The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Astrocyte glypicans 4 and 6 promote formation of excitatory synapses via GluA1 AMPA receptors
Open accessAbstract
In the developing central nervous system (CNS), the control of synapse number and function is critical to the formation of neural circuits. We previously demonstrated that astrocyte-secreted factors powerfully induce the formation of functional excitatory synapses between CNS neurons. Astrocyte-secreted thrombospondins induce the formation of structural synapses, but these synapses are postsynaptically silent. Here we use biochemical fractionation of astrocyte-conditioned medium to identify glypican 4 (Gpc4) and glypican 6 (Gpc6) as astrocyte-secreted signals sufficient to induce functional synapses between purified retinal ganglion cell neurons, and show that depletion of these molecules from astrocyte-conditioned medium significantly reduces its ability to induce postsynaptic activity. Application of Gpc4 to purified neurons is sufficient to increase the frequency and amplitude of glutamatergic synaptic events. This is achieved by increasing the surface level and clustering, but not overall cellular protein level, of the GluA1 subunit of the AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) glutamate receptor (AMPAR). Gpc4 and Gpc6 are expressed by astrocytes in vivo in the developing CNS, with Gpc4 expression enriched in the hippocampus and Gpc6 enriched in the cerebellum. Finally, we demonstrate that Gpc4-deficient mice have defective synapse formation, with decreased amplitude of excitatory synaptic currents in the developing hippocampus and reduced recruitment of AMPARs to synapses. These data identify glypicans as a family of novel astrocyte-derived molecules that are necessary and sufficient to promote glutamate receptor clustering and receptivity and to induce the formation of postsynaptically functioning CNS synapses.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In the developing brain, astrocytes regulate synapse number by secreting synaptogenic signals, such as thrombospondins, hevin, and glypicans, that induce synapse formation (Allen et al., 2012; Christopherson et al., 2005; Kucukdereli et al., 2011)”
From The aging astrocyte transcriptome from multiple regions of the mouse brain. (2018) · cites this paper as Allen et al., 2012
In the citing paper
“In line with this, Gpc4 and Gpc6 were recently also discovered as astrocytic factors, which stimulate the excitatory synapse formation by regulating glutamate receptor clustering57.”
From Elimination of the four extracellular matrix molecules tenascin-C, tenascin-R, brevican and neurocan alters the ratio of excitatory and inhibitory synapses (2019) · cites this paper as [57]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Glutamate Receptor Ion Channels: Structure, Regulation, and Function
Traynelis, S. F., Wollmuth, L. P., McBain, C. J., Menniti, F. S., Vance, K. M., Ogden, K. K., Hansen, K. B., Yuan, H., Myers, S. J., & Dingledine, R. (2010) · Pharmacological Reviews · doi:10.1124/pr.109.002451 · Cited by 3,568
Cahoy, J. D., Emery, B., Kaushal, A., Foo, L. C., Zamanian, J. L., Christopherson, K. S., Xing, Y., Lubischer, J. L., Krieg, P. A., Krupenko, S. A., et al. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4178-07.2008 · Cited by 3,129
Self-citationAMPA Receptor Trafficking and Synaptic Plasticity
Malinow, R., & Malenka, R. C. (2002) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.25.112701.142758 · Cited by 2,588
Thrombospondins are astrocyte-secreted proteins that promote CNS synaptogenesis
