The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Barium distributions in teeth reveal early-life dietary transitions in primates
Open accessAbstract
Early-life dietary transitions reflect fundamental aspects of primate evolution and are important determinants of health in contemporary human populations. Weaning is critical to developmental and reproductive rates; early weaning can have detrimental health effects but enables shorter inter-birth intervals, which influences population growth. Uncovering early-life dietary history in fossils is hampered by the absence of prospectively validated biomarkers that are not modified during fossilization. Here we show that large dietary shifts in early life manifest as compositional variations in dental tissues. Teeth from human children and captive macaques, with prospectively recorded diet histories, demonstrate that barium (Ba) distributions accurately reflect dietary transitions from the introduction of mother's milk through the weaning process. We also document dietary transitions in a Middle Palaeolithic juvenile Neanderthal, which shows a pattern of exclusive breastfeeding for seven months, followed by seven months of supplementation. After this point, Ba levels in enamel returned to baseline prenatal levels, indicating an abrupt cessation of breastfeeding at 1.2 years of age. Integration of Ba spatial distributions and histological mapping of tooth formation enables novel studies of the evolution of human life history, dietary ontogeny in wild primates, and human health investigations through accurate reconstructions of breastfeeding history.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The observed metal distributions were in agreement with previous studies using tooth-matrix biomarkers1419.”
From Fetal and postnatal metal dysregulation in autism (2017) · cites this paper as [19]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Observational study of behavior: sampling methods
Altmann, J. (1974) · Behaviour · doi:10.1163/156853974x00534 · Cited by 13,891
Breastfeeding and Maternal and Infant Health Outcomes In Developed Countries
(2007) · AAP Grand Rounds · doi:10.1542/gr.18-2-15 · Cited by 1,556
Breastfeeding and maternal and infant health outcomes in developed countries.
Ip, S., Chung, M. C., Raman, G., Chew, P., Magula, N. P., DeVine, D., Trikalinos, T. A., & Lau, J. (2007) · PubMed Central · Cited by 1,416
Dentin structure composition and mineralization
Goldberg, M. (2010) · Frontiers in Bioscience-Elite · doi:10.2741/e281 · Cited by 823
Cellular and Chemical Events During Enamel Maturation
Smith, C. E. (1998) · Critical Reviews in Oral Biology & Medicine · doi:10.1177/10454411980090020101 · Cited by 721
Eskenazi, B., Harley, K. G., Bradman, A., Weltzien, E. K., Jewell, N. P., Barr, D. B., Furlong, C. E., & Holland, N. (2004) · Environmental Health Perspectives · doi:10.1289/ehp.6789 · Cited by 542
Self-citationAltered states: effects of diagenesis on fossil tooth chemistry
Kohn, M. J., Schoeninger, M. J., & Barker, W. W. (1999) · Geochimica et Cosmochimica Acta · doi:10.1016/s0016-7037(99)00208-2 · Cited by 475
Growth, weaning and maternal investment from a comparative perspective
Lee, P. C., Majluf, P., & Gordon, I. J. (1991) · Journal of Zoology · doi:10.1111/j.1469-7998.1991.tb03804.x · Cited by 345
Weaning behaviour in human evolution
Humphrey, L. (2009) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2009.11.003 · Cited by 202
Rapid dental development in a Middle Paleolithic Belgian Neanderthal
Smith, T. M., Toussaint, M., Reid, D. J., Olejniczak, A. J., & Hublin, J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707051104 · Cited by 200
Self-citationSellen, D. (2001) · Journal of Nutrition · doi:10.1093/jn/131.10.2707 · Cited by 196
