Cited by 339Neuroendocrine regulation and behaviorNeuroscience and Neuropharmacology ResearchNeural dynamics and brain function

The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.

Oxytocin enhances hippocampal spike transmission by modulating fast-spiking interneurons

Open access

Owen, Scott F., Tuncdemir, Sebnem N., Bader, Patrick L., Tirko, Natasha N., Fishell, Gord, Tsien, Richard W.·2013·Nature

DOI 10.1038/nature12330PMC PMC5283693

Open this paper in CoChat — free account

Abstract

Neuromodulatory control by oxytocin is essential to a wide range of social, parental and stress-related behaviours. Autism spectrum disorders (ASD) are associated with deficiencies in oxytocin levels and with genetic alterations of the oxytocin receptor (OXTR). Thirty years ago, Mühlethaler et al. found that oxytocin increases the firing of inhibitory hippocampal neurons, but it remains unclear how elevated inhibition could account for the ability of oxytocin to improve information processing in the brain. Here we describe in mammalian hippocampus a simple yet powerful mechanism by which oxytocin enhances cortical information transfer while simultaneously lowering background activity, thus greatly improving the signal-to-noise ratio. Increased fast-spiking interneuron activity not only suppresses spontaneous pyramidal cell firing, but also enhances the fidelity of spike transmission and sharpens spike timing. Use-dependent depression at the fast-spiking interneuron-pyramidal cell synapse is both necessary and sufficient for the enhanced spike throughput. We show the generality of this novel circuit mechanism by activation of fast-spiking interneurons with cholecystokinin or channelrhodopsin-2. This provides insight into how a diffusely delivered neuromodulator can improve the performance of neural circuitry that requires synapse specificity and millisecond precision.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/nature12330

Cites

36 of 36 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Interneurons of the hippocampus
Freund, T. F., & Buzsáki, G. (1998) · Hippocampus · doi:10.1002/(sici)1098-1063(1996)6:4 · Cited by 3,478
Oxytocin improves “mind-reading” in humans
Domes, G., Heinrichs, M., Michel, A., Berger, C., & Herpertz, S. C. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.07.015 · Cited by 1,298 · cited 6×
“TGOT was simulated by (1) reducing the evoked somatic IPSC conductance to 60% of “baseline”, while sparing the evoked EPSC and the dendritic IPSC, (2) doubling the spontaneous IPSC amplitude, and (3) increasing the spontaneous IPSC rate from 5 Hz to 35 Hz.”
BackgroundMethodInfluential
Inhibitory Interneuron Deficit Links Altered Network Activity and Cognitive Dysfunction in Alzheimer Model
Verret, L., Mann, E. O., Hang, G. B., Barth, A. M. I., Cobos, I., Ho, K., Devidze, N., Masliah, E., Kreitzer, A. C., Mody, I., et al. (2012) · Cell · doi:10.1016/j.cell.2012.02.046 · Cited by 1,216
A Developmental Switch in the Response of DRG Neurons to ETS Transcription Factor Signaling
Hippenmeyer, S., Pecho‐Vrieseling, E., Sigrist, M., Portmann, T., Laengle, C., Ladle, D. R., & Arber, S. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030159 · Cited by 1,111
Enforcement of Temporal Fidelity in Pyramidal Cells by Somatic Feed-Forward Inhibition
Pouille, F., & Scanziani, M. (2001) · Science · doi:10.1126/science.1060342 · Cited by 1,097
Evoked axonal oxytocin release in the central amygdala attenuates fear response
Knobloch, H. S., Charlet, A., Hoffmann, L. C., Eliava, M., Khrulev, S., Cetin, A. H., Osten, P., Schwarz, M. K., Seeburg, P. H., Stoop, R., et al. (2012) · Neuron · doi:10.1016/j.neuron.2011.11.030 · Cited by 1,049
Oxytocin in the Medial Amygdala is Essential for Social Recognition in the Mouse
Ferguson, J. N., Aldag, J. M., Insel, T. R., & Young, L. J. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-20-08278.2001 · Cited by 1,043 · cited 9×
“TGOT increased the spontaneous firing of presynaptic FSIs and also diminished the FSI-pyramidal cell unitary IPSC, without affecting RS interneurons (Fig 3a,b).”
BackgroundMethodInfluential
Intranasal oxytocin improves emotion recognition for youth with autism spectrum disorders.
Guastella, A. J., Einfeld, S. L., Gray, K. M., Rinehart, N. J., Tonge, B. J., Lambert, T. J., & Hickie, I. B. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.020 · Cited by 962
Plasma oxytocin levels in autistic children
Modahl, C., Green, L. A., Fein, D., Morris, M., Waterhouse, L., Feinstein, C., & Levin, H. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(97)00439-3 · Cited by 728
Instantaneous Modulation of Gamma Oscillation Frequency by Balancing Excitation with Inhibition
Atallah, B. V., & Scanziani, M. (2009) · Neuron · doi:10.1016/j.neuron.2009.04.027 · Cited by 614