Christopherson, K. S., Ullian, E. M., Stokes, C. C. A., Mullowney, C. E., Hell, J. W., Agah, A., Lawler, J., Mosher, D. F., Bornstein, P., & Barres, B. A. (2005) · Cell · doi:10.1016/j.cell.2004.12.020 · Cited by 1,688
Self-citationControl of Synapse Number by Glia
Ullian, E. M., Sapperstein, S. K., Christopherson, K. S., & Barres, B. A. (2001) · Science · doi:10.1126/science.291.5504.657 · Cited by 1,380
Self-citationControl of Synaptic Strength by Glial TNFα
Beattie, E. C., Stellwagen, D., Morishita, W., Bresnahan, J. C., Ha, B. K., Von Zastrow, M., Beattie, M. S., & Malenka, R. C. (2002) · Science · doi:10.1126/science.1067859 · Cited by 1,344
Schaeren‐Wiemers, N., & Gerfin-Moser, A. (1993) · Histochemistry and Cell Biology · doi:10.1007/bf00267823 · Cited by 1,151
Eroglu, Ç., Allen, N. J., Susman, M. W., O'Rourke, N. A., Park, C. Y., Özkan, E., Chakraborty, C., Mulinyawe, S. B., Annis, D. S., Huberman, A. D., et al. (2009) · Cell · doi:10.1016/j.cell.2009.09.025 · Cited by 893
Self-citationNeuroligins Determine Synapse Maturation and Function
Varoqueaux, F., Aramuni, G., Rawson, R. L., Mohrmann, R., Missler, M., Gottmann, K., Zhang, W., Südhof, T. C., & Brose, N. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.003 · Cited by 837
Micheva, K. D., & Smith, S. J. (2007) · Neuron · doi:10.1016/j.neuron.2007.06.014 · Cited by 787
Self-citation
Cited by
Sorted by citations
Items 401–500 of 764
The Effects of Immune System Modulation on Prion Disease Susceptibility and Pathogenesis
Mabbott, N. A., Bradford, B. M., Pal, R., Young, R. A., & Donaldson, D. S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197299 · Cited by 22
Александровна, К. С., Cingolani, L. A., Kuznetsova, T., Bologna, L. L., Chiappalone, M., & Dityatev, A. E. (2014) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2014.0134 · Cited by 21
Puzzling out presynaptic differentiation
Pinto, M. J., & Almeida, R. D. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13702 · Cited by 22
Vellucci, L., Mazza, B., Barone, A., Nasti, A., Simone, G. D., Iasevoli, F., & de Bartolomeis, A. (2025) · Biomolecules · doi:10.3390/biom15050615 · Cited by 23
Kamimura, K., Odajima, A., Ikegawa, Y., Chikako, M., & Maeda, N. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.08.032 · Cited by 19
Chen, Z., Gao, M. Q., Su, Y., Liu, P., & Sun, B. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.633618 · Cited by 20
Astrocytic NMDA Receptors in the Basolateral Amygdala Contribute to Facilitation of Fear Extinction
Shelkar, G. P., Liu, J., & Dravid, S. M. (2021) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyab055 · Cited by 20
Zourray, C., Kurian, M. A., Barral, S., & Lignani, G. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.839366 · Cited by 20
Jalilian, E., & Shin, S. (2023) · Scientific Reports · doi:10.1038/s41598-023-35077-9 · Cited by 19
Talking to the Synapse: How Antidepressants Can Target Glial Cells to Reshape Brain Circuits
Benedetto, B. D., Rupprecht, R., & Czéh, B. (2013) · Current Drug Targets · doi:10.2174/1389450111314110011 · Cited by 21
Sobieski, C. A., Jiang, X., Crawford, D. C., & Mennerick, S. J. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.1289-15.2015 · Cited by 21
Intracellular protein complexes involved in synapse assembly in presynaptic neurons
Han, K. A., Um, J. W., & Ko, J. (2018) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2018.11.008 · Cited by 19
Oikari, L. E., Yu, C., Okolicsanyi, R. K., Avgan, N., Peall, I. W., Griffiths, L. R., & Haupt, L. M. (2020) · Journal of Neuroscience Research · doi:10.1002/jnr.24666 · Cited by 20
