · Cited by 64
NLRP3 inflammasome in hepatic diseases: A pharmacological target
Ramos‐Tovar, E., & Muriel, P. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115861 · Cited by 66
Is the Intestinal Goblet Cell a Major Immune Cell?
Johansson, M., & Hansson, G. C. (2014) · Cell Host & Microbe · doi:10.1016/j.chom.2014.02.014 · Cited by 63
The intestinal microbiota and microenvironment in liver
Ma, H.-D., Wang, Y., Chang, C. C.-C., Gershwin, M. E., & Lian, Z. (2014) · Autoimmunity Reviews · doi:10.1016/j.autrev.2014.10.013 · Cited by 64
Helicobacter pyloriinfection and liver diseases: Epidemiology and insights into pathogenesis
Okushin, K., Tsutsumi, T., Ikeuchi, K., Kado, A., Enooku, K., Fujinaga, H., Moriya, K., Yotsuyanagi, H., & Koike, K. (2018) · World Journal of Gastroenterology · doi:10.3748/wjg.v24.i32.3617 · Cited by 63
Gut Microbiota-Derived Mediators as Potential Markers in Nonalcoholic Fatty Liver Disease
Aragonès, G., González-García, S., Aguilar, C., Richart, C., & Auguet, T. (2019) · BioMed Research International · doi:10.1155/2019/8507583 · Cited by 69
Nistal, E., de Miera, L. E. S., Ballesteros-Pomar, M. D., Sánchez‐Campos, S., García‐Mediavilla, M. V., Álvarez-Cuenllas, B., Linares, P., Olcoz, J. L., Arias, M., Lobo, J. M. G., et al. (2019) · Revista Española de Enfermedades Digestivas · doi:10.17235/reed.2019.6068/2018 · Cited by 64
Zhang, Y., Zhao, F., Deng, Y., Zhao, Y., & Ren, H. (2015) · Journal of Proteome Research · doi:10.1021/pr5011263 · Cited by 62
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Duan, R., Huang, K., Guan, X., Li, S., Xia, J., Shen, M., Sun, Z., & Yu, Z. (2022) · Food and Chemical Toxicology · doi:10.1016/j.fct.2022.112948 · Cited by 62
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Alegre, M.-L., Mannon, R. B., & Mannon, P. (2014) · American Journal of Transplantation · doi:10.1111/ajt.12760 · Cited by 65
Gao, M., Zhang, C., Ma, Y., Bu, L., Yan, L., & Liu, D. (2013) · Molecular Therapy · doi:10.1038/mt.2013.125 · Cited by 62
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Okeke, F. C., Roland, B. C., & Mullin, G. E. (2014) · Global Advances in Health and Medicine · doi:10.7453/gahmj.2014.018 · Cited by 63
Research advances in the relationship between nonalcoholic fatty liver disease and atherosclerosis
Xu, X. Y., Lu, L., Dong, Q., Li, X., Zhang, N., Xin, Y., & Xuan, S. (2015) · Lipids in Health and Disease · doi:10.1186/s12944-015-0141-z · Cited by 62
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Czaja, A. J. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i42.9257 · Cited by 63
Zhao, X., Yang, Y.-Z., Zheng, Y.-J., Wang, S.-C., Gu, H.-M., Pan, Y., Wang, S., Xu, H., & Kong, L. (2017) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2017.05.032 · Cited by 62
Lv, W.-J., Wu, X.-L., Chen, W.-Q., Li, Y.-F., Zhang, G.-F., Chao, L.-M., Zhou, J.-H., Guo, A., Liu, C., & Guo, S.-N. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/7902874 · Cited by 61
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Engelmann, C., & Tacke, F. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020652 · Cited by 61
Dugas, L. R., Bernabé, B. P., Priyadarshini, M., Fei, N., Park, S. J., Brown, L., Plange‐Rhule, J., Nelson, D. E., Toh, E. C., Gao, X., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-35230-9 · Cited by 64
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Functions of intestinal microflora in children
Buccigrossi, V., Nicastro, E., & Guarino, A. (2012) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e32835a3500 · Cited by 63
Goossens, N., Hoshida, Y., Song, W., Jung, M. K., Morel, P., Nakagawa, S., Zhang, B., Frossard, J., Spahr, L., Friedman, S. L., et al. (2015) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2015.10.010 · Cited by 62
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Tsutsui, H., Cai, X., & Hayashi, S. (2015) · Mediators of Inflammation · doi:10.1155/2015/630265 · Cited by 63
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DeSantis, D., Ko, C.-W., Liu, Y., Liu, X., Hise, A. G., Núñez, G., & Croniger, C. M. (2013) · Mediators of Inflammation · doi:10.1155/2013/751374 · Cited by 61