Relationship between subsistence and age at weaning in “preindustrial” societies
Sellen, D. W., & Smay, D. B. (2001) · Human Nature · doi:10.1007/s12110-001-1013-y · Cited by 182
Unlocking evidence of early diet from tooth enamel
Humphrey, L., Dean, C., Jeffries, T. E., & Penn, M. G. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711513105 · Cited by 164
Life history, maintenance, and the early origins of immune function
McDade, T. W. (2004) · American Journal of Human Biology · doi:10.1002/ajhb.20095 · Cited by 149
Rhesus macaque milk: Magnitude, sources, and consequences of individual variation over lactation
Hinde, K., Power, M. L., & Oftedal, O. T. (2008) · American Journal of Physical Anthropology · doi:10.1002/ajpa.20911 · Cited by 138
Self-citationRevisiting Neandertal diversity with a 100,000 year old mtDNA sequence
Orlando, L., Darlu, P., Toussaint, M., Bonjean, D., Otte, M., & Hänni, C. (2006) · Current Biology · doi:10.1016/j.cub.2006.05.019 · Cited by 136
Sponheimer, M., & Lee‐Thorp, J. A. (2006) · Geochimica et Cosmochimica Acta · doi:10.1016/j.gca.2005.12.022 · Cited by 128
Hare, D. J., Austin, C. E., Doble, P., & Arora, M. (2011) · Journal of Dentistry · doi:10.1016/j.jdent.2011.03.004 · Cited by 118
Self-citationNew visions of dental tissue research: Tooth development, chemistry, and structure
Smith, T. M., & Tafforeau, P. (2008) · Evolutionary Anthropology Issues News and Reviews · doi:10.1002/evan.20176 · Cited by 118
Self-citationEvidence for dietary change but not landscape use in South African early hominins
Balter, V., Braga, J., Télouk, P., & Thackeray, F. (2012) · Nature · doi:10.1038/nature11349 · Cited by 116
Recall of age of weaning and other breastfeeding variables
Gillespie, B. W., d’Arcy, H., Schwartz, K., Bobo, J. K., & Foxman, B. (2006) · International Breastfeeding Journal · doi:10.1186/1746-4358-1-4 · Cited by 98
The effect of tissue structure and soil chemistry on trace element uptake in fossils
Hinz, E. A., & Kohn, M. J. (2010) · Geochimica et Cosmochimica Acta · doi:10.1016/j.gca.2010.03.011 · Cited by 92
The Effect of Time in the U.S. on the Duration of Breastfeeding in Women of Mexican Descent
Harley, K. G., Stamm, N., & Eskenazi, B. (2007) · Maternal and Child Health Journal · doi:10.1007/s10995-006-0152-5 · Cited by 90
Self-citationFirst molar eruption, weaning, and life history in living wild chimpanzees
Smith, T. M., Machanda, Z. P., Bernard, A. B., Donovan, R. M., Papakyrikos, A. M., Muller, M. N., & Wrangham, R. W. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1218746110 · Cited by 90
Self-citationConcentrations of trace elements in sera of newborns, young infants, and adults
Krachler, M., Rossipal, E., & Mičetić‐Turk, D. (1999) · Biological Trace Element Research · doi:10.1007/bf02784401 · Cited by 83
Kohn, M. J., & Moses, R. J. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1209513110 · Cited by 81
Kohn, M. J., Morris, J., & Olin, P. (2013) · Journal of Archaeological Science · doi:10.1016/j.jas.2012.11.012 · Cited by 80
Improving acquisition times of elemental bio-imaging for quadrupole-based LA-ICP-MS
Lear, J., Hare, D. J., Adlard, P. A., Finkelstein, D. I., & Doble, P. (2011) · Journal of Analytical Atomic Spectrometry · doi:10.1039/c1ja10301f · Cited by 74
Self-citationDental Wear in Immature Late Pleistocene European Hominines
Skinner, M. F. (1997) · Journal of Archaeological Science · doi:10.1006/jasc.1996.0151 · Cited by 62
Humphrey, L., Dirks, W., Dean, C., & Jeffries, T. E. (2008) · Folia Primatologica · doi:10.1159/000113457 · Cited by 59
Zaichick, V., Zaichick, S., Карандашев, В. К., & Nosenko, S. (2008) · Biological Trace Element Research · doi:10.1007/s12011-008-8302-9 · Cited by 54
Extraction and sequencing of human and Neanderthal mature enamel proteins using MALDI-TOF/TOF MS