Star power: the emerging role of astrocytes as neuronal partners during cortical plasticity
Wahis, J., Hennes, M., Arckens, L., & Holt, M. G. (2020) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2020.12.001 · Cited by 21
Stem and Progenitor Cell-Derived Astroglia Therapies for Neurological Diseases
Chen, C., Chan, A., Han, W., Chung, S., Deng, W., & Jiang, P. (2015) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2015.09.003 · Cited by 20
Wang, Y., Liu, J., Li, P., Peng, Z., Zhang, Y., Liu, Y., Li, M., Gong, X., Liu, D., Xu, E., et al. (2025) · Advanced Science · doi:10.1002/advs.202504486 · Cited by 20
Chen, R., Routh, B. N., Gaudet, A. D., & Fonken, L. K. (2023) · Journal of Biological Rhythms · doi:10.1177/07487304231178950 · Cited by 21
Akinlaja, Y. O., & Nishiyama, A. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1418100 · Cited by 23
Singhal, G., Singhal, S., & Baune, B. T. (2025) · Neuroprotection/Neuroprotection (Chichester, England. Print) · doi:10.1002/nep3.70009 · Cited by 22
Cai, M., Zhang, Y., Chen, S. X., Wu, Z., & Zhu, L. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.968444 · Cited by 20
Astrocytes-Derived Small Extracellular Vesicles Hinder Glioma Growth
Serpe, C., Michelucci, A., Monaco, L., Rinaldi, A., Luca, M. D., Familiari, P., Relucenti, M., Pietro, E. D., Castro, M. A. D., D’Agnano, I., et al. (2022) · Biomedicines · doi:10.3390/biomedicines10112952 · Cited by 17
Park, H. J., Kim, J., & Ryou, C. (2023) · Cell Proliferation · doi:10.1111/cpr.13399 · Cited by 18
Puliatti, G., Puma, D. D. L., Aceto, G., Lazzarino, G., Acquarone, E., Mangione, R., D'adamio, L., Ripoli, C., Arancio, O., Piacentini, R., et al. (2023) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2023.102482 · Cited by 19
Astrocytes in the adult dentate gyrus—balance between adult and developmental tasks
Chalmers, N., Masouti, E., & Beckervordersandforth, R. (2024) · Molecular Psychiatry · doi:10.1038/s41380-023-02386-4 · Cited by 19
Byun, Y. G., & Chung, W. (2018) · Journal of Visualized Experiments · doi:10.3791/56647 · Cited by 18
Maïza, A., Sidahmed‐Adrar, N., Michel, P. P., Carpentier, G., Habert, D., Dalle, C., Redouane, W., Hamza, M. M., van Kuppevelt, T., Ouidja, M. O., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-76030-4 · Cited by 21
Type IIa RPTPs and Glycans: Roles in Axon Regeneration and Synaptogenesis
Sakamoto, K., Ozaki, T., Suzuki, Y., & Kadomatsu, K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115524 · Cited by 18
Ohayon, D., Aguirrebengoa, M., Escalas, N., Jungas, T., & Soula, C. (2021) · iScience · doi:10.1016/j.isci.2021.102806 · Cited by 20
Response of Astrocyte Subpopulations Following Spinal Cord Injury
Allahyari, R. V., Heinsinger, N. M., Hwang, D. H., Jaffe, D. A., Rasouli, J., Shiers, S. I., Thomas, S. J., Price, T. J., Rostami, A. M., & Lepore, A. C. (2022) · Cells · doi:10.3390/cells11040721 · Cited by 18
CRISPRi screens in human astrocytes elucidate regulators of distinct inflammatory reactive statesPreprint
Leng, K., Rose, I. V. L., Kim, H., Xia, W., Romero‐Fernandez, W., Rooney, B., Koontz, M., Li, E., Ao, Y., Wang, S., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.08.23.457400 · Cited by 18
Zhang, X., Hashimoto, J. G., Han, X., Zhang, F., Linhardt, R. J., & Guizzetti, M. (2021) · Neurochemical Research · doi:10.1007/s11064-020-03195-9 · Cited by 17
Zhou, B., Zhang, C., Zheng, L., Wang, Z., Chen, X., Feng, X., Zhang, Q., Hao, S., Wei, L., Gu, W., et al. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.794766 · Cited by 17
Shelkar, G. P., Gandhi, P. J., Liu, J., & Dravid, S. M. (2022) · Science Advances · doi:10.1126/sciadv.abo6574 · Cited by 18
