The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Noncoding RNA transcription targets AID to divergently transcribed loci in B cells
Open accessAbstract
The vast majority of the mammalian genome has the potential to express noncoding RNA (ncRNA). The 11-subunit RNA exosome complex is the main source of cellular 3'-5' exoribonucleolytic activity and potentially regulates the mammalian noncoding transcriptome. Here we generated a mouse model in which the essential subunit Exosc3 of the RNA exosome complex can be conditionally deleted. Exosc3-deficient B cells lack the ability to undergo normal levels of class switch recombination and somatic hypermutation, two mutagenic DNA processes used to generate antibody diversity via the B-cell mutator protein activation-induced cytidine deaminase (AID). The transcriptome of Exosc3-deficient B cells has revealed the presence of many novel RNA exosome substrate ncRNAs. RNA exosome substrate RNAs include xTSS-RNAs, transcription start site (TSS)-associated antisense transcripts that can exceed 500 base pairs in length and are transcribed divergently from cognate coding gene transcripts. xTSS-RNAs are most strongly expressed at genes that accumulate AID-mediated somatic mutations and/or are frequent translocation partners of DNA double-strand breaks generated at Igh in B cells. Strikingly, translocations near TSSs or within gene bodies occur over regions of RNA exosome substrate ncRNA expression. These RNA exosome-regulated, antisense-transcribed regions of the B-cell genome recruit AID and accumulate single-strand DNA structures containing RNA-DNA hybrids. We propose that RNA exosome regulation of ncRNA recruits AID to single-strand DNA-forming sites of antisense and divergent transcription in the B-cell genome, thereby creating a link between ncRNA transcription and overall maintenance of B-cell genomic integrity.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“Pathogenic variants in EXOSC3, a noncatalytic subunit of the RNA exosome, cause pontocerebellar hypoplasia type 1B (PCH1B)”
From EXOSC3 G191 Variants Trigger System-Wide Recalibration of RNA Processing Machinery (2026) · cites this paper as [22]
Experimental — accuracy not yet measuredThe check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“PCH1B is a subtype characterized by marked hypotonia, progressive cerebellar atrophy, and motor neuron dysfunction and caused by variants in the EXOSC3 gene15,18,21–23,25.”
From EXOSC3 G191 Variants Trigger System-Wide Recalibration of RNA Processing Machinery (2026) · cites this paper as [22]
Experimental — accuracy not yet measuredThe check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“variants in genes encoding several subunits of the RNA exosome complex have been linked to PCH, including EXOSC3 (PCH1B), EXOSC8 (PCH1C), EXOSC9 (PCH1D), and provisionally EXOSC1 (PCH1F)15–25.”
From EXOSC3 G191 Variants Trigger System-Wide Recalibration of RNA Processing Machinery (2026) · cites this paper as [22]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Fast and accurate short read alignment with Burrows-Wheeler transform
Li, H., & Durbin, R. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp324 · Cited by 58,607
BEDTools: a flexible suite of utilities for comparing genomic features
