The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation
Open accessAbstract
Malnutrition affects up to one billion people in the world and is a major cause of mortality. In many cases, malnutrition is associated with diarrhoea and intestinal inflammation, further contributing to morbidity and death. The mechanisms by which unbalanced dietary nutrients affect intestinal homeostasis are largely unknown. Here we report that deficiency in murine angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 (Ace2), which encodes a key regulatory enzyme of the renin-angiotensin system (RAS), results in highly increased susceptibility to intestinal inflammation induced by epithelial damage. The RAS is known to be involved in acute lung failure, cardiovascular functions and SARS infections. Mechanistically, ACE2 has a RAS-independent function, regulating intestinal amino acid homeostasis, expression of antimicrobial peptides, and the ecology of the gut microbiome. Transplantation of the altered microbiota from Ace2 mutant mice into germ-free wild-type hosts was able to transmit the increased propensity to develop severe colitis. ACE2-dependent changes in epithelial immunity and the gut microbiota can be directly regulated by the dietary amino acid tryptophan. Our results identify ACE2 as a key regulator of dietary amino acid homeostasis, innate immunity, gut microbial ecology, and transmissible susceptibility to colitis. These results provide a molecular explanation for how amino acid malnutrition can cause intestinal inflammation and diarrhoea.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“and ACE2 deficiency has been shown to result in impaired tryptophan homeostasis (Hashimoto et al., 2012).”
From Viral Infections, the Microbiome, and Probiotics (2021) · cites this paper as Hashimoto et al., 2012
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Schloss, P. D., Westcott, S. L., Ryabin, T., Hall, J. R., Hartmann, M., Hollister, E. B., Lesniewski, R. A., Oakley, B. B., Parks, D. H., Robinson, C. J., et al. (2009) · Applied and Environmental Microbiology · doi:10.1128/aem.01541-09 · Cited by 21,481
Naive Bayesian Classifier for Rapid Assignment of rRNA Sequences into the New Bacterial Taxonomy
Wang, Q., Garrity, G. M., Tiedje, J. M., & Cole, J. R. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.00062-07 · Cited by 20,145
PAST: PALEONTOLOGICAL STATISTICAL SOFTWARE PACKAGE FOR EDUCATION AND DATA ANALYSIS
Hammer, Ø., Harper, D. A. T., & Ryan, P. D. (2001) · Palaeontologia Electronica · Cited by 17,871
UCHIME improves sensitivity and speed of chimera detection
Edgar, R. C., Haas, B. J., Clemente, J. C., Quince, C., & Knight, R. (2011) · Bioinformatics · doi:10.1093/bioinformatics/btr381 · Cited by 15,114
Non‐parametric multivariate analyses of changes in community structure
Clarke, K. R. (1993) · Australian Journal of Ecology · doi:10.1111/j.1442-9993.1993.tb00438.x · Cited by 14,449
Pruesse, E., Quast, C., Knittel, K., Fuchs, B. M., Ludwig, W., Peplies, J., & Glöckner, F. O. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm864 · Cited by 6,682
A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus–induced lung injury
Kuba, K., Imai, Y., Rao, S., Gao, H., Guo, F., Guan, B., Huan, Y., Yang, P., Zhang, Y., Deng, W., et al. (2005) · Nature Medicine · doi:10.1038/nm1267 · Cited by 3,445
