DNA damage in germ cells induces an innate immune response that triggers systemic stress resistance

THE GENETICS OF CAENORHABDITIS ELEGANS

Brenner, S. (1974) · Genetics · doi:10.1093/genetics/77.1.71 · Cited by 15,220

SignalP 4.0: discriminating signal peptides from transmembrane regions

Petersen, T. N., Brunak, S., von Heijne, G., & Nielsen, H. (2011) · Nature Methods · doi:10.1038/nmeth.1701 · Cited by 8,847

WoLF PSORT: protein localization predictor

Horton, P., Park, K., Obayashi, T., Fujita, N., Harada, H., Adams-Collier, C. J., & Nakai, K. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm259 · Cited by 4,154

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

Rodier, F., Coppé, J.-P., Patil, C. K., Hoeijmakers, W. A. M., Muñoz, D. P., Raza, S. R., Freund, A., Campeau, E., Davalos, A. R., & Campisi, J. (2009) · Nature Cell Biology · doi:10.1038/ncb1909 · Cited by 2,232

Regulation of aging and age-related disease by DAF-16 and heat-shock factor

Hsu, A.-L., Murphy, C. T., & Kenyon, C. (2003) · Science · doi:10.1126/science.1083701 · Cited by 1,513

The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor

Gasser, S., Orsulic, S., Brown, E. J., & Raulet, D. H. (2005) · Nature · doi:10.1038/nature03884 · Cited by 1,308

Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling

Lin, K., Hsin, H., Libina, N., & Kenyon, C. J. (2001) · Nature Genetics · doi:10.1038/88850 · Cited by 1,027

The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response

Muruve, D. A., Pétrilli, V., Zaiss, A. K., White, L. R., Clark, S. A., Ross, P. J., Parks, R. J., & Tschopp, J. (2008) · Nature · doi:10.1038/nature06664 · Cited by 965

A Conserved p38 MAP Kinase Pathway in Caenorhabditis elegans Innate Immunity

Kim, D. H., Feinbaum, R. L., Alloing, G., Emerson, F. E., Garsin, D. A., Inoue, H., Tanaka‐Hino, M., Hisamoto, N., Matsumoto, K., Tan, M., et al. (2002) · Science · doi:10.1126/science.1073759 · Cited by 860

DNA damage checkpoints: from initiation to recovery or adaptation

Bartek, J., & Lukas, J. (2007) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2007.02.009 · Cited by 784

Systematic mapping of organism-scale gene-regulatory networks in aging using population asynchrony

Eder, M., Martin, O. M. F., Oswal, N., Sedlackova, L., Moutinho, C., Carmen-Fabregat, A. D., Bravo, S. M., Sebé-Pedrós, A., Heyn, H., & Stroustrup, N. (2024) · Cell · doi:10.1016/j.cell.2024.05.050 · Cited by 24

Chromosomal instability triggers cell death via local signalling through the innate immune receptor Toll

Liu, D., Shaukat, Z., Saint, R. B., & Gregory, S. L. (2015) · Oncotarget · doi:10.18632/oncotarget.6035 · Cited by 23

Proteostasis in the Male and Female Germline: A New Outlook on the Maintenance of Reproductive Health

Cafe, S. L., Nixon, B., Ecroyd, H. W., Martin, J. H., Skerrett-Byrne, D. A., & Bromfield, E. G. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.660626 · Cited by 23

On the role of germ cells in mammalian gonad development: quiet passengers or back-seat drivers?

Rojas, C. J. R., Bowles, J., & Koopman, P. A. (2015) · Reproduction · doi:10.1530/rep-14-0663 · Cited by 22

Hsp90-downregulation influences the heat-shock response, innate immune response and onset of oocyte development in nematodes

Eckl, J. M., Sima, S., Marcus, K., Lindemann, C., & Richter, K. (2017) · PLoS ONE · doi:10.1371/journal.pone.0186386 · Cited by 21

Reproduction disrupts stem cell homeostasis in testes of aged male Drosophila via an induced microenvironment

Chang, Y. C., Tu, H., Chen, J., Chang, C.-C., Yang, S. Y., & Pi, H. (2019) · PLoS Genetics · doi:10.1371/journal.pgen.1008062 · Cited by 22

C. elegans monitor energy status via the AMPK pathway to trigger innate immune responses against bacterial pathogens

Ju, S., Chen, H., Wang, S., Lin, J., Ma, Y., Aroian, R. V., Peng, D., & Sun, M. (2022) · Communications Biology · doi:10.1038/s42003-022-03589-1 · Cited by 24

