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ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation
Open accessAbstract
Malnutrition affects up to one billion people in the world and is a major cause of mortality. In many cases, malnutrition is associated with diarrhoea and intestinal inflammation, further contributing to morbidity and death. The mechanisms by which unbalanced dietary nutrients affect intestinal homeostasis are largely unknown. Here we report that deficiency in murine angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 (Ace2), which encodes a key regulatory enzyme of the renin-angiotensin system (RAS), results in highly increased susceptibility to intestinal inflammation induced by epithelial damage. The RAS is known to be involved in acute lung failure, cardiovascular functions and SARS infections. Mechanistically, ACE2 has a RAS-independent function, regulating intestinal amino acid homeostasis, expression of antimicrobial peptides, and the ecology of the gut microbiome. Transplantation of the altered microbiota from Ace2 mutant mice into germ-free wild-type hosts was able to transmit the increased propensity to develop severe colitis. ACE2-dependent changes in epithelial immunity and the gut microbiota can be directly regulated by the dietary amino acid tryptophan. Our results identify ACE2 as a key regulator of dietary amino acid homeostasis, innate immunity, gut microbial ecology, and transmissible susceptibility to colitis. These results provide a molecular explanation for how amino acid malnutrition can cause intestinal inflammation and diarrhoea.
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“and ACE2 deficiency has been shown to result in impaired tryptophan homeostasis (Hashimoto et al., 2012).”
From Viral Infections, the Microbiome, and Probiotics (2021) · cites this paper as Hashimoto et al., 2012
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Cites
Naive Bayesian Classifier for Rapid Assignment of rRNA Sequences into the New Bacterial Taxonomy
Wang, Q., Garrity, G. M., Tiedje, J. M., & Cole, J. R. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.00062-07 · Cited by 20,145
Schloss, P. D., Westcott, S. L., Ryabin, T., Hall, J. R., Hartmann, M., Hollister, E. B., Lesniewski, R. A., Oakley, B. B., Parks, D. H., Robinson, C. J., et al. (2009) · Applied and Environmental Microbiology · doi:10.1128/aem.01541-09 · Cited by 19,549
PAST: PALEONTOLOGICAL STATISTICAL SOFTWARE PACKAGE FOR EDUCATION AND DATA ANALYSIS
Hammer, Ø., Harper, D. A. T., & Ryan, P. D. (2001) · Palaeontologia Electronica · Cited by 17,871
UCHIME improves sensitivity and speed of chimera detection
Edgar, R. C., Haas, B. J., Clemente, J. C., Quince, C., & Knight, R. (2011) · Bioinformatics · doi:10.1093/bioinformatics/btr381 · Cited by 15,114
Non‐parametric multivariate analyses of changes in community structure
Clarke, K. R. (1993) · Australian Journal of Ecology · doi:10.1111/j.1442-9993.1993.tb00438.x · Cited by 14,449
Pruesse, E., Quast, C., Knittel, K., Fuchs, B. M., Ludwig, W., Peplies, J., & Glöckner, F. O. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm864 · Cited by 6,682
A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus–induced lung injury
Kuba, K., Imai, Y., Rao, S., Gao, H., Guo, F., Guan, B., Huan, Y., Yang, P., Zhang, Y., Deng, W., et al. (2005) · Nature Medicine · doi:10.1038/nm1267 · Cited by 3,445
Self-citationDonoghue, M., Hsieh, F., Baronas, E., Godbout, K., Gosselin, M., Stagliano, N., Donovan, M., Woolf, B., Robison, K., Jeyaseelan, R., et al. (2000) · Circulation Research · doi:10.1161/01.res.87.5.e1 · Cited by 2,485
Angiotensin-converting enzyme 2 protects from severe acute lung failure
Imai, Y., Kuba, K., Rao, S., Huan, Y., Guo, F., Guan, B., Yang, P., Sarao, R., Wada, T., Leong-Poi, H., et al. (2005) · Nature · doi:10.1038/nature03712 · Cited by 2,453
Self-citationOkayasu, I., Hatakeyama, S., Yamada, M., Ohkusa, T., Inagaki, Y., & NAKAYA, R. (1990) · Gastroenterology · doi:10.1016/0016-5085(90)90290-h · Cited by 2,408
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Hill, L. J., & Williams, A. C. (2017) · International Journal of Tryptophan Research · doi:10.1177/1178646917704662 · Cited by 23
Fetriyuna, F., Purwestri, R. C., Jati, I. R. A. P., Setiawan, B., Huda, S., Wirawan, N. N., & Andoyo, R. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e22478 · Cited by 44