Self-citationDonoghue, M., Hsieh, F., Baronas, E., Godbout, K., Gosselin, M., Stagliano, N., Donovan, M., Woolf, B., Robison, K., Jeyaseelan, R., et al. (2000) · Circulation Research · doi:10.1161/01.res.87.5.e1 · Cited by 2,485
Angiotensin-converting enzyme 2 protects from severe acute lung failure
Imai, Y., Kuba, K., Rao, S., Huan, Y., Guo, F., Guan, B., Yang, P., Sarao, R., Wada, T., Leong-Poi, H., et al. (2005) · Nature · doi:10.1038/nature03712 · Cited by 2,453
Self-citationOkayasu, I., Hatakeyama, S., Yamada, M., Ohkusa, T., Inagaki, Y., & NAKAYA, R. (1990) · Gastroenterology · doi:10.1016/0016-5085(90)90290-h · Cited by 2,408
Flagged first, then by citations
Cited by
Sorted by citations
Items 401–500 of 998
Molecules in pathogenesis: angiotensin converting enzyme 2 (ACE2)
Wiese, O. J., Zemlin, A. E., & Pillay, T. S. (2020) · Journal of Clinical Pathology · doi:10.1136/jclinpath-2020-206954 · Cited by 47
Widyadharma, I. P. E., Sari, N. N. S. P., Pradnyaswari, K. E., Yuwana, K. T., Adikarya, I. P. G. D., Tertia, C., Wijayanti, I. A. S., Indrayani, I. A. S., & Utami, D. K. I. (2020) · The Egyptian Journal of Neurology Psychiatry and Neurosurgery · doi:10.1186/s41983-020-00258-0 · Cited by 43
Michaud, V., Deodhar, M., Arwood, M. J., Rihani, S. B. A., Dow, P., & Turgeon, J. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9072096 · Cited by 42
Protein Digestion and Absorption
Bhutia, Y. D., & Ganapathy, V. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-809954-4.00047-5 · Cited by 42
Fecal Microbiota Transplantation during and Post-COVID-19 Pandemic
Kazemian, N., Kao, D. H., & Pakpour, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22063004 · Cited by 41
Variability in digestive and respiratory tract Ace2 expression is associated with the microbiome
Koester, S. T., Li, N., Lachance, D. M., Morella, N. M., & Dey, N. (2021) · PLoS ONE · doi:10.1371/journal.pone.0248730 · Cited by 42
Battaglini, D., Robba, C., Fedele, A., Trancă, S., Sukkar, S. G., Pilato, V. D., Bassetti, M., Giacobbe, D. R., Vena, A., Patroniti, N. A., et al. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.671714 · Cited by 44
Foolchand, A., Ghazi, T., & Chuturgoon, A. A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052654 · Cited by 46
ACE2 contributes to the maintenance of mouse epithelial barrier function
Yu, W., Ou, X., Liu, X., Zhang, S., Gao, X., Cheng, H., Zhu, B., & Yan, J. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.10.002 · Cited by 41
The intestine: A highly dynamic microenvironment for IgA plasma cells
Pracht, K., Wittner, J., Kagerer, F., Jäck, H., & Schuh, W. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1114348 · Cited by 44
Nutrients and antinutrient constituents of Amaranthus caudatus L. Cultivated on different soils
Jimoh, M. O., Afolayan, A. J., & Lewu, F. B. (2020) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2020.07.029 · Cited by 44
Relationship between intestinal microbiota, diet and biological systems: an integrated view
Ferreira, R. D. S., Mendonça, L. A. B. M., Ribeiro, C. F. A., Calças, N. C., Guimarães, R. D. C. A., do Nascimento, V. A., Freitas, K. D. C., Carvalho, C. M. E., de Castro, A. P., & Franco, O. L. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1836605 · Cited by 46
Severo, J. S., Barros, V. J. D. S., da Silva, A. C. A., Parente, J. M. L., Lima, M. M., Lima, A. Â. M., dos Santos, A. A., Neto, E. M. D. M., & da Silva, M. T. B. (2021) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2020.12.023 · Cited by 46