Quinlan, A. R., & Hall, I. M. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq033 · Cited by 27,437
Differential expression analysis for sequence count data
Anders, S., & Huber, W. (2010) · Genome Biology · doi:10.1186/gb-2010-11-10-r106 · Cited by 15,581
Trapnell, C., Williams, B. A., Pertea, G., Mortazavi, A., Kwan, G., van Baren, M. J., Salzberg, S. L., Wold, B. J., & Pachter, L. (2010) · Nature Biotechnology · doi:10.1038/nbt.1621 · Cited by 15,556
TopHat: discovering splice junctions with RNA-Seq
Trapnell, C., Pachter, L. S., & Salzberg, S. L. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp120 · Cited by 11,682
Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity
Ran, F. A., Hsu, P. D., Lin, C.-Y., Gootenberg, J. S., Konermann, S., Trevino, A. E., Scott, D. A., Inoue, A., Matoba, S., Zhang, Y., et al. (2013) · Cell · doi:10.1016/j.cell.2013.08.021 · Cited by 3,299
A new logic for DNA engineering using recombination in Escherichia coli
Zhang, Y., Buchholz, F., Muyrers, J. P. P., & Stewart, A. F. (1998) · Nature Genetics · doi:10.1038/2417 · Cited by 1,228
Lohr, J. G., Stojanov, P., Lawrence, M. S., Auclair, D., Chapuy, B., Sougnez, C. L., Cruz‐Gordillo, P., Knoechel, B., Asmann, Y. W., Slager, S. L., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1121343109 · Cited by 992
Analysis of the coding genome of diffuse large B-cell lymphoma
Pasqualucci, L., Trifonov, V. A., Fabbri, G., Ma, J., Rossi, D., Chiarenza, A., Wells, V. A., Grunn, A., Messina, M., Elliott, O., et al. (2011) · Nature Genetics · doi:10.1038/ng.892 · Cited by 971
R-Loop Formation Is a Distinctive Characteristic of Unmethylated Human CpG Island Promoters
Ginno, P. A., Lott, P. C., Christensen, H. C., Korf, I. F., & Chedin, F. L. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.01.017 · Cited by 930
Flagged first, then by citations
Cited by
Sorted by citations
Items 101–200 of 201
Recent advances in understanding transcription termination by RNA polymerase II
Loya, T. J., & Reines, D. (2016) · F1000Research · doi:10.12688/f1000research.8455.1 · Cited by 17
RNA Exosome Complex-Mediated Control of Redox Status in Pluripotent Stem Cells
Skamagki, M., Zhang, C., Ross, C. A., Ananthanarayanan, A., Liu, Z., Mu, Q., Basu, U., Wang, J., Zhao, R., Li, H., et al. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.08.024 · Cited by 16
Self-citationLeeman‐Neill, R. J., Lim, J., & Basu, U. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1801246 · Cited by 16
Self-citationLoop extrusion promotes an alternate pathway for isotype switching
Shen, H. M., Wuerffel, R., Cantillo, J. F., Priyadarshi, S., Lei, X., Liang, J., Wu, Y. L., & Kenter, A. L. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.110059 · Cited by 16
Khair, L., Baker, R. E., Linehan, E. K., Schrader, C. E., & Stavnezer, J. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1005438 · Cited by 16
Maity, A., Chaudhuri, A., & Das, B. (2016) · FEMS Yeast Research · doi:10.1093/femsyr/fow088 · Cited by 14
Roles of G4-DNA and G4-RNA in Class Switch Recombination and Additional Regulations in B-Lymphocytes
Dézé, O., Laffleur, B., & Cogné, M. (2023) · Molecules · doi:10.3390/molecules28031159 · Cited by 15
Wu, L., Yadavalli, A. D., Šenigl, F., Matos-Rodrigues, G. E., Xu, D., Pintado-Urbanc, A. P., Simon, M. D., Wu, W., Nussenzweig, A., & Schatz, D. G. (2024) · Molecular Cell · doi:10.1016/j.molcel.2025.02.007 · Cited by 14