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Sakai, K., Maeda, S., Yonezawa, T., & Matsuki, N. (2017) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2017.11.001 · Cited by 22
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Lenglet, A., Fabresse, N., Taupin, M., Gomila, C., Liabeuf, S., Kamel, S., Alvarez, J., Drüeke, T. B., & Massy, Z. A. (2019) · Drugs · doi:10.1007/s40265-019-01118-9 · Cited by 21
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Gazi, M. A., Das, S., Siddique, M. A., Alam, M. A., Fahim, S. M., Hasan, M. M., Hossaini, F., Kabir, M. M., Noor, Z., Haque, R., et al. (2020) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.20-0049 · Cited by 23
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Farsijani, S., Cauley, J. A., Peddada, S., Langsetmo, L., Shikany, J. M., ORWOLL, E. S., Ensrud, K. E., Cawthon, P. M., & Newman, A. B. (2022) · Journal of Nutrition · doi:10.1093/jn/nxac231 · Cited by 21
Alterations of the gut microbiota in coronavirus disease 2019 and its therapeutic potential
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Wang, F., Pan, B., Xu, S., Xu, Z., Zhang, T., Zhang, Q., Bao, Y., Wang, Y., Zhang, J., Xu, C., et al. (2021) · Bioscience Reports · doi:10.1042/bsr20203638 · Cited by 24
The Role of the Gastrointestinal System in Neuroinvasion by SARS-CoV-2
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Suntornsaratoon, P., Antonio, J. M., Flores, J., Upadhyay, R., Veltri, J., Bandyopadhyay, S., Dadala, R., Kim, M., Liu, Y., Balasubramanian, I., et al. (2024) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2024.04.003 · Cited by 23
Barlattani, T., Celenza, G., Cavatassi, A., Minutillo, F., Socci, V., Pinci, C., Santini, R., & Pacitti, F. (2024) · Current Neuropharmacology · doi:10.2174/011570159x343115241030094848 · Cited by 20
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Muñoz-Olivos, C., Bautista, E., Jose, R.-A. M., Berenice, P.-G., Zacapa, D., & Cortez-Sánchez, J. L. (2025) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-025-10475-9 · Cited by 26
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Rahban, M., Stanek, A., Hooshmand, A., Khamineh, Y., Ahi, S., Kazim, S. N., Ahmad, F., Muronetz, V. I., Abousenna, M. S., Zolghadri, S., et al. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10214802 · Cited by 20
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Biagioli, M., Marchianò, S., Roselli, R., Giorgio, C. D., Bellini, R., Bordoni, M., Distrutti, E., Catalanotti, B., Zampella, A., Graziosi, L., et al. (2022) · Cells · doi:10.3390/cells11071187 · Cited by 22
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Zong, Y., Wang, X., & Wang, J. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1256940 · Cited by 20
Das, S., Rajeswari, V. D., Venkatraman, G., Elumalai, R., Sivaraman, D., & Ramanathan, G. (2023) · Translational research · doi:10.1016/j.trsl.2023.11.002 · Cited by 22
COVID-19 and gastrointestinal system: A brief review
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Li, S., Yang, S., Zhang, Y., Huang, K., Liang, T., Chen, Y., Guan, Y. A., Shang, R., Guan, T., Wu, J., et al. (2022) · European Journal of Nutrition · doi:10.1007/s00394-022-02906-y · Cited by 20
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Dipasquale, V., Passanisi, S., Cucinotta, U., Cascio, A., & Romano, C. (2021) · The Italian Journal of Pediatrics/Italian journal of pediatrics · doi:10.1186/s13052-021-01020-9 · Cited by 20
Wu, S., Zhang, Q., Cong, G., Xiao, Y., Shen, Y., Zhang, S., Zhao, W., & Shi, S. (2023) · Animal nutrition · doi:10.1016/j.aninu.2023.06.001 · Cited by 19
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Li, J., Yan, Y., Fu, Y., Chen, Z., Yang, Y., Li, Y., Pan, J., Li, F., Zha, C., Miao, K., et al. (2024) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-024-00603-8 · Cited by 22
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Pang, X. C., Zhang, H. X., Zhang, Z., Suguro, R., Cui, Y., & Zhu, Y. Z. (2020) · Molecules · doi:10.3390/molecules26010142 · Cited by 18
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Bachour, S. P., Dalal, R. S., & Allegretti, J. R. (2023) · Therapeutic Advances in Gastroenterology · doi:10.1177/17562848231165581 · Cited by 18