Mechanisms of Kwashiorkor-Associated Immune Suppression: Insights From Human, Mouse, and Pig Studies
Michael, H., Amimo, J. O., Rajashekara, G., Saif, L. J., & Vlasova, A. N. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.826268 · Cited by 44
The role of intestinal microbiota and metabolites in intestinal inflammation
Ma, W., Huang, Z., Liu, K., Li, D., Mo, T., & Liu, Q. (2024) · Microbiological Research · doi:10.1016/j.micres.2024.127838 · Cited by 45
Li, W., Liu, Y., Zheng, X., Han, J., Shi, A., Wong, C. C., Wang, R., Jing, X., Li, Y., Fan, S., et al. (2024) · ACS Nano · doi:10.1021/acsnano.4c12801 · Cited by 40
Ren, G., Zhang, J., Li, M., Tang, Z., Yang, Z., Cheng, G., & Wang, J. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2020.04.030 · Cited by 41
Gross, L. Z. F., Sacerdoti, M., Piiper, A., Zeuzem, S., Leroux, A. E., & Biondi, R. M. (2020) · ChemMedChem · doi:10.1002/cmdc.202000368 · Cited by 43
ACE2: Its potential role and regulation in severe acute respiratory syndrome and COVID‐19
Rezaei, M. S., Ziai, S. A., Fakhri, S., & Pouriran, R. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.30041 · Cited by 40
Pathogenesis and Mechanism of Gastrointestinal Infection With COVID-19
Zhang, H., Shao, B., Dang, Q., Chen, Z., Zhou, Q., Luo, H., Yuan, W., & Sun, Z. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.674074 · Cited by 39
Pathogenesis and Mechanisms of SARS-CoV-2 Infection in the Intestine, Liver, and Pancreas
Khreefa, Z., Barbier, M. T., Köksal, A. R., Love, G. L., & Valle, L. D. (2023) · Cells · doi:10.3390/cells12020262 · Cited by 41
Intestinal barrier dysfunction as a key driver of severe COVID-19
Tsounis, E. P., Triantos, C. K., Konstantakis, C., Marangos, M. N., & Assimakopoulos, S. F. (2023) · World Journal of Virology · doi:10.5501/wjv.v12.i2.68 · Cited by 39
Salt-Responsive Gut Microbiota Induces Sex-Specific Blood Pressure Changes
Bardhan, P., Mei, X., Lai, N. T., Mell, B., Tummala, R., Aryal, S., Manandhar, I., Hwang, H., Jhuma, T. A., Atluri, R., et al. (2024) · Circulation Research · doi:10.1161/circresaha.124.325056 · Cited by 39
Pan, H., Xu, L., Huang, M.-Y., Zha, Q., Zhao, G., Hou, X.-F., Shi, Z., Lin, Q.-R., Ouyang, D., & He, X. (2015) · Oncotarget · doi:10.18632/oncotarget.5957 · Cited by 39
Fischer, D. D., Kandasamy, S., Paim, F. C., Langel, S. N., Alhamo, M. A., Shao, L., Chepngeno, J., Miyazaki, A., Huang, H., Kumar, A., et al. (2017) · Clinical and Vaccine Immunology · doi:10.1128/cvi.00172-17 · Cited by 39
Miyazaki, A., Kandasamy, S., Michael, H., Langel, S. N., Paim, F. C., Chepngeno, J., Alhamo, M. A., Fischer, D. D., Huang, H., Srivastava, V., et al. (2018) · Vaccine · doi:10.1016/j.vaccine.2018.09.008 · Cited by 40
The benefits of Vitamin D in the COVID-19 pandemic: biochemical and immunological mechanisms
Musavi, H., Abazari, O., Barartabar, Z., Kalaki-Jouybari, F., Hemmati-Dinarvand, M., Esmaeili, P., & Mahjoub, S. (2020) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2020.1826530 · Cited by 38
Follmer, C. (2020) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.0c00671 · Cited by 37
Suresh, V., Parida, D., Minz, A. P., Sethi, M., Sahoo, B. S., & Senapati, S. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.579330 · Cited by 38
From the Role of Microbiota in Gut‐Lung Axis to SARS‐CoV‐2 Pathogenesis