Bauminger, H., & Gaisler‐Salomon, I. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158617 · Cited by 16
Zhang, N., Jiang, H., Wang, H., Wang, Y., Peng, Y., Liu, Y., Xia, C., Xu, Y., Chu, S., Zhang, Y., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010575 · Cited by 17
Astrocytes Excessively Engulf Synapses in a Mouse Model of Alzheimer’s Disease
Li, L., Lü, S., Zhu, J., Yu, X., Hou, S., Huang, Y., Niu, X., Du, X., & Liu, R. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25021160 · Cited by 17
Gliomas: a reflection of temporal gliogenic principles
Sojka, C., & Sloan, S. A. (2024) · Communications Biology · doi:10.1038/s42003-024-05833-2 · Cited by 18
Espírito‐Santo, S., Coutinho, V. G., Dezonne, R. S., Stipursky, J., dos Santos‐Rodrigues, A., Batista, C., Paes‐de‐Carvalho, R., Fuss, B., & Gomes, F. C. A. (2021) · Glia · doi:10.1002/glia.23971 · Cited by 19
Astrocytes increase the activity of synaptic GluN2B NMDA receptors
Hahn, J., Wang, X., & Margeta, M. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00117 · Cited by 18
Synapse-specific roles for microglia in development: New horizons in the prefrontal cortex
Blagburn-Blanco, S. V., Chappell, M. S., Biase, L. M. D., & DeNardo, L. A. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.965756 · Cited by 16
β-Adrenergic Signaling Promotes Morphological Maturation of Astrocytes in Female Mice
Rosenberg, M. F., Godoy, M. I., Wade, S. D., Paredes, M. F., Zhang, Y., & Molofsky, A. V. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.0357-23.2023 · Cited by 18
Circadian Biology and the Neurovascular Unit
Li, W., Tiedt, S., Lawrence, J. H., Harrington, M. E., Musiek, E. S., & Lo, E. H. (2024) · Circulation Research · doi:10.1161/circresaha.124.323514 · Cited by 17
Acute and Chronic Mu Opioids Differentially Regulate Thrombospondins 1 and 2 Isoforms in Astrocytes
Phamduong, E., Rathore, M. K., Crews, N. R., D’Angelo, A. S., Leinweber, A. L., Kappera, P., Krenning, T. M., Rendell, V. R., Belcheva, M. M., & Coscia, C. J. (2013) · ACS Chemical Neuroscience · doi:10.1021/cn400172n · Cited by 18
Luo, J. D., Huang, X., Li, Y., Yang, L., Xu, X., Gao, Y., Shi, R., Yao, W., Liu, J., & Ke, C. (2016) · Oncotarget · doi:10.18632/oncotarget.11867 · Cited by 16
Microglia and Astrocytes in Postnatal Neural Circuit Formation
Duffy, A., & Eyo, U. B. (2024) · Glia · doi:10.1002/glia.24650 · Cited by 15
The role of reactive astrocytes in neurotoxicity induced by ultrafine particulate matter
Li, B., Chang, X., Liang, X., Liu, T., Shen, Y., Zhang, Q., Yang, X., Lyu, Y., Liu, L., Guo, J., et al. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.161416 · Cited by 17
Cytosolic DNA sensors and glial responses to endogenous DNA
Suptela, A. J., & Marriott, I. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1130172 · Cited by 15
Brandebura, A. N., Paumier, A., Asbell, Q. N., Tao, T., Micael, M. K. B., Sanchez, S., & Allen, N. J. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.116300 · Cited by 17
Self-citationRennert, R. C., Schäfer, R., Bliss, T. M., Januszyk, M., Sorkin, M., Achrol, A. S., Rodrigues, M., Maan, Z. N., Kluba, T., Steinberg, G. K., et al. (2016) · Frontiers in Neurology · doi:10.3389/fneur.2016.00041 · Cited by 15
Román, C., Egert, L., & Benedetto, B. D. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14900 · Cited by 16
Kandasamy, L. C., Tsukamoto, M., Banov, V., Sambuu, T., Nagasawa, Y., Kato, M., Matsumoto, N., Takeda, J., Itohara, S., Ogawa, S., et al. (2021) · Human Molecular Genetics · doi:10.1093/hmg/ddab052 · Cited by 15
