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Cited by 63Barrier Structure and Function StudiesDrug Transport and Resistance MechanismsFatty Acid Research and Health

Double function at the blood–brain barrier

Betsholtz, Christer·2014·Nature
DOI 10.1038/nature13339
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1 of 1 references verified0 citation errors · 0 not checkable

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  • Mfsd2a-deficient mice exhibit impaired brain uptake of lysophosphatidylcholine-long fatty acyl chains and develop blood-brain barrier breakdown, accompanied by neuronal loss in hippocampus and cerebellum causing microcephaly and behavioral deficits.

    “Mfsd2a -deficient mice exhibit impaired brain uptake of lysophosphatidylcholine-long fatty acyl chains and develop BBB breakdown, which is accompanied by neuronal loss in hippocampus and cerebellum causing microcephaly and behavioral deficits (62, 63, 430, 684).”

    From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [63]

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Authors
Betsholtz, C.
Affiliations
Uppsala University (SE)
Corresponding author
Betsholtz, Christer
ORCID
Betsholtz, Christer
Venue
Nature
Publisher
Springer Science and Business Media LLC
Published
2014-05-14
Volume
509
Issue
7501
Pages
432-433
ISSN
  • 0028-0836 (ISSN-L)
  • 1476-4687
DOI
10.1038/nature13339
OpenAlex
W1986638713
Cited by
63
References
1
Citations by year
2026: 3 · 2025: 6 · 2024: 7 · 2023: 4 · 2022: 5 · 2021: 6 · 2020: 6 · 2019: 2 · 2018: 7 · 2017: 3 · 2016: 3 · 2015: 9 · 2014: 2
FWCI
2.95
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Nature (publishedVersion)
  • PubMed (publishedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
  • Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Keywords
blood-brain barrier, MFSD2A, major facilitator superfamily, docosahexaenoic acid, endothelium, brain development, neuronal loss
MeSH terms
Animals, Blood-Brain Barrier, Brain, Docosahexaenoic Acids, Female, Male, Membrane Transport Proteins, Symporters

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