Compartmentalized calcium dynamics in a C. elegans interneuron encode head movement
Open accessAbstract
The confinement of neuronal activity to specific subcellular regions is a mechanism for expanding the computational properties of neurons. Although the circuit organization underlying compartmentalized activity has been studied in several systems, its cellular basis is still unknown. Here we characterize compartmentalized activity in Caenorhabditis elegans RIA interneurons, which have multiple reciprocal connections to head motor neurons and receive input from sensory pathways. We show that RIA spatially encodes head movement on a subcellular scale through axonal compartmentalization. This subcellular axonal activity is dependent on acetylcholine release from head motor neurons and is simultaneously present and additive with glutamate-dependent globally synchronized activity evoked by sensory inputs. Postsynaptically, the muscarinic acetylcholine receptor GAR-3 acts in RIA to compartmentalize axonal activity through the mobilization of intracellular calcium stores. The compartmentalized activity functions independently of the synchronized activity to modulate locomotory behaviour.
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C. elegans neurons are largely isopotential, but activity-controlling properties such as calcium levels may be compartmentalized, as shown in one example.
“Although C. elegans neurons are largely isopotential48, the properties of these neurons that control activity, such as calcium levels, may be compartmentalized, as has been previously demonstrated in one example49.”
From Whole-animal connectomes of both Caenorhabditis elegans sexes (2019) · cites this paper as [49]
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- Authors
- Hendricks, M., Ha, H., Maffey, N., & Zhang, Y.
- Affiliations
- Harvard University (US)
- Corresponding author
- Zhang, Yun
- Venue
- Nature
- Published
- 2012-05-13
- Volume
- 487
- Issue
- 7405
- Pages
- 99-103
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC3393794
- OpenAlex
- W2078100642
- Cited by
- 173
- References
- 30
- Citations by year
- 2026: 10 · 2025: 13 · 2024: 16 · 2023: 14 · 2022: 16 · 2021: 16 · 2020: 9 · 2019: 9 · 2018: 14 · 2017: 12 · 2016: 11 · 2015: 8 · 2014: 10 · 2013: 13 · 2012: 2
- FWCI
- 4.35
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- Wellcome Trust
- National Institute on Deafness and Other Communication Disorders (DC009852, R01DC009852)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Keywords
- Caenorhabditis elegans, intracellular calcium stores, acetylcholine release, locomotion behaviour, sensorimotor integration
- MeSH terms
- Acetylcholine, Animals, Axons, Calcium, Cell Compartmentation, Interneurons, Motor Neurons, Neural Pathways, Synaptic Transmission, Receptors, Muscarinic, Caenorhabditis elegans, Glutamic Acid, Head Movements, Calcium Signaling
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