Flagged first, then by citations

Show all 36 references

Sorted by citations

Items 201–300 of 339

Histone Deacetylase Inhibitor Improves the Dysfunction of Hippocampal Gamma Oscillations and Fast Spiking Interneurons in Alzheimer’s Disease Model Mice
Takasu, K., Niidome, K., Hasegawa, M., & Ogawa, K. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.782206 · Cited by 18
Targeting Neurons with Functional Oxytocin Receptors: A Novel Set of Simple Knock-In Mouse Lines for Oxytocin Receptor Visualization and Manipulation
Inoue, Y., Miwa, H., Hori, K., Kaneko, R., Morimoto, Y., Koike, E., Asami, J., Kamijo, S., Yamada, M., Hoshino, M., et al. (2022) · eNeuro · doi:10.1523/eneuro.0423-21.2022 · Cited by 18
Hippocampal oxytocin is involved in spatial memory and synaptic plasticity deficits following acute high-fat diet intake in juvenile rats
Khazen, T., Narattil, N. R., Ferreira, G., & Maroun, M. (2022) · Cerebral Cortex · doi:10.1093/cercor/bhac317 · Cited by 20
Impaired approach to novelty and striatal alterations in the oxytocin receptor deficient mouse model of autism
Leonzino, M., Ponzoni, L., Braida, D., Gigliucci, V., Busnelli, M., Ceresini, I., Duque‐Wilckens, N., Nishimori, K., Trainor, B. C., Sala, M., et al. (2019) · Hormones and Behavior · doi:10.1016/j.yhbeh.2019.06.007 · Cited by 18
Oxytocin and Brain Plasticity
Froemke, R. C., & Carcea, I. (2017) · Principles of Gender-Specific Medicine · doi:10.1016/b978-0-12-803506-1.00037-1 · Cited by 20
Oxytocin Receptor in Cerebellar Purkinje Cells Does Not Engage in Autism-Related Behaviors
Shen, L.-P., Li, W., Pei, L.-Z., Yin, J., Xie, S.-T., Li, H.-Z., Yan, C., Wang, J., Zhang, Q., Zhang, X., et al. (2022) · The Cerebellum · doi:10.1007/s12311-022-01466-5 · Cited by 16
“0378, n = 6 neurons from 3 mice) of sIPSCs in CA1 pyramidal neurons, which is in accordance with the reports from other groups [55, 56].”
Result
Sex-specific and social experience-dependent oxytocin–endocannabinoid interactions in the nucleus accumbens: implications for social behaviour
Borie, A. M., Young, L. J., & Liu, R. C. (2022) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2021.0057 · Cited by 17
“Like others before [86,87], we saw that oxytocin impacts the signal-to-noise ratio (SNR) in neurotransmission, but went further to demonstrate that pair bonding influences how this change in SNR is achieved.”
Background
Oxytocin: An Old Hormone, a Novel Psychotropic Drug and its Possible Use in Treating Psychiatric Disorders
Marazziti, D., Diep, P.-T., Carter, C. S., & Carbone, M. G. (2022) · Current Medicinal Chemistry · doi:10.2174/0929867329666220727120646 · Cited by 16
Resting-state brain network properties mediate the association between the oxytocin receptor gene and interdependence
Luo, S., Zhu, Y., Fan, L., Gao, D., & Han, S. (2020) · Social Neuroscience · doi:10.1080/17470919.2020.1714718 · Cited by 16
“Animal research has also shown that oxytocin administration enhances hippocampal function (Owen et al., 2013; Tomizawa et al., 2003).”
Background
Exogenous estradiol and oxytocin modulate sex differences in hippocampal reactivity during the encoding of episodic memories
Coenjaerts, M., Trimborn, I., Adrovic, B., Stoffel‐Wagner, B., Cahill, L. F., Philipsen, A., Hurlemann, R., & Scheele, D. (2022) · NeuroImage · doi:10.1016/j.neuroimage.2022.119689 · Cited by 17
“Likewise, OXT has been found to enhance cortical information transfer in the hippocampus irrespective of sex by exciting fast-spiking interneurons (Owen et al., 2013).”
Background
Slc20a1 and Slc20a2 regulate neuronal plasticity and cognition independently of their phosphate transport ability
Ramos-Brossier, M., Romeo-Guitart, D., Lanté, F., Boitez, V., Mailliet, F., Saha, S., Rivagorda, M., Siopi, E., Nemazanyy, I., Leroy, C., et al. (2024) · Cell Death and Disease · doi:10.1038/s41419-023-06292-z · Cited by 15
Neural Computation and Neuromodulation Underlying Social Behavior
Bergan, J. F. (2015) · Integrative and Comparative Biology · doi:10.1093/icb/icv061 · Cited by 16
Multiplexing of Information about Self and Others in Hippocampal Ensembles
Bos, J. J., Vinck, M. A., Marchesi, P., Keestra, A., Mourik-Donga, L. A. V., Jackson, J. C., Verschure, P. F. M. J., & Pennartz, C. M. A. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.11.057 · Cited by 14
“The neuropeptide oxytocin, which has been implicated in regulating social discrimination andmemory through its hippocampal targets (Raam et al., 2017), strongly depolarizes fastspiking interneurons in both areas CA1 and CA2 (Owen et al., 2013; Tirko et al., 2018).”
Background
Oxytocin receptor activation in the basolateral complex of the amygdala enhances discrimination between discrete cues and promotes configural processing of cues
Fam, J. P., Holmes, N. M., Delaney, A., Crane, J. W., & Westbrook, R. F. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.06.006 · Cited by 14
Duplications and domain-generality.
Endress, A. D. (2019) · Psychological Bulletin · doi:10.1037/bul0000213 · Cited by 15
Chronic oxytocin improves neural decoupling at rest in children with autism: an exploratory RCT