RNA Exosomes and Their Cofactors
Kilchert, C. (2019) · Methods in molecular biology · doi:10.1007/978-1-4939-9822-7_11 · Cited by 14
The Rat Brain Transcriptome: From Infancy to Aging and Sporadic Alzheimer’s Disease-like Pathology
Stefanova, N. A., & Kolosova, N. G. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021462 · Cited by 15
Müller, J. S., Giunta, M., & Horváth, R. (2015) · Journal of Neuromuscular Diseases · doi:10.3233/jnd-150086 · Cited by 14
Effects of senataxin and RNA exosome on B-cell chromosomal integrity
Kazadi, D., Lim, J., Rothschild, G., Grinstein, V., Laffleur, B., Bécherel, O. J., Lavin, M. F., & Basu, U. (2020) · Heliyon · doi:10.1016/j.heliyon.2020.e03442 · Cited by 13
Self-citationNew twists on long noncoding RNAs: from mobile elements to motile cancer cells
Nguyen, T. M., Alchalabi, S., Adewunmi, O., Ropri, A. S., Herschkowitz, J. I., & Rosen, J. M. (2020) · RNA Biology · doi:10.1080/15476286.2020.1760535 · Cited by 13
Generation of Genomic Alteration from Cytidine Deamination
Liu, X., & Meng, F. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-0593-1_5 · Cited by 13
RNA Polymerase Collision versus DNA Structural Distortion: Twists and Turns Can Cause Break Failure
Pannunzio, N. R., & Lieber, M. R. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.03.034 · Cited by 12
Jin, Y., Lu, Y., Lin, L., Liu, C., Ma, X., Chen, X., Zhou, Z., Hu, Z., Pu, J., Guo, C., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2215155120 · Cited by 12
RNA-regulatory exosome complex confers cellular survival to promote erythropoiesis
Mehta, C., de Andrade, I. F., Matson, D. R., Dewey, C. N., & Bresnick, E. H. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab367 · Cited by 11
A Chemical Biology Approach to Model Pontocerebellar Hypoplasia Type 1B (PCH1B)
François‐Moutal, L., Jahanbakhsh, S., Nelson, A. D. L., Ray, D., Scott, D. D., Hennefarth, M. R., Moutal, A., Perez‐Miller, S., Ambrose, A. J., Al-Shamari, A., et al. (2018) · ACS Chemical Biology · doi:10.1021/acschembio.8b00745 · Cited by 12
Noncoding RNAs in B cell responses
Wigton, E. J., & Ansel, K. M. (2021) · RNA Biology · doi:10.1080/15476286.2021.1885876 · Cited by 11
AID hits the jackpot when missing the target
Kenter, A. L., Kumar, S., Wuerffel, R., & Grigera, F. (2016) · Current Opinion in Immunology · doi:10.1016/j.coi.2016.01.008 · Cited by 11
Sterrett, M. C., Enyenihi, L., Leung, S. W., Hess, L., Strassler, S. E., Farchi, D., Lee, R. S., Withers, E. S., Kremsky, I., Baker, R. E., et al. (2021) · RNA · doi:10.1261/rna.078618.120 · Cited by 9
Super-Enhancer Transcription Converges on AID
Alinikula, J., & Schatz, D. G. (2014) · Cell · doi:10.1016/j.cell.2014.12.007 · Cited by 10
Sterrett, M. C., Cureton, L. A., Cohen, L. N., van Hoof, A., Khoshnevis, S., Fasken, M. B., Corbett, A. H., & Ghalei, H. (2025) · RNA · doi:10.1261/rna.080447.125 · Cited by 9
Heo, D., Kuś, K., Grzechnik, P., Tan‐Wong, S. M., Birot, A., Kecman, T., Nielsen, S., Zenkin, N., & Vasiljeva, L. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109671 · Cited by 9
Wu, D., & Dean, J. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113247 · Cited by 10
RNA processing mechanisms contribute to genome organization and stability in B cells