The role of astrocytes in behaviors related to emotion and motivation
Shigetomi, E., & Koizumi, S. (2022) · Neuroscience Research · doi:10.1016/j.neures.2022.09.015 · Cited by 16
Acupuncture Treatment of Epilepsy
Chao, D., & Xia, Y. (2012) · Springer eBooks · doi:10.1007/978-1-4614-3357-6_6 · Cited by 14
Xie, C., Wang, Z., Tang, J., Shi, Z., & He, Z. (2014) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-014-0213-0 · Cited by 15
Cisternas, P., Louveau, A., Bueno, S. M., Kalergis, A. M., Boudin, H., & Riedel, C. A. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9609-0 · Cited by 15
Antiepileptogenic repair of excitatory and inhibitory synaptic connectivity after neocortical trauma
Prince, D. A., Gu, F., & Parada, I. (2016) · Progress in brain research · doi:10.1016/bs.pbr.2016.03.013 · Cited by 15
Neutrophils-astrocyte interactions in central nervous system inflammation
Yuan, B., Zhang, X., Liu, L., Chai, Y., Zhang, J., & Chen, X. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-07945-x · Cited by 15
Necl2/3-mediated mechanism for tripartite synapse formation
Nozawa, O., Miyata, M., Shiotani, H., Kameyama, T., Komaki, R., Shimizu, T., Kuriu, T., Kashiwagi, Y., Sato, Y., Koebis, M., et al. (2022) · Development · doi:10.1242/dev.200931 · Cited by 13
How Are Synapses Born? A Functional and Molecular View of the Role of the Wnt Signaling Pathway
Bonansco, C., Cerpa, W. F., & Inestrosa, N. C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010708 · Cited by 13
Abnormal Morphology and Synaptogenic Signaling in Astrocytes Following Prenatal Opioid Exposure
Niebergall, E. B., Weekley, D., Mazur, A., Olszewski, N. A., DeSchepper, K. M., Radant, N. P., Vijay, A., & Risher, W. C. (2024) · Cells · doi:10.3390/cells13100837 · Cited by 14
Melrose, J. (2024) · Journal of Neuroscience Research · doi:10.1002/jnr.25361 · Cited by 15
A smarter mouse with human astrocytes
Zhang, Y., & Barres, B. A. (2013) · BioEssays · doi:10.1002/bies.201300070 · Cited by 14
Self-citationHeparan sulfate proteoglycans in Drosophila neuromuscular development
Kamimura, K., & Maeda, N. (2017) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2017.06.015 · Cited by 14
Friends Turn Foe—Astrocytes Contribute to Neuronal Damage in NeuroAIDS
Pandey, H. S., & Seth, P. (2019) · Journal of Molecular Neuroscience · doi:10.1007/s12031-019-01357-1 · Cited by 13
Trans-synaptic interactions of ionotropic glutamate receptors
Fossati, M., & Charrier, C. (2020) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2020.09.001 · Cited by 19
VER/VEGF receptors regulate AMPA receptor surface levels and glutamatergic behavior
Luth, E. S., Hodul, M., Rennich, B. J., Riccio, C., Hofer, J., Markoja, K., & Juo, P. (2021) · PLoS Genetics · doi:10.1371/journal.pgen.1009375 · Cited by 16
The Astrogenic Balance in the Aging Brain
Andromidas, F., Atashpanjeh, S., Myers, A. J., MacKinnon, B., Shaffer, M. M., & Koob, A. O. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666210420095118 · Cited by 13
Reconstitution of Giant Mammalian Synapses in Culture for Molecular Functional and Imaging Studies
Dimitrov, D., Takagi, H., Guillaud, L., Saitoh, N., Eguchi, K., & Takahashi, T. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.3869-15.2016 · Cited by 14
Glia Development and Function in the NematodeCaenorhabditis elegansPreprint
Singhvi, A., Shaham, S., & Rapti, G. (2024) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a041346 · Cited by 15
Senescent Astrocytes: A New Player in Brain Aging and Cognitive Decline
Pessoa, B., Hayashide, L. D. S., Dias, G. R., Pontes, B., Pinto, R. S., & Diniz, L. P. (2026) · Brain Sciences · doi:10.3390/brainsci16010076 · Cited by 13