Badi, S. A., Tarashi, S., Fateh, A., Rohani, P., Masotti, A., & Siadat, S. D. (2021) · Mediators of Inflammation · doi:10.1155/2021/6611222 · Cited by 39
Tang, Q., Wang, Y., Ou, L., Li, J., Zheng, K., Zhan, H., Gu, J., Zhou, G., Xie, S., Zhang, J., et al. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.57802 · Cited by 38
Potential Associations Between Microbiome and COVID-19
Wang, H., Wang, H., Sun, Y., Ren, Z., Zhu, W., Li, A., & Cui, G. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.785496 · Cited by 41
SARS‐CoV‐2 triggered oxidative stress and abnormal energy metabolism in gut microbiota
Zhou, T., Wu, J., Zeng, Y., Li, J., Yan, J., Meng, W., Han, H., Feng, F., He, J., Zhao, S., et al. (2022) · MedComm · doi:10.1002/mco2.112 · Cited by 40
Steegenga, W. T., Mischke, M., Lute, C., Boekschoten, M. V., Lendvai, Á., Pruis, M. G. M., Verkade, H. J., van de Heijning, B. J. M., Boekhorst, J., Timmerman, H. M., et al. (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201600141 · Cited by 39
Maintenance of Enteral ACE2 Prevents Diabetic Retinopathy in Type 1 Diabetes
Prasad, R., Floyd, J. L., Dupont, M., Harbour, A., Adu-Agyeiwaah, Y., Asare‐Bediako, B., Chakraborty, D., Kichler, K., Rohella, A., Calzi, S. L., et al. (2022) · Circulation Research · doi:10.1161/circresaha.122.322003 · Cited by 41
Microbial modulation of tryptophan metabolism links gut microbiota to disease and its treatment
Zhao, P., Chen, Y., Zhou, S., & Li, F. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107896 · Cited by 40
Doroftei, B., Ilie, O., Cojocariu, R.-O., Ciobica, A. S., Maftei, R., Grab, D., Anton, E., McKenna, J., Dhunna, N., & Simionescu, G. (2020) · Molecules · doi:10.3390/molecules25153323 · Cited by 40
Premises among SARS-CoV-2, dysbiosis and diarrhea: Walking through the ACE2/mTOR/autophagy route
de Oliveira, A. P., Lopes, A. L. F., Pacheco, G., Nolêto, I. R. D. S. G., Nicolau, L. A. D., & Medeiros, J. V. R. (2020) · Medical Hypotheses · doi:10.1016/j.mehy.2020.110243 · Cited by 38
Olaniyan, O. T., Dare, A., Okotie, G. E., Adetunji, C. O., Ibitoye, B. O., Okoli, B. J., & Eweoya, O. O. (2020) · Journal of Basic and Clinical Physiology and Pharmacology · doi:10.1515/jbcpp-2020-0156 · Cited by 38
Ceccarelli, G., Scagnolari, C., Pugliese, F. R., Mastroianni, C. M., & d’Ettorre, G. (2020) · The Lancet. Gastroenterology & hepatology · doi:10.1016/s2468-1253(20)30196-5 · Cited by 38
Targeting RAGE to prevent SARS-CoV-2-mediated multiple organ failure: Hypotheses and perspectives
Chiappalupi, S., Salvadori, L., Vukašinović, A., Donato, R., Sorci, G., & Riuzzi, F. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119251 · Cited by 39
Zhang, Y., Xie, Z., Zhou, J., Li, Y., Ning, C., Su, Q., Ye, L., Ai, S., Lai, J., Pan, P., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1020822 · Cited by 37
Research progress of post-acute sequelae after SARS-CoV-2 infection
Jiao, T., Huang, Y., Sun, H., & Yang, L. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06642-5 · Cited by 41
Nozato, S., Yamamoto, K. I., Takeshita, H., Nozato, Y., Imaizumi, Y., Fujimoto, T., Yokoyama, S., Nagasawa, M., Takeda, M., Hongyo, K., et al. (2019) · Clinical Science · doi:10.1042/cs20190573 · Cited by 37
Shin, J., Lee, Y.-K., Shon, W.-J., Kim, B., Jeon, C. O., Cho, J., Morse, H. C., Choi, E. Y., & Shin, D.-M. (2020) · European Journal of Nutrition · doi:10.1007/s00394-020-02194-4 · Cited by 37