Alaerts, K., Moerkerke, M., Daniëls, N., Zhang, Q., Ricchiuti, G., Steyaert, J. G., Prinsen, J., & Boets, B. (2024) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.13966 · Cited by 14
Physical exercise activates a PVN–NAc oxytocin circuit to relieve stress-induced depressive-like behaviors
Xia, J., Zou, Y., Cui, Y., Zhang, S., Huo, K., Liu, W., Huang, Z., Zhang, Q., Qi, Z., & Liu, W. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2503675122 · Cited by 19
“Notably, OT reduces GABA release in PARV interneurons ( 38 ) and modulates serotonin release in serotonergic terminals ( 19 ), potentially balancing excitation and inhibition to facilitate NAc activation.”
Vasopressin and oxytocin excite BNST neurons via oxytocin receptors, which reduce anxious arousal
Francesconi, W., Olivera-Pasilio, V., Berton, F., Olson, S. L., Chudoba, R., Monroy, L. M., Krabichler, Q., Grinevich, V., & Dabrowska, J. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115768 · Cited by 14
The Neurobiology of Affiliation; Maternal-Infant Bonding to Life Within Social Groups
Feldman, R. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819641-0.00058-x · Cited by 12
The association of oxytocin with major depressive disorder: role of confounding effects of antidepressants
Xie, S., Hu, Y., Fang, L., Chen, S., Botchway, B. O. A., Tan, X., Fang, M., & Hu, Z. (2021) · Reviews in the Neurosciences · doi:10.1515/revneuro-2020-0128 · Cited by 14
Neuromodulatory functions exerted by oxytocin on different populations of hippocampal neurons in rodents
Talpo, F., Spaiardi, P., Castagno, A. N., Maniezzi, C., Raffin, F., Terribile, G., Sancini, G., Pisani, A., & Biella, G. R. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1082010 · Cited by 15
“The administration of TGOT induces a sustained depolarization of the membrane potential of the fast-spiking GABAergic INs that determines a significant increase in their firing rate when it occurs at their spike threshold (Figure 3B), as verified by two independent studies (Owen et al., 2013; Maniezzi et al., 2019).”
BackgroundResultInfluential
The neuropeptide oxytocin modulates consumer brand relationships
Fürst, A., Thron, J., Scheele, D., Marsh, N., & Hurlemann, R. (2015) · Scientific Reports · doi:10.1038/srep14960 · Cited by 14
A variation in the infant oxytocin receptor gene modulates infant hippocampal volumes in association with sex and prenatal maternal anxiety
Acosta, H., Tuulari, J. J., Kantojärvi, K., Lewis, J. D., Hashempour, N., Scheinin, N. M., Lehtola, S. J., Fonov, V., Collins, D. L., Evans, A. C., et al. (2020) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2020.111207 · Cited by 13
Effects of single- and multiple-dose oxytocin treatment on amygdala low-frequency BOLD fluctuations and BOLD spectral dynamics in autism
Alaerts, K., Bernaerts, S., & Wenderoth, N. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02158-8 · Cited by 12
“Within distinct lines of work, the induction of high signal-tonoise states has been suggested to form a shared over-arching mechanism by which OT may exert its widespread neuromodulatory function [46].”
Background
A Biomimetic C-Terminal Extension Strategy for Photocaging Amidated Neuropeptides
Layden, A. E., Ma, X., Johnson, C. A., He, X. J., Buczynski, S. A., & Banghart, M. R. (2023) · Journal of the American Chemical Society · doi:10.1021/jacs.3c03913 · Cited by 12
Oxytocin modulates respiratory heart rate variability through a hypothalamus–brainstem–heart neuronal pathway
Buron, J., Linossier, A., Gestreau, C., Schaller, F., Tyzio, R., Félix, M., Matarazzo, V. A., Thoby‐Brisson, M., Muscatelli, F., & Menuet, C. (2025) · Nature Neuroscience · doi:10.1038/s41593-025-02074-2 · Cited by 13
“5j), which tended to be amplified by TGOT.”
Influential
A blueprint for research on Shankopathies: A view from research on autism spectrum disorder
Carbonetto, S. (2013) · Developmental Neurobiology · doi:10.1002/dneu.22150 · Cited by 13
Differential effects of oxytocin on mouse hippocampal oscillations in vitro
Maier, P., Kaiser, M. E., Grinevich, V., Draguhn, A., & Both, M. (2016) · European Journal of Neuroscience · doi:10.1111/ejn.13412 · Cited by 12
Activation of Oxytocin Receptors Excites Subicular Neurons by Multiple Signaling and Ionic Mechanisms
Hu, B., Boyle, C. A., & Lei, S. (2020) · Cerebral Cortex · doi:10.1093/cercor/bhaa363 · Cited by 13
“For instance, OXTR activation induces membrane depolarization by inhibiting KCNQ-based M channels in CA2 pyramidal neurons of the hippocampus (Tirko et al. 2018) and the inwardly rectifying K+ channels in the lateral nucleus of the central amygdala (Hu et al. 2020); OXTR activation up-modulates L-type Ca2+ channels to…”
BackgroundInfluential
The effect of oxytocin on group formation and strategic thinking in men
Aydogan, G., Jobst, A., Loy, F., Dehning, S., Zill, P., Müller, N., & Kocher, M. G. (2018) · Hormones and Behavior · doi:10.1016/j.yhbeh.2018.02.003 · Cited by 13
Genetic influences of autism candidate genes on circuit wiring and olfactory decoding