Crosstalk between Blood Vessels and Glia during the Central Nervous System Development
Tabata, H. (2022) · Life · doi:10.3390/life12111761 · Cited by 14
Impact of Aβ40 and Aβ42 Fibrils on the Transcriptome of Primary Astrocytes and Microglia
Zhu, X. A., Schrader, J. M., Irizarry, B. A., Smith, S. O., & Nostrand, W. E. V. (2022) · Biomedicines · doi:10.3390/biomedicines10112982 · Cited by 14
Self-citationShan, W., Wang, J., Cheng, R., Xuan, Y., & Yin, Z. (2023) · Inflammopharmacology · doi:10.1007/s10787-023-01311-z · Cited by 13
Thomas, C. I., Ryan, M. A., McNabb, M. C., Kamasawa, N., & Scholl, B. (2024) · Glia · doi:10.1002/glia.24582 · Cited by 19
Glial Control of Cortical Neuronal Circuit Maturation and Plasticity
Faust, T. E., Devlin, B. A., Farhy-Tselnicker, I., Ferro, A., Postolache, M., & Xin, W. (2024) · Journal of Neuroscience · doi:10.1523/jneurosci.1208-24.2024 · Cited by 13
Physiology of Astroglia: Channels, Receptors, Transporters, Ion Signaling and Gliotransmission
Verkhratsky, A., & Parpura, V. (2015) · Colloquium Series on Neuroglia in Biology and Medicine From Physiology to Disease · doi:10.4199/c00123ed1v01y201501ngl004 · Cited by 12
Astrocytes, Makers of New Neurons
Kempermann, G. (2015) · Neuron · doi:10.1016/j.neuron.2015.11.017 · Cited by 13
Sato, K., Takahashi, K., Shigemoto‐Mogami, Y., Chujo, K., & Sekino, Y. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00259 · Cited by 13
Pinheiro, P. D. S. M., Diniz, L. P., Franco, L. S., Siqueira, M., & Gomes, F. C. A. (2025) · Pharmaceuticals · doi:10.3390/ph18101471 · Cited by 13
Translational modulator ISRIB alleviates synaptic and behavioral phenotypes in Fragile X syndrome
Coulson, R. L., Frattini, V., Moyer, C. E., Hodges, J., Walter, P., Mourrain, P., Zuo, Y., & Wang, G. X. (2024) · iScience · doi:10.1016/j.isci.2024.109259 · Cited by 12
Self-citationLi, Y., Luo, Y., Zhu, P., Liang, X., Li, J., Dou, X., Liu, L., Qin, L., Zhou, M., Deng, Y., et al. (2024) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2024.173750 · Cited by 13
Neuronal Circuit Dysfunction in Amyotrophic Lateral Sclerosis
Salzinger, A., Ramesh, V., Sharma, S. D., Chandran, S., & Selvaraj, B. T. (2024) · Cells · doi:10.3390/cells13100792 · Cited by 14
Garau, G., Magotti, P., Heine, M., Александровна, К. С., Lievens, P., Berezin, V., & Dityatev, A. E. (2015) · Experimental Neurology · doi:10.1016/j.expneurol.2015.08.006 · Cited by 12
Hartmann, J., Lauria, I., Bendt, F., Rütten, S., Koch, K., Blaeser, A., & Fritsche, E. (2022) · Advanced Materials Interfaces · doi:10.1002/admi.202200580 · Cited by 13
The Synucleins and the Astrocyte
Myers, A. J., Brahimi, A., Jenkins, I. J., & Koob, A. O. (2023) · Biology · doi:10.3390/biology12020155 · Cited by 12
Berryer, M. H., Rizki, G., Nathanson, A. J., Klein, J. A., Trendafilova, D., Susco, S. G., Lam, D., Messana, A., Holton, K. M., Karhohs, K. W., et al. (2023) · eLife · doi:10.7554/elife.80168 · Cited by 14
Training-induced circuit-specific excitatory synaptogenesis in mice is required for effort control
Severino, F. P. U., Lawal, O. O., Sakers, K., Wang, S., Kim, N., Friedman, A. D., Johnson, S. A., Sriworarat, C., Hughes, R. N., Soderling, S. H., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-41078-z · Cited by 13
Ma, K., Hu, H., Zhou, J.-S., Ji, C., Yan, Q.-S., Peng, S.-M., Ren, L.-D., Yang, B., Xiao, X.-L., Ma, Y., et al. (2021) · Experimental Neurology · doi:10.1016/j.expneurol.2021.113918 · Cited by 12
Neuronal and Glial α7 Nicotinic Acetylcholine Receptors: Role in Alzheimer’s Disease Pathophysiology