The Contribution of Endothelial Dysfunction in Systemic Injury Subsequent to SARS-Cov-2 Infection
Maiuolo, J., Mollace, R., Gliozzi, M., Musolino, V., Carresi, C., Paone, S., Scicchitano, M., Macrì, R., Nucera, S., Bosco, F., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21239309 · Cited by 38
Gastrointestinal mucosal immunity and COVID-19
Velikova, T. V., Snegarova, V., Kukov, A., Batselova, H., Mihova, A., & Nakov, R. (2021) · World Journal of Gastroenterology · doi:10.3748/wjg.v27.i30.5047 · Cited by 37
ACE2 pathway regulates thermogenesis and energy metabolism
Cao, X., Shi, T., Zhang, C., Jin, W., Song, L., Zhang, Y., Liu, J., Yang, F., Rotimi, C. N., Xu, A., et al. (2022) · eLife · doi:10.7554/elife.72266 · Cited by 37
The potential application of probiotics for the prevention and treatment of COVID-19
Elekhnawy, E., & Negm, W. A. (2022) · Egyptian Journal of Medical Human Genetics · doi:10.1186/s43042-022-00252-6 · Cited by 40
Retrospective analysis of clinical characteristics of 405 patients with COVID-19
Zhan, T., Liu, M., Tang, Y., Han, Z., Cheng, X., Deng, J., Chen, X., Xia, T., & Huang, X. (2020) · Journal of International Medical Research · doi:10.1177/0300060520949039 · Cited by 36
Li, Q., You, Y., Zeng, Y., Wang, X., Pan, Z., Pang, J., Chen, Q., Zhou, Y., Jin, Y., Yang, Y., et al. (2022) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqac170 · Cited by 36
Gut microbial response to host metabolic phenotypes
Hou, J., Xiang, J., Li, D., Liu, X., & Pan, W. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.1019430 · Cited by 38
Gao, N., Yang, Y., Liu, S., Fang, C., Dou, X., Zhang, L., & Shan, A. (2022) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c05381 · Cited by 36
The causal links between gut microbiota and COVID‐19: A Mendelian randomization study
Song, J., Wu, Y., Yin, X., Ma, H., & Zhang, J. (2023) · Journal of Medical Virology · doi:10.1002/jmv.28784 · Cited by 35
Nutrition, microbiomes, and intestinal inflammation
Devkota, S., & Chang, E. B. (2013) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e328365d38f · Cited by 36
Zhang, Z.-Z., Shang, Q., Jin, H., Song, B., Oudit, G. Y., Lu, L., Zhou, T., Xu, Y., Gao, P., Zhu, D., et al. (2013) · Journal of Translational Medicine · doi:10.1186/1479-5876-11-229 · Cited by 36
Self-citationMicrobiome as an Immunological Modifier
Kumar, M., Singh, P., Murugesan, S., Vétizou, M., McCulloch, J. A., Badger, J. H., Trinchieri, G., & Khodor, S. A. (2019) · Methods in molecular biology · doi:10.1007/978-1-4939-9773-2_27 · Cited by 36
Therapeutic Delivery of Ang(1–7) via Genetically Modified Probiotic: A Dosing Study
Carter, C. S., Morgan, D., Verma, A., Lobaton, G. O., Aquino, V. P., Sumners, E., Raizada, M. K., Li, Q., & Buford, T. W. (2019) · The Journals of Gerontology Series A · doi:10.1093/gerona/glz222 · Cited by 36
Wang, X., Bhullar, K. S., Fan, H., Liao, W., Qiao, Y., Su, D., & Wu, J. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c00028 · Cited by 37
Heteromeric Solute Carriers: Function, Structure, Pathology and Pharmacology
Fairweather, S. J., Shah, N., & Bröer, S. (2020) · Advances in experimental medicine and biology · doi:10.1007/5584_2020_584 · Cited by 37
Angiotensin-converting enzyme 2 and COVID-19 in cardiorenal diseases
Sharma, R. K., Li, J., Krishnan, S., Richards, E. M., Raizada, M. K., & Mohandas, R. (2021) · Clinical Science · doi:10.1042/cs20200482 · Cited by 36
