The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Memory and modularity in cell-fate decision making
Open accessAbstract
Genetically identical cells sharing an environment can display markedly different phenotypes. It is often unclear how much of this variation derives from chance, external signals, or attempts by individual cells to exert autonomous phenotypic programs. By observing thousands of cells for hundreds of consecutive generations under constant conditions, we dissect the stochastic decision between a solitary, motile state and a chained, sessile state in Bacillus subtilis. We show that the motile state is ‘memoryless’, exhibiting no autonomous control over the time spent in the state. In contrast, the time spent as connected chains of cells is tightly controlled, enforcing coordination among related cells in the multicellular state. We show that the three-protein regulatory circuit governing the decision is modular, as initiation and maintenance of chaining are genetically separable functions. As stimulation of the same initiating pathway triggers biofilm formation, we argue that autonomous timing allows a trial commitment to multicellularity that external signals could extend.
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Cites
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Self-citationMemory and Fitness Optimization of Bacteria under Fluctuating Environments
Lambert, G., & Kussell, E. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004556 · Cited by 259
Levin, M. (2022) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2022.768201 · Cited by 195
In situ genotyping of a pooled strain library after characterizing complex phenotypes
Lawson, M. J., Camsund, D., Larsson, J., Baltekin, Ö., Fange, D., & Elf, J. (2017) · Molecular Systems Biology · doi:10.15252/msb.20177951 · Cited by 82
Metadata
- Authors
- Norman, T. M., Lord, N. D., Paulsson, J., & Losick, R.
- Venue
- Nature
- Published
- 2013-11
- Volume
- 503
- Issue
- 7477
- Pages
- 481-486
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2138538544
- Cited by
- 264
- References
- 48
- FWCI
- 8.20
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
