The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Piezo1 integration of vascular architecture with physiological force
Open accessAbstract
The mechanisms by which physical forces regulate endothelial cells to determine the complexities of vascular structure and function are enigmatic. Studies of sensory neurons have suggested Piezo proteins as subunits of Ca2+-permeable non-selective cationic channels for detection of noxious mechanical impact. Here we show Piezo1 (Fam38a) channels as sensors of frictional force (shear stress) and determinants of vascular structure in both development and adult physiology. Global or endothelial-specific disruption of mouse Piezo1 profoundly disturbed the developing vasculature and was embryonic lethal within days of the heart beating. Haploinsufficiency was not lethal but endothelial abnormality was detected in mature vessels. The importance of Piezo1 channels as sensors of blood flow was shown by Piezo1 dependence of shear-stress-evoked ionic current and calcium influx in endothelial cells and the ability of exogenous Piezo1 to confer sensitivity to shear stress on otherwise resistant cells. Downstream of this calcium influx there was protease activation and spatial reorganization of endothelial cells to the polarity of the applied force. The data suggest that Piezo1 channels function as pivotal integrators in vascular biology.
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Cites
Universal sample preparation method for proteome analysis
Wiśniewski, J. R., Zougman, A., Nagaraj, N., & Mann, M. (2009) · Nature Methods · doi:10.1038/nmeth.1322 · Cited by 8,352
VEGF receptor signalling ? in control of vascular function
Olsson, A.-K., Dimberg, A., Kreuger, J., & Claesson-Welsh, L. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1911 · Cited by 3,122
The Mechanosensitive Ion Channel Piezo1 Is Inhibited by the Peptide GsMTx4
Bae, C., Sachs, F., & Gottlieb, P. A. (2011) · Biochemistry · doi:10.1021/bi200770q · Cited by 566
Fluid forces control endothelial sprouting
Song, J. W., & Munn, L. L. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1105316108 · Cited by 498
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Disturbed Flow Promotes Endothelial Senescence via a p53-Dependent Pathway
Warboys, C. M., de Luca, A., Amini, N., Luong, L., Duckles, H., Hsiao, S., White, A., Biswas, S., Khamis, R., Chong, C. K., et al. (2014) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.114.303415 · Cited by 227
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Recent insights into the cellular biology of atherosclerosis
Tabas, I., García-Cardeña, G., & Owens, G. K. (2015) · Journal of Cell Biology · doi:10.1083/jcb.201412052 · Cited by 1,016
Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity
Solis, A. G., Bielecki, P., Steach, H. R., Sharma, L., Harman, C. C. D., Yun, S., de Zoete, M. R., Warnock, J. N., To, S. D. F., York, A. G., et al. (2019) · Nature · doi:10.1038/s41586-019-1485-8 · Cited by 678
Stretch-activated ion channel Piezo1 directs lineage choice in human neural stem cells
Pathak, M. M., Nourse, J. L., Tran, T., Hwe, J., Arulmoli, J., Le, D. T. T., Bernardis, E., Flanagan, L. A., & Tombola, F. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1409802111 · Cited by 657
Mechanosensing is critical for axon growth in the developing brain
Koser, D. E., Thompson, A. J., Foster, S. K., Dwivedy, A., Pillai, E. K., Sheridan, G. K., Svoboda, H., Viana, M., Costa, L. D. F., Guck, J., et al. (2016) · Nature Neuroscience · doi:10.1038/nn.4394 · Cited by 649
Mechanically Activated Ion Channels
Ranade, S. S., Syeda, R., & Patapoutian, A. (2015) · Neuron · doi:10.1016/j.neuron.2015.08.032 · Cited by 652
Metadata
- Authors
- Li, J., Hou, B., Tumova, S., Muraki, K., Bruns, A., Ludlow, M. J., Sedo, A., Hyman, A. J., McKeown, L., Young, R. S., Yuldasheva, N. Y., Majeed, Y., Wilson, L. A., Rode, B., Bailey, M. A., Kim, H. R., Fu, Z., Carter, D. A. L., Bilton, J., Imrie, H., Ajuh, P., Dear, T. N., Cubbon, R. M., Kearney, M. T., Prasad, K. R., Evans, P. C., Ainscough, J. F. X., & Beech, D. J.
- Venue
- Nature
- Published
- 2014-08-10
- Volume
- 515
- Issue
- 7526
- Pages
- 279-282
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1983897833
- Cited by
- 1,223
- References
- 6
- FWCI
- 23.90
- Type
- journal article
- Language
- en
- Open access
- green
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