Hartig, R., Wolf, D., Schmeißer, M. J., & Kelsch, W. (2021) · Cell and Tissue Research · doi:10.1007/s00441-020-03390-8 · Cited by 11
Territorial blueprint in the hippocampal system
Wirth, S., Soumier, A., Eliava, M., Derdikman, D., Wagner, S., Grinevich, V., & Sirigu, A. (2021) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2021.06.005 · Cited by 10
Oxytocin via oxytocin receptor excites neurons in the endopiriform nucleus of juvenile mice
Biggs, L. M., & Hammock, E. A. D. (2022) · Scientific Reports · doi:10.1038/s41598-022-15390-5 · Cited by 11
Connectome dysfunction in patients at clinical high risk for psychosis and modulation by oxytocin
Davies, C., Martins, D., Dipasquale, O., McCutcheon, R. A., Micheli, A. D., Ramella‐Cravaro, V., Provenzani, U., Rutigliano, G., Cappucciati, M., Oliver, D., et al. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02406-x · Cited by 9
Linking Social Cognition, Parvalbumin Interneurons, and Oxytocin in Alzheimer’s Disease: An Update
Černotová, D., Hrůzová, K., Levčík, D., Svoboda, J., & Stuchlı́k, A. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-230333 · Cited by 12
“This interneuronal depolarization is cell-speciﬁc and restricted to PV interneurons [134].”
Background
Gamma oscillatory activity in vitro: a model system to assess pathophysiological mechanisms of comorbidity between autism and epilepsy
Subramanian, D., Pralong, É., Daniel, R. T., Chacko, A. G., Stoop, R., & Babu, K. S. (2018) · Translational Psychiatry · doi:10.1038/s41398-017-0065-7 · Cited by 9
Loss of oxytocin receptors in hilar mossy cells impairs social discrimination
Hung, Y.-C., Wu, Y., Chien, M.-E., Lin, Y., Tsai, C., & Hsu, K. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106311 · Cited by 10
“Nevertheless, the precise mechanism by which OXTR stimulation depolarizes MC directly is still not clear, although it may dependent on phospholipase C-mediated inactivation of KCNQ K + channels (Tirko et al., 2018) or enhancement of non-selective cation channels (Owen et al., 2013).”
Capacities and neural mechanisms for auditory statistical learning across species
Schiavo, J. K., & Froemke, R. C. (2019) · Hearing Research · doi:10.1016/j.heares.2019.02.002 · Cited by 9
Tracking transient changes in the intrinsic neural frequency architecture: Oxytocin facilitates non-harmonic relationships between alpha and theta rhythms in the resting brain
Alaerts, K., Taillieu, A., Prinsen, J., & Daniëls, N. (2021) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2021.105397 · Cited by 9
The Pathophysiology of Autism
Compart, P. J. (2013) · Global Advances in Health and Medicine · doi:10.7453/gahmj.2013.092 · Cited by 10
Sniffing and Oxytocin: Effects on Olfactory Memories
Stoop, R. (2016) · Neuron · doi:10.1016/j.neuron.2016.04.033 · Cited by 10
“…main inputs from the olfactory pathway, by exciting pyramidal neurons in the AON: The increased inhibition by OT of MCs is reminiscent of recent findings in the hippocampus where OT increases spontaneous IPSCs, leading to increased signal to noise ratio for excitatory inputs (Owen et al., 2013).”
Result
Hippocampal gene expression patterns in oxytocin male knockout mice are related to impaired social interaction
Lazzari, V. M., Zimmermann-Peruzatto, J. M., Agnes, G., Becker, R. O., de Moura, A. C., Almeida, S., Guedes, R. P., & Giovenardi, M. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.10.034 · Cited by 8
“This activation can improve the performance of neuronal circuitry that requires synapse specificity and millisecond precision [22].”
Neurochemical effects of oxytocin in people at clinical high risk for psychosis
Davies, C., Rutigliano, G., Micheli, A. D., Stone, J. M., Ramella‐Cravaro, V., Provenzani, U., Cappucciati, M., Scutt, E., Paloyelis, Y., Oliver, D., et al. (2019) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2019.03.008 · Cited by 8
Oxytocin Modifies the Excitability and the Action Potential Shape of the Hippocampal CA1 GABAergic Interneurons
Castagno, A. N., Spaiardi, P., Trucco, A., Maniezzi, C., Raffin, F., Mancini, M., Nicois, A., Cazzola, J., Pedrinazzi, M., Papa, P., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25052613 · Cited by 7
“Similar results were obtained by Owen et al. [20].”
BackgroundMethodResultInfluential
Neuropeptides in control of left–right neural circuits
Kolber, B. J., Neugebauer, V., Thorn, C. A., Froemke, R. C., & Bakalkin, G. Y. (2026) · Trends in Neurosciences · doi:10.1016/j.tins.2025.12.003 · Cited by 9
Reframing oxytocin as a behavioral flexibility hormone
Walle, K. M., Sartorius, A. M., Deilhaug, E., Kang, H., Nærland, T., Andreassen, O. A., Westlye, L. T., & Quintana, D. S. (2026) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2026.106628 · Cited by 10
Designing Tools for Assumption-Proof Brain Mapping
Marblestone, A. H., & Boyden, E. S. (2014) · Neuron · doi:10.1016/j.neuron.2014.09.004 · Cited by 7
Presynaptic glutamatergic transmission and feedback system of oxytocinergic neurons in the hypothalamus of a rat model of adjuvant arthritis
