Schumacher, Björn

The central role of DNA damage in the ageing process

Schumacher, B., Pothof, J., Vijg, J., & Hoeijmakers, J. H. J. (2021) · Nature

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 907

p53 in the DNA–Damage–Repair Process

Williams, A. B., & Schumacher, B. (2016) · Cold Spring Harbor Perspectives in Medicine

Cancer-related Molecular PathwaysDNA Repair Mechanisms

Cited by 835

The p53 network: cellular and systemic DNA damage responses in aging and Cancer

Reinhardt, H. C., & Schumacher, B. (2012) · Trends in Genetics

Cancer-related Molecular PathwaysTelomeres, Telomerase, and Senescence

Cited by 458

DNA damage responses and p53 in the aging process

Ou, H.-L., & Schumacher, B. (2018) · Blood

Genetics, Aging, and Longevity in Model OrganismsCancer-related Molecular Pathways

Cited by 377

DNA damage in germ cells induces an innate immune response that triggers systemic stress resistance

Ermolaeva, M. A., Segref, A., Dakhovnik, A., Ou, H.-L., Schneider, J. I., Utermöhlen, O., Hoppe, T., & Schumacher, B. (2013) · Nature

Genetics, Aging, and Longevity in Model OrganismsDNA Repair Mechanisms

Cited by 221

Delayed and Accelerated Aging Share Common Longevity Assurance Mechanisms

Schumacher, B., van der Pluijm, I., Moorhouse, M. J., Kosteas, T., Robinson, A. R., Suh, Y., Breit, T. M., van Steeg, H., Niedernhofer, L. J., van IJcken, W., et al. (2008) · PLoS Genetics

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 212

Impact of genomic damage and ageing on stem cell function

Behrens, A., van Deursen, J. M., Rudolph, K. L., & Schumacher, B. (2014) · Nature Cell Biology

Telomeres, Telomerase, and SenescenceDNA Repair Mechanisms

Cited by 207

BiT age: A transcriptome‐based aging clock near the theoretical limit of accuracy

Meyer, D. H., & Schumacher, B. (2021) · Aging Cell

Genetics, Aging, and Longevity in Model OrganismsSingle-cell and spatial transcriptomics

Cited by 165

Persistent transcription-blocking DNA lesions trigger somatic growth attenuation associated with longevity

Garinis, G. A., Uittenboogaard, L. M., Stachelscheid, H., Fousteri, M., van Ijcken, W., Breit, T. M., van Steeg, H., Mullenders, L. H. F., van der Horst, G. T. J., Brüning, J. C., et al. (2009) · Nature Cell Biology

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 138

Accurate aging clocks based on accumulating stochastic variation

Schumacher, B., & Meyer, D. (2023) · Nature Aging

Genetics, Aging, and Longevity in Model OrganismsEpigenetics and DNA Methylation

Cited by 128

Aging clocks based on accumulating stochastic variation

Meyer, D. H., & Schumacher, B. (2024) · Nature Aging

Genetics, Aging, and Longevity in Model OrganismsEpigenetics and DNA Methylation

Cited by 128

Accurate aging clocks based on accumulating stochastic variation

Schumacher, B., & Meyer, D. (2023) · Nature Aging

Genetics, Aging, and Longevity in Model OrganismsEpigenetics and DNA Methylation

Cited by 128

Systemic DNA damage responses in aging and diseases

Ribezzo, F., Shiloh, Y., & Schumacher, B. (2016) · Seminars in Cancer Biology

DNA Repair MechanismsGenetics, Aging, and Longevity in Model Organisms

Cited by 116

DAF-16/FOXO and EGL-27/GATA promote developmental growth in response to persistent somatic DNA damage

Mueller, M. M., Castells-Roca, L., Babu, V., Ermolaeva, M. A., Müller, R.-U., Frommolt, P., Williams, A. B., Greiss, S., Schneider, J. I., Benzing, T., et al. (2014) · Nature Cell Biology

FOXO transcription factor regulationGenetics, Aging, and Longevity in Model Organisms

Cited by 108

Inheritance of paternal DNA damage by histone-mediated repair restriction

Wang, S., Meyer, D. H., & Schumacher, B. (2023) · Nature

DNA Repair MechanismsEffects of Radiation Exposure

Cited by 68

H3K4me2 regulates the recovery of protein biosynthesis and homeostasis following DNA damage

Wang, S., Meyer, D. H., & Schumacher, B. (2020) · Nature Structural & Molecular Biology

Epigenetics and DNA MethylationDNA Repair Mechanisms

Cited by 49

Recent advances in understanding the mechanisms determining longevity

Bayersdorf, R., & Schumacher, B. (2019) · F1000Research

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 14

Restoration of Proteostasis in the Endoplasmic Reticulum Reverses an Inflammation-Like Response to Cytoplasmic DNA in Caenorhabditis elegans

Williams, A. B., Heider, F., Messling, J.-E., Rieckher, M., Bloch, W., & Schumacher, B. (2019) · Genetics

Genetics, Aging, and Longevity in Model OrganismsEndoplasmic Reticulum Stress and Disease

Cited by 10