Miglierina, E., Ordanoska, D., Noir, S. L., & Laffleur, B. (2024) · Oncogene · doi:10.1038/s41388-024-02952-2 · Cited by 7
Yuan, Y., Mao, X., Abubakar, Y. S., Zheng, W., Wang, Z., Zhou, J., & Zheng, H. (2023) · Microbiology Spectrum · doi:10.1128/spectrum.05058-22 · Cited by 8
Repair of programmed DNA lesions in antibody class switch recombination: common and unique features
Shang, Y., & Meng, F. (2021) · Genome Instability & Disease · doi:10.1007/s42764-021-00035-0 · Cited by 8
Somatic hypermutation mechanisms during lymphomagenesis and transformation
Lauring, M. C., & Basu, U. (2024) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2024.102165 · Cited by 7
Self-citationThe RNA exosome maintains cellular RNA homeostasis by controlling transcript abundance in the brain
Higginson, L. A., Wang, X., He, K., Torstrick, M., Kim, M., Wijeratne, H. R. S., Runnebohm, A. M., Benayoun, B. A., MacLean, A., Chanfreau, G. F., et al. (2026) · Cell Reports · doi:10.1016/j.celrep.2025.116729 · Cited by 7
Taming AID mutator activity in somatic hypermutation
Qin, Y., & Meng, F. (2024) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2024.03.011 · Cited by 7
Zheng, X., Gan, S., Su, C., Zheng, Z., Liao, Y., Shao, J., Zhu, Z., & Chen, W. (2022) · Bioengineered · doi:10.1080/21655979.2022.2044274 · Cited by 6
Prediction and Dissection of Protein-RNA Interactions by Molecular Descriptors
Liu, Z.-P., & Chen, L. (2015) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026615666150819110703 · Cited by 6
Regulating infidelity: RNA‐mediated recruitment of AID to DNA during class switch recombination
DiMenna, L. J., & Chaudhuri, J. (2016) · European Journal of Immunology · doi:10.1002/eji.201545809 · Cited by 6
Wang, R., Zhang, X., Ding, H., Qiao, Y., Han, X., Geng, W., Guan, G., Cui, H., Zhao, B., Wu, Y., et al. (2017) · FEBS Letters · doi:10.1002/1873-3468.12954 · Cited by 6
Sterrett, M. C., Farchi, D., Strassler, S. E., Boise, L. H., Fasken, M. B., & Corbett, A. H. (2023) · G3: Genes, Genomes, Genetics · doi:10.1093/g3journal/jkad049 · Cited by 5
Putative RNA-directed adaptive mutations in cancer evolution
Auboeuf, D. (2016) · Transcription · doi:10.1080/21541264.2016.1221491 · Cited by 4
Kim, A., Han, L., & Yu, K. (2020) · Molecular and Cellular Biology · doi:10.1128/mcb.00125-20 · Cited by 5
The IgH Eµ-MAR regions promote UNG-dependent error-prone repair to optimize somatic hypermutation
Martin, O. A., Thomas, M., Marquet, M., Bruzeau, C., Garot, A., Brousse, M., Bender, S., Carrion, C., Choi, J. E., Vuong, B. Q., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1030813 · Cited by 5
AID in non-Hodgkin B-cell lymphomas: The consequences of on- and off-target activity
Leeman‐Neill, R. J., Bhagat, G., & Basu, U. (2024) · Advances in immunology · doi:10.1016/bs.ai.2024.03.005 · Cited by 5
Self-citationCellular imbalance of specific RNA-binding proteins associates with harmful R-loops
Mérida-Cerro, J. A., Chevreux, G., Palancade, B., Rondón, A. G., & Aguilera, A. (2025) · PLoS Genetics · doi:10.1371/journal.pgen.1011491 · Cited by 4
Cheon, Y., Alvstad, E., Torre, D., Quach, D. T., Nguyen, J., Hyun, K., Zhou, M., Yu, T., Liu, L., Yoon, Y., et al. (2026) · Nature Structural & Molecular Biology · doi:10.1038/s41594-026-01757-z · Cited by 4
Self-citationDIS3 licenses B cells for plasma cell differentiation in humans
Miglierina, E., Bouder, J., Ordanoska, D., Pineau, M., Léonard, S., Schavgoulidze, A., Quéré, G., Goff, M. L., Bouchet, M., Genebrier, S., et al. (2025) · Cellular and Molecular Immunology · doi:10.1038/s41423-025-01369-5 · Cited by 3
Mikhova, M., Kapanka, M., Han, L., Ungor, G., Schmidt, J. C., & Yu, K. (2026) · Molecular Cell · doi:10.1016/j.molcel.2026.06.012 · Cited by 4
Mechanism and regulation of secondary immunoglobulin diversification
Bello, A., Hirth, G., Voigt, S., Tepper, S., & Jungnickel, B. (2023) · Cell Cycle · doi:10.1080/15384101.2023.2275397 · Cited by 3
Lu, G., Liu, H., Wang, H., Tang, X., Luo, S., Du, M., Christiani, D. C., & Wei, Q. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1440454 · Cited by 4
de Amorim, J. L., Asafu-Adjaye, D., & Corbett, A. H. (2023) · RNA & DISEASE · doi:10.14800/rd.1247 · Cited by 3
Ridani, J., Barbulescu, P., Martín, A., & Noia, J. M. D. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95895-0.00012-x · Cited by 3
Kassab, M. A., Chen, Y., Wang, X., He, B., Brown, E. J., & Yu, X. (2024) · BMC Biology · doi:10.1186/s12915-024-01947-5 · Cited by 3
Unfolding the Role of Splicing Factors and RNA Debranching in AID Mediated Antibody Diversification
Jaiswal, A. K., Singh, A. K., Tamrakar, A., & Kodgire, P. (2020) · International Reviews of Immunology · doi:10.1080/08830185.2020.1815725 · Cited by 3
The RNA helicase DDX1 associates with the nuclear RNA exosome and modulates R-loopsPreprint
de Amorim, J. L., Leung, S. W., Haji‐Seyed‐Javadi, R., Hou, Y., Yu, D. S., Ghalei, H., Khoshnevis, S., Yao, B., & Corbett, A. H. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.04.17.537228 · Cited by 3
Multiple Myeloma associated DIS3 mutations drive AID-dependent IGH TranslocationsPreprint
Kuliński, T. M., Gewartowska, O., Mahé, M., Kasztelan, K., Durys, J., Stroynowska-Czerwińska, A., Jedynak-Slyvka, M., Owczarek, E. P., Chaudhury, D., Nowotny, M., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.07.27.550610 · Cited by 3
Kuliński, T. M., Gewartowska, O., Mroczek, S., Szpila, M., Sałas, K., Liudkovska, V., & Dziembowski, A. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.07.27.550471 · Cited by 3
Wu, M., Schmid, M., Jensen, T. H., & Sandelin, A. (2022) · NAR Genomics and Bioinformatics · doi:10.1093/nargab/lqac071 · Cited by 2
Regulation of mRNA metabolism in immune cells
Negi, M. S., Soskic, B., & Legnini, I. (2025) · FEBS Letters · doi:10.1002/1873-3468.70132 · Cited by 2
AID and TET2 cooperate to demethylate Irf4 for plasma cell fate in germinal center B cells
He, M., D’Aulerio, R., Pinho, L. G., Doukoumopoulos, E., Yong, T., Vieira, R. C., Oliveira, M. M. S., Eiben, L., Termote, M., Galvani, R. G. A., et al. (2026) · The Journal of Experimental Medicine · doi:10.1084/jem.20260096 · Cited by 3
The Molecular Logic of Immunoglobulin Heavy Chain Class Switch Recombination
Yewdell, W. T., Fernandez, K. C., Downs‐Canner, S., & Chaudhuri, J. (2026) · Annual Review of Immunology · doi:10.1146/annurev-immunol-082323-121803 · Cited by 2
Malaria-Induced B Cell Genomic Instability
Rothschild, G., von Krusenstiern, A. N., & Basu, U. (2015) · Cell · doi:10.1016/j.cell.2015.07.051 · Cited by 2
Self-citationWang, W. T., Ding, Y., Xu, Y., Yang, H., Liu, W., Wang, H., Chen, C., Liu, R., & Li, S. (2019) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmz064 · Cited by 2
Long Non-coding RNAs in the Development and Maintenance of Lymphoid Malignancies
Winkle, M., Dzikiewicz‐Krawczyk, A., Kluiver, J. L., & van den Berg, A. (2019) · Springer eBooks · doi:10.1007/978-3-030-17086-8_6 · Cited by 2
Schoeberl, U. E., Fitz, J., Froussios, K., Valieris, R., Ourailidis, I., Makharova, M., Bauer, B., Neumann, T., Wiedemann, E.-M., Steininger, M., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.05.21.492925 · Cited by 2
Schoeberl, U. E., Fitz, J., Froussios, K., Valieris, R., Ourailidis, I., Makharova, M., Bauer, B., Neumann, T., Wiedemann, E.-M., Steininger, M., et al. (2025) · eLife · doi:10.7554/elife.106566.1 · Cited by 2
EXOSC3 G191 Variants Trigger System-Wide Recalibration of RNA Processing Machinery
Wijeratne, H. R. S., Runnebohm, A. M., Barron, M. P., Hampton, A. J., Li, R., Peck Justice, S. A., Lenceski, S. H., Rooney, J. D., Smith-Kinnaman, W. R., Chang, G. S., et al. (2026) · doi:10.64898/2026.01.26.701775 · Cited by 1
de Andrade, I. F., Johnson, K. D., Mehta, C., Dewey, C. N., Basu, U., & Bresnick, E. H. (2022) · Blood Advances · doi:10.1182/bloodadvances.2022008481 · Cited by 2
Self-citationSomatic hypermutation patterns are shaped by both motif position and sequence grammar
Bartl, B., Schoeberl, U. E., Valieris, R., Fitz, J., Röder, K., Vinothkumar, K. R., Gundinger, B., da Silva, I. T., & Pavri, R. (2025) · The EMBO Journal · doi:10.1038/s44318-025-00640-9 · Cited by 1
Kuliński, T. M., Gewartowska, O., Mahé, M., Kasztelan, K., Durys, N., Stroynowska-Czerwińska, A., Jedynak-Slyvka, M., Owczarek, E. P., Chaudhury, D., Nowotny, M., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-70386-3 · Cited by 5
A 3D genome atlas of human tonsil and the role of loop extrusion in B cell somatic hypermutation
Cheng, Y., Wang, J., Zhang, Y., Yadavalli, A. D., Liu, M., Jin, S., Buddle, G., Haberman, A. M., Schatz, D. G., & Wang, S. S. (2026) · Science · doi:10.1126/science.adw4243 · Cited by 1
Self-citationHistone readers MLLT1 and MLLT3 concentrate AID to confer locus specificity
Seija, N., Gannon, S., Häfner, K. A., Gemeinhardt, T. M., Ridani, J., Álvarez-Saravia, D., Provencher, M., Subramani, P. G., Poitras, C., Piskor, E.-M., et al. (2026) · Nature · doi:10.1038/s41586-026-11087-1 · Cited by 1
Mechanism and Regulation of Immunoglobulin Class Switch Recombination
Meng, F., Nair, L., Fernandez, K. C., Basu, U., & Chaudhuri, J. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95895-0.00021-0 · Cited by 1
Self-citationTambe, A., MacCarthy, T., & Pavri, R. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1407470 · Cited by 1
The IgH Eμ -MAR regions promote UNG-dependent error-prone repair to optimize somatic hypermutationPreprint
Martin, O. A., Thomas, M., Marquet, M., Garot, A., Brousse, M., Bender, S., Carrion, C., Choi, J. E., Vuong, B. Q., Gearhart, P. J., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.08.15.503996 · Cited by 1
AID in Somatic Hypermutation and Class Switch Recombination
Zahn, A., & Noia, J. M. D. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-374279-7.05014-1
Investigation of Ring Finger Protein 8 in Mammalian Physiology and Pathogenesis
Li, L. (2015) · TSpace (University of Toronto)
Molecular Mechanisms of Activation Induced Deaminase Specificity
Prado, Á. F. Á. (2018) · doi:10.4321/repisalud.6447
Economos, N. G., Delker, R. K., Stavropoulos, P., & Papavasiliou, F. N. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/469775
Biochemical And Cellular Studies Of Apobec3 Family Dna-Cytosine Deaminases
Siriwardena, S. U. (2018) · Human Biology
OHLSSON, R. I., & Göndör, A. (2018) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.727652056.793546050
Sterrett, M. C., Farchi, D., Strassler, S. E., Boise, L., Fasken, M. B., & Corbett, A. H. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.10.31.514520
Alternative DNA structures in hematopoiesis and adaptive immunity
Kligfeld, H., Han, I., Abraham, A., & Shukla, V. (2024) · Advances in immunology · doi:10.1016/bs.ai.2024.03.002
Oestrogen influences B cell class-switching in individuals with an XX sex chromosome complementPreprint
Peckham, H., Radziszewska, A., de Gruijter, N. M., Restuadi, R., Kartawinata, M., Robinson, G., Martin‐Gutierrez, L., Deakin, C. T., Wedderburn, L. R., Jury, E. C., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.07.18.604160
Activation Induced Deaminase in Antibody Diversification by DNA Editing
Häfner, K., Ridani, J., Zahn, A., & Noia, J. M. D. (2024) · Elsevier eBooks · doi:10.1016/b978-0-128-24465-4.00084-3
Different alterations in mRNP composition trigger an increase in harmful R-loopsPreprint
Mérida-Cerro, J. A., Chevreux, G., Palancade, B., Rondón, A. G., & Aguilera, A. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.11.11.622913
AID facilitates TET2 demethylation of Irf4 for plasma cell fate in germinal center B cellsPreprint
He, M., D’Aulerio, R., Pinho, L. G., Doukoumopoulos, E., Yong, T., Vieira, R. C., Oliveira, M. M. S., Galvani, R. G. A., Sedimbi, S. K., Seitz, C., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.02.651162
Schoeberl, U. E., Fitz, J., Froussios, K., Valieris, R., Ourailidis, I., Makharova, M., Bauer, B., Neumann, T., Wiedemann, E.-M., Steininger, M., et al. (2025) · eLife · doi:10.7554/elife.106566
Pan, Y., Zuo, H., Yan, X., Li, J., Li, Y., Li, J., Wu, Y., Hong, L., Wang, M., Wu, A., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.116650
The cohesin and mediator complexes control immunoglobulin class switch recombination
Thomas-Claudepierre, A.-S. (2014) · theses.fr (ABES) · doi:10.70675/260132cfze9b6z46ddzb034z6678b5125b15
Transcriptional regulation of the IgH locus during class switch recombination
Villa, R. A. (2019) · theses.fr (ABES) · doi:10.70675/225724a2z0ab6z4f8bzbb39zefb79aaf044e
Precision in RNA degradation: helicases, ribosome and RNA polymerase stalling, and RNA modifications
Whisenant, D., Soltys, J., Estrella, J. D., & Basu, U. (2026) · Trends in Cell Biology · doi:10.1016/j.tcb.2026.04.005
Self-citationSun, S., Yang, C., Wang, X., Hu, N., Zhang, S., Li, X., Chen, Y., Zhai, J., 唐湘凤, Lu, W., et al. (2026) · Advanced Science · doi:10.1002/advs.75609
Long non-coding RNAs and survival outcomes in chronic lymphocytic leukemia
Karan-Djurašević, T., Marjanović, I., & Tos̆ić, N. (2026) · Pharmacogenomics · doi:10.1080/14622416.2026.2671918
Deriglazov, D. A., Petrova, N. V., Luzhin, A. V., Pavlenko, N. G., Tatarskiy, V. V., Kazakov, E. P., Kireev, I. I., Kurkin, A. V., Novoselov, A. M., Efremov, Y. M., et al. (2026) · Nucleus · doi:10.1080/19491034.2026.2672818
The RNA exosome: mechanisms of RNA surveillance, regulation, and disease
Upadhyai, P., Quadri, N., & Chandran, D. (2026) · RNA Biology · doi:10.1080/15476286.2026.2685379
RNA exonuclease REXO4 resolves m6A-marked R-loops and suppresses anti-tumor immunity
Zhang, J., Bao, K., Hou, Y., Zhao, N., Chen, Q., Yang, Z., Nie, R., Zhang, C., Wang, H., Zhang, H., et al. (2026) · Molecular Cell · doi:10.1016/j.molcel.2026.06.036
Biallelic pathogenic variants in EXOSC3 mediate thrombotic microangiopathy of the kidney
Walsh, P. R., Basu, U., Barakat, T. S., Beck, B. B., Bertini, E., Brocklebank, V., Corderio, N., Ćomić, J., Abazi‐Emini, N., Fluss, J., et al. (2026) · Kidney International · doi:10.1016/j.kint.2026.06.028
Self-citationHUSH, NEXT PROMPT: Epigenetics and the Nuclear RNA Exosome in Human Aging and Disease
Newman, A. G., & Singh, P. B. (2026) · Cells · doi:10.3390/cells15151378
Co-option of retrotransposons promotes antibody diversification
Lauring, M. C., Yang, M., Sarode, A. Y., Wang, J., Ni, Z., Froehlich, K. A., Zhang, W., Wahed, S., Zheng, S., Goff, S. P., et al. (2026) · Cell · doi:10.1016/j.cell.2026.07.021
Self-citationYang-Fischer, R., Shearer, A., Zhao, J., Nelson, T., Santín, I., Leão, F. B., Castellanos–Rubio, A., Bhagat, G., Basu, U., & Ghosh, S. (2026) · Immunity · doi:10.1016/j.immuni.2026.07.019
Self-citation
Metadata
- Authors
- Pefanis, E., Wang, J., Rothschild, G., Lim, J., Chao, J., Rabadan, R., Economides, A. N., & Basu, U.
- Affiliations
- Columbia University (US)
- Regeneron (United States) (US)
- Corresponding author
- Basu, Uttiya
- Venue
- Nature
- Published
- 2014-08-06
- Volume
- 514
- Issue
- 7522
- Pages
- 389-393
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC4372240
- OpenAlex
- W1987152324
- Cited by
- 201
- References
- 40
- Citations by year
- 2026: 19 · 2025: 12 · 2024: 15 · 2023: 17 · 2022: 14 · 2021: 15 · 2020: 14 · 2019: 15 · 2018: 18 · 2017: 15 · 2016: 22 · 2015: 19 · 2014: 6
- FWCI
- 8.48
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Rare & Special e-Zone (The Hong Kong University of Science and Technology) (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- National Institutes of Health (1dp2od008651-01)
- National Cancer Institute (U54CA121852, R01CA185486, R01CA179044)
- National Institute of Allergy and Infectious Diseases (R01AI099195)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
- Keywords
- RNA exosome, EXOSC3, activation-induced cytidine deaminase, AID, non-coding RNA, antisense transcription, divergent transcription, class switch recombination, somatic hypermutation, R-loops, genomic instability, chromosomal translocation, B cells, conditional knockout mice, transcription start sites, antibody diversity, 3'-5' exoribonuclease
- MeSH terms
- AICDA (Activation-Induced Cytidine Deaminase), Animals, B-Lymphocytes, Cytidine Deaminase, DNA, Single-Stranded, Female, Immunoglobulin Heavy Chains, Male, Nucleic Acid Hybridization, Substrate Specificity, Transcription, Genetic, Translocation, Genetic, RNA, Antisense, RNA-Binding Proteins, Genome, Immunoglobulin Class Switching, Base Pairing, RNA, Untranslated, Transcription Initiation Site, Somatic Hypermutation, Immunoglobulin, Genomic Instability, Mice, DNA Breaks, Double-Stranded, Exosomes, Exosome Multienzyme Ribonuclease Complex
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