Rennie, K. (2025) · Life · doi:10.3390/life15071032 · Cited by 11
Glypican-2 defines age-dependent axonal response to chondroitin sulfate
Ouchida, J., Ozaki, T., Segi, N., Suzuki, Y., Imagama, S., Kadomatsu, K., & Sakamoto, K. (2023) · Experimental Neurology · doi:10.1016/j.expneurol.2023.114444 · Cited by 12
Astrocytes and Alcohol Throughout the Lifespan
Guizzetti, M., Mangieri, R. A., Ezerskiy, L. A., Hashimoto, J. G., Bajo, M., Farris, S. P., Homanics, G. E., Lasek, A. W., Mayfield, R. D., Messing, R. O., et al. (2025) · Biological Psychiatry · doi:10.1016/j.biopsych.2025.04.013 · Cited by 13
Holmes, B. B., Weigel, T. K., Chung, J. M., Kaufman, S. K., Apresa, B. I., Byrnes, J. R., Kumru, K. S., Vaquer‐Alicea, J., Gupta, A., Rose, I. V. L., et al. (2025) · Molecular Neurodegeneration · doi:10.1186/s13024-025-00883-4 · Cited by 14
Abnormal Ca2+ Signals in Reactive Astrocytes as a Common Cause of Brain Diseases
Koizumi, S., Shigetomi, E., Sano, F., Saito, K., Kim, S. K., & Nabekura, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010149 · Cited by 12
Wang, G. X., Smith, S. J., & Mourrain, P. (2016) · eLife · doi:10.7554/elife.20560 · Cited by 10
Self-citationPurification and Culture of Retinal Ganglion CellsPreprint
Winzeler, A. M., & Wang, J. T. (2013) · Cold Spring Harbor Protocols · doi:10.1101/pdb.top070961 · Cited by 11
Sideris, E., Yu, A., Chen, J., Carmichael, S. T., & Segura, T. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/768291 · Cited by 11
Milestone Review: Unlocking the Proteomics of Glycine Receptor Complexes
Fraser, S. D., Klaassen, R. V., Villmann, C., Smit, A. B., & Harvey, R. J. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70061 · Cited by 10
Regulation of AMPA receptor trafficking by secreted protein factors
Rennich, B. J., Luth, E. S., Moores, S., & Juo, P. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1271169 · Cited by 10
Silva, A. I., Socodato, R., Pinto, C., Terceiro, A. F., Canedo, T., Relvas, J. B., Saraiva, M., & Summavielle, T. (2024) · Glia · doi:10.1002/glia.24542 · Cited by 11
Astrocytic proteostasis in the tale of aging and neurodegeneration
Cabral‐Miranda, F., Matias, I. C. P., & Gomes, F. C. A. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102580 · Cited by 10
Metadata
- Authors
- Allen, N. J., Bennett, M. L., Foo, L. C., Wang, G. X., Chakraborty, C., Smith, S. J., & Barres, B. A.
- Affiliations
- Stanford Medicine (US)
- Corresponding author
- Allen, Nicola J.
- ORCID
- Venue
- Nature
- Published
- 2012-05-27
- Volume
- 486
- Issue
- 7403
- Pages
- 410-414
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC3383085
- OpenAlex
- W2012935976
- Cited by
- 764
- References
- 32
- Citations by year
- 2026: 49 · 2025: 58 · 2024: 61 · 2023: 72 · 2022: 61 · 2021: 72 · 2020: 64 · 2019: 47 · 2018: 43 · 2017: 56 · 2016: 39 · 2015: 48 · 2014: 46 · 2013: 36 · 2012: 11
- FWCI
- 18.58
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- National Institute on Drug Abuse (R01DA015043)
- National Institute of Neurological Disorders and Stroke (R01NS0725252, R01NS075252, R01NS077601)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- GPC4, astrocytes, excitatory synapse formation, retinal ganglion cells, glutamatergic neurotransmission, synaptic plasticity, synaptic dysfunction, astrocyte-neuron interaction, hippocampus
- MeSH terms
- Animals, Astrocytes, Cerebellum, Female, Hippocampus, Humans, Male, Mice, Inbred C57BL, Retinal Ganglion Cells, Synapses, Culture Media, Conditioned, Rats, Sprague-Dawley, Receptors, AMPA, Excitatory Postsynaptic Potentials, Mice, Rats, Glypicans
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review