Genetic recombination is directed away from functional genomic elements in mice

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Mapping and analysis of chromatin state dynamics in nine human cell types

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A Chromatin Landmark and Transcription Initiation at Most Promoters in Human Cells

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Identification of 67 Histone Marks and Histone Lysine Crotonylation as a New Type of Histone Modification

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PRDM9 Is a Major Determinant of Meiotic Recombination Hotspots in Humans and Mice

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Drive Against Hotspot Motifs in Primates Implicates the PRDM9 Gene in Meiotic Recombination

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Krüppel-associated boxes are potent transcriptional repression domains.

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Prdm9 Controls Activation of Mammalian Recombination Hotspots

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Genome-wide identification of in vivo protein-DNA binding sites from ChIP-Seq data

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A Hierarchical Combination of Factors Shapes the Genome-wide Topography of Yeast Meiotic Recombination Initiation

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The mop1 mutation affects the recombination landscape in maize

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Sycp1 Is Not Required for Subtelomeric DNA Double-Strand Breaks but Is Required for Homologous Alignment in Zebrafish Spermatocytes

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Meiotic Chromosome Dynamics in Zebrafish

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Fine-scale contemporary recombination variation and its fitness consequences in adaptively diverging stickleback fish

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Analysis of DNA polymerase ν function in meiotic recombination, immunoglobulin class-switching, and DNA damage tolerance

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Novel Insights into the Landscape of Crossover and Noncrossover Events in Rhesus Macaques ( Macaca mulatta )

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Specific Modifications of Histone Tails, but Not DNA Methylation, Mirror the Temporal Variation of Mammalian Recombination Hotspots

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PRDM9 Diversity at Fine Geographical Scale Reveals Contrasting Evolutionary Patterns and Functional Constraints in Natural Populations of House Mice

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EWSR1 affects PRDM9-dependent histone 3 methylation and provides a link between recombination hotspots and the chromosome axis protein REC8

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Diversity in Recombination Hotspot Characteristics and Gene Structure Shape Fine-Scale Recombination Patterns in Plant Genomes

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The long zinc finger domain of PRDM9 forms a highly stable and long-lived complex with its DNA recognition sequence

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Synaptonemal Complex in Human Biology and Disease

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Suppression of genetic recombination in the pseudoautosomal region and at subtelomeres in mice with a hypomorphic Spo11 allele

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The roles of homologous recombination and the immune system in the genomic evolution of cancer

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A common genomic code for chromatin architecture and recombination landscape

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Molecular mechanisms for environmentally induced and evolutionarily rapid redistribution (plasticity) of meiotic recombination

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Prdm6 Is Essential for Cardiovascular Development In Vivo

Gewies, A., Castiñeiras-Vilariño, M., Ferch, U., Jährling, N., Heinrich, K., Höckendorf, U., Przemeck, G. K. H., Munding, M., Groß, O., Schroeder, T., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0081833 · Cited by 19

FIGNL1-FIRRM is essential for meiotic recombination and prevents DNA damage-independent RAD51 and DMC1 loading

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Chromatin remodeler CHD8 is required for spermatogonial proliferation and early meiotic progression

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Recombination rate variation in mice from an isolated island

Wang, R. J., GRAY, M. M., Parmenter, M. D., Broman, K. W., & Payseur, B. A. (2016) · Molecular Ecology · doi:10.1111/mec.13932 · Cited by 16

Age and Genetic Background Modify Hybrid Male Sterility in House Mice

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Sexual dimorphism in the meiotic requirement for PRDM9: A mammalian evolutionary safeguard

Powers, N. R., Dumont, B. L., Emori, C., Lawal, R. A., Brunton, C., Paigen, K., Handel, M. A., Bolcun‐Filas, E., Petkov, P. M., & Bhattacharyya, T. (2020) · Science Advances · doi:10.1126/sciadv.abb6606 · Cited by 18

Evidence of positive selection and concerted evolution in the rapidly evolving PRDM 9 zinc finger domain in goats and sheep

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The molecular control of meiotic double-strand break (DSB) formation and its significance in human infertility

Li, Y., Wu, Y.-F., Jiang, H., Khan, R., Han, Q., Iqbal, F., Jiang, X., & Shi, Q.-H. (2021) · Asian Journal of Andrology · doi:10.4103/aja.aja_5_21 · Cited by 17

