The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Juno is the egg Izumo receptor and is essential for mammalian fertilization
Open accessAbstract
Fertilization occurs when sperm and egg recognize each other and fuse to form a new, genetically distinct organism. The molecular basis of sperm–egg recognition is unknown, but is likely to require interactions between receptor proteins displayed on their surface. Izumo1 is an essential sperm cell-surface protein, but its receptor on the egg has not been described. Here we identify folate receptor 4 (Folr4) as the receptor for Izumo1 on the mouse egg, and propose to rename it Juno. We show that the Izumo1–Juno interaction is conserved within several mammalian species, including humans. Female mice lacking Juno are infertile and Juno-deficient eggs do not fuse with normal sperm. Rapid shedding of Juno from the oolemma after fertilization suggests a mechanism for the membrane block to polyspermy, ensuring eggs normally fuse with just a single sperm. Our discovery of an essential receptor pair at the nexus of conception provides opportunities for the rational development of new fertility treatments and contraceptives.
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Cites
A conditional knockout resource for the genome-wide study of mouse gene function
Skarnes, W. C., Rosen, B., West, A. P., Koutsourakis, M., Bushell, W., Iyer, V., Mujica, A. O., Thomas, M., Harrow, J., Cox, T., et al. (2011) · Nature · doi:10.1038/nature10163 · Cited by 1,708
Tetraspanin functions and associated microdomains
Hemler, M. E. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1736 · Cited by 1,355 · cited 1×
“Tetraspanins are known to organise other membrane proteins within microdomains 32 and quantitative differences in sperm adhesion to Cd9-deficient eggs have been reported 33 .”
Izumo is part of a multiprotein family whose members form large complexes on mammalian sperm
Ellerman, D. A., Pei, J., Gupta, S., Snell, W. J., Myles, D., & Primakoff, P. (2009) · Molecular Reproduction and Development · doi:10.1002/mrd.21092 · Cited by 143
Cited by
Pegtel, D. M., & Gould, S. J. (2019) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-013118-111902 · Cited by 2,682
Exploiting the folate receptor α in oncology
Scaranti, M., Cojocaru, E., Banerjee, S., & Banerji, U. (2020) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-020-0339-5 · Cited by 593
Extracellular vesicles: roles in gamete maturation, fertilization and embryo implantation
Machtinger, R., Laurent, L. C., & Baccarelli, A. A. (2015) · Human Reproduction Update · doi:10.1093/humupd/dmv055 · Cited by 426
Ledermann, J. A., Canevari, S., & Thigpen, T. (2015) · Annals of Oncology · doi:10.1093/annonc/mdv250 · Cited by 347
Hachem, A., Godwin, J., Ruas, M., Lee, H. C., Ferrer Buitrago, M., Ardestani, G., Bassett, A., Fox, S., Navarrete, F., de Sutter, P., et al. (2017) · Development · doi:10.1242/dev.150227 · Cited by 157
Metadata
- Authors
- Bianchi, E., Doe, B., Goulding, D., & Wright, G. J.
- Venue
- Nature
- Published
- 2014-04
- Volume
- 508
- Issue
- 7497
- Pages
- 483-487
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1983611278
- Cited by
- 671
- References
- 3
- FWCI
- 55.76
- Type
- journal article
- Language
- en
- Open access
- green
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