Quality control mechanisms in cellular and systemic DNA damage responses

Ermolaeva, M., Dakhovnik, A., & Schumacher, B. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2014.12.009 · Cited by 23

UPS Activation in the Battle Against Aging and Aggregation-Related Diseases: An Extended Review

Papaevgeniou, N., & Chondrogianni, N. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-3756-1_1 · Cited by 23

DNA repair deficiencies and neurodegeneration

Ropert, B., Gallrein, C., & Schumacher, B. (2024) · DNA repair · doi:10.1016/j.dnarep.2024.103679 · Cited by 21

Remodeling of Proteostasis Upon Transition to Adulthood is Linked to Reproduction Onset

Shai, N., Shemesh, N., & Ben‐Zvi, A. (2014) · Current Genomics · doi:10.2174/1389202915666140221005023 · Cited by 21

In Situ Detection of Complex DNA Damage Using Microscopy: A Rough Road Ahead

Nikitaki, Z., Pariset, E., Sudar, D., Costes, S. V., & Georgakilas, A. G. (2020) · Cancers · doi:10.3390/cancers12113288 · Cited by 21

Genome instability: Linking ageing and brain degeneration

Barzilai, A., Schumacher, B., & Shiloh, Y. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.03.011 · Cited by 22

Hormesis as an adaptive response to infection

Bauer, M. W., Ermolaeva, M., Singer, M., Wetzker, R., & Soares, M. P. (2024) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2024.04.012 · Cited by 20

Ubiquitin-related processes and innate immunity in C. elegans

Garcia-Sanchez, J. A., Ewbank, J. J., & Visvikis, O. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-03787-w · Cited by 21

DNA damage responses and stress resistance: Concepts from bacterial SOS to metazoan immunity

Williams, A. B., & Schumacher, B. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.09.007 · Cited by 21

ALG-2/AGO-Dependent mir-35 Family Regulates DNA Damage-Induced Apoptosis Through MPK-1/ERK MAPK Signaling Downstream of the Core Apoptotic Machinery in Caenorhabditis elegans

Doll, M. A., Soltanmohammadi, N., & Schumacher, B. (2019) · Genetics · doi:10.1534/genetics.119.302458 · Cited by 19

Patterns of pathogenesis in innate immunity: insights from C. elegans

Tse, S. Y., Wani, K. A., & Pukkila-Worley, R. (2025) · Nature reviews. Immunology · doi:10.1038/s41577-025-01167-0 · Cited by 18

A germline-to-soma signal triggers an age-related decline of mitochondrial stress response

Zhou, L., Jiang, L., Li, L., Ma, C., Xia, P., Ding, W., & Liu, Y. (2024) · Nature Communications · doi:10.1038/s41467-024-53064-0 · Cited by 18

Modulation of inflammation and disease tolerance by DNA damage response pathways

Neves‐Costa, A., & Moita, L. F. (2016) · FEBS Journal · doi:10.1111/febs.13910 · Cited by 20

The innate immune system as mediator of systemic DNA damage responses

Ermolaeva, M., & Schumacher, B. (2013) · Communicative & Integrative Biology · doi:10.4161/cib.26926 · Cited by 18

The disposable soma theory of aging in reverse

Douglas, P. M., & Dillin, A. G. (2013) · Cell Research · doi:10.1038/cr.2013.148 · Cited by 19

Synergism between soluble guanylate cyclase signaling and neuropeptides extends lifespan in the nematodeCaenorhabditis elegans

Abergel, R., Livshits, L., Shaked, M., Chatterjee, A. K., & Gross, E. (2017) · Aging Cell · doi:10.1111/acel.12569 · Cited by 16

Reproductive regulation of the mitochondrial stress response in Caenorhabditis elegans

Charmpilas, N., Sotiriou, A., Axarlis, K., Tavernarakis, N., & Hoppe, T. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114336 · Cited by 15

Measurements of Innate Immune Function in C. elegans

Foster, K. J., McEwan, D. L., & Pukkila-Worley, R. (2020) · Methods in molecular biology · doi:10.1007/978-1-0716-0592-9_13 · Cited by 14

Self-DNA Exposure Induces Developmental Defects and Germline DNA Damage Response in Caenorhabditis elegans