Deep learning identifies and quantifies recombination hotspot determinants

Li, Y., Chen, S., Rapakoulia, T., Kuwahara, H., Yip, K. Y.-L., & Gao, X. (2022) · Bioinformatics · doi:10.1093/bioinformatics/btac234 · Cited by 15

Chromosomal rearrangements, genome reorganization, and speciation

Bakloushinskaya, I. (2016) · Biology Bulletin · doi:10.1134/s1062359016080057 · Cited by 16

Complexity of genetic mechanisms conferring nonuniformity of recombination in maize

Pan, Q., Deng, M., Yan, J., & Li, L. (2017) · Scientific Reports · doi:10.1038/s41598-017-01240-2 · Cited by 17

Fragile, unfaithful and persistent Ys—on how meiosis can shape sex chromosome evolution

Ruiz‐Herrera, A., & Waters, P. D. (2022) · Heredity · doi:10.1038/s41437-022-00532-2 · Cited by 17

Rapid Evolution of the Fine-scale Recombination Landscape in Wild House Mouse ( Mus musculus ) Populations

Wooldridge, L. K., & Dumont, B. L. (2022) · Molecular Biology and Evolution · doi:10.1093/molbev/msac267 · Cited by 14

Multiple Genomic Landscapes of Recombination and Genomic Divergence in Wild Populations of House Mice—The Role of Chromosomal Fusions and Prdm9

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Fine mapping of meiotic NAHR-associated crossovers causing largeNF1deletions

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Diverse DNA Sequence Motifs Activate Meiotic Recombination Hotspots Through a Common Chromatin Remodeling Pathway

Mukiza, T. O., Protacio, R. U., Davidson, M. K., Steiner, W. W., & Wahls, W. P. (2019) · Genetics · doi:10.1534/genetics.119.302679 · Cited by 16

Runaway GC Evolution in Gerbil Genomes

Pracana, R., Hargreaves, A. D., Mulley, J. F., & Holland, P. W. H. (2020) · Molecular Biology and Evolution · doi:10.1093/molbev/msaa072 · Cited by 16

Altering the Binding Properties of PRDM9 Partially Restores Fertility across the Species Boundary

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Bridging the gap between the evolutionary dynamics and the molecular mechanisms of meiosis: A model based exploration of the PRDM9 intra-genomic Red Queen

Genestier, A., Duret, L., & Lartillot, N. (2024) · PLoS Genetics · doi:10.1371/journal.pgen.1011274 · Cited by 19

Keeping it safe: control of meiotic chromosome breakage

Raghavan, A. R., & Hochwagen, A. (2024) · Trends in Genetics · doi:10.1016/j.tig.2024.11.006 · Cited by 20

ATF7IP2, a meiosis-specific partner of SETDB1, is required for proper chromosome remodeling and crossover formation during spermatogenesis

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The GC-content at the 5′ ends of human protein-coding genes is undergoing mutational decay

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PRDM9 and the evolution of recombination hotspots

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Prophase I: Preparing Chromosomes for Segregation in the Developing Oocyte

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Sexually Dimorphic Properties in Meiotic Chromosome

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DNA polymerase epsilon interacts with SUVH2/9 to repress the expression of genes associated with meiotic DSB hotspot in Arabidopsis

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PRDM9 drives the location and rapid evolution of recombination hotspots in salmonid fish

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Differentiated function and localisation of SPO11-1 and PRD3 on the chromosome axis during meiotic DSB formation in Arabidopsis thaliana

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Essential roles of the ANKRD31–REC114 interaction in meiotic recombination and mouse spermatogenesis

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Chromatin architecture may dictate the target site for DMC1, but not for RAD51, during homologous pairing

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High Resolution View on the Regulation of Recombinase Accumulation in Mammalian Meiosis

Mhaskar, A. N., Koornneef, L., Zelensky, A. N., Houtsmuller, A. B., & Baarends, W. M. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.672191 · Cited by 13

Zinc Finger Binding Motifs Do Not Explain Recombination Rate Variation within or between Species of Drosophila

Heil, C. S., & Noor, M. A. F. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045055 · Cited by 13

Modulating crossover positioning by introducing large structural changes in chromosomes