Gao, N., Dou, X., Yin, T., Yang, Y., Yan, D., Ma, Z., Bi, C., & Shan, A. (2021) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.1c05820 · Cited by 36
In Silico Analysis of Bacteriocins from Lactic Acid Bacteria Against SARS-CoV-2
Erol, İ., Kotil, S., Fidan, Ö., Yetiman, A. E., Durdağı, S., & Ortakcı, F. (2021) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-021-09879-0 · Cited by 36
COVID-19: Gastrointestinal manifestations, liver injury and recommendations
Özkurt, Z., & Tanrıverdi, E. Ç. (2022) · World Journal of Clinical Cases · doi:10.12998/wjcc.v10.i4.1140 · Cited by 39
Hu, G., Ling, C., Chi, L., Thind, M. K., Furse, S., Koulman, A., Swann, J. R., Lee, D., Calon, M. M., Bourdon, C., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-35317-y · Cited by 37
Durairajan, S. S. K., Singh, A. K., Saravanan, U. B., Namachivayam, M., Radhakrishnan, M., Huang, J., Dhodapkar, R., & Zhang, H. (2023) · Viruses · doi:10.3390/v15061231 · Cited by 37
Luo, Y., Wu, J., Zhu, F., Wu, J., Wu, P., & Liu, Y. (2022) · Drug Design Development and Therapy · doi:10.2147/dddt.s352467 · Cited by 34
Metabolic networks of the human gut microbiota
Selber‐Hnatiw, S., Sultana, T., Tse, W., Abdollahi, N., Abdullah, S., Rahbani, J. A., Alazar, D., Alrumhein, N. J., Aprikian, S., Arshad, R., et al. (2019) · Microbiology · doi:10.1099/mic.0.000853 · Cited by 38
Buford, T. W., Sun, Y., Roberts, L. M., Banerjee, A., Peramsetty, S., Knighton, A., Verma, A., Morgan, D., Torres, G. E., Li, Q., et al. (2020) · GeroScience · doi:10.1007/s11357-020-00196-y · Cited by 35
Immunometabolic Status of COVID-19 Cancer Patients
Sica, A., Colombo, M. P., Trama, A., Horn, L., Garassino, M. C., & Torri, V. (2020) · Physiological Reviews · doi:10.1152/physrev.00018.2020 · Cited by 35
Gut Dysbiosis in Pancreatic Diseases: A Causative Factor and a Novel Therapeutic Target
Zhang, T., Gao, G., Sakandar, H. A., Kwok, L., & Sun, Z. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.814269 · Cited by 39
Role of the Microbiome in the Pathogenesis of COVID-19
De, R., & Dutta, S. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.736397 · Cited by 35
SARS‐CoV‐2 spike spurs intestinal inflammation via VEGF production in enterocytes
Zeng, F., Li, Y., Deng, Z., He, J., Li, W., Wang, L., Lyu, T., Li, Z., Mei, C., Yang, M., et al. (2022) · EMBO Molecular Medicine · doi:10.15252/emmm.202114844 · Cited by 35
McMillan, A., Orimadegun, A. E., Sumarah, M. W., Renaud, J. B., Muc, M., Gloor, G. B., Akinyinka, O. O., Reid, G., & Allen, S. J. (2016) · Metabolomics · doi:10.1007/s11306-016-1150-2 · Cited by 37
Gut Microbiota Metabolites: Unveiling Their Role in Inflammatory Bowel Diseases and Fibrosis
Bernardi, F., D’Amico, F., Bencardino, S., Faggiani, I., Fanizza, J., Zilli, A., Parigi, T. L., Allocca, M., Danese, S., & Furfaro, F. (2024) · Pharmaceuticals · doi:10.3390/ph17030347 · Cited by 39
AYUSH- 64: A potential therapeutic agent in COVID-19
Panda, A. K., Kar, S., Kumar, A., Rao, B. C. S., & Srikanth, N. (2022) · Journal of Ayurveda and Integrative Medicine · doi:10.1016/j.jaim.2021.100538 · Cited by 34
Clerbaux, L., Filipovska, J., Muñoz, A., Petrillo, M., Coecke, S., Amorim, M. J., & Grenga, L. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11185400 · Cited by 36
Angiotensin Converting Enzyme-Inhibitor Reduces Colitis Severity in an IL-10 Knockout Model
