Non-synaptic inhibition between grouped neurons in an olfactory circuit
Open accessAbstract
Diverse sensory organs, including mammalian taste buds and insect chemosensory sensilla, show a marked compartmentalization of receptor cells; however, the functional impact of this organization remains unclear. Here we show that compartmentalized Drosophila olfactory receptor neurons (ORNs) communicate with each other directly. The sustained response of one ORN is inhibited by the transient activation of a neighbouring ORN. Mechanistically, such lateral inhibition does not depend on synapses and is probably mediated by ephaptic coupling. Moreover, lateral inhibition in the periphery can modulate olfactory behaviour. Together, the results show that integration of olfactory information can occur via lateral interactions between ORNs. Inhibition of a sustained response by a transient response may provide a means of encoding salience. Finally, a CO(2)-sensitive ORN in the malaria mosquito Anopheles can also be inhibited by excitation of an adjacent ORN, suggesting a broad occurrence of lateral inhibition in insects and possible applications in insect control.
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EM field communication between neurons is an ancient mode of neuronal communication, found in vertebrates, insects, arthropods, and molluscs.
“The first point is that it is clearly a very ancient mode of neuronal communication as it is found not only in vertebrates but also in insects [75], arthropods [76] and molluscs [77].”
From The electromagnetic will (2021) · cites this paper as [75]
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- Authors
- Su, C.-Y., Menuz, K., Reisert, J., & Carlson, J. R.
- Affiliations
- Yale University (US)
- Monell Chemical Senses Center (US)
- Corresponding author
- Carlson, John R.
- Venue
- Nature
- Published
- 2012-11-21
- Volume
- 492
- Issue
- 7427
- Pages
- 66-71
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC3518700
- OpenAlex
- W2059225708
- Cited by
- 254
- References
- 50
- Citations by year
- 2026: 9 · 2025: 13 · 2024: 25 · 2023: 16 · 2022: 19 · 2021: 15 · 2020: 17 · 2019: 15 · 2018: 18 · 2017: 18 · 2016: 21 · 2015: 16 · 2014: 24 · 2013: 27 · 2012: 1
- FWCI
- 8.96
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute on Deafness and Other Communication Disorders (F32DC011242, DC009613, R01DC009613, R01DC004729, R01DC011697)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Keywords
- lateral inhibition, olfactory sensory neurons, ephaptic coupling, Drosophila olfaction, olfactory behavior, insect control
- MeSH terms
- Animals, Anopheles, Carbon Dioxide, Dose-Response Relationship, Drug, Drosophila melanogaster, Female, Neural Inhibition, Synaptic Transmission, Olfactory Pathways, Smell, Synapses, Olfactory Receptor Neurons, Sensilla
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