Germoglio, M., Adamo, A., Incerti, G., Cartenì, F., Gigliotti, S., Storlazzi, A., & Mazzoleni, S. (2022) · Biology · doi:10.3390/biology11020262 · Cited by 14

Scope of 2D materials for immune response-a review

Hossain, N., Chowdhury, M. A., Sultana, S., & Nandee, R. (2022) · Results in Engineering · doi:10.1016/j.rineng.2022.100413 · Cited by 14

The Impact of Hormesis, Neuronal Stress Response, and Reproduction, upon Clinical Aging: A Narrative Review

Kyriazis, M., Swas, L., & Orlova, T. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12165433 · Cited by 8

DNA damage in protective and adverse inflammatory responses: Friend of foe?

Poliezhaieva, T., & Ermolaeva, M. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.06.004 · Cited by 15

A virus-acquired host cytokine controls systemic aging by antagonizing apoptosis

Mlih, M., Khericha, M., Birdwell, C. E., West, A. P., & Karpac, J. (2018) · PLoS Biology · doi:10.1371/journal.pbio.2005796 · Cited by 16

Radioadaptive Response for Reproductive Cell Death Demonstrated in In Vivo Tissue Model of Caenorhabditis elegans

Tang, H., Chen, L., Liu, J., Shi, J., Li, Q., Wang, T., Wu, L., Zhan, F., & Bian, P. (2016) · Radiation Research · doi:10.1667/rr14368.1 · Cited by 13

Constitutive MAP-kinase activation suppresses germline apoptosis in NTH-1 DNA glycosylase deficient C. elegans

Kassahun, H., SenGupta, T., Schiavi, A., Maglioni, S., Skjeldam, H. K., Arczewska, K. D., Brockway, N. L., Estes, S., Eide, L., Ventura, N., et al. (2017) · DNA repair · doi:10.1016/j.dnarep.2017.11.009 · Cited by 13

Spatial function of the oxidative DNA damage response in radiation induced bystander effects in intra- and inter-system of Caenorhabditis elegans

Li, Q., Shi, J., Chen, L., Zhan, F., Yuan, H., Wang, J., Xu, A., & Wu, L. (2017) · Oncotarget · doi:10.18632/oncotarget.17229 · Cited by 12

MAPK10 Expression as a Prognostic Marker of the Immunosuppressive Tumor Microenvironment in Human Hepatocellular Carcinoma

Li, H., Li, Y., Zhang, Y., Tan, B., Huang, T., Xiong, J., Tan, X., Ermolaeva, M., & Fu, L. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.687371 · Cited by 12

Stress Responses During Ageing: Molecular Pathways Regulating Protein Homeostasis

Kyriakakis, E., Princz, A., & Tavernarakis, N. (2015) · Methods in molecular biology · doi:10.1007/978-1-4939-2522-3_16 · Cited by 11

A nucleolar mechanism suppresses organismal proteostasis by modulating TGFβ/ERK signalling

Zhu, H., Bruck‐Haimson, R., Zaretsky, A., Cohen, I., Falk, R. T., Achache, H., Tzur, Y. B., & Cohen, E. (2025) · Nature Cell Biology · doi:10.1038/s41556-024-01564-y · Cited by 11

Loss of DNase II function in the gonad is associated with a higher expression of antimicrobial genes in Caenorhabditis elegans

Yu, H., Lai, H.-J., Lin, T.-W., Chen, C., & Lo, S. J. (2015) · Biochemical Journal · doi:10.1042/bj20150563 · Cited by 11

Development of a transcription-based bioanalytical tool to quantify the toxic potencies of hydrophilic compounds in water using the nematode Caenorhabditis elegans

Karengera, A., Bao, C., Riksen, J. A. G., van Veelen, H. P. J., Sterken, M. G., Kammenga, J. E., Murk, A. J., & Dinkla, I. J. T. (2021) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2021.112923 · Cited by 11

Evolution of immune pathways in regeneration and repair: Recent concepts and translational perspectives

Eming, S. A. (2014) · Seminars in Immunology · doi:10.1016/j.smim.2014.09.001 · Cited by 11

Exploiting inter-tissue stress signaling mechanisms to preserve organismal proteostasis during aging

van Oosten‐Hawle, P. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1228490 · Cited by 10

L-Theanine Prolongs the Lifespan by Activating Multiple Molecular Pathways in Ultraviolet C-Exposed Caenorhabditis elegans

