Cited by 66Adipokines, Inflammation, and Metabolic DiseasesT-cell and B-cell ImmunologyAdipose Tissue and Metabolism

Adipose Tissue Inflammation Induces B Cell Inflammation and Decreases B Cell Function in Aging

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Frasca, Daniela, Blomberg, Bonnie B.·2017·Frontiers in Immunology

Abstract

Aging is the greatest risk factor for developing chronic diseases. Inflamm-aging, the age-related increase in low-grade chronic inflammation, may be a common link in age-related diseases. This review summarizes recent published data on potential cellular and molecular mechanisms of the age-related increase in inflammation, and how these contribute to decreased humoral immune responses in aged mice and humans. Briefly, we cover how aging and related inflammation decrease antibody responses in mice and humans, and how obesity contributes to the mechanisms for aging through increased inflammation. We also report data in the literature showing adipose tissue infiltration with immune cells and how these cells are recruited and contribute to local and systemic inflammation. We show that several types of immune cells infiltrate the adipose tissue and these include macrophages, neutrophils, NK cells, innate lymphoid cells, eosinophils, T cells, B1, and B2 cells. Our main focus is how the adipose tissue affects immune responses, in particular B cell responses and antibody production. The role of leptin in generating inflammation and decreased B cell responses is also discussed. We report data published by us and by other groups showing that the adipose tissue generates pro-inflammatory B cell subsets which induce pro-inflammatory T cells, promote insulin resistance, and secrete pathogenic autoimmune antibodies.

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Authors
Frasca, D., & Blomberg, B. B.
Affiliations
University of Miami (US)
Corresponding author
Blomberg, Bonnie B.
Venue
Frontiers in Immunology
Published
2017-08-28
Volume
8
Pages
1003-1003
ISSN
1664-3224 (ISSN-L)
OpenAlex
W2747063627
Cited by
66
References
97
Citations by year
2026: 2 · 2025: 7 · 2024: 5 · 2023: 6 · 2022: 14 · 2021: 9 · 2020: 8 · 2019: 8 · 2018: 6 · 2017: 1
FWCI
0.83
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Frontiers in Immunology (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
National Institutes of Health (AG023717, AG32576, AI096446, AG042826, AG032576)
Topics
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Keywords
inflammaging, adipose tissue inflammation, B cell function, aging, obesity, humoral immune response, antibody production, immune cell infiltration, adipose tissue macrophages, leptin, insulin resistance, autoantibodies, T cell polarization

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