Mao, J., Tang, H., Zhao, T., Tan, X., Bi, J., Wang, B., & Wang, Y.-D. (2015) · Europe PMC (PubMed Central) · Cited by 61
Intestinal Microbiota Protects against MCD Diet-Induced Steatohepatitis
Schneider, K. M., Mohs, A., Kilic, K., Candels, L. S., Elfers, C., Bennek, E., Schneider, L. B., Heymann, F., Gaßler, N., Penders, J., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20020308 · Cited by 61
Deficiency of Mitochondrial Glycerol 3‐Phosphate Dehydrogenase Contributes to Hepatic Steatosis
Zheng, Y., Qu, H., Xiong, X., Wang, Y., Liu, X., Zhang, L., Liao, X., Liao, Q., Sun, Z., Ouyang, Q., et al. (2019) · Hepatology · doi:10.1002/hep.30507 · Cited by 63
Wang, Y., Wu, Y., Wang, B., Xu, H., Mei, X., Xu, X., Zhang, X., Ni, J., & Li, W. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.01161 · Cited by 61
Dong, Z., Zhuang, Q., Ning, M., Wu, S., Lu, L., & Wan, X. (2020) · Annals of Translational Medicine · doi:10.21037/atm.2020.02.21 · Cited by 61
Dong, Z., Zhuang, Q., Ye, X., Ning, M., Wu, S., Lu, L., & Wan, X. (2020) · Frontiers in Medicine · doi:10.3389/fmed.2020.546445 · Cited by 61
Fuchs, C. D., Radun, R., Dixon, E. D., Mlitz, V., Timelthaler, G., Halilbasic, E., Herac, M., Jonker, J. W., Ronda, O. A. H. O., Tardelli, M., et al. (2021) · Hepatology · doi:10.1002/hep.32112 · Cited by 60
Zhang, H., Zha, X., Zhang, B., Zheng, Y., Elsabagh, M., Wang, H., & Wang, M. (2024) · Microbiome · doi:10.1186/s40168-024-01749-5 · Cited by 61
Ferreira, D. M. S., Simão, A. L., Rodrigues, C. M. P., & Castro, R. E. (2014) · FEBS Journal · doi:10.1111/febs.12806 · Cited by 61
Hepatocyte DUSP14 maintains metabolic homeostasis and suppresses inflammation in the liver
Wang, S., Yan, Z., Yang, X., An, S., Zhang, K., Qi, Y., Zheng, J., Ji, Y., Wang, P., Fang, C., et al. (2017) · Hepatology · doi:10.1002/hep.29616 · Cited by 60
Chen, Y., Chiu, C.-C., Hung, S., Huang, W.-C., Lee, Y.-P., Liu, J.-Y., Huang, Y.-T., Chen, T.-H., & Chuang, H.-L. (2019) · Nutrition Research · doi:10.1016/j.nutres.2019.07.001 · Cited by 60
Metadata
- Authors
- Henao-Mejia, J., Elinav, E., Jin, C., Hao, L., Mehal, W. Z., Strowig, T., Thaiss, C. A., Kau, A. L., Eisenbarth, S. C., Jurczak, M. J., Camporez, J.-P., Shulman, G. I., Gordon, J. I., Hoffman, H. M., & Flavell, R. A.
- Affiliations
- Yale University (US)
- Washington University in St. Louis (US)
- Howard Hughes Medical Institute (US)
- University of California San Diego (US)
- Corresponding author
- Flavell, Richard A.
- ORCID
- Venue
- Nature
- Published
- 2012-02
- Volume
- 482
- Issue
- 7384
- Pages
- 179-185
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC3276682
- OpenAlex
- W2144275312
- Cited by
- 2,435
- References
- 41
- Citations by year
- 2026: 83 · 2025: 103 · 2024: 137 · 2023: 165 · 2022: 158 · 2021: 182 · 2020: 215 · 2019: 188 · 2018: 197 · 2017: 184 · 2016: 172 · 2015: 195 · 2014: 181 · 2013: 185 · 2012: 85
- FWCI
- 154.13
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- Crohn's and Colitis Foundation
- U.S. Public Health Service (K08A1085038)
- National Heart, Lung, and Blood Institute (T32HL007974)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK45735, R01-DK40936, R01DK040936, U24DK059635, R01DK076674, R24DK085638, P30DK045735)
- Topics
- Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Keywords
- non-alcoholic fatty liver disease, nonalcoholic steatohepatitis, NLRP3 inflammasome, NLRP6 inflammasome, IL-18, gut dysbiosis, metabolic syndrome, obesity, hepatic steatosis, liver inflammation, TLR4, TLR9, TNF-α, Porphyromonadaceae, host-microbiota interactions, autoinflammatory disease
- MeSH terms
- NLR Family, Pyrin Domain-Containing 3 Protein, Animals, Carrier Proteins, Choline, Colon, Cytoskeletal Proteins, Disease Models, Animal, Fatty Liver, Inflammation, Male, Methionine, Mice, Inbred C57BL, Obesity, Receptors, Cell Surface, RNA, Ribosomal, 16S, Tumor Necrosis Factor-alpha, Disease Progression, Interleukin-18, Apoptosis Regulatory Proteins, Toll-Like Receptor 4, Toll-Like Receptor 9, Mice, CARD Signaling Adaptor Proteins, Metagenome, Inflammasomes, Non-alcoholic Fatty Liver Disease
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