Fujitani, T., Matsuura, T., Kawasaki, M., Suzuki, H., Nishimura, H., Baba, K., Yamanaka, Y., Ohnishi, H., Ueta, Y., & Sakai, A. (2020) · Molecular Pain · doi:10.1177/1744806920943334 · Cited by 8
“OXT also enhances the synaptic transmission in the hippocampus in vitro.(29,30) We hypothesize that the upregulated OXTergic mechanism is associated with the presynaptic glutamate release and the surrounding synthesized OXT, Figure 9.”
Background
Robust GRK2/3/6-dependent desensitization of oxytocin receptor in neurons
George, K., Hoang, H., Tibbs, T., Nagaraja, R. Y., Li, G., Troyano‐Rodriguez, E., & Ahmad, M. (2024) · iScience · doi:10.1016/j.isci.2024.110047 · Cited by 7
Ambient GABA modulates septo-hippocampal inhibitory terminals via presynaptic GABAb receptors
Turi, G. F., Wittmann, G., Lechan, R. M., & Losonczy, A. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.10.005 · Cited by 8
Interplay of MeCP2/REST/Synaptophysin-BDNF and intranasal oxytocin influence on Aβ-induced memory and cognitive impairments
Sarahian, N., Khodagholi, F., Valian, N., & Ahmadiani, A. (2024) · Behavioural Brain Research · doi:10.1016/j.bbr.2024.115235 · Cited by 6
Editorial: Oxytocin's routes in social behavior: into the 21st century
Andari, E. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00224 · Cited by 5
“…behaviors based on contextual demands and individual predispositions, possibly through its interaction with GABAergic neurons (Tyzio et al., 2014), serotonin (Mottolese et al., 2014), reward system (Burkett and Young, 2012) and neuronal signaling (Owen et al., 2013; Marlin et al., 2015).”
Background
Evolution of neuropeptides: From diffusing molecules to modulators of synaptic transmission
Leroy, F., Gimenez, P., Krabichler, Q., & Grinevich, V. (2026) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2026.102920 · Cited by 5
Oxytocin signals via Gi and Gq to drive persistent CA2 pyramidal cell firing and strengthen CA3-CA1 neurotransmissionPreprint
Eyring, K. W., Liu, J., König, G. M., Hidema, S., Nishimori, K., Kostenis, E., & Tsien, R. W. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.05.07.082727 · Cited by 5
“We have previously reported that TGOT application acutely reduces evoked inhibition in the CA1 region of juvenile rats via activity-dependent depression of inhibitory synaptic output (Owen et al., 2013).”
Background
The Na+ leak channel NALCN controls spontaneous activity and mediates synaptic modulation by α2-adrenergic receptors in auditory neurons
Ngodup, T., Irie, T., Elkins, S. P., & Trussell, L. O. (2024) · eLife · doi:10.7554/elife.89520.3 · Cited by 5
Oxytocin Release: A Remedy for Cerebral Inflammaging
Buemann, B. (2022) · Current Aging Science · doi:10.2174/1874609815666220414104832 · Cited by 4
Lateralized local circuit tuning in female mouse auditory cortex
Song, S. C., & Froemke, R. C. (2025) · Neuroscience Research · doi:10.1016/j.neures.2025.03.009 · Cited by 4
“…oxytocin receptors (Nakajima et al., 2014; Marlin et al., 2015; Yao et al., 2021), and oxytocin directly depolarizes interneurons in cortex and hippocampus, leading to increased spontaneous and reduced evoked inhibitory transmission (Owen et al., 2013; Marlin et al., 2015; Tirko et al., 2018).”
Neuromodulation of Hippocampal Cells and Circuits
Lawrence, J. J., & Cobb, S. (2018) · Springer series in computational neuroscience · doi:10.1007/978-3-319-99103-0_7 · Cited by 4
The Na+ leak channel NALCN controls spontaneous activity and mediates synaptic modulation by α2-adrenergic receptors in auditory neurons
Ngodup, T., Irie, T., Elkins, S. P., & Trussell, L. O. (2023) · eLife · doi:10.7554/elife.89520 · Cited by 8
“A related mechanism was later identified in the action of oxytocin in hippocampal interneurons ( Owen et al., 2013 ; Tirko et al., 2018 ).”
Background
Heralding a new era of oxytocinergic research: New tools, new problems?
Althammer, F. (2023) · Journal of Neuroendocrinology · doi:10.1111/jne.13333 · Cited by 4
Attachment Reminders Trigger Widespread Synchrony across Multiple Brains
Shimon-Raz, O., Yeshurun, Y., Ulmer-Yaniv, A., Levinkron, A., Salomon, R., & Feldman, R. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.0026-23.2023 · Cited by 7
Stimulating oxytocin receptors in the basolateral amygdala enhances stimulus processing: Differential and consistent effects for stimuli paired with fear versus sucrose in extinction and reversal learning
Fam, J. P., Holmes, N. M., & Westbrook, R. F. (2023) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2023.106917 · Cited by 4
“…signal-to-noise ratios of information, such as increased probability of evoked spikes and synchronous firing, reductions in baseline neuronal firing and in the variability of spike timing (Marlin et al., 2015; Mitre et al., 2016; Oettl et al., 2016; Owen et al., 2013; Rossoni et al., 2008).”
Background
The effects of Cognitive Bias Modification training and oxytocin administration on trust in maternal support: study protocol for a randomized controlled trial
