The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
DNA methylation dynamics of the human preimplantation embryo
Open accessAbstract
In mammals, cytosine methylation is predominantly restricted to CpG dinucleotides and stably distributed across the genome, with local, cell-type-specific regulation directed by DNA binding factors. This comparatively static landscape is in marked contrast with the events of fertilization, during which the paternal genome is globally reprogrammed. Paternal genome demethylation includes the majority of CpGs, although methylation remains detectable at several notable features. These dynamics have been extensively characterized in the mouse, with only limited observations available in other mammals, and direct measurements are required to understand the extent to which early embryonic landscapes are conserved. We present genome-scale DNA methylation maps of human preimplantation development and embryonic stem cell derivation, confirming a transient state of global hypomethylation that includes most CpGs, while sites of residual maintenance are primarily restricted to gene bodies. Although most features share similar dynamics to those in mouse, maternally contributed methylation is divergently targeted to species-specific sets of CpG island promoters that extend beyond known imprint control regions. Retrotransposon regulation is also highly diverse, and transitions from maternally to embryonically expressed elements. Together, our data confirm that paternal genome demethylation is a general attribute of early mammalian development that is characterized by distinct modes of epigenetic regulation.
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Cites
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Self-citationSingle-cell RNA-Seq profiling of human preimplantation embryos and embryonic stem cells
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Self-citationA unique regulatory phase of DNA methylation in the early mammalian embryo
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Cited by
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A Unique Gene Regulatory Network Resets the Human Germline Epigenome for Development
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Principles of DNA methylation and their implications for biology and medicine
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Dynamic stem cell states: Naive to primed pluripotency in rodents and humans
Weinberger, L., Ayyash, M., Novershtern, N., & Hanna, J. H. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2015.28 · Cited by 622
Roles of transposable elements in the regulation of mammalian transcription
Fueyo, R., Judd, J., Feschotte, C., & Wysocka, J. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00457-y · Cited by 451
Metadata
- Authors
- Smith, Z. D., Chan, M. M., Humm, K. C., Karnik, R., Mekhoubad, S., Regev, A., Eggan, K., & Meissner, A.
- Venue
- Nature
- Published
- 2014-07-23
- Volume
- 511
- Issue
- 7511
- Pages
- 611-615
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2107202213
- Cited by
- 580
- References
- 31
- FWCI
- 27.01
- Type
- journal article
- Language
- en
- Open access
- green
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- Smith, Z. D., Chan, M. M., Humm, K. C., Karnik, R., Mekhoubad, S., Regev, A., Eggan, K., & Meissner, A. (2014). DNA methylation dynamics of the human preimplantation embryo. Nature. https://doi.org/10.1038/nature13581
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