Nielsen-Marsh, C. M., Stegemann, C., Hoffmann, R., Smith, T., Feeney, R., Toussaint, M., Harvati, K., Panagopoulou, E., Hublin, J.-J., & Richards, M. P. (2009) · Journal of Archaeological Science · doi:10.1016/j.jas.2009.04.004 · Cited by 33
Self-citationA test of diet versus diagenesis at Ventana Cave, Arizona
Ezzo, J. A. (1992) · Journal of Archaeological Science · doi:10.1016/0305-4403(92)90004-m · Cited by 30
Porte, N., Mauerhofer, E., & Denschlag, H. O. (1997) · Journal of Radioanalytical and Nuclear Chemistry · doi:10.1007/bf02034620 · Cited by 17
Flagged first, then by citations
Cited by
Sorted by citations
Tsutaya, T., & Yoneda, M. (2014) · American Journal of Physical Anthropology · doi:10.1002/ajpa.22657 · Cited by 269
Becker, J. S., Matusch, A., & Wu, B. (2014) · Analytica Chimica Acta · doi:10.1016/j.aca.2014.04.048 · Cited by 239
Imaging metals in biology: balancing sensitivity, selectivity and spatial resolution
Hare, D. J., New, E. J., de Jonge, M. D., & McColl, G. (2015) · Chemical Society Reviews · doi:10.1039/c5cs00055f · Cited by 206
Self-citationBiospecimens and the ABCD study: Rationale, methods of collection, measurement and early data
Uban, K. A., Horton, M. K., Jacobus, J., Heyser, C., Thompson, W. K., Tapert, S. F., Madden, P. A. F., & Sowell, E. R. (2018) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2018.03.005 · Cited by 175
Fetal and postnatal metal dysregulation in autism
Arora, M., Reichenberg, A., Willfors, C., Austin, C., Gennings, C., Berggren, S., Lichtenstein, P., Anckarsäter, H., Tammimies, K., & Bölte, S. (2017) · Nature Communications · doi:10.1038/ncomms15493 · Cited by 169
Self-citation
Metadata
- Authors
- Austin, C., Smith, T. M., Bradman, A., Hinde, K., Joannes-Boyau, R., Bishop, D., Hare, D. J., Doble, P., Eskenazi, B., & Arora, M.
- Affiliations
- The University of Sydney (AU)
- Harvard University (US)
- University of California, Berkeley (US)
- Southern Cross University (AU)
- University of Technology Sydney (AU)
- Corresponding author
- Arora, Manish
- ORCID
- Venue
- Nature
- Published
- 2013-05-22
- Volume
- 498
- Issue
- 7453
- Pages
- 216-219
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC3725337
- OpenAlex
- W2102110053
- Cited by
- 234
- References
- 34
- Citations by year
- 2026: 11 · 2025: 16 · 2024: 16 · 2023: 15 · 2022: 15 · 2021: 25 · 2020: 21 · 2019: 16 · 2018: 19 · 2017: 26 · 2016: 15 · 2015: 18 · 2014: 16 · 2013: 4
- FWCI
- 82.53
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- Cross Connect (Southern Cross University) (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Minerva Access (University of Melbourne) (submittedVersion)
- UTS ePRESS (University of Technology Sydney) (submittedVersion)
- Griffith Research Online (submittedVersion)
- Funders
- National Science Foundation (0921978)
- U.S. Environmental Protection Agency (RD83171001, RD-82670901, PO1 ES009605)
- Max-Planck-Institut für Evolutionäre Anthropologie
- Australian Research Council (LP100200254, DP120101752)
- National Health and Medical Research Council (1028372)
- National Institute of Environmental Health Sciences (R00ES019597, P01ES009605)
- Topics
- Social Sciences › Anthropology › Pleistocene-Era Hominins and Archaeology
- Social Sciences › Arts and Humanities › Archeology (arts and humanities) › Forensic Anthropology and Bioarchaeology Studies
- Social Sciences › Archeology › Archaeology and ancient environmental studies
- Keywords
- weaning, lactation, breastfeeding, nutrition transition, macaque, dental biomarkers, barium to calcium ratio, Middle Palaeolithic
- MeSH terms
- Adult, Animals, Barium, Breast Feeding, Calcium, Child, Preschool, Diet, Female, Fossils, Humans, Infant, Macaca, Tooth, Weaning, Reproducibility of Results, History, Ancient, Neanderthals
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