Sueyoshi, R., Ignatoski, K. M. W., Daignault, S. D., Okawada, M., & Teitelbaum, D. H. (2013) · Digestive Diseases and Sciences · doi:10.1007/s10620-013-2825-4 · Cited by 34
Hirata, Y., Ihara, S., & Koike, K. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.09.044 · Cited by 35
Yu, F., Du, Y., Li, C., Zhang, H., Lai, W., Li, S., Ye, Z., Fu, W., Li, S., Li, X., et al. (2024) · Scientific Reports · doi:10.1038/s41598-023-50990-9 · Cited by 36
D-Amino acids from foods and gut microbiota and their effects in health and disease
Roskjær, A. B., Roager, H. M., & Dragsted, L. O. (2024) · Food Reviews International · doi:10.1080/87559129.2024.2347472 · Cited by 35
Pei, T., Li, W., Zhou, Z., Zhang, Q., Yu, G., Yin, S., Chen, H., & Tang, J. (2025) · Microbiological Research · doi:10.1016/j.micres.2025.128211 · Cited by 40
Xenobiotic Receptor-Mediated Regulation of Intestinal Barrier Function and Innate Immunity
Ranhotra, H. S., Flannigan, K. L., Brave, M., Mukherjee, S., Lukin, D. J., Hirota, S. A., & Mani, S. (2016) · Nuclear Receptor Research · doi:10.11131/2016/101199 · Cited by 37
Díaz, L. A., García‐Salum, T., Fuentes–López, E., Marcela Ferrés, G., Medina, R., & Riquelme, A. J. (2020) · Gastroenterology · doi:10.1053/j.gastro.2020.05.014 · Cited by 33
Precision Nutrition in Chronic Inflammation
Demetrowitsch, T. J., Schlicht, K., Knappe, C., Zimmermann, J., Jensen‐Kroll, J., Pisarevskaja, A., Brix, F., Brandes, J., Geisler, C., Μαρίνος, Γ., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.587895 · Cited by 35
Meng, Z., Guo, S., Zhou, Y., Li, M., Wang, M., & Ying, B. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00731-z · Cited by 35
Impact of COVID-19 on the Gastrointestinal Tract: A Clinical Review
Ghazanfar, H., Kandhi, S., Shin, D., Muthumanickam, A., Gurjar, H., Qureshi, Z. A., Shaban, M., FARAG, M. E., Haider, A., Budhathoki, P., et al. (2022) · Cureus · doi:10.7759/cureus.23333 · Cited by 33
Devi, P., Maurya, R., Mehta, P., Shamim, U., Yadav, A., Chattopadhyay, P., Kanakan, A., Khare, K., Vasudevan, J. S., Sahni, S., et al. (2022) · Microbiology Spectrum · doi:10.1128/spectrum.02311-21 · Cited by 32
Leone, V., Cham, C. M., & Chang, E. B. (2014) · Current Opinion in Immunology · doi:10.1016/j.coi.2014.08.004 · Cited by 32
Hardenberg, J.-H., & Luft, F. C. (2020) · Acta Physiologica · doi:10.1111/apha.13539 · Cited by 32
Mithal, A., Hume, A. J., Lindstrom-Vautrin, J., Villacorta-Martín, C., Olejnik, J., Bullitt, E., Hinds, A., Mühlberger, E., & Mostoslavsky, G. (2020) · Stem Cell Reports · doi:10.1016/j.stemcr.2021.02.019 · Cited by 36
COVID-19: biologic and immunosuppressive therapy in gastroenterology and hepatology
Neurath, M. F. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00480-y · Cited by 30
Microbiota-Gut-Brain Communication in the SARS-CoV-2 Infection
Manosso, L. M., Arent, C. O., Borba, L. A., Ceretta, L. B., Quevedo, J., & Réus, G. Z. (2021) · Cells · doi:10.3390/cells10081993 · Cited by 36
Molecular Insights into SARS-CoV2-Induced Alterations of the Gut/Brain Axis
Nataf, S., & Pays, L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910440 · Cited by 33
Alterations in the Composition of Intestinal DNA Virome in Patients With COVID-19
Lü, Z., Zhou, H., Wu, W., Fu, T., Yan, M., He, Z., Sun, S., Ji, Z., & Shao, Z. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.790422 · Cited by 30
Roles of Microbiota in Cancer: From Tumor Development to Treatment
