Cited by 922Psoriasis: Treatment and PathogenesisT-cell and B-cell ImmunologyIL-33, ST2, and ILC Pathways

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Pathogen-induced human TH17 cells produce IFN-γ or IL-10 and are regulated by IL-1β

Zielinski, Christina E., Mele, Federico, Aschenbrenner, Dominik, Jarrossay, David, Ronchi, Francesca, Gattorno, Marco, Monticelli, Silvia, Lanzavecchia, Antonio, Sallusto, Federica·2012·Nature

DOI 10.1038/nature10957

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Abstract

IL-17-producing CD4+ T helper cells (TH17) have been extensively investigated in mouse models of autoimmunity. However, the requirements for differentiation and the properties of pathogen-induced human TH17 cells remain poorly defined. Using an approach that combines the in vitro priming of naive T cells with the ex vivo analysis of memory T cells, we describe here two types of human TH17 cells with distinct effector function and differentiation requirements. Candida albicans-specific TH17 cells produced IL-17 and IFN-γ, but no IL-10, whereas Staphylococcus aureus-specific TH17 cells produced IL-17 and could produce IL-10 upon restimulation. IL-6, IL-23 and IL-1β contributed to TH17 differentiation induced by both pathogens, but IL-1β was essential in C. albicans-induced TH17 differentiation to counteract the inhibitory activity of IL-12 and to prime IL-17/IFN-γ double-producing cells. In addition, IL-1β inhibited IL-10 production in differentiating and in memory TH17 cells, whereas blockade of IL-1β in vivo led to increased IL-10 production by memory TH17 cells. We also show that, after restimulation, TH17 cells transiently downregulated IL-17 production through a mechanism that involved IL-2-induced activation of STAT5 and decreased expression of ROR-γt. Taken together these findings demonstrate that by eliciting different cytokines C. albicans and S. aureus prime TH17 cells that produce either IFN-γ or IL-10, and identify IL-1β and IL-2 as pro- and anti-inflammatory regula…

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Ivanov, I. I., McKenzie, B. S., Zhou, L., Tadokoro, C. E., Lepelley, A., Lafaille, J. J., Cua, D. J., & Littman, D. R. (2006) · Cell · doi:10.1016/j.cell.2006.07.035 · Cited by 5,145
IL-17 and th17 cells
Korn, T., Bettelli, E., Oukka, M., & Kuchroo, V. K. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132710 · Cited by 4,873
Development, cytokine profile and function of human interleukin 17-producing helper T cells
Wilson, N. J., Boniface, K., Chan, J. R., McKenzie, B. S., Blumenschein, W. M., Mattson, J. D., Basham, B., Smith, K., Chen, T., Morel, F., et al. (2007) · Nature Immunology · doi:10.1038/ni1497 · Cited by 2,035
Phenotypic and functional features of human Th17 cells
Annunziato, F., Cosmi, L., Santarlasci, V., Maggi, L., Liotta, F., Mazzinghi, B., Parente, E., Filì, L., Ferri, S., Frosali, F., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070663 · Cited by 1,861
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Acosta-Rodriguez, E. V., Napolitani, G., Lanzavecchia, A., & Sallusto, F. (2007) · Nature Immunology · doi:10.1038/ni1496 · Cited by 1,857
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Acosta-Rodriguez, E. V., Rivino, L., Geginat, J., Jarrossay, D., Gattorno, M., Lanzavecchia, A., Sallusto, F., & Napolitani, G. (2007) · Nature Immunology · doi:10.1038/ni1467 · Cited by 1,828
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Romani, L. (2011) · Nature Reviews Immunology · doi:10.1038/nri2939 · Cited by 1,793
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McGeachy, M. J., Bak-Jensen, K. S., Chen, Y., Tato, C. M., Blumenschein, W., McClanahan, T., & Cua, D. J. (2007) · Nature Immunology · doi:10.1038/ni1539 · Cited by 1,520
Interleukin-2 Signaling via STAT5 Constrains T Helper 17 Cell Generation
Laurence, A., Tato, C. M., Davidson, T. S., Kanno, Y., Chen, Z., Yao, Z., Blank, R. B., Meylan, F., Siegel, R., Hennighausen, L., et al. (2007) · Immunity · doi:10.1016/j.immuni.2007.02.009 · Cited by 1,507
Generation of pathogenic TH17 cells in the absence of TGF-β signalling
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Rammaert, B., Candon, S., Maunoury, C., Bougnoux, M., Jouvion, G., Braun, T., Corréas, J.-M., & Lortholary, O. (2016) · Transplant Infectious Disease · doi:10.1111/tid.12637 · Cited by 7
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Authors: Zielinski, C. E., Mele, F., Aschenbrenner, D., Jarrossay, D., Ronchi, F., Gattorno, M., Monticelli, S., Lanzavecchia, A., & Sallusto, F.
Affiliations: Institute for Research in Biomedicine (CH)
Istituto Giannina Gaslini (IT)
ETH Zurich (CH)
Corresponding author: Zielinski, Christina E.
Sallusto, Federica
ORCID: Zielinski, Christina E.
Mele, Federico
Aschenbrenner, Dominik
Jarrossay, David
Ronchi, Francesca
Gattorno, Marco
Monticelli, Silvia
Lanzavecchia, Antonio
Sallusto, Federica
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2012-04
Volume: 484
Issue: 7395
Pages: 514-518
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature10957
OpenAlex: W2144288685
Cited by: 919
References: 31
Citations by year: 2026: 25 · 2025: 39 · 2024: 62 · 2023: 49 · 2022: 55 · 2021: 70 · 2020: 63 · 2019: 71 · 2018: 68 · 2017: 78 · 2016: 72 · 2015: 72 · 2014: 74 · 2013: 82 · 2012: 38
FWCI: 37.06
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
Keywords: Th17 cells, Candida albicans, Staphylococcus aureus, IL-1β, IL-17, interferon-gamma, IL-10, interleukin-2, STAT5, RORγt, IL-12, IL-23, interleukin-6, T cell differentiation, memory T cells, fungal infection, bacterial infection
MeSH terms: Candida albicans, Cell Differentiation, Humans, Immunologic Memory, Interferon-gamma, Interleukin-2, Lymphocyte Activation, Staphylococcus aureus, Tumor Necrosis Factor-alpha, Down-Regulation, Interleukin-10, Antigen Presentation, Interleukin-17, STAT5 Transcription Factor, Interleukin-1beta, Nuclear Receptor Subfamily 1, Group F, Member 3, Th17 Cells

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Pathogen-induced human TH17 cells produce IFN-γ or IL-10 and are regulated by IL-1β

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