Ederveen, A., Lai, Y., van Driel, M. A., Gerats, T., & Peters, J. L. (2015) · BMC Genomics · doi:10.1186/s12864-015-1276-z · Cited by 13

To incise or not and where: SET-domain methyltransferases know

Yancoskie, M. N., Maritz, C., van Eijk, P., Reed, S. H., & Naegeli, H. (2022) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2022.10.003 · Cited by 12

No Evidence that Infection Alters Global Recombination Rate in House Mice

Dumont, B. L., Devlin, A. A., Truempy, D. M., Miller, J. C., & Singh, N. D. (2015) · PLoS ONE · doi:10.1371/journal.pone.0142266 · Cited by 12

Physiology of the read–write genome

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Germline mutation rates and fine-scale recombination parameters in zebra finch

Prentout, D., Bykova, D., Hoge, C., Hooper, D. M., McDiarmid, C. S., Wu, F. L., Griffith, S. C., de Manuel, M., & Przeworski, M. (2025) · PLoS Genetics · doi:10.1371/journal.pgen.1011661 · Cited by 14

Inferring the Landscapes of Mutation and Recombination in the Common Marmoset ( Callithrix jacchus ) in the Presence of Twinning and Hematopoietic Chimerism

Soni, V., Versoza, C. J., Jensen, J. D., & Pfeifer, S. P. (2026) · American Journal of Primatology · doi:10.1002/ajp.70208 · Cited by 11

Epigenetic regulator Cfp1 safeguards male meiotic progression by regulating meiotic gene expression

Ki, B. S., Shim, S. H., Park, C., Yoo, H., La, H., Lee, O., Kwon, Y., Skalnik, D. G., Okada, Y., Yoon, H., et al. (2022) · Experimental & Molecular Medicine · doi:10.1038/s12276-022-00813-0 · Cited by 11

Adaptive Divergence of Meiotic Recombination Rate in Ecological Speciation

Neupane, S., & Xu, S. (2020) · Genome Biology and Evolution · doi:10.1093/gbe/evaa182 · Cited by 11

Analyzing the impact of CFP1 mutational landscape on epigenetic signaling

Yang, Y., Yang, Y., Chan, K., & Couture, J. (2021) · The FASEB Journal · doi:10.1096/fj.202100427r · Cited by 12

Adaptive Control of the Meiotic Recombination Landscape by DNA Site-dependent Hotspots With Implications for Evolution

Protacio, R. U., Davidson, M. K., & Wahls, W. P. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.947572 · Cited by 11

Meiotic chromosome dynamics and double strand break formation in reptiles

Marín-Gual, L., González-Rodelas, L., Garcias, M. M., Kratochvíl, L., Valenzuela, N., Georges, A., Waters, P. D., & Ruiz‐Herrera, A. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1009776 · Cited by 11

Lessons from the meiotic recombination landscape of the ZMM deficient budding yeast Lachancea waltii

Dutreux, F., Dutta, A., Peltier, É., Bibi‐Triki, S., Friedrich, A., Llorente, B., & Schacherer, J. (2023) · PLoS Genetics · doi:10.1371/journal.pgen.1010592 · Cited by 11

Putting the breaks on meiosis

Lichten, M. (2015) · Science · doi:10.1126/science.aad5404 · Cited by 10

Deciphering meiotic chromatin organization by SYCP3

Guo, S., Zhang, Y., Fei, C., Liu, X., Xia, W., Luo, M., Wei, G., Qin, W., Xiong, C., Li, H., et al. (2025) · Nucleic Acids Research · doi:10.1093/nar/gkaf460 · Cited by 10

PRDM9 forms a trimer by interactions within the zinc finger array

Schwarz, T., Striedner, Y., Hörner, A., Haase, K., Kemptner, J., Zeppezauer, N., Hermann, P., & Tiemann‐Boege, I. (2019) · Life Science Alliance · doi:10.26508/lsa.201800291 · Cited by 13

A Rad50-null mutation in mouse germ cells causes reduced DSB formation, abnormal DSB end resection and complete loss of germ cells

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Correlation of Meiotic DSB Formation and Transcription Initiation Around Fission Yeast Recombination Hotspots

Yamada, S., Okamura, M., Oda, A., Murakami, H., Ohta, K., & Yamada, T. (2017) · Genetics · doi:10.1534/genetics.116.197954 · Cited by 10