Bagheri, Z., Moeinzadeh, L., & Razmkhah, M. (2022) · Journal of Oncology · doi:10.1155/2022/3845104 · Cited by 32
Xu, L., Yang, C. S., Liu, Y., & Zhang, X. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.895193 · Cited by 33
Diverse biological functions of the renin‐angiotensin system
Rao, A., Bhat, S. A., Shibata, T., Giani, J. F., Rader, F., Bernstein, K. E., & Khan, Z. (2023) · Medicinal Research Reviews · doi:10.1002/med.21996 · Cited by 31
Protein energy malnutrition increases arginase activity in monocytes and macrophages
Corware, K., Yardley, V., Mack, C., Schuster, S., Al-Hassi, H. O., Herath, S., Bergin, P. J., Modolell, M., Munder, M., Müller, I., et al. (2014) · Nutrition & Metabolism · doi:10.1186/1743-7075-11-51 · Cited by 31
Bortoluzzi, C., Fernandes, J. I. M., Doranalli, K., & Applegate, T. J. (2019) · Animal Feed Science and Technology · doi:10.1016/j.anifeedsci.2019.114383 · Cited by 31
Metadata
- Authors
- Hashimoto, T., Perlot, T., Rehman, A., Trichereau, J., Ishiguro, H., Paolino, M., Sigl, V., Hanada, T., Hanada, R., Lipinski, S., Wild, B., Camargo, S. M. R., Singer, D., Richter, A., Kuba, K., Fukamizu, A., Schreiber, S., Clevers, H., Verrey, F., Rosenstiel, P., & Penninger, J. M.
- Affiliations
- Institute of Molecular Biotechnology (AT)
- University Medical Center Freiburg (DE)
- Yokohama City University (JP)
- Christian-Albrechts-Universität zu Kiel (DE)
- University of Vienna (AT)
- University of Zurich (CH)
- Akita University (JP)
- University of Tsukuba (JP)
- Royal Netherlands Academy of Arts and Sciences (NL)
- Corresponding author
- Rosenstiel, Philip
- Penninger, Josef M.
- ORCID
- Venue
- Nature
- Published
- 2012-07-25
- Volume
- 487
- Issue
- 7408
- Pages
- 477-481
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC7095315
- OpenAlex
- W2017614891
- Cited by
- 1,271
- References
- 44
- Citations by year
- 2026: 35 · 2025: 70 · 2024: 96 · 2023: 135 · 2022: 180 · 2021: 229 · 2020: 259 · 2019: 39 · 2018: 44 · 2017: 31 · 2016: 35 · 2015: 28 · 2014: 32 · 2013: 46 · 2012: 11
- FWCI
- 15.03
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Nature (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- KNAW Research Portal (The Royal Netherlands Academy of Arts and Sciences) (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- European Respiratory Society
- Deutsche Forschungsgemeinschaft (SFB 877, SPP 1399)
- Österreichischen Akademie der Wissenschaften
- Bundesministerium für Bildung und Forschung
- Exzellenzclusters Entzündungsforschung
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
- Keywords
- ACE2, angiotensin-converting enzyme 2, protein malnutrition, colitis, intestinal inflammation, gut microbiota, tryptophan metabolism, nicotinamide, renin-angiotensin system, innate immunity, antimicrobial peptides, microbial ecology, epithelial damage, germ-free mice, microbiota transplantation
- MeSH terms
- Angiotensin-Converting Enzyme 2, Animals, Colitis, Diarrhea, Dietary Proteins, Female, Germ-Free Life, Homeostasis, Immunity, Innate, Intestines, Peptidyl-Dipeptidase A, Male, Models, Biological, Niacinamide, Renin-Angiotensin System, Trinitrobenzenesulfonic Acid, Tryptophan, Dextran Sulfate, Gene Deletion, Genetic Predisposition to Disease, Malnutrition, Mice, Metagenome, Biocatalysis, TOR Serine-Threonine Kinases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