Verhees, M. W. F. T., Ceulemans, E., Bakermans‐Kranenburg, M. J., van IJzendoorn, M. H., Winter, S. D., & Bosmans, G. (2017) · Trials · doi:10.1186/s13063-017-2077-2 · Cited by 4
An oligarchy of NO-producing interneurons controls basal and evoked blood flow in the cortexPreprint
Echagarruga, C. T., Gheres, K. W., & Drew, P. J. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/555151 · Cited by 4
Oxytocin and Social Isolation: Nonapeptide Regulation of Social Homeostasis
Kareklas, K., & Oliveira, R. F. (2024) · Masterclass in neuroendocrinology · doi:10.1007/978-3-031-51112-7_8 · Cited by 3
Oxytocin attenuates cocaine-associated place preference via the dorsal hippocampus in male and female rats
Bensing, P. C., Moye, C., & Leong, K.-C. (2024) · Physiology & Behavior · doi:10.1016/j.physbeh.2024.114599 · Cited by 3
Selective inhibition in CA3: A mechanism for stable pattern completion through heterosynaptic plasticity
Kim, G., & Kim, P. (2025) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1013267 · Cited by 4
Oxytocin's Influence on Social Decision-Making
Lefèvre, A., & Sirigu, A. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-805308-9.00031-2 · Cited by 3
Bridging the Gap Between People and Animals: The Roots of Social Behavior and Its Relationship to Pain
Acland, E. L., Lidhar, N. K., & Martin, L. J. (2018) · Springer eBooks · doi:10.1007/978-3-319-78340-6_10 · Cited by 3
Stress and parental behaviors
Wang, Y., & Lin, D. (2024) · Neuroscience Research · doi:10.1016/j.neures.2024.12.004 · Cited by 2
“…al., 2024), changing the local circuit elements (e.g., inhibitory interneurons) that influence the principal output cells (second-order modulation) (Owen et al., 2013; Sato et al., 2020), or changing activities of other neuro-modulatory systems (third-order modulation) (Froemke and Young, 2021; D…”
Sex-dimorphic oxytocin regulation of CA1-dependent spatial memory and synaptic plasticity in juvenile rats
Shehadeh, E., Narattil, N. R., Kritman, M., & Maroun, M. (2025) · Behavioral and Brain Functions · doi:10.1186/s12993-025-00307-9 · Cited by 2
Fatherhood is life changing: Uncovering structural and functional changes in the dad brain
Dickson, R. G., Jacobs, M. W., & Kim, E. J. (2022) · Neuron · doi:10.1016/j.neuron.2022.05.023 · Cited by 2
Possible Mechanisms of the Influence of Oxytocin and Vasopressin on Perception and Memory of Odors and on Social Behavior
Silkis, I. G. (2024) · Neurochemical Journal · doi:10.1134/s1819712424010215 · Cited by 2
The Dynamicity of the Oxytocin Receptor in the Brain May Trigger Sensory Deficits in Autism Spectrum Disorder
Camerino, C. (2025) · Current Issues in Molecular Biology · doi:10.3390/cimb47010061 · Cited by 2
ASD: ML Perspective for Individual Performance Evaluation
Luise, D. L. D., Vuelta, M. F., Azor, R., Agüero, M., Párraga, C., Lopez, N. L., Bustamante, P. V., Marquez, M., Bielli, R., Hisgen, D., et al. (2015) · Advances in intelligent systems and computing · doi:10.1007/978-3-319-18296-4_32 · Cited by 2
Oxytocin and Plasticity of Social Behavior
Hammock, E. A. D. (2017) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780190635374.013.9 · Cited by 2
A Simple, Biologically Plausible Feature Detector for Language Acquisition
Endress, A. D. (2019) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_01494 · Cited by 4
“…Gaffan, & Duncan, 2010), behavioral response selection (Zhao et al., 2019; Jovanic et al., 2016), associative learning (Letzkus et al., 2011), plasticity (Fu, Kaneko, Tang, Alvarez-Buylla, & Stryker, 2015), and social behavior (Marlin, Mitre, D’amour, Chao, & Froemke, 2015; Owen et al., 2013).”
Selective oxytocin receptor activation prevents prefrontal circuit dysfunction and social behavioral alterations in response to chronic prefrontal cortex activation in male rats
Janz, P., Knoflach, F., Bleicher, K., Belli, S., Biemans, B. A. M., Schnider, P., Ebeling, M., Grundschober, C., & Benekareddy, M. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1286552 · Cited by 2
Does activation of oxytocinergic reward circuits postpone the decline of the aging brain?
Buemann, B. (2023) · Frontiers in Psychology · doi:10.3389/fpsyg.2023.1250745 · Cited by 2
Oxytocin in the Developing Brain
Chini, B., Leonzino, M., & Gigliucci, V. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-800109-7.00016-9 · Cited by 2
Specialized Networks for Social Cognition: A Defining Role for the Oxytocin Receptor
King, L. B. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.1446-16.2016 · Cited by 3
Estrus-Cycle Regulation of Cortical InhibitionPreprint
Clemens, A. M., Lenschow, C., Beed, P. S., Li, L., Sammons, R. P., Naumann, R. K., Wang, H., Schmitz, D., & Brecht, M. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/314641 · Cited by 2
“Additionally, changes in inhibition have been observed to occur independently of changes in excitation in other instances of neuromodulation such as by oxytocin [56] and noradrenalin [57].”
Background
Inhibitory synaptic vesicles have unique dynamics and exocytosis propertiesPreprint