Mammalian Meiosis

Cohen, P. E., & Holloway, J. K. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-397175-3.00001-6 · Cited by 11

Orchestrating recombination initiation in mice and men

Damm, E., & Odenthal-Hesse, L. (2022) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2022.05.001 · Cited by 9

Advances Towards How Meiotic Recombination Is Initiated: A Comparative View and Perspectives for Plant Meiosis Research

Jing, J., Zhang, T., Wang, Y., & He, Y. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20194718 · Cited by 12

Spatiotemporal regulation of meiotic recombination by Liaisonin

Miyoshi, T., Ito, M., & Ohta, K. (2013) · BioArchitecture · doi:10.4161/bioa.23966 · Cited by 10

Nucleosomes and DNA methylation shape meiotic DSB frequency in Arabidopsis transposons and gene regulatory regionsPreprint

Choi, K., Zhao, X., Lambing, C., Underwood, C. J., Hardcastle, T. J., Serra, H., Tock, A. J., Ziółkowski, P. A., Yelina, N. E., Martienssen, R. A., et al. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/160911 · Cited by 10

Background selection under evolving recombination rates

Booker, T. R., Payseur, B. A., & Tigano, A. (2022) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2022.0782 · Cited by 9

Increased Positive Selection in Highly Recombining Genes Does not Necessarily Reflect an Evolutionary Advantage of Recombination

Joseph, J. (2024) · Molecular Biology and Evolution · doi:10.1093/molbev/msae107 · Cited by 9

Reconstructing past changes in locus-specific recombination rates

Cox, M. P., Holland, B. R., Wilkins, M. C., & Schmid, J. (2013) · BMC Genetics · doi:10.1186/1471-2156-14-11 · Cited by 9

Chromosome behavior and the molecular basis of meiosis

Jiang, X., Jiang, H., Li, T., Shi, Q., & Fan, S. (2017) · Scientia Sinica Vitae · doi:10.1360/n052016-00336 · Cited by 8

Reproductive genomics of the mouse: implications for human fertility and infertility

Garretson, A., Dumont, B. L., & Handel, M. A. (2023) · Development · doi:10.1242/dev.201313 · Cited by 9

Chromatin yo-yo: expansion and condensation during DNA repair

Covington, M. L., Yuan, G., & Greenberg, R. A. (2014) · Trends in Cell Biology · doi:10.1016/j.tcb.2014.09.004 · Cited by 8

Uncoupling of transcriptomic and cytological differentiation in mouse spermatocytes with impaired meiosis

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Spp1 Links Sites of Meiotic DNA Double-Strand Breaks to Chromosome Axes

de Massy, B. (2013) · Molecular Cell · doi:10.1016/j.molcel.2012.12.011 · Cited by 8

A high-resolution map of non-crossover events reveals impacts of genetic diversity on mammalian meiotic recombinationPreprint

Li, R., Bitoun, E., Altemose, N., Davies, R. W., Davies, B., & Myers, S. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/428987 · Cited by 10

Multifaceted Roles of Histone Lysine Lactylation in Meiotic Gene Dynamics and RecombinationPreprint

Zhang, X., Liu, Y., & Wang, N. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.01.25.576681 · Cited by 8

Epigenetic regulation during meiosis and crossover

Chowdary, K. V. S. K. A., Saini, R., & Singh, A. K. (2023) · Physiology and Molecular Biology of Plants · doi:10.1007/s12298-023-01390-w · Cited by 7

X marks the spot: PRDM9 rescues hybrid sterility by finding hidden treasure in the genome

Żelazowski, M. J., & Cole, F. (2016) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.3201 · Cited by 8

The pioneering role of PRDM9 indel mutations in tarsier evolution

Heerschop, S., Zischler, H., Merker, S., Perwitasari‐Farajallah, D., & Driller, C. (2016) · Scientific Reports · doi:10.1038/srep34618 · Cited by 8

Making chromosomes hot for breakage

Martı́n-Castellanos, C., Fowler, K. R., & Smith, G. R. (2013) · Cell Cycle · doi:10.4161/cc.24576 · Cited by 7

R-Loop Formation in Meiosis: Roles in Meiotic Transcription-Associated DNA Damage

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