Yousef, M., Rob, M., Varghese, S., Rao, S., Zamir, F., Paul, P., & Châari, A. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122535 · Cited by 21
Nobis, S., Achamrah, N., Goichon, A., L’Huillier, C., Morin, A., Guérin, C., Chan, P., do Rego, J. L., do Rego, J. L., Vaudry, D., et al. (2018) · PROTEOMICS · doi:10.1002/pmic.201700395 · Cited by 17
Zhang, Y., Hou, Q., Ma, C., Zhao, J., Xu, H., Li, W., Wang, Y., Ma, H., Zhang, H., & Sun, Z. (2019) · European Journal of Nutrition · doi:10.1007/s00394-019-02001-9 · Cited by 18
Tang, Z., Shi, B., Sun, W., Yin, Y., Chen, Q., Mohamed, T. M., Lu, C., & Sun, Z. (2020) · RSC Advances · doi:10.1039/c9ra10477a · Cited by 18
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Hu, C., Wu, Q., Hu, D., & Tkebuchava, T. (2017) · Chronic Diseases and Translational Medicine · doi:10.1016/j.cdtm.2017.05.002 · Cited by 18
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Pagliaro, P., Thairi, C., Alloatti, G., & Penna, C. R. R. (2021) · Journal of Cardiovascular Medicine · doi:10.2459/jcm.0000000000001218 · Cited by 17
Tan, R., Jin, M., Chen, Z., Shao, Y., Song, Y., Yin, J., Wang, L., Chen, T., Lǐ, J., & Yang, D. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2156764 · Cited by 19
Gastrointestinal disorders in post-COVID syndrome. Clinical guidelines
Grinevich, V. B., Лазебник, Л. Б., Kravchuk, Y. A., Радченко, В. Г., Ei, T., Першко, А. М., Seliverstov, P. V., Salikova, S. P., Zhdanov, K. V., Kozlov, K. V., et al. (2023) · Экспериментальная и клиническая гастроэнтерология · doi:10.31146/1682-8658-ecg-208-12-4-68 · Cited by 20
Zhang, Y., Wan, Y., Xin, X., Qiao, Y., Qiao, W., Ping, J., & Su, J. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1435180 · Cited by 19
Nuding, S., Antoni, L., & Stange, E. F. (2013) · Digestive Diseases · doi:10.1159/000354680 · Cited by 20
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Metadata
- Authors
- Hashimoto, T., Perlot, T., Rehman, A., Trichereau, J., Ishiguro, H., Paolino, M., Sigl, V., Hanada, T., Hanada, R., Lipinski, S., Wild, B., Camargo, S. M. R., Singer, D., Richter, A., Kuba, K., Fukamizu, A., Schreiber, S., Clevers, H., Verrey, F., Rosenstiel, P., & Penninger, J. M.
- Affiliations
- Institute of Molecular Biotechnology (AT)
- University Medical Center Freiburg (DE)
- Yokohama City University (JP)
- Christian-Albrechts-Universität zu Kiel (DE)
- University of Vienna (AT)
- University of Zurich (CH)
- Akita University (JP)
- University of Tsukuba (JP)
- Royal Netherlands Academy of Arts and Sciences (NL)
- Corresponding author
- Rosenstiel, Philip
- Penninger, Josef M.
- ORCID
- Venue
- Nature
- Published
- 2012-07-25
- Volume
- 487
- Issue
- 7408
- Pages
- 477-481
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC7095315
- OpenAlex
- W2017614891
- Cited by
- 1,271
- References
- 44
- Citations by year
- 2026: 35 · 2025: 70 · 2024: 96 · 2023: 135 · 2022: 180 · 2021: 229 · 2020: 259 · 2019: 39 · 2018: 44 · 2017: 31 · 2016: 35 · 2015: 28 · 2014: 32 · 2013: 46 · 2012: 11
- FWCI
- 15.03
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Nature (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- KNAW Research Portal (The Royal Netherlands Academy of Arts and Sciences) (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- European Respiratory Society
- Deutsche Forschungsgemeinschaft (SFB 877, SPP 1399)
- Österreichischen Akademie der Wissenschaften
- Bundesministerium für Bildung und Forschung
- Exzellenzclusters Entzündungsforschung
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
- Keywords
- ACE2, angiotensin-converting enzyme 2, protein malnutrition, colitis, intestinal inflammation, gut microbiota, tryptophan metabolism, nicotinamide, renin-angiotensin system, innate immunity, antimicrobial peptides, microbial ecology, epithelial damage, germ-free mice, microbiota transplantation
- MeSH terms
- Angiotensin-Converting Enzyme 2, Animals, Colitis, Diarrhea, Dietary Proteins, Female, Germ-Free Life, Homeostasis, Immunity, Innate, Intestines, Peptidyl-Dipeptidase A, Male, Models, Biological, Niacinamide, Renin-Angiotensin System, Trinitrobenzenesulfonic Acid, Tryptophan, Dextran Sulfate, Gene Deletion, Genetic Predisposition to Disease, Malnutrition, Mice, Metagenome, Biocatalysis, TOR Serine-Threonine Kinases
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