Park, C., Chen, X., Tian, C.-L., Park, G. N., Chenouard, N., Lee, H., Yeo, X. Y., Jung, S., Bi, G., Tsien, R. W., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.09.21.289314 · Cited by 2
Neuromodulation-induced burst firing in parvalbumin interneurons of the basolateral amygdala mediates transition between fear-associated network and behavioral statesPreprint
Fu, X., Teboul, E., Maguire, J. L., & Tasker, J. G. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.04.19.440525 · Cited by 2
“5 μM, 30 min), or YM 254890 (10 μM, 20 min) to block P/Q-type calcium channels, N-type calcium channels and Gαq/11 activity, respectively (Takasaki et al., 2004; Owen et al., 2013).”
Background
Exogenous estradiol and oxytocin modulate sex differences in hippocampal reactivity and episodic memoryPreprint
Coenjaerts, M., Trimborn, I., Adrovic, B., Stoffel‐Wagner, B., Cahill, L. F., Philipsen, A., Hurlemann, R., & Scheele, D. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.11.22.469500 · Cited by 2
Oxytocin facilitates communicative adjustments by upregulating broadband aperiodic activity in the prefrontal cortexPreprint
Liu, R., Stolk, A., de Boer, M., Oostenveld, R., & Toni, I. (2021) · PsyArXiv (OSF Preprints) · doi:10.31234/osf.io/kq9g6 · Cited by 2
The Na+ leak channel NALCN controls spontaneous activity and mediates synaptic modulation by α2-adrenergic receptors in auditory neuronsPreprint
Ngodup, T., Irie, T., Elkins, S. P., & Trussell, L. O. (2023) · eLife · doi:10.7554/elife.89520.1 · Cited by 2
Hormones and the Regulation of Neuronal Voltage-Sensing Ion Channels
Lyons, D. J. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813814-4.00011-0 · Cited by 1
Contextual modulation of endogenous oxytocin signaling and its influence on exogenous oxytocin effects: A conceptual framework
Alaerts, K., Weert, E. V., Theunissen, L., Tuerlinckx, E., & der Gucht, K. V. (2025) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2025.106424 · Cited by 1
Effects of binge-like ethanol drinking on nest building behavior in mice
Silva-Borges, A. L., & Barkley‐Levenson, A. M. (2025) · Scientific Reports · doi:10.1038/s41598-025-24138-w · Cited by 1
Oxytocin may promote hippocampal neurogenesis in ischemic stroke rats via a pathway related to DNMT1-mediated Wnt3a/β-catenin
Li, X., Shi, G., Guo, W., Wen, K., Liu, Y., Cheng, J., Liu, M., Yang, Y., & Fan, X. (2025) · Neuropharmacology · doi:10.1016/j.neuropharm.2025.110785 · Cited by 1
CNTNAP2 Mutations in Autism
Peñagarikano, O. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-800109-7.00012-1 · Cited by 1
An oxytocin receptor gene polymorphism is associated with distinct neural responses to mating encounters in male prairie voles
King, L. B., Walum, H., Xiao, Y., Caslin, A. Y., Haddad, F. C., Young, L. J., & Johnson, Z. V. (2025) · Hormones and Behavior · doi:10.1016/j.yhbeh.2025.105761 · Cited by 1
Excitement about Inhibitory Presynaptic Terminals
Vandael, D. H. F., Espinoza, C., & Jónás, P. (2015) · Neuron · doi:10.1016/j.neuron.2015.03.006 · Cited by 1
“Thus, depression in inhibitory synapses may be critically important for setting the Neuron 85 signal-to-noise ratio in neuronal networks (Owen et al., 2013).”
Background
Rôle émergent des astrocytes dans le contrôle des circuits neuronaux et des fonctions cérébrales modulés par l’ocytocine
Baudon, A., Creusot, E. C., & Charlet, A. (2022) · Biologie Aujourd hui · doi:10.1051/jbio/2022022 · Cited by 1
“…(Buijs, 1983 ; Landgraf & Neumann, 2004 ; Leng & Ludwig, 2008 ; Stoop, 2012 ; Althammer et al. , 2021) et comme un neuromodulateur (Stoop, 2012 ; Owen et al. , 2013 ; Mitre et al., 2018 ; Tirko et al. , 2018), affectant ainsi un large éventail de comportements (Grinevich & Neumann, 2020 ;…”
Special issue on: “Oxytocin in development and plasticity”
Stoop, R., & Yu, X. (2016) · Developmental Neurobiology · doi:10.1002/dneu.22470 · Cited by 1
The Habenular Receptor GPR151 Regulates Addiction Vulnerability Across Drug ClassesPreprint
Antolin‐Fontes, B., Li, K., Ables, J. L., Riad, M. H., Görlich, A., Williams, M., Wang, C., Lipford, S. M., Dao, M. T., Molina, H., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/720508 · Cited by 1
“Although enhanced synaptic fidelity improves the precision of information transfer through brain networks (Owen et al., 2013), in some cases, increased synaptic fidelity might be deleterious, for instance, when it is a consequence of chronic drug administration.”
Background
Oxytocin ameliorates cognitive impairments by attenuating excitation/inhibition imbalance of neurotransmitters acting on parvalbumin interneurons in a mouse model of sepsis-associated encephalopathy
Li, R., Zeng, Q., Ji, M., Zhang, Y., Mao, M., Feng, S., Duan, M., & Zhou, Z. (2025) · Journal of Biomedical Research · doi:10.7555/jbr.37.20230318 · Cited by 1
Optogenetics for Neurohormones and Neuropeptides: Focus on Oxytocin
Tang, Y., Wahis, J., Melchior, M., Grinevich, V., & Charlet, A. (2017) · Cambridge University Press eBooks · doi:10.1017/9781107281875.016
催产素对社会决策行为的影响
Zhang, X., Hang, Y. I. N., Peng, L. I., & Li, H. (2018) · Advances in Psychological Science · doi:10.3724/sp.j.1042.2018.01438

