The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Pif1 family helicases suppress genome instability at G-quadruplex motifs
Open accessAbstract
The Saccharomyces cerevisiae Pif1 helicase is the prototypical member of the Pif1 DNA helicase family, which is conserved from bacteria to humans. Here we show that exceptionally potent G-quadruplex unwinding is conserved among Pif1 helicases. Moreover, Pif1 helicases from organisms separated by more than 3 billion years of evolution suppressed DNA damage at G-quadruplex motifs in yeast. The G-quadruplex-induced damage generated in the absence of Pif1 helicases led to new genetic and epigenetic changes. Furthermore, when expressed in yeast, human PIF1 suppressed both G-quadruplex-associated DNA damage and telomere lengthening.
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Cites
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860
Paeschke, K., Capra, J. A., & Zakian, V. A. (2011) · Cell · doi:10.1016/j.cell.2011.04.015 · Cited by 566
Self-citationHall, B. M., Ma, C.-X., Liang, P., & Singh, K. K. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp253 · Cited by 375
Pif1p Helicase, a Catalytic Inhibitor of Telomerase in Yeast
Zhou, J.-Q., Monson, E. K., Teng, S.-C., Schulz, V. P., & Zakian, V. A. (2000) · Science · doi:10.1126/science.289.5480.771 · Cited by 236
Self-citationAnalysis of Gross‐Chromosomal Rearrangements in Saccharomyces cerevisiae
Schmidt, K. H., Pennaneach, V., Putnam, C. D., & Kolodner, R. D. (2006) · Methods in Enzymology · doi:10.1016/s0076-6879(05)09027-0 · Cited by 52
Cited by
Causes and consequences of replication stress
Zeman, M. K., & Cimprich, K. A. (2014) · Nature Cell Biology · doi:10.1038/ncb2897 · Cited by 2,079
The Structure and Function of DNA G-Quadruplexes
Spiegel, J., Adhikari, S., & Balasubramanian, S. (2020) · Trends in Chemistry · doi:10.1016/j.trechm.2019.07.002 · Cited by 920
“instability and prevent DNA strand breaks [92,93].”
BackgroundCX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours
Xu, H., Di Antonio, M., McKinney, S., Mathew, V., Ho, B., O’Neil, N. J., Santos, N. D., Silvester, J., Wei, V., Garcia, J., et al. (2017) · Nature Communications · doi:10.1038/ncomms14432 · Cited by 580
G-quadruplexes: a promising target for cancer therapy
Kosiol, N., Juranek, S., Brossart, P., Heine, A., & Paeschke, K. (2021) · Molecular Cancer · doi:10.1186/s12943-021-01328-4 · Cited by 533
Self-citationElevated Levels of G-Quadruplex Formation in Human Stomach and Liver Cancer Tissues
Biffi, G., Tannahill, D., Miller, J., Howat, W. J., & Balasubramanian, S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0102711 · Cited by 223
Metadata
- Authors
- Paeschke, K., Bochman, M. L., Garcia, P. D., Cejka, P., Friedman, K. L., Kowalczykowski, S. C., & Zakian, V. A.
- Venue
- Nature
- Published
- 2013-05-08
- Volume
- 497
- Issue
- 7450
- Pages
- 458-462
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2093320042
- Cited by
- 457
- References
- 5
- FWCI
- 18.83
- Type
- journal article
- Language
- en
- Open access
- green
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- Paeschke, K., Bochman, M. L., Garcia, P. D., Cejka, P., Friedman, K. L., Kowalczykowski, S. C., & Zakian, V. A. (2013). Pif1 family helicases suppress genome instability at G-quadruplex motifs. Nature. https://doi.org/10.1038/nature12149
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