Chen, L., Chen, G., Gai, T., Zhou, X., Zhu, J., Wang, R., Wang, X., Guo, Y., Wang, Y., & Xie, Z. (2024) · Molecules · doi:10.3390/molecules29112691 · Cited by 9

The soma-germline communication: implications for somatic and reproductive aging

Gaddy, M. A., Kuang, S., Alfhili, M. A., & Lee, M. (2021) · BMB Reports · doi:10.5483/bmbrep.2021.54.5.198 · Cited by 10

Induction of innate immune gene expression following methyl methanesulfonate-induced DNA damage in sea urchins

Reinardy, H. C., Chapman, J., & Bodnar, A. G. (2016) · Biology Letters · doi:10.1098/rsbl.2015.1057 · Cited by 10

Costs, benefits and redundant mechanisms of adaption to chronic low-dose stress in yeast

Markiewicz-Potoczny, M., & Lydall, D. A. (2016) · Cell Cycle · doi:10.1080/15384101.2016.1218104 · Cited by 10

HandKAchip - Hands-free killing assay on a chip

Lee, K. S., Lee, L. E., & Levine, E. (2016) · Scientific Reports · doi:10.1038/srep35862 · Cited by 10

Quercetin ameliorates diminished ovarian reserve via modulating intestinal BNIP3/dct-1-mediated mitophagy and subsequently activating the ovarian TGF-β signaling pathway

Xiao, X., Zheng, M., Zhao, Y., Huang, K., Shi, Y., Ren, Y., Chen, L., Sun, J., Ye, R., Zheng, Z., et al. (2025) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2025.120736 · Cited by 9

DNA damage signals from somatic uterine tissue arrest oogenesis through activated DAF-16

Sarkar, G. C., Rautela, U., Goyala, A., Datta, S., Anand, N., Singh, A., Singh, P., Chamoli, M., & Mukhopadhyay, A. (2023) · Development · doi:10.1242/dev.201472 · Cited by 9

A Novobiocin Derivative, XN4, Inhibits the Proliferation of Chronic Myeloid Leukemia Cells by Inducing Oxidative DNA Damage

Wu, L., Chen, X., Huang, L., Tian, J., Ke, F., Xu, J., Chen, Y., & Zheng, M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0123314 · Cited by 9

DNA Damage as a Critical Factor of Stem Cell Aging and Organ Homeostasis

Espada, L., & Ermolaeva, M. (2016) · Current Stem Cell Reports · doi:10.1007/s40778-016-0052-6 · Cited by 9

BRCA1 and BARD1 mediate apoptotic resistance but not longevity upon mitochondrial stress in Caenorhabditis elegans

Torgovnick, A., Schiavi, A., Shaik, A., Kassahun, H., Maglioni, S., Rea, S. L., Johnson, T. E., Reinhardt, H. C., Honnen, S., Schumacher, B., et al. (2018) · EMBO Reports · doi:10.15252/embr.201845856 · Cited by 7

Defying c-Abl signaling circuits through small allosteric compounds

Gonfloni, S. (2014) · Frontiers in Genetics · doi:10.3389/fgene.2014.00392 · Cited by 7

HSF1 Regulation in Aging and Its Role in Longevity

Shemesh, N., & Ben‐Zvi, A. (2016) · Springer eBooks · doi:10.1007/978-4-431-55852-1_5 · Cited by 7

Rec-8 dimorphism affects longevity, stress resistance and X-chromosome nondisjunction in C. elegans, and replicative lifespan in S. cerevisiae

Ayyadevara, S., Tazearslan, C., Alla, R., Jiang, J. C., Jazwinski, S. M., & Reis, R. J. S. (2014) · Frontiers in Genetics · doi:10.3389/fgene.2014.00211 · Cited by 7

The unfolded protein response of the endoplasmic reticulum protects Caenorhabditis elegans against DNA damage caused by stalled replication forks

Xu, J., Sabatino, B., Yan, J., Ermakova, G., Doering, K. R. S., & Taubert, S. (2024) · G3 Genes Genomes Genetics · doi:10.1093/g3journal/jkae017 · Cited by 6

XPC Promotes Pluripotency of Human Dental Pulp Cells through Regulation of Oct‐4/Sox2/c‐Myc

Liu, L., Peng, Z., Xu, Z., & Wei, X. (2016) · Stem Cells International · doi:10.1155/2016/3454876 · Cited by 6

Gonadotropin-releasing hormone-like receptor 2 inversely regulates somatic proteostasis and reproduction in Caenorhabditis elegans

Kishner, M., Habaz, L., Meshnik, L., Meidan, T. D., Polonsky, A., & Ben‐Zvi, A. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.951199 · Cited by 6

Regulation of the proteostasis network by the neuronal system

Zhu, H., & Cohen, E. (2023) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2023.1290118 · Cited by 6

Stress Signaling: Serotonin Spreads Systemic Stress

Ghazi, A., & Lamitina, T. (2015) · Current Biology · doi:10.1016/j.cub.2014.11.055 · Cited by 6

Floxuridine supports UPS independent of germline signaling and proteostasis regulators via involvement of detoxification in C. elegans

Dubey, A. A., Sarkar, A., Milcz, K., Szulc, N. A., Thapa, P. S., Piechota, M. J., Serwa, R. A., & Pokrzywa, W. (2024) · PLoS Genetics · doi:10.1371/journal.pgen.1011371 · Cited by 5

Prevention of anticancer therapy-induced neurotoxicity: Putting DNA damage in perspective

Brinkmann, V., & Fritz, G. (2022) · NeuroToxicology · doi:10.1016/j.neuro.2022.04.009 · Cited by 5

Editorial: DNA Damage and Inflammation under Stress

Georgakilas, A. G., & Kotsinas, A. (2017) · Frontiers in Genetics · doi:10.3389/fgene.2017.00152 · Cited by 5

Characterization of cellular and molecular immune components of the painted white sea urchin Lytechinus pictus in response to bacterial infection

Nesbit, K. T., Hargadon, A. C., Renaudin, G., Kraieski, N. D., Buckley, K. M., Darin, E., Lee, Y., Hamdoun, A. M., & Schrankel, C. S. (2024) · Immunology and Cell Biology · doi:10.1111/imcb.12828 · Cited by 4

Xeroderma pigmentosum protein XPD controls caspase-mediated stress responses

Wei, H., Weaver, Y. M., & Weaver, B. P. (2024) · Nature Communications · doi:10.1038/s41467-024-53755-8 · Cited by 4

The Somatic Impact on Inheritance and the Germline Control of the Soma

Ishikawa, S., & Schumacher, B. (2025) · Annual Review of Genetics · doi:10.1146/annurev-genet-020325-040022 · Cited by 5

Stress Response: Anything that Doesn’t Kill You Makes You Stronger

Gartner, A., & Akay, A. (2013) · Current Biology · doi:10.1016/j.cub.2013.09.036 · Cited by 4

DNA-Damage-Induced Hormetic Responses

Mägdefrau, A.-S., Ludwig, K., Weigel, C., Köse-Vogel, N., Guerra, G. M., Dakhovnik, A., & Kosan, C. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-814253-0.00013-9 · Cited by 4

Destabilizing the genome as a therapeutic strategy to enhance response to immune checkpoint blockade: a systematic review of clinical trials evidence from solid and hematological tumors

Alotaibi, F., Alshammari, K. M., Alotaibi, B. A., & Alsaab, H. O. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1280591 · Cited by 6

Enhancement of DNA damage repair potential in germ cells of Caenorhabditis elegans by a volatile signal from their irradiated partners

Tang, H., Chen, L., Dai, Z., Zhang, W., Wang, T., Wu, L., Wang, G., & Bian, P. (2019) · DNA repair · doi:10.1016/j.dnarep.2019.102755 · Cited by 4

Active transcriptomic and proteomic reprogramming in theC. elegansnucleotide excision repair mutant xpa-1

Kassahun, H., & Nilsen, H. L. (2013) · Worm · doi:10.4161/worm.27337 · Cited by 4

Hormesis running hot and cold

Bujarrabal-Dueso, A., & Schumacher, B. (2016) · Cell Cycle · doi:10.1080/15384101.2016.1235859 · Cited by 4

The chromatin remodeler LET-418/Mi-2 regulates the intracellular pathogen response in the C. elegans intestine

Rajopadhye, S., Lažetić, V., Rodríguez-Crespo, D., Troemel, E. R., Meister, P., & Wicky, C. (2025) · BMC Genomics · doi:10.1186/s12864-025-12153-0 · Cited by 3

Bushen Huoxue decoction alleviates bisphenol a-induced infertility through the PMK-1 mitogen-activated protein kinases signaling pathway and downstream mitochondrial unfolded protein response in Caenorhabditis elegans

Chen, L., Wu, K., Shou, C., Zhang, L., Tu, M., Wang, B., Cai, Y., Zheng, Z., Sun, J., Ruan, Q., et al. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1713681 · Cited by 3

Beyond the mouse: 3R-guided alternative animal models transforming cancer research

Faehling, T., Reiff, T., Schumacher, B., Arndt, R., Amatruda, J. F., Grünewald, T. G. P., & Cidre‐Aranaz, F. (2026) · Molecular Cancer · doi:10.1186/s12943-026-02601-0 · Cited by 4

Interplay between proteostasis pathways and innate immune responses in Caenorhabditis elegans

Ghosh, A., & Singh, J. (2026) · Infection and Immunity · doi:10.1128/iai.00037-26 · Cited by 3

Molecular Basis for Adaptive Response to Environmental Toxicants or Stresses

Wang, D. (2019) · Springer eBooks · doi:10.1007/978-981-13-3633-1_14 · Cited by 3

Multigenerational downregulation of insulin/IGF‐1 signaling in adulthood improves lineage survival, reproduction, and fitness in Caenorhabditis elegans supporting the developmental theory of ageing

Duxbury, E., Carlsson, H., Sales, K., Sultanova, Z., Immler, S., Chapman, T., & Maklakov, A. A. (2022) · Evolution · doi:10.1111/evo.14640 · Cited by 3

Heat stress impact on reproductive performance in goats

Daramola, J. O., Majekodunmi, B. C., Iyasere, O. S., ADEKUNLE, E. O., Ndubuisi-Ogbonna, L. C., Abioja, M. O., & Oke, O. E. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-13525-5.00004-8 · Cited by 3

Development: Sketch for a Theory of Oct4

Wagner, R. T., & Zwaka, T. P. (2013) · Current Biology · doi:10.1016/j.cub.2013.10.003 · Cited by 3

A novel synthetic novobiocin analog, FM-Nov17, induces DNA damage in CML cells through generation of reactive oxygen species

Zhang, N., Huang, L., Tian, J., Chen, X., Ke, F., Zheng, M., Xu, J., & Wu, L. (2015) · Pharmacological Reports · doi:10.1016/j.pharep.2015.11.002 · Cited by 3

Analysis of representative mutants for key DNA repair pathways on healthspan in Caenorhabditis elegans

Marchal, L., Hamsanathan, S., Karthikappallil, R., Han, S., Shinglot, H., & Gurkar, A. U. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111573 · Cited by 3

In memoriam Olivier Toussaint – Stress-induced premature senescence and the role of DNA damage

Bürkle, A. (2017) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2017.06.003 · Cited by 4

Thermosensory neuron dysfunction alters transposable element regulationPreprint

Szántó, P. R., Meyer, D. H., Bazin-Gelis, M., Vuong-Brender, T. T. K., Teichman, G., Pérez-Llanos, F. J., Rickert, D., Köhrer, K., Rechavi, O., & Schumacher, B. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.12.02.626368 · Cited by 3

Stress Responses as Master Keys to Epigenomic Changes in Transcriptome and Metabolome for Cancer Etiology and Therapeutics

Mondal, A., Bhattacharya, A., Singh, V., Pandita, S., Bacolla, A., PANDITA, R. K., Tainer, J. A., Ramos, K. S., Pandita, T. K., & Das, C. (2021) · Molecular and Cellular Biology · doi:10.1128/mcb.00483-21 · Cited by 2

A Non-Cell-Autonomous Mode of DNA Damage Response in Soma of Caenorhabditis elegans

Dai, Z., Zhang, W., Shang, M., Tang, H., Wu, L., Wu, Y., Wang, T., & Bian, P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23147544 · Cited by 2

Antimicrobial peptide 2K4L inhibits the inflammatory response in macrophages and Caenorhabditis elegans and protects against LPS-induced septic shock in mice

Ji, F., Tian, G., & Shang, D. (2024) · Scientific Reports · doi:10.1038/s41598-024-64511-9 · Cited by 2

Inhibition of the nucleolar RNA exosome facilitates adaptation to starvation

Feng, X., Wang, X., Guang, S., Pang, S., & Tang, H. (2025) · PLoS Biology · doi:10.1371/journal.pbio.3003190 · Cited by 2

Genome Stability in Caenorhabditis elegans

Rieckher, M., Lopes, A. F. C., & Schumacher, B. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803309-8.00011-2 · Cited by 2

Environmental challenges may impact on somatic repairPreprint

Kyriazis, M. (2015) · doi:10.7287/peerj.preprints.1560v1 · Cited by 2

Ultraviolet B acts as a dietary restriction mimetic by targeting mitochondrial bioenergeticsPreprint

Martirosyan, A., Li, Y., Woitzat, Y., Lee, S. H., Fu, L., & Ermolaeva, M. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.03.05.583543 · Cited by 2

Mutation Accumulation Underpins Evolution of Lifespan Extension by Dietary Restriction

Irish, S. D., Kimberley, A. J., Immler, S., Moorad, J. A., & Maklakov, A. A. (2026) · Aging Cell · doi:10.1101/2025.06.18.660314 · Cited by 3

View Micronuclei in the Extent of Evolution: New Insight Into an Old Issue

Yang, S., Yao, H., Zhang, Y., Zhang, W., Jin, S., Huang, K., Song, J., Feng, Y., Li, X., & Wang, X. (2025) · Journal of Cellular Physiology · doi:10.1002/jcp.70079 · Cited by 1

The different meanings of tolerating the gut microbiome

Vidal, V. M., Montes‐Cobos, E., Canto, F. B., & Bozza, M. T. (2026) · mBio · doi:10.1128/mbio.01736-24 · Cited by 1

Single-cell multiomics gene regulatory landscape reveals impaired spermatogonial stem cells and macrophage-driven inflammaging during testicular aging

Lin, N., Zhang, Z., Sha, X., Yao, J., Sun, X.-Z., Sun, R., 杨佳佳, Yu, Q., Wu, Z., Guan, J., et al. (2026) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2026.05.005 · Cited by 1

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

Dubey, A. A., & Ermolaeva, M. (2026) · FEBS Letters · doi:10.1002/1873-3468.70386 · Cited by 1

Honor thy Go(na)ds

Chovatiya, R., & Medzhitov, R. M. (2013) · Immunology and Cell Biology · doi:10.1038/icb.2013.50 · Cited by 1

Germline Signaling Pathways Required for the Regulation of Toxicity of Environmental Toxicants or Stresses

Wang, D. (2019) · Springer eBooks · doi:10.1007/978-981-13-6010-7_11 · Cited by 1

Genome stability in Caenorhabditis elegans

Kovalchuk, I. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-85679-9.00011-8 · Cited by 1

Nematoda: The Caenorhabditis elegans Model for Innate Immunity – Interactions Between Worms and Pathogens, and Their Responses to Immunogenic Damage

Williams, A. B., & Schumacher, B. (2018) · Springer eBooks · doi:10.1007/978-3-319-76768-0_5 · Cited by 1

Sensory neurons safeguard from mutational inheritance by controlling the CEP-1/p53-mediated DNA damage response in primordial germ cellsPreprint

Uszkoreit, S., Meyer, D. H., Rechavi, O., & Schumacher, B. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.07.19.500657 · Cited by 1

The Identification of Novel Mechanisms in Neuronal Development and Degeneration

Jablonski, A. M. (2015) · ScholarlyCommons (University of Pennsylvania)

The innate immune system as mediator of systemic DNA damage responses

Ermolaeva, M., & Schumacher, B. (2013) · Communicative & Integrative Biology · doi:10.4161/cib.26926 · Cited by 18

Differential regulation of DNA damage response activation between somatic and germline cells in Caenorhabditis elegans

Vermezovic, J., Stergiou, L., Hengartner, M. O., & di Fagagna, F. D. (2012) · Cell Death and Differentiation · doi:10.1038/cdd.2012.69 · Cited by 76

Honor thy Go(na)ds

Chovatiya, R., & Medzhitov, R. M. (2013) · Immunology and Cell Biology · doi:10.1038/icb.2013.50 · Cited by 1

Tissue specific response to DNA damage: C. elegans as role model

Lans, H., & Vermeulen, W. (2015) · DNA repair · doi:10.1016/j.dnarep.2015.04.025 · Cited by 58

A Non-Cell-Autonomous Mode of DNA Damage Response in Soma of Caenorhabditis elegans

Dai, Z., Zhang, W., Shang, M., Tang, H., Wu, L., Wu, Y., Wang, T., & Bian, P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23147544 · Cited by 2