Authors: Owen, S. F., Tuncdemir, S. N., Bader, P. L., Tirko, N. N., Fishell, G., & Tsien, R. W.
Affiliations: Stanford Medicine (US)
New York University (US)
Corresponding author: Tsien, Richard W.
ORCID: Owen, Scott F.
Tuncdemir, Sebnem N.
Fishell, Gord
Tsien, Richard W.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2013-08
Volume: 500
Issue: 7463
Pages: 458-462
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature12330
PMC: PMC5283693
OpenAlex: W2008069212
Cited by: 339
References: 36
Citations by year: 2026: 8 · 2025: 16 · 2024: 21 · 2023: 26 · 2022: 22 · 2021: 28 · 2020: 21 · 2019: 23 · 2018: 35 · 2017: 35 · 2016: 33 · 2015: 37 · 2014: 26 · 2013: 7
FWCI: 51.39
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: National Institute of Mental Health (F31MH084430, MH071739, MH064070, R01MH071739, R37MH071739)
National Institute of Neurological Disorders and Stroke (NS024067, R01NS024067, R01NS074785)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords: oxytocin, hippocampus, fast-spiking interneurons, signal-to-noise ratio, neuromodulation, synaptic depression, pyramidal neurons, cholecystokinin, channelrhodopsin-2, autism spectrum disorder, oxytocin receptor, inhibitory interneurons
MeSH terms: Action Potentials, Animals, Brain, Cholecystokinin, Glycine, Hippocampus, Interneurons, Neural Pathways, Synaptic Transmission, Oxytocin, Rhodopsin, Synapses, Threonine, Pyramidal Cells, Receptors, Oxytocin, Excitatory Postsynaptic Potentials, Feedback, Physiological, Mice, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Oxytocin enhances hippocampal spike transmission by modulating fast-spiking interneurons

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks